LOCUS       NM_007523               2018 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus BCL2-antagonist/killer 1 (Bak1), transcript variant 1,
            mRNA.
ACCESSION   NM_007523 XM_359297
VERSION     NM_007523.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Wright,T., Turnis,M.E., Grace,C.R., Li,X., Brakefield,L.A.,
            Wang,Y.D., Xu,H., Kaminska,E., Climer,L.K., Mukiza,T.O.,
            Chang,C.L., Moldoveanu,T. and Opferman,J.T.
  TITLE     Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation
            through interaction with ACSL1
  JOURNAL   Mol Cell 84 (7), 1338-1353 (2024)
   PUBMED   38503284
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Sovilj,D., Kelemen,C.D., Dvorakova,S., Zobalova,R., Raabova,H.,
            Kriska,J., Hermanova,Z., Knotek,T., Anderova,M., Klener,P.,
            Filimonenko,V., Neuzil,J. and Andera,L.
  TITLE     Cell-specific modulation of mitochondrial respiration and
            metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak
  JOURNAL   Apoptosis 29 (3-4), 424-438 (2024)
   PUBMED   38001340
  REMARK    GeneRIF: Cell-specific modulation of mitochondrial respiration and
            metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak.
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Wei,L., Feng,Z., Dou,Q., Tan,L., Zhao,X. and Hao,B.
  TITLE     Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates
            to idiopathic non-obstructive azoospermia via inhibiting
            mitochondrial fission and inducing mitochondrial dysfunctiondagger
  JOURNAL   Biol Reprod 110 (2), 408-418 (2024)
   PUBMED   37903059
  REMARK    GeneRIF: Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells
            relates to idiopathic non-obstructive azoospermia via inhibiting
            mitochondrial fission and inducing mitochondrial dysfunctiondagger.
REFERENCE   4  (bases 1 to 2018)
  AUTHORS   Bouman,B.J., Demerdash,Y., Sood,S., Grunschlager,F., Pilz,F.,
            Itani,A.R., Kuck,A., Marot-Lassauzaie,V., Haas,S., Haghverdi,L. and
            Essers,M.A.
  TITLE     Single-cell time series analysis reveals the dynamics of HSPC
            response to inflammation
  JOURNAL   Life Sci Alliance 7 (3), e202302309 (2023)
   PUBMED   38110222
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2018)
  AUTHORS   Yusupova,M., Ankawa,R., Yosefzon,Y., Meiri,D., Bachelet,I. and
            Fuchs,Y.
  TITLE     Apoptotic dysregulation mediates stem cell competition and tissue
            regeneration
  JOURNAL   Nat Commun 14 (1), 7547 (2023)
   PUBMED   37985759
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2018)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   7  (bases 1 to 2018)
  AUTHORS   Chittenden,T., Flemington,C., Houghton,A.B., Ebb,R.G., Gallo,G.J.,
            Elangovan,B., Chinnadurai,G. and Lutz,R.J.
  TITLE     A conserved domain in Bak, distinct from BH1 and BH2, mediates cell
            death and protein binding functions
  JOURNAL   EMBO J 14 (22), 5589-5596 (1995)
   PUBMED   8521816
REFERENCE   8  (bases 1 to 2018)
  AUTHORS   Kiefer,M.C., Brauer,M.J., Powers,V.C., Wu,J.J., Umansky,S.R.,
            Tomei,L.D. and Barr,P.J.
  TITLE     Modulation of apoptosis by the widely distributed Bcl-2 homologue
            Bak
  JOURNAL   Nature 374 (6524), 736-739 (1995)
   PUBMED   7715731
REFERENCE   9  (bases 1 to 2018)
  AUTHORS   Chittenden,T., Harrington,E.A., O'Connor,R., Flemington,C.,
            Lutz,R.J., Evan,G.I. and Guild,B.C.
  TITLE     Induction of apoptosis by the Bcl-2 homologue Bak
  JOURNAL   Nature 374 (6524), 733-736 (1995)
   PUBMED   7715730
REFERENCE   10 (bases 1 to 2018)
  AUTHORS   Farrow,S.N., White,J.H., Martinou,I., Raven,T., Pun,K.T.,
            Grinham,C.J., Martinou,J.C. and Brown,R.
  TITLE     Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
  JOURNAL   Nature 374 (6524), 731-733 (1995)
   PUBMED   7715729
  REMARK    Erratum:[Nature 1995 Jun 1;375(6530):431]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132404.5, BY197389.1, CX564692.1, BC057589.1 and AW045927.1.
            
            On Sep 26, 2017 this sequence version replaced NM_007523.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13231.1, AK089220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC132404.5         92211-92211         c
            2-341               BY197389.1         2-341
            342-918             CX564692.1         274-850
            919-2002            BC057589.1         890-1973
            2003-2018           AW045927.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.65 cM"
     gene            1..2018
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /note="BCL2-antagonist/killer 1"
                     /db_xref="GeneID:12018"
                     /db_xref="MGI:MGI:1097161"
     exon            1..217
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..318
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..884
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /note="apoptosis regulator BAK; Bcl2 homologous
                     antagonist/killer"
                     /codon_start=1
                     /product="bcl-2 homologous antagonist/killer"
                     /protein_id="NP_031549.2"
                     /db_xref="CCDS:CCDS28558.1"
                     /db_xref="GeneID:12018"
                     /db_xref="MGI:MGI:1097161"
                     /translation="MASGQGPGPPKVGCDESPSPSEQQVAQDTEEVFRSYVFYLHQQE
                     QETQGAAAPANPEMDNLPLEPNSILGQVGRQLALIGDDINRRYDTEFQNLLEQLQPTA
                     GNAYELFTKIASSLFKSGISWGRVVALLGFGYRLALYVYQRGLTGFLGQVTCFLADII
                     LHHYIARWIAQRGGWVAALNFRRDPILTVMVIFGVVLLGQFVVHRFFRS"
     exon            319..454
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..598
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..779
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..2003
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1981..1986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /note="hexamer: AATAAA"
     polyA_site      2003
                     /gene="Bak1"
                     /gene_synonym="Bak; N-Bak; N-BAK1"
                     /note="major polyA site"
ORIGIN      
        1 cattgccggg agctgggacc tcctctatgg tcacaaagtc gcgaggtttc ctgggccaag
       61 aggcaacccg aggcggcatc cagcaccatg aatccactga taccagttcc tgccagtcag
      121 gcctgaaacc ttggcccctg gaagcagcca gcaagccctt cggggtcttc gtctttgcac
      181 ggctgagcca tcccacatct ggagcagagt cattcaggtg acaagtgacg gtggtctcca
      241 ccaagacctg aaaaatggca tctggacaag gaccaggtcc cccgaaggtg ggctgcgatg
      301 agtccccgtc cccttctgaa cagcaggttg cccaggacac agaggaggtc tttcgaagct
      361 acgtttttta cctccaccag caggaacagg agacccaggg ggcggccgcc cctgccaacc
      421 ccgagatgga caacttgccc ctggaaccca acagcatctt gggtcaggtg ggtcggcagc
      481 ttgctctcat cggagatgat attaaccggc gctacgacac agagttccag aatttactag
      541 aacagcttca gcccacagcc gggaatgcct acgaactctt caccaagatc gcctccagcc
      601 tatttaagag tggcatcagc tggggccgcg tggtggctct cctgggcttt ggctaccgtc
      661 tggccctgta cgtctaccag cgtggtttga ccggcttcct gggccaggtg acctgctttt
      721 tggctgatat catactgcat cattacatcg ccagatggat cgcacagaga ggcggttggg
      781 tggcagccct gaattttcgt agagacccca tcctgaccgt aatggtgatt tttggtgtgg
      841 ttctgttggg ccaattcgtg gtacacagat tcttcagatc atgactcccg gggagcccca
      901 ctggggcccc agccacgtgc ctggctggac taaacctctc tccctacccc accccctacc
      961 ccccacccca acagtcctct ccttcctccc cagggcaaag acgctttagc aaacaggcac
     1021 ccctgatttg gagagccacc gcccaggggt catcaatacc ccaacattgc atggtgctac
     1081 tgaaccccat cctgtctcag aggcactgac tgacgcactg gggggggtgg gtgggggatg
     1141 gagaggctgg gccactaatt cccagaaaac taggtttgtt tttatactac cctttagata
     1201 caatccaccc tttttctcca ctgtgcccaa agtcagaaca tggagggctt ggggactggt
     1261 ggttcgaacc tgtgttccca acactcctgc tactttggaa ggtcagccct tgagaagaga
     1321 cctgagcaca atccttgccc tccctacatt ggctcccaag accaactgta ggagactgca
     1381 tgacctactt cacccccacc tcatcgtcca tttccccaac cctacccccc acaccccctc
     1441 ccctcctatc tcctacccca atccatccat ttttgccttg gcggctggac tctcagggat
     1501 tctgagccca gagtgagggc agaggtgaga gttcagacca cagctgtctg aacacatcca
     1561 tcaggctctc caatcctgtg tccttcctga cccgtgctcc caacctagtg ggtaggggaa
     1621 gacgccactt tctccccagg gctctcaggt gagcctgcct gctggggcgg aggccttcct
     1681 gacagacgga cggacagagc ctcagactca gccactatga caggggaggg ggtgggcact
     1741 ctttggaggt gtccacacta gagaactact ccagcagaag caactgtgga cctgggtgca
     1801 gttcctcccc ggaacctatg attacttgaa ccccaccttc actccttgtc tgcctaggtc
     1861 ctcctcgggt tgggtggggt gggtgttttt ctctgtcttg cacaacatag gggtgagaag
     1921 ttttgattaa gccaaatgta tcggggaaga gggggaggca gagggtgctc tgtgtctgga
     1981 aataaactgt gcaatgcccc caaaaaaaaa aaaaaaaa
//
