LOCUS       NM_177580               2072 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus BAI1-associated protein 2-like 2 (Baiap2l2), mRNA.
ACCESSION   NM_177580
VERSION     NM_177580.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2072)
  AUTHORS   Yan,K., Zhang,H., Qu,C., Xi,Y., Han,Z.G. and Xu,Z.
  TITLE     BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia
            morphology
  JOURNAL   FASEB J 38 (15), e23860 (2024)
   PUBMED   39093051
  REMARK    GeneRIF: BAIAP2L1 and BAIAP2L2 differently regulate hair cell
            stereocilia morphology.
REFERENCE   2  (bases 1 to 2072)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2072)
  AUTHORS   Tholen,L.E., Schigt,H., Kleuskens,S.G.E., Bos,C., Spruijt,C.G.,
            Willemsen,B., Vermeulen,M., Hoenderop,J.G.J. and de Baaij,J.H.F.
  TITLE     HNF1beta-associated cyst development and electrolyte disturbances
            are not explained by BAIAP2L2 expression
  JOURNAL   FASEB J 37 (1), e22696 (2023)
   PUBMED   36520027
  REMARK    GeneRIF: HNF1beta-associated cyst development and electrolyte
            disturbances are not explained by BAIAP2L2 expression.
REFERENCE   4  (bases 1 to 2072)
  AUTHORS   Halford,J., Bateschell,M. and Barr-Gillespie,P.G.
  TITLE     Ca2+ entry through mechanotransduction channels localizes BAIAP2L2
            to stereocilia tips
  JOURNAL   Mol Biol Cell 33 (4), br6 (2022)
   PUBMED   35044843
  REMARK    GeneRIF: Ca(2+) entry through mechanotransduction channels
            localizes BAIAP2L2 to stereocilia tips.
REFERENCE   5  (bases 1 to 2072)
  AUTHORS   Yan,K., Zong,W., Du,H., Zhai,X., Ren,R., Liu,S., Xiong,W., Wang,Y.
            and Xu,Z.
  TITLE     BAIAP2L2 is required for the maintenance of mechanotransducing
            stereocilia of cochlear hair cells
  JOURNAL   J Cell Physiol 237 (1), 774-788 (2022)
   PUBMED   34346063
  REMARK    GeneRIF: BAIAP2L2 is required for the maintenance of
            mechanotransducing stereocilia of cochlear hair cells.
REFERENCE   6  (bases 1 to 2072)
  AUTHORS   Urbanek,M.E. and Zuo,J.
  TITLE     Genetic predisposition to tinnitus in the UK Biobank population
  JOURNAL   Sci Rep 11 (1), 18150 (2021)
   PUBMED   34518561
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2072)
  AUTHORS   Carlton,A.J., Halford,J., Underhill,A., Jeng,J.Y., Avenarius,M.R.,
            Gilbert,M.L., Ceriani,F., Ebisine,K., Brown,S.D.M., Bowl,M.R.,
            Barr-Gillespie,P.G. and Marcotti,W.
  TITLE     Loss of Baiap2l2 destabilizes the transducing stereocilia of
            cochlear hair cells and leads to deafness
  JOURNAL   J Physiol 599 (4), 1173-1198 (2021)
   PUBMED   33151556
  REMARK    GeneRIF: Loss of Baiap2l2 destabilizes the transducing stereocilia
            of cochlear hair cells and leads to deafness.
REFERENCE   8  (bases 1 to 2072)
  AUTHORS   Jung,H., Park,H., Choi,Y., Kang,H., Lee,E., Kweon,H., Roh,J.D.,
            Ellegood,J., Choi,W., Kang,J., Rhim,I., Choi,S.Y., Bae,M.,
            Kim,S.G., Lee,J., Chung,C., Yoo,T., Park,H., Kim,Y., Ha,S.,
            Um,S.M., Mo,S., Kwon,Y., Mah,W., Bae,Y.C., Kim,H., Lerch,J.P.,
            Paik,S.B. and Kim,E.
  TITLE     Sexually dimorphic behavior, neuronal activity, and gene expression
            in Chd8-mutant mice
  JOURNAL   Nat Neurosci 21 (9), 1218-1228 (2018)
   PUBMED   30104731
REFERENCE   9  (bases 1 to 2072)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   10 (bases 1 to 2072)
  AUTHORS   Pykalainen,A., Boczkowska,M., Zhao,H., Saarikangas,J., Rebowski,G.,
            Jansen,M., Hakanen,J., Koskela,E.V., Peranen,J., Vihinen,H.,
            Jokitalo,E., Salminen,M., Ikonen,E., Dominguez,R. and
            Lappalainen,P.
  TITLE     Pinkbar is an epithelial-specific BAR domain protein that generates
            planar membrane structures
  JOURNAL   Nat Struct Mol Biol 18 (8), 902-907 (2011)
   PUBMED   21743456
  REMARK    GeneRIF: Pinkbar, is specifically expressed in intestinal
            epithelial cells, where it localizes to Rab13-positive vesicles and
            to the plasma membrane at intercellular junctions.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591913.14.
            
            On Dec 19, 2006 this sequence version replaced NM_177580.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AL591913.14        161925-162096
            173-248             AL591913.14        162784-162859
            249-335             AL591913.14        163341-163427
            336-397             AL591913.14        163947-164008
            398-469             AL591913.14        175838-175909
            470-586             AL591913.14        176116-176232
            587-733             AL591913.14        176782-176928
            734-886             AL591913.14        185469-185621
            887-1025            AL591913.14        185894-186032
            1026-1239           AL591913.14        186147-186360
            1240-1362           AL591913.14        187660-187782
            1363-1570           AL591913.14        188039-188246
            1571-1614           AL591913.14        188587-188630
            1615-2072           AL591913.14        188782-189239
FEATURES             Location/Qualifiers
     source          1..2072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..2072
                     /gene="Baiap2l2"
                     /note="BAI1-associated protein 2-like 2"
                     /db_xref="GeneID:207495"
                     /db_xref="MGI:MGI:2652819"
     exon            1..172
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1690
                     /gene="Baiap2l2"
                     /note="brain-specific angiogenesis inhibitor 1-associated
                     protein 2-like protein 2; BAI1-associated protein 2-like
                     protein 2; pinkbar; planar intestinal- and kidney-specific
                     BAR domain protein"
                     /codon_start=1
                     /product="BAR/IMD domain-containing adapter protein 2-like
                     2"
                     /protein_id="NP_808248.1"
                     /db_xref="CCDS:CCDS37140.1"
                     /db_xref="GeneID:207495"
                     /db_xref="MGI:MGI:2652819"
                     /translation="MAPEMDQFYRSTMAIYKSIMEQFNPALENLVYLGNNYLRAFHAL
                     SEAAEVYFSAIQKIGEQALQSSTSQILGEILVQMSDTQRHLNSDLEVVVQTFHGDLLQ
                     HMEKNTKLDMQFIKDSCQHYEIEYRHRAANLEKCMSELWRMERKRDKNAREMKESVNR
                     LHAQMQAFVSESKRAAELEEKRRYRFLAEKHLLLSNTFLQFLGRARGMLQNRVLLWKE
                     QSEASRSPSRAHSPGLLGPALGPPYPSGRLTPTRLDMPPRPLGEYGSPRSRHGSGSYG
                     PEPAEARSASQLEPDRRSLPRTPSASSLYASSTQRSRSNSFGERLGGGGARRVRALVS
                     HSEGANHTLLRFSAGDVVEVLVPEAQNGWLYGKLEGSSASGWFPEAYVKPVEEIPVNP
                     MNPVAPMNSMAPMSPMNELPSRSYPLRGSHSLDDLLDRPGNPTASSEYWDSQSRSRTP
                     SRVPSRAPSPAPPPLPSSRRSSVGSMGAATDVKKLMSWEQNPPELFPRGTNPFATVKL
                     RPTVTNDRSAPLIR"
     exon            173..248
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..335
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..397
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            398..469
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..586
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..733
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            734..886
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1025
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1239
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1362
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1570
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1614
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..2072
                     /gene="Baiap2l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Baiap2l2"
                     /note="hexamer: GATAAA"
     regulatory      2053..2058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Baiap2l2"
                     /note="hexamer: AATAAA"
     polyA_site      2054
                     /gene="Baiap2l2"
                     /note="major polyA site"
     polyA_site      2072
                     /gene="Baiap2l2"
                     /note="major polyA site"
ORIGIN      
        1 agtccatctg cagggcctac tctacagcca cctctgcctg ctgcctgtcc agagcactgg
       61 gcacggggca cacccagcca gccactagcc acctgcctcc ttggtgccag caccaccttc
      121 catggccccc gaaatggacc agttctacag gtccaccatg gccatctaca agagcatcat
      181 ggagcagttt aatcccgccc tggagaatct ggtgtacctg ggcaacaact acctccgggc
      241 cttccatgct ctgtccgagg cggctgaggt gtatttcagc gccatacaga agattgggga
      301 gcaggcccta cagagctcca catcgcagat tctgggggag atcttggttc agatgtcaga
      361 cacccagcgg cacttgaact cagacctgga ggtggtggtg cagacattcc acggagactt
      421 gcttcagcac atggagaaga acaccaagct ggacatgcag ttcatcaagg atagctgcca
      481 acactacgag attgagtatc gccaccgagc ggccaacctg gagaagtgca tgtctgagct
      541 atggcgcatg gaacgcaaga gagacaaaaa cgcgcgggag atgaaggaga gtgtgaaccg
      601 gctgcacgcc cagatgcagg ccttcgtgtc cgagagcaag cgcgccgccg agctggaaga
      661 gaagcggcgc taccgcttcc tggctgagaa gcacctgctg ctctccaaca ctttcctgca
      721 gttcttgggc cgggcccggg ggatgctgca gaaccgcgtc ttgctatgga aggagcaatc
      781 ggaggccagc cgcagcccgt cgcgtgccca ctccccgggg ctgctgggcc ccgcgctggg
      841 gccgccctac ccctcgggcc gcctgacgcc cacccggctg gacatgcccc cgaggcccct
      901 gggagagtac ggctcccccc gcagccggca cggctccggc tcctacggcc ccgagcccgc
      961 cgaggcgagg tccgcgtccc agttggagcc agaccgccga tcgctgcccc ggacgccgtc
     1021 ggcctcctcg ctctacgcta gcagcaccca gcgctcgcgg tccaattcct tcggcgagcg
     1081 cctgggcggc ggcggcgcca ggagagtccg cgccctggtc tcccactcgg agggtgccaa
     1141 tcacacgctg ctgcgcttct cggctggaga cgtagttgag gtgctggtgc ccgaagctca
     1201 gaacggctgg ctctacggca aactggaggg ctcgtccgcg agtggctggt tccctgaggc
     1261 ctatgtgaaa cctgtggagg agataccagt gaatcccatg aaccctgtgg cccctatgaa
     1321 ctccatggcc cccatgagcc caatgaatga actgccttcc aggtcctacc cactccgggg
     1381 cagccacagc cttgatgacc tcttggaccg gccaggcaat cccacagcgt cttcggaata
     1441 ctgggatagt cagtcccgct cgcggacccc gagccgtgtc cccagccgtg cccccagccc
     1501 cgcacccccg cccttaccca gcagcaggcg cagcagtgtg ggcagcatgg gggcagccac
     1561 cgacgtcaag aaacttatgt cctgggaaca gaacccccca gagctctttc cacggggtac
     1621 aaatcccttt gccaccgtga agcttcgtcc cacagtcacc aacgaccgct cagcacccct
     1681 catccgctga ggcaaagccc tccgccgggg cctgaggtgg cccagtacac ctgcccagag
     1741 ctattccatc cggcagcagg cagcagcagc agtggatctg agatgccagg cgccaaccca
     1801 ggggaccatt cttacccctt tgcccctagc ccaggatctc cctgagggct ggacttgcaa
     1861 caggaagcag gtagaagggg gtggaagcat agagcaactt gttgctttcg ggacccaaag
     1921 actcttccgg ggatccagca tcttgccttc cattctcttt ctgcctgtgc cccaatggga
     1981 agcaccccct ctcccacctc tgtcccaact gtacccctgt ttaacttttt gtaaatgata
     2041 aaaaaataaa taaataaagg aagtggacac ag
//
