LOCUS       NM_025833               3248 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus BAI1-associated protein 2-like 1 (Baiap2l1), mRNA.
ACCESSION   NM_025833
VERSION     NM_025833.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3248)
  AUTHORS   Xie,J., Lu,Z.N., Bai,S.H., Cui,X.F., Lian,H.Y., Xie,C.Y., Wang,N.,
            Wang,L. and Han,Z.G.
  TITLE     Heterochromatin formation and remodeling by IRTKS condensates
            counteract cellular senescence
  JOURNAL   EMBO J 43 (20), 4542-4577 (2024)
   PUBMED   39192031
  REMARK    GeneRIF: Heterochromatin formation and remodeling by IRTKS
            condensates counteract cellular senescence.
REFERENCE   2  (bases 1 to 3248)
  AUTHORS   Yan,K., Zhang,H., Qu,C., Xi,Y., Han,Z.G. and Xu,Z.
  TITLE     BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia
            morphology
  JOURNAL   FASEB J 38 (15), e23860 (2024)
   PUBMED   39093051
  REMARK    GeneRIF: BAIAP2L1 and BAIAP2L2 differently regulate hair cell
            stereocilia morphology.
REFERENCE   3  (bases 1 to 3248)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3248)
  AUTHORS   Postema,M.M., Grega-Larson,N.E., Neininger,A.C. and Tyska,M.J.
  TITLE     IRTKS (BAIAP2L1) Elongates Epithelial Microvilli Using
            EPS8-Dependent and Independent Mechanisms
  JOURNAL   Curr Biol 28 (18), 2876-2888 (2018)
   PUBMED   30197089
  REMARK    GeneRIF: IRTKS localizes to the distal tips of actively growing
            microvilli via a mechanism that requires its N-terminal I-BAR
            domain. At microvillar tips, IRTKS promotes elongation through a
            mechanism involving its C-terminal actin-binding WH2 domain.
REFERENCE   5  (bases 1 to 3248)
  AUTHORS   Chou,A.M., Sem,K.P., Lam,W.J., Ahmed,S. and Lim,C.Y.
  TITLE     Redundant functions of I-BAR family members, IRSp53 and IRTKS, are
            essential for embryonic development
  JOURNAL   Sci Rep 7, 40485 (2017)
   PUBMED   28067313
  REMARK    GeneRIF: double knockout of IRSp53 and its closest family member,
            IRTKS, resulted in exacerbated placental abnormalities,
            particularly in spongiotrophoblast differentiation and development,
            giving rise to complete embryonic lethality.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3248)
  AUTHORS   Sudhaharan,T., Sem,K.P., Liew,H.F., Yu,Y.H., Goh,W.I., Chou,A.M.
            and Ahmed,S.
  TITLE     The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to
            generate dorsal membrane ruffles and filopodia
  JOURNAL   J Cell Sci 129 (14), 2829-2840 (2016)
   PUBMED   27278019
  REMARK    GeneRIF: Rho family GTPases use the I-BAR proteins, IRSp53 (also
            known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to
            modulate cell morphology.
REFERENCE   7  (bases 1 to 3248)
  AUTHORS   Xia,P., Wang,S., Xiong,Z., Ye,B., Huang,L.Y., Han,Z.G. and Fan,Z.
  TITLE     IRTKS negatively regulates antiviral immunity through PCBP2
            sumoylation-mediated MAVS degradation
  JOURNAL   Nat Commun 6, 8132 (2015)
   PUBMED   26348439
  REMARK    GeneRIF: IRTKS functions as a negative modulator of excessive
            inflammation in viral infections.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3248)
  AUTHORS   Huang,L.Y., Wang,Y.P., Wei,B.F., Yang,J., Wang,J.Q., Wu,B.H.,
            Zhang,Z.Z., Hou,Y.Y., Sun,W.M., Hu,R.M., Ning,G. and Han,Z.G.
  TITLE     Deficiency of IRTKS as an adaptor of insulin receptor leads to
            insulin resistance
  JOURNAL   Cell Res 23 (11), 1310-1321 (2013)
   PUBMED   23896986
  REMARK    GeneRIF: The IRTKS, as an adaptor of the insulin receptor (IR),
            modulates IR-IRS1-PI3K-AKT signaling via regulating the
            phosphorylation of IR.
REFERENCE   9  (bases 1 to 3248)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3248)
  AUTHORS   Millard,T.H., Dawson,J. and Machesky,L.M.
  TITLE     Characterisation of IRTKS, a novel IRSp53/MIM family actin
            regulator with distinct filament bundling properties
  JOURNAL   J Cell Sci 120 (Pt 9), 1663-1672 (2007)
   PUBMED   17430976
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004918.2 and AV224233.1.
            
            On Apr 15, 2006 this sequence version replaced NM_025833.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004918.2, BC015459.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3244              AK004918.2         2-3245
            3245-3248           AV224233.1         275-278
FEATURES             Location/Qualifiers
     source          1..3248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 83.24 cM"
     gene            1..3248
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /note="BAI1-associated protein 2-like 1"
                     /db_xref="GeneID:66898"
                     /db_xref="MGI:MGI:1914148"
     exon            1..322
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1816
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /note="brain-specific angiogenesis inhibitor 1-associated
                     protein 2-like protein 1; BAI1-associated protein 2-like
                     protein 1; insulin receptor tyrosine kinase substrate"
                     /codon_start=1
                     /product="BAR/IMD domain-containing adapter protein 2-like
                     1"
                     /protein_id="NP_080109.1"
                     /db_xref="CCDS:CCDS39378.1"
                     /db_xref="GeneID:66898"
                     /db_xref="MGI:MGI:1914148"
                     /translation="MSRGPEEVNRLTENTYRNVMEQFNPGLRNLINLGKNYEKAVNAM
                     ILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNETLDENFKKFHKDIIH
                     ELEKKTELDVKYMNATLKRYQAEHRNKLDSLEKSQAELKKIRRKSQGGRNALKYEHKE
                     IEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCSFASHIHYYHMQSAELL
                     NSKLPRWQETCCDATKVPEKIMNMIEEIKTPISTPVSGTPQPSPMIERSKMIGKDYDT
                     LSKYSPKMPPAPSVKAYTSPLIDMFNNPATAAQSSEKTNNSTANTGEDPSLQRSVSVA
                     TGLNMMKKQKVKTIFPHTAGNNKTLLSFAQGDVLTLLIPEEKDGWLYGEHDTTKARGW
                     FPSSYTKLLEENEAMSVPTPSPAPVRSISTVDLTEKSSVVIPPPDYLECLSMGATSDK
                     KAGAPKVPSASTFRAPVSRPDATSTSPSDANGTAKPPFLSGENPFATVKLRPTVTNDR
                     SAPIIR"
     exon            323..398
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            399..485
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            486..547
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            548..619
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            620..757
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            758..910
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1078
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1226
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1437
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1509
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1702
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1740
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..3248
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /note="hexamer: ATTAAA"
     polyA_site      2311
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /note="major polyA site"
     regulatory      3226..3231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /note="hexamer: AATAAA"
     polyA_site      3247
                     /gene="Baiap2l1"
                     /gene_synonym="1300006M19Rik; IRTKS"
                     /note="major polyA site"
ORIGIN      
        1 cactccgccc gcctcaggtg gggctgcccg tccctttgct cgtcccagcc ttggcaggct
       61 acgtctacct cgcagctcct tacagaccga agcgccgcaa agttttgaca ttttggcagc
      121 agagacgcgc actgactctc tcccgctgac agctgtggcg gcggccgact ctcaaggacc
      181 actcagtctc aagtcctagg cgctcccgcc gcccggcggc cacgaggccc cgccgcgtcc
      241 tcccgcgctc gccctcccgg aggctgcagc catgtctcgg gggccggagg aggtgaaccg
      301 gctcacggag aacacgtacc ggaatgtgat ggaacaattc aaccctggac tacggaactt
      361 aataaaccta ggaaaaaatt atgaaaaagc ggtgaatgct atgatcctgg caggaaaagc
      421 ctactacgac ggcgtggcca agattggtga aattgccact gggtctcctg tgtcaacaga
      481 gctaggccat gtcctcatag agatttccag cacccacaag aaactcaatg agactcttga
      541 tgaaaatttc aaaaaattcc ataaggatat tatccatgag ctggagaaga agacagaact
      601 tgatgtaaag tatatgaacg ctactcttaa aagatatcaa gcagagcaca ggaataaatt
      661 agattctttg gagaaatctc aggcggagct gaagaagatc agaagaaaaa gtcaaggtgg
      721 acgaaacgca ctcaaatacg agcacaaaga aattgagtat gtggagacgg tgacgtctcg
      781 ccagagtgag atccagaagt tcattgccga tggctgcaaa gaagccctgc ttgaggaaaa
      841 aaggcgcttc tgctttctgg tggacaagca ctgcagcttt gccagtcaca tacactacta
      901 tcacatgcag tctgcagagt tacttaattc caagctgccc cggtggcagg aaacctgttg
      961 tgatgccaca aaagtcccag agaaaatcat gaacatgata gaagagataa agacgcccat
     1021 ctccaccccc gtgtccggga cgccgcagcc atcgcccatg atcgagagaa gcaagatgat
     1081 tgggaaagat tatgacaccc tttctaaata ctcaccaaag atgccccctg ctccttcagt
     1141 caaagcctac accagtcctt tgattgacat gttcaataac ccagctacag ctgcacagag
     1201 ttcagaaaaa acaaacaact ccacagcaaa cactggggaa gatcccagtc tacagcgatc
     1261 ggtttctgtt gcaactgggc tgaacatgat gaagaagcag aaggtgaaga ccatcttccc
     1321 tcacacggct ggcaacaata agaccctact gagctttgcc cagggggacg tcctcacact
     1381 gctcatccct gaggagaagg acggctggct ctacggggag catgacacca ccaaagcgag
     1441 gggctggttc ccatcgtcat atacaaagtt gctggaagaa aatgaagcaa tgtctgtccc
     1501 tacaccaagc cctgcacccg tgagaagcat cagcacggtg gacctgactg agaagagcag
     1561 cgttgtcatc ccacctcccg actacttgga gtgcctgtcc atgggagcca cctcagacaa
     1621 gaaagcgggc gctcccaagg tgccttctgc ttctaccttc agagcgccag tgtccagacc
     1681 agacgccaca tccacctctc ccagcgatgc caacgggacc gcaaagccgc cattcctcag
     1741 tggagaaaac ccctttgcca ccgtgaaact ccggccaaca gtgacaaatg accgatcagc
     1801 accgatcatc cgatgaagat gcaggggaca gtgccagtcc ctctactcga gttctcaccc
     1861 acagggcgat aggtatacat tgctggacag caggcactgt caaagattgc agagtgcctg
     1921 atgtcaatga agccccactt gagcaaatca atgtactttc tcagattgac agaggtgggt
     1981 ttacacattt ctgtctttaa ggtaaatgag tagcttagtg aataaatcaa tcatttgaaa
     2041 tattttcttt tctattcaaa aagcagtaaa tttggctcaa atttttaaat ttttattttt
     2101 aaggaaatag ccagaataag ggatagtcgg tgtatgcttt tatgtctggc tttctgtagc
     2161 tgaatgcaaa taagaccaga gttttatttt ataaagcctg tgttcttaag tagcattatg
     2221 atgttcatta tattatgtaa gtttgcatca gagcatgcaa atccagtaag cagtgtaaat
     2281 tatgaaaata tattaaatat tttttaaatg acccaatttt taccttttga ttaaacaagt
     2341 agaactccaa cctcattgac aggcattgct gcagagctga gacagtcagc ctgcttcatt
     2401 ggcacttgta aatttatctc caggagttac tgaattcagt gttacaaagg ttgccagcag
     2461 gggtctcaat acgtctgagg gctctgtaca aaccaaacca ggtaaccaaa gccccgtcat
     2521 ggttctgggg tcacctcctg tcactcattt tttaaccagc cactggcctg taaatagcga
     2581 ttctgaagcc tggtgggcag gagggtgggc ctgccattcc agcccaacac tgtcccatgc
     2641 gcagaccaac atctgctcag gccactgcat agagccttga gccagaggtc aggctgcccc
     2701 tacctgccca agatgtagac cttgtctaga atagcaaata attaaaaccc atcctcagga
     2761 cagtcactgt tgatagaaac ttgctgctta tcagattctc agatctcacc gagaaattat
     2821 ccccaaattg gtccgggtct atgtacagga aacgccgtcc tttccagctg ggccaagcag
     2881 tggcaagctc ccatgggaga gcaagcctga tggccccatc aagggtaact tagtacaggc
     2941 ctgcccatgc cagtgacctc cctaaagtac agagcctggg tcatgccatc cattaccacc
     3001 gtgttaggca ggtgtcctgg cctgataggg gaaatacagt ccatgttctc cctgtgacca
     3061 acctatgtgc aggataaggt gggaagtggg ctgaggactc atgtcctggc tccgcacacg
     3121 agtacaggaa ccagtctgct gtgccctcct agccctgggt ctccctccct tacgcgaact
     3181 taccttgact gcagacacaa aggttaacat ttgtttaatg ttaataataa aagagatttg
     3241 aaacacat
//
