LOCUS       NM_001037755            2083 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus brain-specific angiogenesis inhibitor 1-associated
            protein 2 (Baiap2), transcript variant 1, mRNA.
ACCESSION   NM_001037755
VERSION     NM_001037755.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2083)
  AUTHORS   Picas,L., Andre-Arpin,C., Comunale,F., Bousquet,H., Tsai,F.C.,
            Rico,F., Maiuri,P., Pernier,J., Bodin,S., Nicot,A.S., Laporte,J.,
            Bassereau,P., Goud,B., Gauthier-Rouviere,C. and Miserey,S.
  TITLE     BIN1 regulates actin-membrane interactions during IRSp53-dependent
            filopodia formation
  JOURNAL   Commun Biol 7 (1), 549 (2024)
   PUBMED   38724689
  REMARK    GeneRIF: BIN1 regulates actin-membrane interactions during
            IRSp53-dependent filopodia formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2083)
  AUTHORS   Tsai,M.H., Lin,W.C., Chen,S.Y., Hsieh,M.Y., Nian,F.S., Cheng,H.Y.,
            Zhao,H.J., Hung,S.S., Hsu,C.H., Hou,P.S., Tung,C.Y., Lee,M.H. and
            Tsai,J.W.
  TITLE     A lissencephaly-associated BAIAP2 variant causes defects in
            neuronal migration during brain development
  JOURNAL   Development 151 (2) (2024)
   PUBMED   38149472
  REMARK    GeneRIF: A lissencephaly-associated BAIAP2 variant causes defects
            in neuronal migration during brain development.
REFERENCE   4  (bases 1 to 2083)
  AUTHORS   Noh,Y.W., Kim,Y., Lee,S., Kim,Y., Shin,J.J., Kang,H., Kim,I.H. and
            Kim,E.
  TITLE     The PFC-LH-VTA pathway contributes to social deficits in
            IRSp53-mutant mice
  JOURNAL   Mol Psychiatry 28 (11), 4642-4654 (2023)
   PUBMED   37730842
  REMARK    GeneRIF: The PFC-LH-VTA pathway contributes to social deficits in
            IRSp53-mutant mice.
REFERENCE   5  (bases 1 to 2083)
  AUTHORS   Madarasz,T., Brunner,B., Halasz,H., Telek,E., Matko,J., Nyitrai,M.
            and Szabo-Meleg,E.
  TITLE     Molecular Relay Stations in Membrane Nanotubes: IRSp53 Involved in
            Actin-Based Force Generation
  JOURNAL   Int J Mol Sci 24 (17), 13112 (2023)
   PUBMED   37685917
  REMARK    GeneRIF: Molecular Relay Stations in Membrane Nanotubes: IRSp53
            Involved in Actin-Based Force Generation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2083)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2083)
  AUTHORS   Rokosh,D.G. and Simpson,P.C.
  TITLE     Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha
            1A/C is expressed in resistance arteries and is required to
            maintain arterial blood pressure
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9474-9479 (2002)
   PUBMED   12093905
REFERENCE   8  (bases 1 to 2083)
  AUTHORS   Alvarez,C.E., Sutcliffe,J.G. and Thomas,E.A.
  TITLE     Novel isoform of insulin receptor substrate p53/p58 is generated by
            alternative splicing in the CRIB/SH3-binding region
  JOURNAL   J Biol Chem 277 (27), 24728-24734 (2002)
   PUBMED   12006592
REFERENCE   9  (bases 1 to 2083)
  AUTHORS   Thomas,E.A., Foye,P.E., Alvarez,C.E., Usui,H. and Sutcliffe,J.G.
  TITLE     Insulin receptor substrate protein p53 localization in rats
            suggests mechanism for specific polyglutamine neurodegeneration
  JOURNAL   Neurosci Lett 309 (3), 145-148 (2001)
   PUBMED   11514062
REFERENCE   10 (bases 1 to 2083)
  AUTHORS   Fujiwara,T., Mammoto,A., Kim,Y. and Takai,Y.
  TITLE     Rho small G-protein-dependent binding of mDia to an Src homology 3
            domain-containing IRSp53/BAIAP2
  JOURNAL   Biochem Biophys Res Commun 271 (3), 626-629 (2000)
   PUBMED   10814512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049469.1, AK145924.1 and CO039918.1.
            
            On Oct 30, 2009 this sequence version replaced NM_001037755.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049469.1, SRR1660821.129816.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               AK049469.1         2-364
            364-1641            AK145924.1         365-1642
            1642-2062           AK049469.1         1643-2063
            2063-2083           CO039918.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.96 cM"
     gene            1..2083
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /note="brain-specific angiogenesis inhibitor 1-associated
                     protein 2"
                     /db_xref="GeneID:108100"
                     /db_xref="MGI:MGI:2137336"
     exon            1..157
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1711
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /note="isoform a is encoded by transcript variant 1;
                     insulin receptor substrate p53; BAI-associated protein 2;
                     BAI1-associated protein 2; insulin receptor substrate
                     protein of 53 kDa; insulin receptor tyrosine kinase 53 kDa
                     substrate; BAR/IMD domain-containing adapter protein 2"
                     /codon_start=1
                     /product="BAR/IMD domain-containing adapter protein 2
                     isoform a"
                     /protein_id="NP_001032844.2"
                     /db_xref="CCDS:CCDS25722.1"
                     /db_xref="GeneID:108100"
                     /db_xref="MGI:MGI:2137336"
                     /translation="MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAG
                     VTFAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEETLKSFHNELL
                     TQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDK
                     ELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKEL
                     LAQKLPLWQQACADPNKIPDRAVQLMQQMANSNGSILPSALSASKSNLVISDPIPGAK
                     PLPVPPELAPFVGRMSAQENVPVMNGVAGPDSEDYNPWADRKAAQPKSLSPPQSQSKL
                     SDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNS
                     TLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQ
                     GKSSSTGNLLDKDDLALPPPDYGTSSRAFPTQTAGTFKQRPYSVAVPAFSQGLDDYGA
                     RSVSRNPFANVHLKPTVTNDRSAPLLS"
     exon            158..233
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            234..320
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            321..382
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            383..454
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            455..592
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            593..745
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            746..970
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1172
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1374
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1443
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1606
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1641
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..2065
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2045..2050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /note="hexamer: AATAAA"
     polyA_site      2065
                     /gene="Baiap2"
                     /gene_synonym="IRSp53"
                     /note="major polyA site"
ORIGIN      
        1 gtggtcctgg tctgcgcgcc ttttcctgtt gctgcagttg tcgctttcct caccgccacc
       61 cgtgcccctg ctctggtctg tggtgtagcc gggacccagg accatgtcgc tttcacgctc
      121 ggaggagatg caccggctca cggaaaatgt ctacaagacc atcatggagc agttcaaccc
      181 cagcctccgc aacttcatcg ccatgggcaa gaactatgag aaagcactgg caggtgtcac
      241 cttcgctgcc aaaggctatt tcgatgctct ggtaaagatg ggggagctgg ccagcgagag
      301 ccagggctct aaggaacttg gggacgtcct cttccagatg gctgaggtgc accggcagat
      361 ccagaaccag ttggaagaga cgctgaagtc ttttcacaat gagctgctca cgcagctgga
      421 gcagaaagta gaactggact ccaggtatct aagtgctgca ctgaagaaat accaaacgga
      481 acagaggagc aaaggggacg ccctggacaa gtgtcaggct gagctgaaga agctccgcaa
      541 gaagagccaa gggagtaaga accctcagaa gtactcagac aaggagctgc agtacatcga
      601 tgccatcagc aataagcagg gcgagctgga gaactacgtg tctgacggct acaagacagc
      661 actcactgag gagcgcagga ggttctgctt cctggtggaa aagcagtgcg ctgtggccaa
      721 gaactctgct gcttaccatt ccaagggcaa ggagttgctg gcccagaagc tgcctctgtg
      781 gcagcaagcc tgtgccgacc ccaacaagat cccagaccgt gctgtccagc tgatgcaaca
      841 gatggccaat agcaatggct ccatccttcc aagtgccctg tcagcttcca agtccaacct
      901 ggtcatctca gatcccattc ctggagccaa gcccttgcca gtgccacctg agctggcacc
      961 atttgtgggg cggatgtctg ctcaggagaa tgtacctgtc atgaatggcg tcgcaggccc
     1021 ggacagcgag gactacaacc cctgggctga ccgaaaggct gcccagccca aatccctgtc
     1081 tcccccgcag tctcaaagca agctgagcga ctcgtactcc aacacactcc ccgtgcgcaa
     1141 gagcgtgacg ccgaagaaca gctatgccac cactgagaac aagacactgc cacgttcaag
     1201 ctccatggca gctggcctag aacgtaatgg ccgcatgcgg gtcaaggcca ttttctccca
     1261 cgcggccggt gacaatagca ctctgctgag cttcaaggag ggcgacctca tcacgctgct
     1321 agtgcctgag gcccgtgacg gctggcacta tggggagagt gagaagacca agatgcgggg
     1381 ctggttcccc ttctcctaca cccgggtcct ggacagtgac ggaagtgaca gattgcatat
     1441 gagcctgcag cagggcaaga gcagcagcac aggcaacctc ctagacaagg atgacctggc
     1501 cctcccccct cctgactacg gcacgtcctc ccgggcattc cccacccaga cagccggcac
     1561 attcaagcag agaccctaca gcgtggccgt tcctgccttc tctcagggtc tggatgacta
     1621 cggggcacgg tctgtgagca ggaatccctt cgccaacgtc catctgaaac caacagtgac
     1681 caatgacaga tcagcccctc tgctcagctg acgggctcct ctgcatcgac actctgtccc
     1741 cacctgccag ctgagggtga tcagggcatg ttcctgtcca gagaagacca caatgcccca
     1801 ctccctagcc tcgcctcaca tcggcccagc ctgggctgga tcccaggtgt tcctggtgag
     1861 gtggctgcct caagaggccg atgccccaac agaggggcca gcacttgggc aacagggacc
     1921 tctgatccta actgtggaac ctcgagagcc tctggacaca gagaggacat tctgccggct
     1981 tgcagggaag ggagcctatt cccatgctga cttttaaact tttttatctc acgtgtgtct
     2041 ggtcaataaa cgtgtgctca ccatgaaaaa aaaaaaaaaa aaa
//
