LOCUS       NM_001372289            3488 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus BCL2-associated athanogene 6 (Bag6), transcript
            variant 31, mRNA.
ACCESSION   NM_001372289
VERSION     NM_001372289.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3488)
  AUTHORS   Sanchez Carretero,L., Cardenosa Perez,A.C., Peces-Barba,G. and
            Perez-Rial,S.
  TITLE     Differential lung gene expression identified Zscan2 and Bag6 as
            novel tissue repair players in an experimental COPD model
  JOURNAL   PLoS One 19 (8), e0309166 (2024)
   PUBMED   39172905
  REMARK    GeneRIF: Differential lung gene expression identified Zscan2 and
            Bag6 as novel tissue repair players in an experimental COPD model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3488)
  AUTHORS   Alashkar Alhamwe,B., Ponath,V., Alhamdan,F., Dorsam,B.,
            Landwehr,C., Linder,M., Pauck,K., Miethe,S., Garn,H.,
            Finkernagel,F., Brichkina,A., Lauth,M., Tiwari,D.K., Buchholz,M.,
            Bachurski,D., Elmshauser,S., Nist,A., Stiewe,T., Pogge von
            Strandmann,L., Szymanski,W., Beutgen,V., Graumann,J.,
            Teply-Szymanski,J., Keber,C., Denkert,C., Jacob,R., Preusser,C. and
            Pogge von Strandmann,E.
  TITLE     BAG6 restricts pancreatic cancer progression by suppressing the
            release of IL33-presenting extracellular vesicles and the
            activation of mast cells
  JOURNAL   Cell Mol Immunol 21 (8), 918-931 (2024)
   PUBMED   38942797
  REMARK    GeneRIF: BAG6 restricts pancreatic cancer progression by
            suppressing the release of IL33-presenting extracellular vesicles
            and the activation of mast cells.
REFERENCE   3  (bases 1 to 3488)
  AUTHORS   Zhou,Y., Li,T., Zhang,Y., Zhang,N., Guo,Y., Gao,X., Peng,W.,
            Shu,S., Zhao,C., Cui,D., Sun,H., Sun,Y., Liu,J., Tang,J., Zhang,R.
            and Pu,J.
  TITLE     BAG6 inhibits influenza A virus replication by inducing viral
            polymerase subunit PB2 degradation and perturbing RdRp complex
            assembly
  JOURNAL   PLoS Pathog 20 (3), e1012110 (2024)
   PUBMED   38498560
  REMARK    GeneRIF: BAG6 inhibits influenza A virus replication by inducing
            viral polymerase subunit PB2 degradation and perturbing RdRp
            complex assembly.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3488)
  AUTHORS   Huang,J.P., Li,J., Xiao,Y.P. and Xu,L.G.
  TITLE     BAG6 negatively regulates the RLR signaling pathway by targeting
            VISA/MAVS
  JOURNAL   Front Immunol 13, 972184 (2022)
   PUBMED   36045679
  REMARK    GeneRIF: BAG6 negatively regulates the RLR signaling pathway by
            targeting VISA/MAVS.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3488)
  AUTHORS   Song,H., Chen,D., Bai,R., Feng,Y., Wu,S., Wang,T., Xia,X., Li,J.,
            Miao,Y.L., Zuo,B. and Li,F.
  TITLE     BCL2-associated athanogene 6 exon24 contributes to testosterone
            synthesis and male fertility in mammals
  JOURNAL   Cell Prolif 55 (7), e13281 (2022)
   PUBMED   35688694
  REMARK    GeneRIF: BCL2-associated athanogene 6 exon24 contributes to
            testosterone synthesis and male fertility in mammals.
REFERENCE   6  (bases 1 to 3488)
  AUTHORS   Lanning,D. and Lafuse,W.P.
  TITLE     Localization of the casein kinase II beta-subunit gene within the
            mouse H-2 complex class III region and comparison of expression
            with Bat genes
  JOURNAL   Mamm Genome 8 (7), 519-521 (1997)
   PUBMED   9196000
REFERENCE   7  (bases 1 to 3488)
  AUTHORS   Dagenais,S.L. and Nakamura,I.
  TITLE     A physical map of the mouse H2 Bat5/Db interval
  JOURNAL   Mamm Genome 8 (1), 39-41 (1997)
   PUBMED   9021146
REFERENCE   8  (bases 1 to 3488)
  AUTHORS   Wang,R. and Liew,C.C.
  TITLE     The human BAT3 ortholog in rodents is predominantly and
            developmentally expressed in testis
  JOURNAL   Mol Cell Biochem 136 (1), 49-57 (1994)
   PUBMED   7854331
REFERENCE   9  (bases 1 to 3488)
  AUTHORS   Gasser,D.L., Sternberg,N.L., Pierce,J.C., Goldner-Sauve,A.,
            Feng,H., Haq,A.K., Spies,T., Hunt,C., Buetow,K.H. and Chaplin,D.D.
  TITLE     P1 and cosmid clones define the organization of 280 kb of the mouse
            H-2 complex containing the Cps-1 and Hsp70 loci
  JOURNAL   Immunogenetics 39 (1), 48-55 (1994)
   PUBMED   7993390
REFERENCE   10 (bases 1 to 3488)
  AUTHORS   Lafuse,W.P., Lanning,D., Spies,T. and David,C.S.
  TITLE     PFGE mapping and RFLP analysis of the S/D region of the mouse H-2
            complex
  JOURNAL   Immunogenetics 36 (2), 110-116 (1992)
   PUBMED   1351875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4994141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               CR974444.18        71495-71623
            130-250             CR974444.18        72110-72230
            251-368             CR974444.18        74367-74484
            369-565             CR974444.18        74581-74777
            566-640             CR974444.18        75230-75304
            641-897             CR974444.18        76228-76484
            898-1027            CR974444.18        76817-76946
            1028-1225           CR974444.18        77421-77618
            1226-1478           CR974444.18        77825-78077
            1479-1556           CR974444.18        78302-78379
            1557-1669           CR974444.18        78722-78834
            1670-1754           CR974444.18        78921-79005
            1755-2104           CR974444.18        79328-79677
            2105-2396           CR974444.18        80146-80437
            2397-2566           CR974444.18        80594-80763
            2567-2620           CR974444.18        80941-80994
            2621-2723           CR974444.18        81132-81234
            2724-2848           CR974444.18        81324-81448
            2849-2995           CR974444.18        81601-81747
            2996-3055           CR974444.18        81857-81916
            3056-3199           CR974444.18        82021-82164
            3200-3307           CR974444.18        82241-82348
            3308-3488           CR974444.18        83136-83316
FEATURES             Location/Qualifiers
     source          1..3488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     gene            1..3488
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /note="BCL2-associated athanogene 6"
                     /db_xref="GeneID:224727"
                     /db_xref="MGI:MGI:1919439"
     exon            1..129
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            130..250
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..3403
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /note="isoform 15 is encoded by transcript variant 31;
                     HLA-B-associated transcript 3; large proline-rich protein
                     BAT3; large proline-rich protein BAG6; protein Scythe; BAG
                     family molecular chaperone regulator 6"
                     /codon_start=1
                     /product="large proline-rich protein BAG6 isoform 15"
                     /protein_id="NP_001359218.1"
                     /db_xref="GeneID:224727"
                     /db_xref="MGI:MGI:1919439"
                     /translation="MEPSDSASTAMEEPDSLEVLVKTLDSQTRTFIVGAQMNVKEFKE
                     HIAASVSIPSEKQRLIYQGRVLQDDKKLQEYNVGGKVIHLVERAPPQTQLPSGASSGT
                     GSASATHGGAPLPGTRGPGASVHDRNANSYVMVGTFNLPSEPRVRLVMAQHMIRDIQT
                     LLSRMECRGGTQAQASQPPPQTPQTVASETVALNSQTSEPVESEAPPREPMESEEMEE
                     RPPTQTPELAPSGPAPAGPAPAGPAPAPETNAPNHPSPAEHVEVLQELQRLQRRLQPF
                     LQRYCEVLGAAATTDYNNNHEGREEDQRLINLVGESLRLLGNTFVALSDLRCNLACAP
                     PRHLHVVRPMSHYTTPMVLQQAAIPIQINVGTTVTMTGNGARPPPAPGAEAATPGSAQ
                     ATSLPPSSTTVDSSTEGAPPPGPAPPPASSHPRVIRISHQSVEPVVMMHMNIQDSGAQ
                     PGGVPSAPTGPLGPPGHGQTLGQQVPGFPTAPTRVVIARPTPPQARPSHPGGPPVSGA
                     LGAGLGTNTSLAQMVSGLVGQLLMQPVLVAQGTPGMAQAQAQAQAQAQAQAQAPAPAP
                     APAPAPATASASAGTTNTATTAGPAPGGPAQPPPPQPSAADLQFSQLLGNLLGPAGPG
                     AGGPGMASPTITVAMPGVPAFLQGMTDFLQASQTAPPPPPPPPPPPPAPEQQSTPPPG
                     SPSGGTASPGGLGPESLPPEFFTSVVQGVLSSLLGSLGARAGSSESIAAFIQRLSGSS
                     NIFEPGADGALGFFGALLSLLCQNFSMVDVVMLLHGHFQPLQRLQPQLRSFFHQHYLG
                     GQEPTPSNIRMATHTLITGLEEYVRESFSLVQVQPGVDIIRTNLEFLQEQFNSIAAHV
                     LHCTDSGFGARLLELCNQGLFECLALNLHCLGGQQMELAAVINGRIRRMSRGVNPSLV
                     SWLTTMMGLRLQVVLEHMPVGPDAILRYVRRVGDPPQTLPEEPMEVQGAERTSPEPQR
                     ENASPAPGTTAEEAMSRGPPPAPEGGSRDEQDGASADAEPWAAAVPPEWVPIIQQDIQ
                     SQRKVKPQPPLSDAYLSGMPAKRRKLRSDIQKRLQEDPNYSPQRFPNAHRAFADDP"
     exon            251..368
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            369..565
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            566..640
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            641..897
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1027
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1225
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1478
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1556
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1669
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1754
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2104
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2396
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2566
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2620
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2723
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2848
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2995
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3055
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3199
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3307
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3488
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3452..3457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /note="hexamer: AATAAA"
     polyA_site      3488
                     /gene="Bag6"
                     /gene_synonym="2410045D21Rik; BAG-6; Bat3; D17H6S52E; G3;
                     Scythe"
                     /note="major polyA site"
ORIGIN      
        1 acagggtggt gggctgtgta tgtgtgtttg tatgtgtttg gtcgcgtgtt ggttaagtcg
       61 tgttgctgga ataccgagga gaggcggagg cggaaggcgg gggcggtcag cgagcccgtc
      121 cagcctccca gagctgtcgg ccatggagcc gagtgatagt gccagtaccg ctatggagga
      181 gcctgacagc ctggaggtac tggtgaagac cctggactct cagactcgga cttttattgt
      241 gggggcccag atgaatgtaa aggagtttaa ggaacacata gctgcctctg tcagcatccc
      301 ttccgagaaa cagcggctca tctaccaggg ccgggtccta caagacgaca agaagctcca
      361 ggagtacaac gttgggggaa aggttattca cctggtggaa cgggctcctc ctcagactca
      421 gcttccttct ggagcatctt ctgggacagg ctctgcctca gcaactcatg gtggggcacc
      481 cctgcctggc actcggggcc ctggggcttc tgttcatgac cggaatgcca acagctatgt
      541 catggttgga accttcaatc ttcctagtga gccccgggtc cggctggtga tggctcagca
      601 catgattagg gatatacaga ccttactgtc ccggatggag tgtcgagggg gaacccaagc
      661 tcaggccagt cagccacccc cgcagacacc gcagactgtg gcctcagaga cggtagcctt
      721 gaactcacaa acatcagaac cagtcgaaag tgaagctcct cctcgagagc ccatggagtc
      781 agaagaaatg gaggaacgtc ccccaaccca gactccagag cttgcgccct caggcccagc
      841 tcccgcaggc ccagctcccg caggcccagc tcccgcgcca gagacaaatg cacccaacca
      901 cccttccccc gcagagcacg tggaggtgct ccaggagctt cagcgcttgc agcgccgtct
      961 tcagcctttc ctacagcgct actgcgaggt cctgggcgct gctgccacca cagactacaa
     1021 caacaaccat gagggccgtg aggaggacca gaggttgatc aacttggttg gggagagcct
     1081 gcggctactg ggcaacactt tcgtggcatt gtctgatctg cgctgcaatc tagcctgtgc
     1141 acccccacgg cacctgcacg tggttcggcc tatgtctcac tacacgactc ccatggtgct
     1201 ccagcaggca gccattccca ttcagatcaa tgtggggact actgtgacca tgacaggcaa
     1261 tggggctcgg cctccaccag ctcctggtgc ggaggcagca accccaggtt ctgcccaggc
     1321 cacatccctg cctccctctt ccaccactgt tgattcatca actgaaggag ctcccccacc
     1381 agggccagca ccgccaccag cctccagcca cccacgggtc atccggattt cccaccagag
     1441 tgtggagccc gtggtcatga tgcacatgaa cattcaagat tctggagcac agcctggtgg
     1501 tgtgccaagt gctcccactg gtccactggg acctcctggt catggacaga ccctgggaca
     1561 gcaggtgccc ggcttcccaa cagcaccaac tcgggtggtg attgcccggc caactcctcc
     1621 acaggctcgg ccttcccatc ctgggggacc tccagtctct ggagctctgg gcgctgggct
     1681 gggtacaaac acttcattgg cccagatggt gagcggcctt gtggggcaac ttcttatgca
     1741 gcctgttctt gtggctcagg ggactccagg aatggctcag gctcaggccc aggcccaggc
     1801 tcaggcccag gcccaggccc aggctccagc tccggctccg gctccagctc cagctcctgc
     1861 cactgcttca gctagtgctg gtactaccaa cacagctacc acagctggcc ctgctcctgg
     1921 gggtcctgcc cagcctccac ctcctcagcc ctctgcagct gatcttcagt tctctcagct
     1981 cctgggaaat ctgctggggc ctgcagggcc aggggctggg gggccaggca tggcttctcc
     2041 caccatcact gtggcaatgc ctggtgtccc tgcttttctc cagggcatga ctgatttttt
     2101 gcaggcatca cagactgccc ctccaccccc tccacctcct ccacccccac cccctgcccc
     2161 agagcagcag agcacacccc caccagggtc tccttctggt ggaacagcaa gccctggagg
     2221 cttaggtcct gagagcctgc caccagagtt tttcacctca gtggtgcagg gcgtgttgag
     2281 ctccctcctg ggctccttgg gggctcgagc tggcagcagt gagagtatcg ctgccttcat
     2341 ccaacgcctc agtggatcca gcaacatctt tgagcctggg gctgatggcg cccttggatt
     2401 cttcggagct ctgctctctc tcctgtgcca gaatttctcc atggtggatg tggtgatgct
     2461 tctccatggc catttccagc cactgcagcg gctccagcca cagctgcgat ctttcttcca
     2521 ccagcactac ctgggtggcc aggagcccac gcctagcaac atccggatgg cgacccacac
     2581 actgatcact gggctggaag agtatgtaag ggagagtttt tctttggtac aggttcagcc
     2641 aggtgtggat atcatccgga caaatttaga atttctccaa gagcagttta acagcattgc
     2701 tgctcatgtg ctgcactgta cagacagtgg atttggagcc cggttgctgg agctgtgtaa
     2761 ccagggcctg tttgaatgct tggccctgaa cctccactgc ttggggggac agcaaatgga
     2821 gcttgctgct gtcatcaatg gtcgaattcg ccgcatgtct cgcggggtga atccatcctt
     2881 ggtgagctgg ctgacaacca tgatgggact gaggcttcag gtggtcttgg agcacatgcc
     2941 tgtgggtccc gacgccatcc tcagatatgt tcgtagggtt ggtgatcctc ctcagacact
     3001 tcctgaagag ccgatggaag ttcagggagc agaaagaact tcccctgaac ctcagagaga
     3061 gaatgcttcc ccagcccctg gaacaacagc agaagaagcc atgtcccgag gcccgccccc
     3121 tgctcctgaa ggaggttccc gagatgaaca ggatggagct tcagctgatg cagaaccctg
     3181 ggcagctgca gtcccccctg aatgggtccc tattatccag caggacattc agagccagcg
     3241 gaaggtgaaa cctcagccgc ccctgagtga tgcctacctc agtggcatgc ctgccaagag
     3301 acgaaagctc cggtctgata tccaaaaacg actgcaggaa gatcccaact acagccccca
     3361 gcgcttccct aatgcccatc gggcatttgc tgatgacccc tagctttctc accaggggac
     3421 cacttccccc cttccttcac agtatttaag aaataaaagt cggattttcc tggctccttt
     3481 gcctagta
//
