LOCUS       NM_027404               2150 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus BCL2-associated athanogene 5 (Bag5), transcript
            variant 1, mRNA.
ACCESSION   NM_027404 XM_127149
VERSION     NM_027404.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2150)
  AUTHORS   Wongong,R., Kijtawornrat,A., Srichomthong,C., Tongkobpeth,S.,
            Od-Ek,P., Assawapitaksakul,A., Caengprasath,N.,
            Khongphatthanayothin,A., Porntaveetus,T. and Shotelersuk,V.
  TITLE     A novel BAG5 variant impairs the ER stress response pathway,
            causing dilated cardiomyopathy and arrhythmia
  JOURNAL   Sci Rep 14 (1), 11980 (2024)
   PUBMED   38796549
  REMARK    GeneRIF: A novel BAG5 variant impairs the ER stress response
            pathway, causing dilated cardiomyopathy and arrhythmia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2150)
  AUTHORS   Gan,S., Zhou,S., Ma,J., Xiong,M., Xiong,W., Fan,X., Liu,K., Gui,Y.,
            Chen,B., Zhang,B., Wang,X., Wang,F., Li,Z., Yan,W., Ma,M. and
            Yuan,S.
  TITLE     BAG5 regulates HSPA8-mediated protein folding required for sperm
            head-tail coupling apparatus assembly
  JOURNAL   EMBO Rep 25 (4), 2045-2070 (2024)
   PUBMED   38454159
  REMARK    GeneRIF: BAG5 regulates HSPA8-mediated protein folding required for
            sperm head-tail coupling apparatus assembly.
REFERENCE   3  (bases 1 to 2150)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2150)
  AUTHORS   Bracho-Valdes,I., Cervantes-Villagrana,R.D., Beltran-Navarro,Y.M.,
            Olguin-Olguin,A., Escobar-Islas,E., Carretero-Ortega,J.,
            Olivares-Reyes,J.A., Reyes-Cruz,G., Gutkind,J.S. and
            Vazquez-Prado,J.
  TITLE     Akt Is Controlled by Bag5 through a Monoubiquitination to
            Polyubiquitination Switch
  JOURNAL   Int J Mol Sci 24 (24), 17531 (2023)
   PUBMED   38139359
  REMARK    GeneRIF: Akt Is Controlled by Bag5 through a Monoubiquitination to
            Polyubiquitination Switch.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2150)
  AUTHORS   Hakui,H., Kioka,H., Miyashita,Y., Nishimura,S., Matsuoka,K.,
            Kato,H., Tsukamoto,O., Kuramoto,Y., Takuwa,A., Takahashi,Y.,
            Saito,S., Ohta,K., Asanuma,H., Fu,H.Y., Shinomiya,H., Yamada,N.,
            Ohtani,T., Sawa,Y., Kitakaze,M., Takashima,S., Sakata,Y. and
            Asano,Y.
  TITLE     Loss-of-function mutations in the co-chaperone protein BAG5 cause
            dilated cardiomyopathy requiring heart transplantation
  JOURNAL   Sci Transl Med 14 (628), eabf3274 (2022)
   PUBMED   35044787
REFERENCE   6  (bases 1 to 2150)
  AUTHORS   Guo,K., Li,L., Yin,G., Zi,X. and Liu,L.
  TITLE     Bag5 protects neuronal cells from amyloid beta-induced cell death
  JOURNAL   J Mol Neurosci 55 (4), 815-820 (2015)
   PUBMED   25367796
  REMARK    GeneRIF: knockdown of Bag5 exacerbated Abeta1-42-induced apoptosis.
REFERENCE   7  (bases 1 to 2150)
  AUTHORS   Beilina,A., Rudenko,I.N., Kaganovich,A., Civiero,L., Chau,H.,
            Kalia,S.K., Kalia,L.V., Lobbestael,E., Chia,R., Ndukwe,K., Ding,J.,
            Nalls,M.A., Olszewski,M., Hauser,D.N., Kumaran,R., Lozano,A.M.,
            Baekelandt,V., Greene,L.E., Taymans,J.M., Greggio,E. and
            Cookson,M.R.
  CONSRTM   International Parkinson's Disease Genomics Consortium; North
            American Brain Expression Consortium
  TITLE     Unbiased screen for interactors of leucine-rich repeat kinase 2
            supports a common pathway for sporadic and familial Parkinson
            disease
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2626-2631 (2014)
   PUBMED   24510904
REFERENCE   8  (bases 1 to 2150)
  AUTHORS   Wang,X., Guo,J., Fei,E., Mu,Y., He,S., Che,X., Tan,J., Xia,K.,
            Zhang,Z., Wang,G. and Tang,B.
  TITLE     BAG5 protects against mitochondrial oxidative damage through
            regulating PINK1 degradation
  JOURNAL   PLoS One 9 (1), e86276 (2014)
   PUBMED   24475098
  REMARK    GeneRIF: BAG5 protects against mitochondrial oxidative damage
            through regulating PINK1 degradation.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2150)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
  REMARK    GeneRIF: Bcl-2-associated athanogene 5 (BAG5) is a negative
            regulator of both Hsp70 and parkin function that sensitizes
            dopaminergic neurons to injury-induced death.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152065.4, CX243791.1 and BC055762.1.
            
            On Feb 2, 2010 this sequence version replaced NM_027404.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023099.1, SRR7652917.367786.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC152065.4         194045-194077
            34-719              CX243791.1         1-686
            720-2150            BC055762.1         640-2070
FEATURES             Location/Qualifiers
     source          1..2150
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.11 cM"
     gene            1..2150
                     /gene="Bag5"
                     /gene_synonym="1600025G07Rik; 4930405J06Rik; Bag-5"
                     /note="BCL2-associated athanogene 5"
                     /db_xref="GeneID:70369"
                     /db_xref="MGI:MGI:1917619"
     exon            1..213
                     /gene="Bag5"
                     /gene_synonym="1600025G07Rik; 4930405J06Rik; Bag-5"
                     /inference="alignment:Splign:2.1.0"
     exon            214..2138
                     /gene="Bag5"
                     /gene_synonym="1600025G07Rik; 4930405J06Rik; Bag-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1582
                     /gene="Bag5"
                     /gene_synonym="1600025G07Rik; 4930405J06Rik; Bag-5"
                     /note="bcl-2-associated athanogene 5; BAG-family molecular
                     chaperone regulator-5 (BAG-5)"
                     /codon_start=1
                     /product="BAG family molecular chaperone regulator 5"
                     /protein_id="NP_081680.1"
                     /db_xref="CCDS:CCDS26185.1"
                     /db_xref="GeneID:70369"
                     /db_xref="MGI:MGI:1917619"
                     /translation="MDMGNQHPSISRLQEIQREVKAIEPQVVGFSGLSDDKNYKRLER
                     ILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNANHPHRIEIQNIFKEAQ
                     ALVKDKIVPFYSGGNCVTDEFEEGIQDIILRLTHVKTGGKVSLRKARYRTLTKICAVQ
                     EVIEDCMKKQPSLPLSEDVHPSVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSC
                     VLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEEEADSTHAFDLGQNHSI
                     IKIENVLKRMREIKNELLQAQSPPELYLRAKTELQGLIGQLDEVSLEKNPCIREARRR
                     AVIEVQILITYLDLKEALEKRKLFPCEEHPPHKAVWEILGNLSEILGEVLSFGGNRTD
                     KNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDMKSDEWEY"
     regulatory      2114..2119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bag5"
                     /gene_synonym="1600025G07Rik; 4930405J06Rik; Bag-5"
                     /note="hexamer: CATAAA"
     polyA_site      2138
                     /gene="Bag5"
                     /gene_synonym="1600025G07Rik; 4930405J06Rik; Bag-5"
                     /note="major polyA site"
ORIGIN      
        1 gttggcgtta cggcggcgtc gcaaagcccg agccgacgcg cggcgaggcc gaccgtgcgc
       61 attccctggg acggacgccg ggcggcgggg cccgcgcggg acgaggagag gacaagtttt
      121 ccccgggctc actgctgacg ggcccgctct gcgaggacgg cgacaacgct gcggaagtgt
      181 aggtggcggg gcgcgatggc gcgtgcggcc cagtgcttgt gaaactgaac acagaagtat
      241 ggatatggga aaccaacacc cctccattag taggcttcag gagatccagc gggaagtaaa
      301 ggctatagag ccgcaagtgg tcggcttcag cggcctgtcg gatgacaaga actacaagag
      361 gctggagagg attctgacca aacaactttt tgaaattgac tctgtggata cggaaggaaa
      421 aggagatatc cagcaagcta ggaagcgggc ggcacaggag acagaacgtc tcctcaagga
      481 gttggagcag aatgccaacc acccacaccg catcgaaatc cagaatatct ttaaggaggc
      541 tcaggccctt gtgaaagaca agattgtgcc cttttacagc ggaggcaact gtgtgactga
      601 cgagtttgag gaaggcatcc aggacatcat tctgaggctg acgcacgtga agaccggagg
      661 gaaggtctcc ttgcggaaag ccaggtaccg cacgctcacc aagatctgcg cggtacagga
      721 ggttattgag gactgtatga agaagcagcc gtccctgcca ctgtctgagg atgtgcatcc
      781 ttcagtggcc aaaatcaact ctgtcatgtg cgaggtgaac aaggccagag ggacgctgat
      841 cgcacttctg atgggcgtgg acagttccga gacttgcagg cacttatcct gcgtgctgtc
      901 aggactgatt gctgacttag atgctctaga tgtgtgtggg cgtacagaga tcagaaatta
      961 tcggagggag gtggtggaag atatcaacaa attactgaaa tacctagact tagaagagga
     1021 agctgacagt acacatgcat ttgacctggg acagaaccat tccattataa aaatagaaaa
     1081 tgttctcaag aggatgagag agataaaaaa tgaacttctc caggcgcaga gccctcctga
     1141 gttgtacctg agggccaaga cagagctgca gggcttgatc ggacagctgg atgaagtgag
     1201 tctggagaaa aacccctgca tccgggaggc caggaggagg gcggtgattg aggtgcagat
     1261 cctgatcacg tacctggacc tgaaggaagc cctcgagaag aggaagctgt tcccatgtga
     1321 ggagcacccc ccacacaagg ccgtgtggga gatccttggg aacctgtctg agatcctggg
     1381 cgaagtcctt tcatttggtg gaaaccgaac tgataagaac tacatccgtc tggaggagct
     1441 actgaccaaa cagttgctgg ctctggatgc cgttgaccca cagggagaag agaagtgtaa
     1501 ggctgccagg aaacaggctg tgaaactggc ccagaacatc ctcagctacc tggacatgaa
     1561 gtcggacgag tgggagtatt gatgggccag gagctgatct cgctggttcg cacctcatct
     1621 cctttagaga gctctcagct catggagcct aaatgtaatt tctatgtgca tagtcaatct
     1681 cagtatttat gatttaatca aattatattc agtatttctg ctgcttttga tgttgcaaac
     1741 gaatatcatt atagcacatt accttttcca tctggctcat tatccttaca atgtgtggtt
     1801 tgtgtttatt ttgtgtgttt ttaatgggaa cacgaaaaag gcagcattcc taagttttaa
     1861 atgggttgtg caagcattag atgcagaatt tgagagtcta gaaacagatt agacttttct
     1921 aactctagcc taatttttaa ctctagccta attaagagga ggaggaggga attccagggt
     1981 tgaataaaat ccaagcatag aaagagacgc tttattatgc taaacagtgc tgggactttt
     2041 taaagttaca aggcctaatg ggtcctgccc agttttaatg gggtggggtt tttgtttgga
     2101 tggtctgttt tatcataaac atttttgctt gaaaaaaaaa aaaaaaaaaa
//
