LOCUS       NM_013863               2607 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus BCL2-associated athanogene 3 (Bag3), mRNA.
ACCESSION   NM_013863
VERSION     NM_013863.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2607)
  AUTHORS   Huang,X., Guo,J., Ning,A., Zhang,N. and Sun,Y.
  TITLE     BAG3 promotes proliferation and migration of arterial smooth muscle
            cells by regulating STAT3 phosphorylation in diabetic vascular
            remodeling
  JOURNAL   Cardiovasc Diabetol 23 (1), 140 (2024)
   PUBMED   38664681
  REMARK    GeneRIF: BAG3 promotes proliferation and migration of arterial
            smooth muscle cells by regulating STAT3 phosphorylation in diabetic
            vascular remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2607)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2607)
  AUTHORS   Lin,H., Sandkuhler,S., Dunlea,C., Rodwell-Bullock,J., King,D.H. and
            Johnson,G.V.W.
  TITLE     BAG3 regulates the specificity of the recognition of specific MAPT
            species by NBR1 and SQSTM1
  JOURNAL   Autophagy 20 (3), 577-589 (2024)
   PUBMED   37899687
  REMARK    GeneRIF: BAG3 regulates the specificity of the recognition of
            specific MAPT species by NBR1 and SQSTM1.
REFERENCE   4  (bases 1 to 2607)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   5  (bases 1 to 2607)
  AUTHORS   Liu,X., Ye,Q., Huang,Z., Li,X., Zhang,L., Liu,X., Wu,Y.C.,
            Brockmeier,U., Hermann,D.M., Wang,Y.C. and Ren,L.
  TITLE     BAG3 Overexpression Attenuates Ischemic Stroke Injury by Activating
            Autophagy and Inhibiting Apoptosis
  JOURNAL   Stroke 54 (8), 2114-2125 (2023)
   PUBMED   37377010
  REMARK    GeneRIF: BAG3 Overexpression Attenuates Ischemic Stroke Injury by
            Activating Autophagy and Inhibiting Apoptosis.
REFERENCE   6  (bases 1 to 2607)
  AUTHORS   Homma,S., Iwasaki,M., Shelton,G.D., Engvall,E., Reed,J.C. and
            Takayama,S.
  TITLE     BAG3 deficiency results in fulminant myopathy and early lethality
  JOURNAL   Am J Pathol 169 (3), 761-773 (2006)
   PUBMED   16936253
  REMARK    GeneRIF: BAG3 is not required for muscle development, this
            co-chaperone appears to be critically important for maintenance of
            mature skeletal muscle.
REFERENCE   7  (bases 1 to 2607)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   8  (bases 1 to 2607)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2607)
  AUTHORS   Antoku,K., Maser,R.S., Scully,W.J. Jr., Delach,S.M. and
            Johnson,D.E.
  TITLE     Isolation of Bcl-2 binding proteins that exhibit homology with
            BAG-1 and suppressor of death domains protein
  JOURNAL   Biochem Biophys Res Commun 286 (5), 1003-1010 (2001)
   PUBMED   11527400
REFERENCE   10 (bases 1 to 2607)
  AUTHORS   Lee,J.H., Takahashi,T., Yasuhara,N., Inazawa,J., Kamada,S. and
            Tsujimoto,Y.
  TITLE     Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in
            preventing cell death
  JOURNAL   Oncogene 18 (46), 6183-6190 (1999)
   PUBMED   10597216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130474.12, AK007414.1 and BY685079.1.
            
            On Jun 10, 2009 this sequence version replaced NM_013863.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041583.1, AK007414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC130474.12        34886-35074         c
            190-2591            AK007414.1         1-2402
            2592-2607           BY685079.1         361-376
FEATURES             Location/Qualifiers
     source          1..2607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 70.26 cM"
     gene            1..2607
                     /gene="Bag3"
                     /gene_synonym="Bis; mg638"
                     /note="BCL2-associated athanogene 3"
                     /db_xref="GeneID:29810"
                     /db_xref="MGI:MGI:1352493"
     exon            1..462
                     /gene="Bag3"
                     /gene_synonym="Bis; mg638"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..2010
                     /gene="Bag3"
                     /gene_synonym="Bis; mg638"
                     /note="Bcl-2-binding protein Bis; BAG-3; bcl-2-associated
                     athanogene 3; Bcl-2-interacting death suppressor"
                     /codon_start=1
                     /product="BAG family molecular chaperone regulator 3"
                     /protein_id="NP_038891.4"
                     /db_xref="CCDS:CCDS21898.1"
                     /db_xref="GeneID:29810"
                     /db_xref="MGI:MGI:1352493"
                     /translation="MSAATQSPMMQMASGNGASDRDPLPPGWEIKIDPQTGWPFFVDH
                     NSRTTTWNDPRVPPEGPKDTASSANGPSRDGSRLLPIREGHPIYPQLRPGYIPIPVLH
                     EGSENRQPHLFHAYSQPGVQRFRTEAAAATPQRSQSPLRGGMTEAAQTDKQCGQMPAT
                     ATTAAAQPPTAHGPERSQSPAASDCSSSSSSASLPSSGRSSLGSHQLPRGYIPIPVIH
                     EQNITRPAAQPSFHQAQKTHYPAQQGEYQPQQPVYHKIQGDDWEPRPLRAASPFRSPV
                     RGASSREGSPARSGTPVHCPSPIRVHTVVDRPQPMTHREPPPVTQPENKPESKPGPAG
                     PDLPPGHIPIQVIRREADSKPVSQKSPPPAEKVEVKVSSAPIPCPSPSPAPSAVPSPP
                     KNVAAEQKAAPSPAPAEPAAPKSGEAETPPKHPGVLKVEAILEKVQGLEQAVDSFEGK
                     KTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPG
                     QVQVYELQPSNLEAEQPLQEIMGAVVADKDKKGPENKDPQTESQQLEAKAATPPNPSN
                     PADSAGNLVAP"
     exon            463..801
                     /gene="Bag3"
                     /gene_synonym="Bis; mg638"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1203
                     /gene="Bag3"
                     /gene_synonym="Bis; mg638"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..2595
                     /gene="Bag3"
                     /gene_synonym="Bis; mg638"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bag3"
                     /gene_synonym="Bis; mg638"
                     /note="hexamer: ATTATA"
     polyA_site      2595
                     /gene="Bag3"
                     /gene_synonym="Bis; mg638"
                     /note="major polyA site"
ORIGIN      
        1 catccaaccc acggcggccg ccaagttctc tggatgggac cagaagtttc tagccggcca
       61 gttgctgcct tctctttatc tcctccttcc cctttggcag ctaggaggct atttccagac
      121 acttccaccc ctcttcggcc acgtcaccca gtcctttaat tcataaaggt gcccggcgcc
      181 ggcttcccgg acacatcggc tacacagagg tgcccgcact ccacgacctc gtgacccgcg
      241 ccctagctct gcgccccggg cggaccctaa cccagcatga gcgccgccac ccaatcgccc
      301 atgatgcaga tggcgtccgg caacggagcc agcgaccgag accccctgcc cccgggctgg
      361 gagatcaaaa tcgacccgca gaccggctgg cccttcttcg tggaccacaa cagccgcacc
      421 acgacgtgga acgacccgcg tgtgcccccc gagggcccta aggacactgc atcttcagcc
      481 aatggccctt cccgcgatgg ctcccgcctg ctgcccatta gggaaggcca ccccatatac
      541 ccccagctcc gaccaggcta cattcccatc cccgtcctcc atgaaggctc cgagaaccgg
      601 cagccccacc ttttccatgc ctactcccag cctggggtgc agcgatttcg taccgaggct
      661 gcagcggcca ctccgcagag gtcccagtct cctttacgtg gcggcatgac agaagccgcc
      721 cagacagata aacagtgtgg acagatgccg gcaactgcaa caactgcagc agctcagccc
      781 ccaactgctc atggacctga gcgatctcag tctccagctg cctctgactg ctcatcctct
      841 tcctcctcgg ccagcctgcc ctcctccggc aggagcagtc tgggtagcca tcagctcccc
      901 aggggctaca tccccatccc cgtgatacat gagcagaata tcacccggcc agcagcccag
      961 ccctccttcc accaagccca gaagacccac tacccagctc agcagggtga ataccagccc
     1021 cagcagcctg tataccacaa gatccagggc gatgactggg agccccggcc gcttcgagcc
     1081 gcttctccat tcaggtcacc cgtcagaggt gcttccagcc gggaaggctc gcccgccaga
     1141 agcggcacac cggttcactg cccatctccc atccgtgtgc acacagtggt tgacaggcct
     1201 cagcccatga cccatcgaga gcctccacct gttacccaac ccgaaaacaa accagaaagt
     1261 aagccaggcc cagccggacc agacctccct cctggacaca tccccatcca agtgatccga
     1321 agggaggcag actctaagcc tgtttcccag aagtcacctc ctcctgctga aaaggtagaa
     1381 gtaaaggtct cctctgctcc aattccttgt ccttctccca gccccgctcc ttcggctgtc
     1441 ccttctcccc ccaagaatgt ggctgcagaa cagaaggcgg cccccagccc tgcccctgca
     1501 gaacctgcag cccccaaatc gggagaagcc gaaacacccc ctaagcatcc aggtgtgctg
     1561 aaagtggaag ccatcctgga gaaggtacaa gggctggagc aggctgtaga cagctttgaa
     1621 ggcaagaaga ctgataaaaa atacctgatg atcgaagagt atttgaccaa agagctgctg
     1681 gccctggatt ccgtagaccc tgaaggacga gctgatgtgc ggcaggccag gagagatggc
     1741 gtcaggaagg ttcagaccat cttggaaaaa cttgagcaga aagcaattga tgtcccaggt
     1801 caagtacaag tctatgaact ccagcccagc aaccttgagg ccgagcagcc actccaggaa
     1861 atcatgggtg ccgtggtagc cgacaaggat aagaaaggtc ctgaaaacaa agatccacaa
     1921 actgaaagcc aacagctaga agccaaagca gccacacctc caaatcccag caacccagca
     1981 gactcagctg gcaacctggt ggctccctag tgtcccctgg gaccatgctg tagagacttt
     2041 taagttgcat gcactgcggg acttgcagtc agctggctgc cattattcat agccgcttgg
     2101 tatgcagtaa cttggggtgg aggtaaaaca ctaacaaagg gggcttttct tccatagtct
     2161 attctgtata aataataagt tgcctgttcc agaagtctaa ccctaacccc tctggttgtc
     2221 tgggacccct ttctgtgcat gggtgcaatg atttagccat ggctgtgggc tatctgggta
     2281 caatgattta gccgtggctg tgggctatct gggtgcaatg atttagccgt ggctgtgggc
     2341 tatcttcctg ttagccttgg actgaagggg ttttaagttt tgaggggtag gaagagagtt
     2401 acaggaatag agaacctgtt tttgagacat gttgtcattt tgatgagata accttcatct
     2461 cgttactgaa atatctaact tcagctagat atgagctatg caaggagcca taggaatagc
     2521 tatatgttgg aatggcttta atgttgttac atttgagggg ggatggaaaa taaagtgatt
     2581 atataactct caaaaaaaaa aaaaaaa
//
