LOCUS       NM_145392               1815 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BCL2-associated athanogene 2 (Bag2), mRNA.
ACCESSION   NM_145392
VERSION     NM_145392.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Liang,S., Wang,F., Bao,C., Han,J., Guo,Y., Liu,F. and Zhang,Y.
  TITLE     BAG2 ameliorates endoplasmic reticulum stress-induced cell
            apoptosis in Mycobacterium tuberculosis-infected macrophages
            through selective autophagy
  JOURNAL   Autophagy 16 (8), 1453-1467 (2020)
   PUBMED   31711362
  REMARK    GeneRIF: BAG2 ameliorates endoplasmic reticulum stress-induced cell
            apoptosis in Mycobacterium tuberculosis-infected macrophages
            through selective autophagy.
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Qu,D., Hage,A., Don-Carolis,K., Huang,E., Joselin,A., Safarpour,F.,
            Marcogliese,P.C., Rousseaux,M.W., Hewitt,S.J., Huang,T., Im,D.S.,
            Callaghan,S., Dewar-Darch,D., Figeys,D., Slack,R.S. and Park,D.S.
  TITLE     BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for
            Mitochondrial Translocation of PARKIN and Neuronal Survival
  JOURNAL   J Biol Chem 290 (51), 30441-30452 (2015)
   PUBMED   26538564
  REMARK    GeneRIF: findings support the notion that BAG2 is an upstream
            regulator of the PINK1/PARKIN signaling pathway.
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Page,R.C., Xu,Z., Amick,J., Nix,J.C. and Misra,S.
  TITLE     Crystallization and preliminary X-ray crystallographic analysis of
            the Bag2 amino-terminal domain from Mus musculus
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (Pt 6), 647-651
            (2012)
   PUBMED   22684061
  REMARK    GeneRIF: Native Bag2-NTD crystals diffracted to 2.27 A resolution
            and belonged to space group P2(1)2(1)2(1), with unit-cell
            parameters a = 75.5, b = 84.7, c = 114.1 A
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Carrettiero,D.C., Hernandez,I., Neveu,P., Papagiannakopoulos,T. and
            Kosik,K.S.
  TITLE     The cochaperone BAG2 sweeps paired helical filament- insoluble tau
            from the microtubule
  JOURNAL   J Neurosci 29 (7), 2151-2161 (2009)
   PUBMED   19228967
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Xu,Z., Page,R.C., Gomes,M.M., Kohli,E., Nix,J.C., Herr,A.B.,
            Patterson,C. and Misra,S.
  TITLE     Structural basis of nucleotide exchange and client binding by the
            Hsp70 cochaperone Bag2
  JOURNAL   Nat Struct Mol Biol 15 (12), 1309-1317 (2008)
   PUBMED   19029896
  REMARK    GeneRIF: Free and Hsc70-bound crystal structures of Bag2-BNB show
            its dimeric structure, in which a flanking linker helix and loop
            bind to Hsc70 to promote nucleotide exchange.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY014303.1, AK144720.1 and BB144537.1.
            
            On Apr 15, 2006 this sequence version replaced NM_145392.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028944.1, AK144720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY014303.1         3-18
            17-1516             AK144720.1         2-1501
            1517-1813           AK144720.1         1503-1799
            1814-1815           BB144537.1         321-322
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 12.81 cM"
     gene            1..1815
                     /gene="Bag2"
                     /gene_synonym="2610042A13Rik"
                     /note="BCL2-associated athanogene 2"
                     /db_xref="GeneID:213539"
                     /db_xref="MGI:MGI:1891254"
     exon            1..172
                     /gene="Bag2"
                     /gene_synonym="2610042A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            173..282
                     /gene="Bag2"
                     /gene_synonym="2610042A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            283..1815
                     /gene="Bag2"
                     /gene_synonym="2610042A13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1792..1797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bag2"
                     /gene_synonym="2610042A13Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1815
                     /gene="Bag2"
                     /gene_synonym="2610042A13Rik"
                     /note="major polyA site"
ORIGIN      
        1 gacggcgacg tgcggctcgc gccactgctg cccgcggacg ccgaggaccc ccggagctca
       61 tggcccaggc gaagatcagc gccaaggccc acgagggccg cttctgccgc tcgtcttcca
      121 tggccgaccg ctccagccgc ctgctggaga gtctggacca gctggagctc agggtggaag
      181 ctttgagaga cgcagctact gctgttgagc aggagaaaga aatccttctg gagatgatcc
      241 acagtatcca aaacagccag gacatgaggc agattagcga tggagaaaga gaggaactaa
      301 acctgactgc caaccgtctg atgggccgga ccctcacggt tgaggtctcg gtggaaacga
      361 tccgaaaccc ccagcaggag gaatccttga agcatgccac gaggattata gacgaggtgg
      421 tcagcaagtt cctagatgac ctggggaatg ccaagagcca cttaatgtca ctttacagtg
      481 cctgctcatc ggaggtgccg cctgggccgg tggaccagaa gtttcaatcg atagtcatcg
      541 gttgcgctct tgaggatcag aagaaaatca agaggcgatt ggagactctg ctgaggaaca
      601 ttgacaactc cgacaaggcc attaaactcc tagagcatgc taaaggagct ggttccaaaa
      661 gcctgcagaa cactgacggc aaatttaatt agccttcaaa ttcaccggcc cttacaaaag
      721 atgtagaaaa gaaaactact attttcaata gctaggtctc tatgttaggc ataaccactt
      781 aattgatatt ggtaattatt tcagatgggg aagtattcca gtgttggcag acacaggtaa
      841 cacttaacac taggaatatt tcagtcacct actttgaagt tttggacagt gttcccatct
      901 tgaactggac tctagcactg tatatttaac ttctgaagat gcacatgtag tgtgtgtgtg
      961 tgtgggggga gtaaaaaaag agggggagca gcaaaagtcc cactgccctt tccttgactt
     1021 cagcacagag catccagcct ctggagcagt gcactcacat cgcagtgtga gcagagcacc
     1081 cagccctgga gtggtgcatt cacaccacag tgaacagaac acccagccct ggagcagtgc
     1141 actcacaccg cagtgtgaac agaacaccca gcccctggaa cagtgtactc acagcacagt
     1201 ttgaacagag cacccagccc ctagagcagt gtattcacac ctcggtgtga agagaacacc
     1261 cagcccccgg agaggtgcac tcacaccagt gtgaacagat cactcagccc ttgagcagtg
     1321 cactcacagc acacagtgta cctagaagga taagcatatc agaacttcac cctgcatggt
     1381 ctccatgttt caggcatctg ttttctctat gcatatgcat ctcataccat gaatttttag
     1441 gtgtgcgtgg aagcatgaca aatgtgagga gcccaccttc attttaccac tgtgaagctc
     1501 cgcccccacc ccagggccag tgctgaccgc tctcttcatg tgctgccttg agctcacgcg
     1561 tgtgcggcgg gagcacttgc ctaaccactt ccctgtgggc agttggatgg tttcaatttg
     1621 ttgctgtgac tacaacatac ttgtatctgc tgagctttat tctgttcttg gtctttttta
     1681 tataaaattc cattaatggg ttcatcaggc caaaggatat atacattttc atggtctaga
     1741 aacatatttc taaattttta taagttatat cagtttgtac tgtcttcagt aattaaaaga
     1801 atccatttcg ctgaa
//
