LOCUS       NM_001285453             941 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus BCL2-associated agonist of cell death (Bad),
            transcript variant 2, mRNA.
ACCESSION   NM_001285453
VERSION     NM_001285453.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 941)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   2  (bases 1 to 941)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   3  (bases 1 to 941)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   4  (bases 1 to 941)
  AUTHORS   Xiao,W., Zhou,K., Yang,M., Sun,C., Dai,L., Gu,J., Yan,R. and Dai,K.
  TITLE     Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia
            Through Protein Kinase A
  JOURNAL   Front Pharmacol 12, 749930 (2021)
   PUBMED   34658890
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 941)
  AUTHORS   Zhang,L., Qian,Y., Li,J., Zhou,X., Xu,H., Yan,J., Xiang,J.,
            Yuan,X., Sun,B., Sisodia,S.S., Jiang,Y.H., Cao,X., Jing,N. and
            Lin,A.
  TITLE     BAD-mediated neuronal apoptosis and neuroinflammation contribute to
            Alzheimer's disease pathology
  JOURNAL   iScience 24 (9), 102942 (2021)
   PUBMED   34430820
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 941)
  AUTHORS   Kelekar,A., Chang,B.S., Harlan,J.E., Fesik,S.W. and Thompson,C.B.
  TITLE     Bad is a BH3 domain-containing protein that forms an inactivating
            dimer with Bcl-XL
  JOURNAL   Mol Cell Biol 17 (12), 7040-7046 (1997)
   PUBMED   9372935
REFERENCE   7  (bases 1 to 941)
  AUTHORS   Moser,M., Pscherer,A., Roth,C., Becker,J., Mucher,G., Zerres,K.,
            Dixkens,C., Weis,J., Guay-Woodford,L., Buettner,R. and Fassler,R.
  TITLE     Enhanced apoptotic cell death of renal epithelial cells in mice
            lacking transcription factor AP-2beta
  JOURNAL   Genes Dev 11 (15), 1938-1948 (1997)
   PUBMED   9271117
REFERENCE   8  (bases 1 to 941)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   9  (bases 1 to 941)
  AUTHORS   Zha,J., Harada,H., Yang,E., Jockel,J. and Korsmeyer,S.J.
  TITLE     Serine phosphorylation of death agonist BAD in response to survival
            factor results in binding to 14-3-3 not BCL-X(L)
  JOURNAL   Cell 87 (4), 619-628 (1996)
   PUBMED   8929531
REFERENCE   10 (bases 1 to 941)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120557.12 and AK151792.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon compared to variant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151792.1, AK169002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC120557.12        56382-56416         c
            36-929              AK151792.1         1-894
            930-941             AC120557.12        47073-47084         c
FEATURES             Location/Qualifiers
     source          1..941
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.1 cM"
     gene            1..941
                     /gene="Bad"
                     /gene_synonym="Bbc2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:12015"
                     /db_xref="MGI:MGI:1096330"
     exon            1..63
                     /gene="Bad"
                     /gene_synonym="Bbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            64..243
                     /gene="Bad"
                     /gene_synonym="Bbc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..560
                     /gene="Bad"
                     /gene_synonym="Bbc2"
                     /note="isoform 2 is encoded by transcript variant 2; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 2"
                     /protein_id="NP_001272382.1"
                     /db_xref="CCDS:CCDS70924.1"
                     /db_xref="GeneID:12015"
                     /db_xref="MGI:MGI:1096330"
                     /translation="MFQIPEFEPSEQEDASATDRGLGPSLTEDQPGPYLAPGLLGSNI
                     HQQGRAATNSHHGGAGAMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAA
                     QRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSAGWTRIIQSWWDRNLGKGGSTP
                     SQ"
     exon            244..434
                     /gene="Bad"
                     /gene_synonym="Bbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..941
                     /gene="Bad"
                     /gene_synonym="Bbc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      910..915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bad"
                     /gene_synonym="Bbc2"
                     /note="hexamer: AATAAA"
     polyA_site      929
                     /gene="Bad"
                     /gene_synonym="Bbc2"
                     /note="major polyA site"
ORIGIN      
        1 ggcgccctta gaactggagg gaggaggcag gcccgggtca ggggcctcga gatcgggctt
       61 gggcccagag tatgttccag atcccagagt ttgagccgag tgagcaggaa gacgctagtg
      121 ctacagatag gggcctgggc cctagcctca ctgaggacca gccaggtccc tacctggccc
      181 caggtctcct ggggagcaac attcatcagc agggacgggc agccaccaac agtcatcatg
      241 gaggcgcagg ggctatggag actcggagtc gccacagttc gtacccagcg gggaccgagg
      301 aggatgaagg gatggaggag gagcttagcc cttttcgagg acgctcgcgt tcggctcccc
      361 ccaatctctg ggcagcgcag cgctacggcc gtgagctccg aaggatgagc gatgagtttg
      421 agggttcctt caagggactt cctcgcccaa agagcgcagg cactgcaaca cagatgcgac
      481 aaagcgccgg ctggacgcgc attatccagt cctggtggga tcgaaacttg ggcaaaggag
      541 gctccacccc ctcccagtga tcttctgctc cacatcccgg aactctaccc gctcccgtcg
      601 cccgccatat tgggtgtggg cggaagtctt tcgaggcctt aggaaaaaaa aagaggatcg
      661 ctgtgtccct ttaacaggga gaagagctga cgtacagctt gagtcccttc cggtgcgtgc
      721 aatagccacg gaggggtggc tcctgtttgg agtttcaaag ttttccacgc accccacccc
      781 ctaagcctcc ggaagtggct gttttccctc tcctgttctg gactgccctc gggtgcctgt
      841 gctaagttgg gggtctgggt gctgtcctgt cataactggg gacccgaggt cgcgagaaac
      901 gtgctttata ataaagcctg cgcatgtgcc gccgcgcctc t
//
