LOCUS       NM_007520               5858 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus BTB and CNC homology 1, basic leucine zipper
            transcription factor 1 (Bach1), mRNA.
ACCESSION   NM_007520 XM_001004169 XM_975273 XM_975308
VERSION     NM_007520.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5858)
  AUTHORS   Liu,Y., Li,X. and Yang,Y.
  TITLE     BACH1 transcriptionally upregulates FOSL2 to induce M2 macrophages
            phenotype by activating TGFbeta/SMAD signaling to promote the
            transformation of lung fibroblasts into myofibroblasts
  JOURNAL   Tissue Cell 88, 102407 (2024)
   PUBMED   38776730
  REMARK    GeneRIF: BACH1 transcriptionally upregulates FOSL2 to induce M2
            macrophages phenotype by activating TGFbeta/SMAD signaling to
            promote the transformation of lung fibroblasts into myofibroblasts.
REFERENCE   2  (bases 1 to 5858)
  AUTHORS   Wang,Y., Qiu,J., Yan,H., Zhang,N., Gao,S., Xu,N., Wang,C. and
            Lou,H.
  TITLE     The Bach1/HO-1 pathway regulates oxidative stress and contributes
            to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells
            and mice
  JOURNAL   Arch Toxicol 98 (6), 1781-1794 (2024)
   PUBMED   38573338
  REMARK    GeneRIF: The Bach1/HO-1 pathway regulates oxidative stress and
            contributes to ferroptosis in doxorubicin-induced cardiomyopathy in
            H9c2 cells and mice.
REFERENCE   3  (bases 1 to 5858)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5858)
  AUTHORS   Wang,Y., Wang,W., Su,L., Ji,F., Zhang,M., Xie,Y., Zhang,T. and
            Jiao,J.
  TITLE     BACH1 changes microglial metabolism and affects astrogenesis during
            mouse brain development
  JOURNAL   Dev Cell 59 (1), 108-124 (2024)
   PUBMED   38101413
  REMARK    GeneRIF: BACH1 changes microglial metabolism and affects
            astrogenesis during mouse brain development.
REFERENCE   5  (bases 1 to 5858)
  AUTHORS   Jin,J., He,Y., Guo,J., Pan,Q., Wei,X., Xu,C., Qi,Z., Li,Q., Ma,S.,
            Lin,J., Jiang,N., Ma,J., Wang,X., Jiang,L., Ding,Q., Osto,E.,
            Zhi,X. and Meng,D.
  TITLE     BACH1 controls hepatic insulin signaling and glucose homeostasis in
            mice
  JOURNAL   Nat Commun 14 (1), 8428 (2023)
   PUBMED   38129407
  REMARK    GeneRIF: BACH1 controls hepatic insulin signaling and glucose
            homeostasis in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5858)
  AUTHORS   Ogawa,K., Sun,J., Taketani,S., Nakajima,O., Nishitani,C., Sassa,S.,
            Hayashi,N., Yamamoto,M., Shibahara,S., Fujita,H. and Igarashi,K.
  TITLE     Heme mediates derepression of Maf recognition element through
            direct binding to transcription repressor Bach1
  JOURNAL   EMBO J 20 (11), 2835-2843 (2001)
   PUBMED   11387216
  REMARK    GeneRIF: Bach1 is a heme-binding transcription factor. DNA binding
            activity of Bach1 is inhibited by heme.
REFERENCE   7  (bases 1 to 5858)
  AUTHORS   Yoshida,C., Tokumasu,F., Hohmura,K.I., Bungert,J., Hayashi,N.,
            Nagasawa,T., Engel,J.D., Yamamoto,M., Takeyasu,K. and Igarashi,K.
  TITLE     Long range interaction of cis-DNA elements mediated by
            architectural transcription factor Bach1
  JOURNAL   Genes Cells 4 (11), 643-655 (1999)
   PUBMED   10620011
  REMARK    GeneRIF: Bach1 forms a multivalent DNA binding complex and
            functions as an architectural transcription factor.
REFERENCE   8  (bases 1 to 5858)
  AUTHORS   Igarashi,K., Hoshino,H., Muto,A., Suwabe,N., Nishikawa,S.,
            Nakauchi,H. and Yamamoto,M.
  TITLE     Multivalent DNA binding complex generated by small Maf and Bach1 as
            a possible biochemical basis for beta-globin locus control region
            complex
  JOURNAL   J Biol Chem 273 (19), 11783-11790 (1998)
   PUBMED   9565602
  REMARK    GeneRIF: Bach1 generates multivalent DNA binding complex through
            protein-protein interaction mediated by its BTB/POZ domain
REFERENCE   9  (bases 1 to 5858)
  AUTHORS   Ohira,M., Seki,N., Nagase,T., Ishikawa,K., Nomura,N. and Ohara,O.
  TITLE     Characterization of a human homolog (BACH1) of the mouse Bach1 gene
            encoding a BTB-basic leucine zipper transcription factor and its
            mapping to chromosome 21q22.1
  JOURNAL   Genomics 47 (2), 300-306 (1998)
   PUBMED   9479503
REFERENCE   10 (bases 1 to 5858)
  AUTHORS   Oyake,T., Itoh,K., Motohashi,H., Hayashi,N., Hoshino,H.,
            Nishizawa,M., Yamamoto,M. and Igarashi,K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140903.1, AK141405.1 and AC164108.2.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001004169.1, XM_975308.1, XM_975273.1, NM_007520.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86603.1, BC057894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1510              AK140903.1         2-1511
            1511-3188           AK141405.1         1446-3123
            3189-4187           AC164108.2         137002-138000
            4188-5858           AC164108.2         138001-139671
FEATURES             Location/Qualifiers
     source          1..5858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 49.84 cM"
     gene            1..5858
                     /gene="Bach1"
                     /gene_synonym="6230421P05Rik"
                     /note="BTB and CNC homology 1, basic leucine zipper
                     transcription factor 1"
                     /db_xref="GeneID:12013"
                     /db_xref="MGI:MGI:894680"
     exon            1..103
                     /gene="Bach1"
                     /gene_synonym="6230421P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            104..397
                     /gene="Bach1"
                     /gene_synonym="6230421P05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2383
                     /gene="Bach1"
                     /gene_synonym="6230421P05Rik"
                     /note="BTB and CNC homology 1 transcription factor; BTB
                     and CNC homolog 1"
                     /codon_start=1
                     /product="transcription regulator protein BACH1"
                     /protein_id="NP_031546.1"
                     /db_xref="CCDS:CCDS28293.1"
                     /db_xref="GeneID:12013"
                     /db_xref="MGI:MGI:894680"
                     /translation="MSVSESAVFAYESSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQR
                     FRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEEVTVKGFEPLIQFAYTAKLILSKDN
                     VDEVCRCVEFLSVHNIEESCFQFLKFKFLDSTSEQQECARKKCFSSHCQKADFKFSFS
                     EQKDLEIDEADEFLEKKRVQTPQCDSRRCQGSVKASPPLQDSVSQACQSLCTDKDGAL
                     ALPSLCPKYRKFQKAFGTDKIRTLESGVRDVHTASVQPNETSELECFGGAQGCADLHV
                     ILKCEGMKAAMESEDTEGQDPSPQCPAEQPQGTPLPQDSAGPHGLYSLSALHTYEQSG
                     DVAFAGVQSKTVKTEKPLSRPDAQDEKPSENQDLYLKSSMGPKEDSSSLASEDRSSVE
                     REVAEHLAKGFWSDICSTDSPCQMQLSPTVAKDGPEQGYSQRRSECPWLGIRISESPE
                     PGQRTFTTLSSVNCPFISTLSSEGCSSNLEIGNYDYVSEPQQEPCPYACVISLGDDSE
                     TDTEGDSESCSAREQDCEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRR
                     RSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLC
                     QQVCKEAALSPEQIQILAKYSASDCPLSFLISEKGKSTPDGELAFTSVFSVSDVPPTA
                     PPPCGRGSSAASQELVQESPPTTAAAPEQATLLEPCRQSAGISDFCQQMSDKCTTDE"
     exon            398..1741
                     /gene="Bach1"
                     /gene_synonym="6230421P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1948
                     /gene="Bach1"
                     /gene_synonym="6230421P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..5858
                     /gene="Bach1"
                     /gene_synonym="6230421P05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5829..5834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bach1"
                     /gene_synonym="6230421P05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5858
                     /gene="Bach1"
                     /gene_synonym="6230421P05Rik"
                     /note="major polyA site"
ORIGIN      
        1 acggagcgca ggggaggaga cgggcggctg tccgcgcaga gggagtgagt cacctgaccg
       61 ccgcttgccg cctgcagtcg ggccgcgccg cgtctcggct ccggtcgatg acagtgagaa
      121 gcatgctttc cactgctctc cctggtccca gttgccaccc aggatgtctg tgagtgagag
      181 tgcggtattt gcctacgagt cctctgtgca tagcaccaac gtcttgctca gcctcaatga
      241 ccagcggaag aaggatgtcc tgtgtgatgt gactgtcctg gtggagggcc agcggttccg
      301 agcccaccgc tcggtgctgg ctgcgtgcag cagctacttc cactcgagaa tcgtaggcca
      361 gactgacgca gagctcaccg tcacactgcc tgaagaggta acggttaaag gatttgaacc
      421 tttaattcag tttgcctaca ctgccaaact cattttaagt aaagacaatg ttgacgaagt
      481 gtgcaggtgt gtggagtttc taagcgtaca caatatcgag gaatcctgct tccagtttct
      541 caagtttaag tttttggact ccacttcaga gcagcaggaa tgcgcaagaa aaaaatgctt
      601 ctcctcacac tgtcagaaag cagattttaa attttcattt tcagaacaga aagatctcga
      661 aatcgatgaa gcagatgaat tcttggaaaa gaaacgtgtt cagacgcctc agtgtgactc
      721 ccgcaggtgt cagggcagtg taaaagcatc cccccctctc caggacagtg tcagtcaggc
      781 gtgccagtcc ctgtgcacgg acaaggatgg agccctggca ttgccatctc tatgccccaa
      841 atacagaaag ttccagaaag cgtttggaac tgacaagatc cgaactctag aatccggtgt
      901 cagagatgtc cacactgcct ctgtccagcc aaatgagacc tctgaacttg agtgttttgg
      961 gggagcgcag ggctgtgcag atttacacgt gattttaaaa tgtgaaggaa tgaaggcagc
     1021 catggagagt gaagacacag agggccagga tccctcccct cagtgccctg cagagcagcc
     1081 ccaagggaca cccttgcctc aggattctgc aggacctcac gggctctact ccttgtcagc
     1141 cttacacaca tatgagcagt caggtgacgt ggcctttgct ggggtgcaga gtaaaaccgt
     1201 gaagacagaa aagcctctgt cgaggccaga tgcccaggac gagaagccat cggaaaatca
     1261 ggatttatat ctgaagtcta gcatgggccc taaagaagac agcagcagcc ttgcatctga
     1321 ggatcggagt agtgtggagc gagaggtggc agagcacctg gccaaaggct tctggagtga
     1381 catttgcagc acggactcgc cttgccaaat gcagttgtcg cccactgtgg ccaaagacgg
     1441 cccagaacag ggctactcgc aaaggcgatc tgagtgtccc tggttgggta tcaggatcag
     1501 tgagagcccc gagccaggcc agcggacttt cacaactctc agttccgtca actgcccttt
     1561 tatcagtact ctgagttccg aaggctgctc aagcaacttg gaaattggaa actacgatta
     1621 tgtctcggag cctcagcagg agccttgccc gtatgcttgt gtgattagcc tgggagatga
     1681 ctctgagacg gacacggaag gtgacagcga gtcctgttct gccagggagc aggactgtga
     1741 ggtgaagctg ccattcaatg cccaacggat aatttcgctc tcacgaaatg atttccaatc
     1801 cttgttgaaa atgcacaaac tgaccccaga gcagctcgac tgtatccatg acatccgcag
     1861 aaggagtaag aacagaatcg ccgcgcaacg ctgtcgcaag aggaaacttg actgtatcca
     1921 gaaccttgag tcggaaatcg agaagctgca aagtgaaaag gagagcttgc tgaaggagcg
     1981 agaccacatt ctgtcaacgc tgggggagac aaagcagaac ctgaccggac tttgtcagca
     2041 ggtgtgcaag gaagccgccc tgagccccga gcagatccag atccttgcca agtactcggc
     2101 ctccgactgc ccgctttcct ttttaatttc tgagaaagga aaaagtactc ccgacggcga
     2161 gcttgctttt acatcggttt tcagtgtgtc tgacgtgcct ccaactgcac cacctccctg
     2221 tgggcgaggg agcagcgcgg ccagccagga gctggtgcag gagtccccgc caaccaccgc
     2281 agctgcccca gagcaggcca cgctgttgga accctgtcgg cagagtgctg ggatctcaga
     2341 cttctgtcag cagatgtctg acaagtgcac tactgacgag taaaccccac gggcagcctt
     2401 cagcccatgg cctccctctg accttcggca ttgtctcgaa gcctagcgtg gccgtgtctt
     2461 cttgcttagc agtcctgtgt cctcctggta gctttctgtt gagggaattt ctctttcagg
     2521 tgatcctgcg ttctccttgg ttttcatagg agatgttcta tctcttgaat gatgggaaat
     2581 tggatgtgaa aatatagaat gaccaggtaa taatctccta gagttcaaac taactagagc
     2641 agcggaagcc gcagcatcca tttcaacagc tcggagcatc tgcacgcagt cctcgtgggc
     2701 cgtggataac ctactgatca ggaagaagag cccttcctat gcggagcagt ggtgatctcc
     2761 ccagaagtgg ggtacttctt gtctatgtgg aaaagaaatc tcctttgaac tctaatgtcc
     2821 tgcacctcag ctccttcaaa gtccagcatt ggctggtgac cctgaggctg ccctggcagg
     2881 acctaggcag aagccacagc tggcctgagc tggaggcctc tgctatcctc agtattgact
     2941 aggagttttg actgcacaaa ccagaaagtg tatcatcgtt ccctgttctc agttctgttc
     3001 ctctctttag tctccacctt gtctagactg ttaggaactt tctgtcccgt ggaggaggag
     3061 ctgccccgga gagctgcaca ctgcacaagg ctgtcgatca tctcattgca ggtcgttgat
     3121 gaccatgagg gcattggagt caatgagagg gaaatgtcta caatgacctg aagagcagct
     3181 cattggaatc ccagtgaaga cttgtagtct gttaaaaaaa aaaaagccgt gttggagaca
     3241 aacacggatc tgaggctctg ccggtgtttg aaacggtaaa attcgggctc ggttcggctc
     3301 ggtccgttaa tgggtttgca cttgagagcc agatttaatc ctcttatttt tttcctattc
     3361 cctcatttgg tatgacgtaa aggcgcgtgt accagtttga cttgggcatt gaaagatcaa
     3421 tcttgtgctt gtttaatgtt ggtagaaaat gaattgataa gaatctgagc agttaccccg
     3481 gtaacatctg cagtgatttt tagccattct ggaatctcac cttgtagacc tcagcagtgg
     3541 aaacaaaacc ttgtttatac aggtccaata tccctgttca aggaatgtga gatgccttaa
     3601 aattggagac attctgagca ctgagatgtt ggatatccag gcctgacctc atgaggcagg
     3661 ttgcagtcag aacaggacat tcaaagtctt ctgaacgcta ttttatatgc ctagggtata
     3721 ggactttatt aaggcttggg ggggggtggg ggtgggtctg accctcaggc tctcataacc
     3781 ttctgttgag agcaggggaa agccggaagt ctgaaggcac tctgcatcag acatttccaa
     3841 caagggagtc catagtcgct ccccgaagca cttacagagt cctgtgtcag ggtgcagggg
     3901 gacagtcagt aggactgcac ctctccaggt ctcatccctg aagagacgct tcattgcatg
     3961 ctgcatcttc tgaagggcag agggacggag ggatggagga ggggagggag gagggaggga
     4021 ggagggaggg aggggagtga gtgcacacta ccctgtgtag catccggtca ctggcaagct
     4081 gatgtttgcc atgaggagat acggggacca gcagcaatag ttcatgattt tatagttagc
     4141 agataattgc cctttatcct tggggtgcag caagggaggg aggaagggtg gtatgtgttt
     4201 tcatctttgg aagagaaaat taaattggaa ttattttcta gaaattttga gaagtccact
     4261 caattttcct gggagagagt gctcactgtg tgaaagtaca tcccatgtta caaaagagtt
     4321 gtatgtgtgt gtgtatatat ataatatatg cacacatgaa attatgtgta tatgtatata
     4381 tacatacata cgtgtatgta tatgtcccca cgcagctatt tggtatttgt aagtttagac
     4441 ttcaacttaa cataatatga aaacttctct ggtttacaaa gtgtaaaatc ttatacaagc
     4501 caatggattt cctacctcac tggacactcg gctgtctgtc atcggttctt gtgtgtacat
     4561 acgtcagatc ttttgcttta aatgtaaata tttgctttga aaagttactt accattttat
     4621 gataaagccc agttctctcc tcagtttaaa ggtatttttt taaagacact tggtttaaat
     4681 ttctctctat gaacagttta gcattaaggg ttaattttaa tggtgtctgg taattggcca
     4741 agtgtaatat ttcttaaaat ttaacattac ttttaacagc cagcatgtaa tacaagtaac
     4801 tacactacct catacacacc tttgtgattt tcaagttgta ttaggtggac aggacaggtt
     4861 ttacctttgt ctttgggcca taaggtgggt aataatagaa atatattgca tagcattata
     4921 catgtatgcc tattttaacg tgaacttcta aaacattttc ttttctaaga agatttgttt
     4981 taaggaaata ttgggggggg ggatgcagaa gacaaatgat aggaggatca tatgtgtaca
     5041 acgtatgcct tttccttcat gcagagcttg gacagtggtt ttagttggtg ttttgcatag
     5101 tcacacaatc agagctcctt attgtataag ccagccttct caaggcgcgg tgattttttt
     5161 tttttaaagc tgtcatgtct gacttgatac aataatgtca tctttgtcat cttaaatttt
     5221 tgccccttat ttgaatcctg tagctacaat caaattaatt tgttaaattg ttatactcag
     5281 aataaatatg gatataacat tggttgtcca cctgcaagct ttctaacagt ttactgtagc
     5341 ttgatgctta gccagtttta cattaggaat tcaacataca tgatacaggg atgagggtac
     5401 tcagccgcgt taacaacttg gaaaaaaaga aagaagcaaa tggcgatgtt acagtgaatt
     5461 ctcaggtgaa ctttccagtt atgaaaacat ctattttgca tttgtaaata ttttaactgt
     5521 tttattaagg catggactaa actattcttt gacacctgtt gggtagagtg aaaatttaaa
     5581 gccataatgg taaaagatgg catactgatt gtaaaataaa caaatgataa taataataat
     5641 gatttttttg tatctttcat aatataattt ttctaactgc aataaaacca ctgaacttat
     5701 atattcctgt cctattaagc ccatgtttca ttagtagtac accttataat atttaattta
     5761 cattttctaa tgtgcttgtc tggatgtgtc agtataagtc ctagatggtg attctagact
     5821 gacggttaaa taaagttcct aacatggctt tcagtcga
//
