LOCUS       NM_019517               7686 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus beta-site APP-cleaving enzyme 2 (Bace2), mRNA.
ACCESSION   NM_019517
VERSION     NM_019517.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7686)
  AUTHORS   He,T., d'Uscio,L.V. and Katusic,Z.S.
  TITLE     BACE2 deficiency impairs expression and function of endothelial
            nitric oxide synthase in brain endothelial cells
  JOURNAL   J Neurochem 166 (6), 928-942 (2023)
   PUBMED   37547981
REFERENCE   3  (bases 1 to 7686)
  AUTHORS   Diaz-Catalan,D., Alcarraz-Vizan,G., Castano,C., de Pablo,S.,
            Rodriguez-Comas,J., Fernandez-Perez,A., Vallejo,M., Ramirez,S.,
            Claret,M., Parrizas,M., Novials,A. and Servitja,J.M.
  TITLE     BACE2 suppression in mice aggravates the adverse metabolic
            consequences of an obesogenic diet
  JOURNAL   Mol Metab 53, 101251 (2021)
   PUBMED   34015524
  REMARK    GeneRIF: BACE2 suppression in mice aggravates the adverse metabolic
            consequences of an obesogenic diet.
REFERENCE   4  (bases 1 to 7686)
  AUTHORS   Angueira,A.R., Sakers,A.P., Holman,C.D., Cheng,L., Arbocco,M.N.,
            Shamsi,F., Lynes,M.D., Shrestha,R., Okada,C., Batmanov,K.,
            Susztak,K., Tseng,Y.H., Liaw,L. and Seale,P.
  TITLE     Defining the lineage of thermogenic perivascular adipose tissue
  JOURNAL   Nat Metab 3 (4), 469-484 (2021)
   PUBMED   33846639
REFERENCE   5  (bases 1 to 7686)
  AUTHORS   Czarnek,M. and Bereta,J.
  TITLE     Proteolytic Processing of Neuregulin 2
  JOURNAL   Mol Neurobiol 57 (4), 1799-1813 (2020)
   PUBMED   31838721
REFERENCE   6  (bases 1 to 7686)
  AUTHORS   Kuhn,P.H., Marjaux,E., Imhof,A., De Strooper,B., Haass,C. and
            Lichtenthaler,S.F.
  TITLE     Regulated intramembrane proteolysis of the interleukin-1 receptor
            II by alpha-, beta-, and gamma-secretase
  JOURNAL   J Biol Chem 282 (16), 11982-11995 (2007)
   PUBMED   17307738
  REMARK    GeneRIF: BACE1 and BACE2 may act as alternative
            alpha-secretase-like proteases in proteolytic processing of IL-1R2
            and APP
REFERENCE   7  (bases 1 to 7686)
  AUTHORS   Willem,M., Garratt,A.N., Novak,B., Citron,M., Kaufmann,S.,
            Rittger,A., DeStrooper,B., Saftig,P., Birchmeier,C. and Haass,C.
  TITLE     Control of peripheral nerve myelination by the beta-secretase BACE1
  JOURNAL   Science 314 (5799), 664-666 (2006)
   PUBMED   16990514
REFERENCE   8  (bases 1 to 7686)
  AUTHORS   Dominguez,D., Tournoy,J., Hartmann,D., Huth,T., Cryns,K.,
            Deforce,S., Serneels,L., Camacho,I.E., Marjaux,E., Craessaerts,K.,
            Roebroek,A.J., Schwake,M., D'Hooge,R., Bach,P., Kalinke,U.,
            Moechars,D., Alzheimer,C., Reiss,K., Saftig,P. and De Strooper,B.
  TITLE     Phenotypic and biochemical analyses of BACE1- and BACE2-deficient
            mice
  JOURNAL   J Biol Chem 280 (35), 30797-30806 (2005)
   PUBMED   15987683
  REMARK    GeneRIF: Data show that BACE1 knockout mice display a complex
            phenotype, and a combined deficiency of BACE2 and BACE1 enhanced
            the bace1-/- lethality.
REFERENCE   9  (bases 1 to 7686)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   10 (bases 1 to 7686)
  AUTHORS   Marcinkiewicz,M. and Seidah,N.G.
  TITLE     Coordinated expression of beta-amyloid precursor protein and the
            putative beta-secretase BACE and alpha-secretase ADAM10 in mouse
            and human brain
  JOURNAL   J Neurochem 75 (5), 2133-2143 (2000)
   PUBMED   11032903
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB857972.1, AK165036.1,
            AK078770.1, AC164088.2, AK034059.1 and BP765266.1.
            
            On Jul 14, 2016 this sequence version replaced NM_019517.4.
            
            Summary: This gene encodes a member of the peptidase A1 family of
            aspartic proteases. The encoded preproprotein undergoes proteolytic
            processing to generate an active endopeptidase enzyme. This
            transmembrane protease catalyzes the proteolysis of amyloid
            precursor protein to produce amyloid beta peptide. Mice lacking the
            encoded product exhibit increased pancreatic beta cell mass and
            improved glucose tolerance due to increased insulin secretion.
            [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078770.1, BC131947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BB857972.1         2-66
            66-1823             AK165036.1         2-1759
            1824-3736           AK078770.1         1791-3703
            3737-4886           AC164088.2         42924-44073         c
            4887-7343           AK034059.1         2-2458
            7344-7686           BP765266.1         1-343               c
FEATURES             Location/Qualifiers
     source          1..7686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 57.4 cM"
     gene            1..7686
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /note="beta-site APP-cleaving enzyme 2"
                     /db_xref="GeneID:56175"
                     /db_xref="MGI:MGI:1860440"
     exon            1..374
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            375..463
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            464..680
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            681..809
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            810..944
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1046
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1196
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1365
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..7660
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /note="hexamer: AATAAA"
     polyA_site      1827
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /note="major polyA site"
     regulatory      3622..3627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /note="hexamer: ATTAAA"
     polyA_site      3648
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
     regulatory      7638..7643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
                     /note="hexamer: AATAAA"
     polyA_site      7660
                     /gene="Bace2"
                     /gene_synonym="1110059C24Rik; AEPLC; ALP56; ARP1; ASP1;
                     ASP21; BAE2; CDA13; CEAP1; DRAP"
ORIGIN      
        1 cctgtccgcc ccgccccggc cggctaagga ccgcagaacc gcgctcgcag actcgccgag
       61 cccccgctgc ggggatgggc gcgctgcttc gagcactctt gctcccggtg ctggcgcagt
      121 ggctcttgag tgcggtcccc gcgctggccc ccgcgccctt cacgctgccc ctccaagtgg
      181 cccgggccac gaaccacaga gcctcggctg ttcccggact cgggaccccc gagttgcccc
      241 gggccgatgg tctggccctc gcactggagc ctgtcagggc tactgccaac ttcttggcta
      301 tggtggacaa ccttcagggg gactctggcc gcggctacta cctagagatg ctgatcggga
      361 cccctccgca gaaggtacag attcttgtgg acactggaag cagtaacttc gctgtggcag
      421 gtgccccaca ctcctacata gacacctact ttgactcaga gagctccagc acataccact
      481 ccaagggctt tgatgtcact gtgaagtaca cacagggaag ctggactggc tttgttggtg
      541 aggaccttgt caccatccca aaaggcttca acagctcttt cttggtcaat attgccacta
      601 ttttcgagtc tgagaatttc tttttgcctg gtattaaatg gaatggaatc cttggacttg
      661 cttatgctgc tttggccaag ccatcaagct ctctggagac attttttgat tccctggtgg
      721 cccaagcaaa gattccagac attttctcca tgcagatgtg cggggctgga ttgccagtag
      781 ctggttctgg taccaacgga ggtagtcttg tcctgggtgg gattgaacca agtttgtata
      841 aaggagatat ctggtatacc ccaattaaag aggaatggta ctatcaaata gaaatcctga
      901 agttggaaat tggaggccag aacctcaacc tggactgcag agagtataac gcagacaagg
      961 ccattgtgga cagtggcacc acgctcctgc gcctgcccca gaaggtgttt gatgcagtgg
     1021 tggaagctgt ggcacgaaca tctctgattc cagagttttc tgatggcttc tggacagggg
     1081 cccagctggc atgctggaca aattctgaaa cgccatgggc atatttccct aagatttcta
     1141 tctacctgag agatgagaat gccagtcgct ccttccggat caccattctc ccacagctct
     1201 acattcagcc catgatggga gctggtttca attatgaatg ctaccgtttt ggtatctcct
     1261 cttccacaaa tgcgctggtg attggtgcga ccgtgatgga aggcttctac gtggtctttg
     1321 acagagctca gaggagggtg ggctttgcag tgagtccctg tgcagagatt gaaggtacca
     1381 cagtgtctga aatttctggg cccttttcca cggaagacat agccagcaac tgtgttccag
     1441 cacaggctct gaatgagccc atcttgtgga ttgtgtccta tgccctgatg agtgtgtgtg
     1501 gagccattct cctggttctg atcctcctcc tgctgctccc gctgcactgc cgtcatgccc
     1561 cccgagaccc tgaggtagtt aacgatgagt cctcactagt cagacatcgc tggaaatgaa
     1621 gagcctcacc tgaactccag cagccttgaa ctcagctctt ccaagaggga cacctccagt
     1681 tggcttctct gcctattagt cgggaacctc aactgtgcaa ctgaatgcct tccagactgt
     1741 atcttgatta ctcttgattt ccaagctttc agatcttttc tacttcagag agaaatgata
     1801 ataaaaacac ctcattgtga accaaaacag tgcattgggc ttcagacttt atgggactgg
     1861 ttatgccaaa ctgcccagtg taccaccaaa accaaaaaca acccaaacaa agaaaaaata
     1921 ggcaagccat ggttagttac tatattctct tcaacctcag gaaaaaatga atgcattcag
     1981 ttgcttgctc tcttgcctag aggaaacttt tgatattgac catattaaag ggtattttgt
     2041 gatagactac tgcctagtct agaacaagtg agaaggcgtt caatgtccta gcaggagaag
     2101 tagacttgag ccagatgaga gaatcactta gccttcttct gcacctgact gtactgcagg
     2161 accttgggta ggtctcaggc tccccaacaa tgagaatcca cacacagatc acactagccc
     2221 ttgccaggaa gttctttgcc catctaggaa gagtgagatg gcattctaat gaagtgtagt
     2281 aactttggca cccaggttaa gatgccactg catgacttgg ccagtgttct gagttagggt
     2341 agggttcagg cagcttgatt cccactattg gcctggcctc tgtgatgagg cagaacaggt
     2401 gttgggctgc atgctgctct tgacattctg tcaccaagct ggccatggtc acactcactt
     2461 actcagattt caagttaatt aatcatgttt taatgaggaa aacaaactct ctcatctctg
     2521 ctgccataat tgtttctttt ctctaaatct tctttggaac taaattggta attactgatc
     2581 tgggaaatgg agacatggcc agatgcctgt gcttctgacc agctgtcagg gaaggaaaac
     2641 tcgtgacttg gagtcatttc cacttttctg agtcctttga agctgtgcat ttcccttcat
     2701 aagatgcctt gggcccaagt gtagcaatcc aaagcaactt gaaggcacct gactggcaga
     2761 taacctctgt ggttcttccc tgggggctgg gggtgggatg gggtatgata aagccttggc
     2821 actgggagat cagcagtacc tttatttact gccatttgag acctttgcca aagaaaggtg
     2881 gaagcatgtt actccatggg gccacttgtt tatgatggga tgttaattga catacaaatt
     2941 ctccttgtgg acacccctcc ccaccactcc tgtgccaagt tcagtgttca ctttgtgatg
     3001 ctacctgtta ccaggatagg ttggacaaaa agcattccac ccagagtgct aagcagcccc
     3061 tctgacagga gggtctttgg tgttgacaac agtctttgtg cggatgtctc agccatctgt
     3121 tctgctcact cagtcacctc cgtattgaga aatacatggc catgccaagg acactcaaga
     3181 gccatccagg aatgtcacag tgaactggaa gactccccag cagccagaga aaccttctgt
     3241 gagattctcg tgtgagagaa gctgagctgt tgaagaagat ccaactgaag cagggatagc
     3301 tttgtgttct caaatgctca cagatatgtc caccatgctc tggttgagtg tgaataattt
     3361 caaaattcac tacagagtta taatctctgg aagtgggata tgtgcacatg ttgatttttc
     3421 cattgattac tatcttctag gcaggaaaag aaccaagttc tcccagactc tgcctccctt
     3481 ccctgttctg tgaggactga gtccctgaaa taggaggatt gctcaatatt cacactcatc
     3541 tgagtctttg tattgggttg ggcttctgaa gtgcaggatg tcaaggcagg aggaagataa
     3601 ccagcacttt ctgtatttca tattaaatgt gtctaccttt gtatctcaga tgctacttga
     3661 tgtgacattt tggtgggaat acttaaatta caaaagcata gcttagcaac cagaatgaaa
     3721 ttggccgttg aatttgggac attttcttgg tgtatactta gtcaaaactg tggtgatgcc
     3781 cacaaattgc aaattgagac ttcacttggc agactttcag gagtgtttgc cttgaacaag
     3841 aatcaaaata gcagcctttt gagggcctca gttatacctt gaatagaatg gggaacagat
     3901 tggaaaatct ttctttccac attgagagtt gtaggtgatc tgtgtccagt ctcctggtat
     3961 ggcctatgga atttcttcct ttgtgttttg tttgtttgtt tgtcttttgt tttttgggag
     4021 ttttcttttt cttgccagaa acaagtgcct ggagttaaag aggtaggtgt gctacacaag
     4081 accatgggat atgcttctcc cagcacatat cactcctgag cattttagaa agaatttatc
     4141 tgactggtcc tgaaacccag acgtttgggt tggagacaca tttggggaga aaactatgac
     4201 cagaaagcag caataaggac tccaagaagc tttgaggaag agatttctcc aaaccatatt
     4261 ccatcctctt ctttaagagg tggggaggga ctacttggtg atttaattaa gaaggagaat
     4321 ttgctaaatt ggccttaaca ctttctcacc tgatggagca gctacacctg tctgggattt
     4381 gagttctagc ttcctccctg ggagtagaat gctgtccaaa agtctgtccc acagacaagg
     4441 ataattgagt ttcacagcat ttatctttat taatggaaac cattttttag ctggacagca
     4501 tcccagtgtg ttttcttttg catggactta ctagaattga tgattggcac agtcacagga
     4561 aaaaataacc tccactatct tctgaggaaa agcaatacga aacaggaaac acacacatat
     4621 aggattatgt acatctccag tatgctttaa gaattacaga ctgaatgtgt agccatttac
     4681 ccattagaca gtaaagcagt ttttcggggg gtggggtggg gtaagaaact catattgggt
     4741 ataaagcaag gtcccagaat aagcagagtt agcgatttgg aaaatgcttc ttccatctgg
     4801 gcattagctt tctttcatcc tccagttagc ctactgtgtt ggaggtgtca tttttatttt
     4861 acagagctat aactcccctc cacccaattt caagaatgtt tgagcactga agtcaatgtt
     4921 ggcatagagg acatgtggga gacaggtagc ctgcatgttg cctgagccaa acagagattg
     4981 ggcaattcca tcagcaaaga gtttaggatc cctgggagtt aataaatgct aaactcttcg
     5041 agggggaaaa ggagaggtat gtcccccacc tcagcctgca gtttcagtgt tctggagagt
     5101 caagatatcc ctgaacagtg taggcaaccc aatttactcc agtgttttta gcatggccta
     5161 catttttgga atctccaaag agaagccctc gaattggtca ctggccactg agcagacatt
     5221 cagcagaaga cgatttgttt tgtttagaag atgcctattc cagtaagacc agaattcctt
     5281 gagttcagga gcaggacccg ggtctgaggc tgcaggttca aggctatgtg ctggggagtt
     5341 cactgggcaa gggaaagtta cttgggccac actgacttgg ccaagtttct tttggggact
     5401 gtgtacccag gaaggactat tgacagccag agctggacag tcccatgata accagccttg
     5461 ttggaccact tacccaccct gttgtcagcc tcaaatctct gccctgtctt cagtggctct
     5521 gatcttcctg tagaagtggg tctcatgggt cttagggtcc ataagtaccc agtctcattc
     5581 agaatcaggc atctgaatta tagtctggtt gactgcactg ggtcagagag taaactgaag
     5641 caattgtcat gttgctaaag attttgaaaa ccaaactgag cctcctggtg gcacccatgt
     5701 gtctacaaag cccacgaatg aggagttcat taggagtggg cgagtgagta ctcataatat
     5761 caaattcaaa ggacagtgat ttttcctccc tcccaccaca caagcttcct atggatttag
     5821 tatcagatgt cacacccaga tgccctatgt ttctaaattt aactgtgccc tattattttt
     5881 attcttaagg agaagatagt agatgaaggc tagactgtaa gttcaaatcc ctattaggac
     5941 ttgtagtgtt ttgtttgctt gtttgttttg ttttgttttt tgatcaaacc ttgggtaaca
     6001 tttgcatccc agtgacaacc agaagtgtat gatattaaat catttattaa ggaatagtca
     6061 gtgtcaggaa agtgccagac gcacacaccc ccatttacaa ctggagaaat gtttgtgtga
     6121 gataagctgt agcacatggc atgtccctca ctcatcagag tagagcacac agccaatatg
     6181 aatttttacc catatgcttc ataattacag ctggtagagg cacaatcagc cctctcttaa
     6241 gctaagcaca gctgtgaatc acattggtgt ctgtaaaaag agaccactga cacctgcgct
     6301 ttctgtgcag ccctacctga tttaacactg ctgtgtcttc tctggtgggg tggaaattag
     6361 atagtttgta tttgtaacag atgcacagat ctgagtggga cctggcttgc tgatttctgc
     6421 tgctccttgt tctgtgtgga cactactaga accttctgag ataagtaaag ctgtggcatc
     6481 ctatcagggg aagaaaactc tcacaggggc tccacgttgt caggatgggt tctgctgaat
     6541 gaagaatgaa gtgttaagag agcattgggt aatctccttc tgagattaaa aaacaaaaca
     6601 aaaaacatag ctagttaagg ctttattaat ccgtagtaaa aatcacaaga agtacaattt
     6661 cttggggtta ggagtgaagt tcacttgtat agttcttgcc tagcattcac aaaaccctaa
     6721 tacgaaaagg aaggtgggag gacgtgagga agggaaatgt cttcgtagct ttgcgaactc
     6781 ttgtcctttg gcccccggag tataaaatgc tgcctcatca attcctcctt tgctgcagga
     6841 tcatgcattc ttaccagtga ggagctgaag gctggtctct ttagcgatga ctcagtccag
     6901 acccacagcg taggtggggt tctcacgtgc aagtaaaagc tgaagtttgg agtgtaaaac
     6961 agcttgtttc ctactgcctc tgttcatcta cacacttgag tacccttaag gtttaagatg
     7021 ctctcctcta ggcactgaaa gggctactca tgtctcctgc ttctcaggca tgtaaggttt
     7081 cggttctgct gggagagctc taagccatgc accaggcata gtggcacatg cttttaatcc
     7141 cagcacttgg aaggcagatg tagatctcta caatgccttc tgtacacagt tccataccac
     7201 ccagaattac atgataagac cttgatggtg agtaagtaaa tacacaaata aataaatgat
     7261 ccaagccatc tactgaattc taaaagaggc agaaagtagt gttttataca gtgtattttt
     7321 gtttttttgt tttttttttt tttctacagg gttcttgagt ggcaattgta tttctgaaga
     7381 tgcttctaac tggttaatgt tttcttgggg gaatctccct ccatttccag ggcactgaac
     7441 tgatttcaaa tcaaattgtg attagaatac tgtgcaaaac agagaggcat tcgtgccaca
     7501 gagtagctcc tcacaaatgg ccacatggtt gctaggccct ccaacctgga gttttctaga
     7561 ataatcttat ttttgtactt gtccaccctg ctaagatata taccactgaa aagaagcgag
     7621 atgtctgact cagtatgaat aaataacact tcctacttgg aaaaaaaaaa aaaaaaaaaa
     7681 aaaaaa
//
