LOCUS       NM_011792               6055 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus beta-site APP cleaving enzyme 1 (Bace1), transcript
            variant 1, mRNA.
ACCESSION   NM_011792
VERSION     NM_011792.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6055)
  AUTHORS   Rajani,R.M., Ellingford,R., Hellmuth,M., Harris,S.S., Taso,O.S.,
            Graykowski,D., Lam,F.K.W., Arber,C., Fertan,E., Danial,J.S.H.,
            Swire,M., Lloyd,M., Giovannucci,T.A., Bourdenx,M., Klenerman,D.,
            Vassar,R., Wray,S., Sala Frigerio,C. and Busche,M.A.
  TITLE     Selective suppression of oligodendrocyte-derived amyloid beta
            rescues neuronal dysfunction in Alzheimer's disease
  JOURNAL   PLoS Biol 22 (7), e3002727 (2024)
   PUBMED   39042667
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6055)
  AUTHORS   Gao,L., Zhuang,Y. and Liu,Z.
  TITLE     Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting
            BACe1-Mediated Autophagy
  JOURNAL   Tissue Eng Regen Med 21 (5), 777-789 (2024)
   PUBMED   38630369
  REMARK    GeneRIF: Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting
            BACe1-Mediated Autophagy.
REFERENCE   3  (bases 1 to 6055)
  AUTHORS   Hong,J., Garfolo,R., Kabre,S., Humml,C., Velanac,V., Roue,C.,
            Beck,B., Jeanette,H., Haslam,S., Bach,M., Arora,S., Acheta,J.,
            Nave,K.A., Schwab,M.H., Jourd'heuil,D., Poitelon,Y. and Belin,S.
  TITLE     PMP2 regulates myelin thickening and ATP production during
            remyelination
  JOURNAL   Glia 72 (5), 885-898 (2024)
   PUBMED   38311982
REFERENCE   4  (bases 1 to 6055)
  AUTHORS   Jia,T., Wang,H., Chi,W., Zhou,W., Guo,L., Dai,Y., Bian,K., Sun,Z.,
            Ding,X. and Yu,Y.
  TITLE     Knockdown of BACE1 by a multistage brain-targeting polyion complex
            improved memory and learning behaviors in APP/PS1 transgenic mouse
            model
  JOURNAL   Int J Pharm 650, 123727 (2024)
   PUBMED   38142018
  REMARK    GeneRIF: Knockdown of BACE1 by a multistage brain-targeting polyion
            complex improved memory and learning behaviors in APP/PS1
            transgenic mouse model.
REFERENCE   5  (bases 1 to 6055)
  AUTHORS   Kandalepas,P.C. and Vassar,R.
  TITLE     The normal and pathologic roles of the Alzheimer's beta-secretase,
            BACE1
  JOURNAL   Curr Alzheimer Res 11 (5), 441-449 (2014)
   PUBMED   24893886
  REMARK    Review article
REFERENCE   6  (bases 1 to 6055)
  AUTHORS   De Pietri Tonelli,D., Mihailovich,M., Di Cesare,A., Codazzi,F.,
            Grohovaz,F. and Zacchetti,D.
  TITLE     Translational regulation of BACE-1 expression in neuronal and
            non-neuronal cells
  JOURNAL   Nucleic Acids Res 32 (5), 1808-1817 (2004)
   PUBMED   15034149
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6055)
  AUTHORS   Luo,Y., Bolon,B., Kahn,S., Bennett,B.D., Babu-Khan,S., Denis,P.,
            Fan,W., Kha,H., Zhang,J., Gong,Y., Martin,L., Louis,J.C., Yan,Q.,
            Richards,W.G., Citron,M. and Vassar,R.
  TITLE     Mice deficient in BACE1, the Alzheimer's beta-secretase, have
            normal phenotype and abolished beta-amyloid generation
  JOURNAL   Nat Neurosci 4 (3), 231-232 (2001)
   PUBMED   11224535
REFERENCE   8  (bases 1 to 6055)
  AUTHORS   Marcinkiewicz,M. and Seidah,N.G.
  TITLE     Coordinated expression of beta-amyloid precursor protein and the
            putative beta-secretase BACE and alpha-secretase ADAM10 in mouse
            and human brain
  JOURNAL   J Neurochem 75 (5), 2133-2143 (2000)
   PUBMED   11032903
REFERENCE   9  (bases 1 to 6055)
  AUTHORS   Yan,R., Bienkowski,M.J., Shuck,M.E., Miao,H., Tory,M.C.,
            Pauley,A.M., Brashier,J.R., Stratman,N.C., Mathews,W.R., Buhl,A.E.,
            Carter,D.B., Tomasselli,A.G., Parodi,L.A., Heinrikson,R.L. and
            Gurney,M.E.
  TITLE     Membrane-anchored aspartyl protease with Alzheimer's disease
            beta-secretase activity
  JOURNAL   Nature 402 (6761), 533-537 (1999)
   PUBMED   10591213
REFERENCE   10 (bases 1 to 6055)
  AUTHORS   Vassar,R., Bennett,B.D., Babu-Khan,S., Kahn,S., Mendiaz,E.A.,
            Denis,P., Teplow,D.B., Ross,S., Amarante,P., Loeloff,R., Luo,Y.,
            Fisher,S., Fuller,J., Edenson,S., Lile,J., Jarosinski,M.A.,
            Biere,A.L., Curran,E., Burgess,T., Louis,J.C., Collins,F.,
            Treanor,J., Rogers,G. and Citron,M.
  TITLE     Beta-secretase cleavage of Alzheimer's amyloid precursor protein by
            the transmembrane aspartic protease BACE
  JOURNAL   Science 286 (5440), 735-741 (1999)
   PUBMED   10531052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC126804.3.
            
            On Aug 8, 2022 this sequence version replaced NM_011792.6.
            
            Summary: This gene encodes a member of the peptidase A1 family of
            aspartic proteases. Alternative splicing results in multiple
            transcript variants, at least one of which encodes a preproprotein
            that is proteolytically processed to generate the mature protease.
            This transmembrane protease catalyzes the first step in the
            formation of amyloid beta peptide from amyloid precursor protein.
            Amyloid beta peptides are the main constituent of amyloid beta
            plaques, which accumulate in the brains of human Alzheimer's
            disease patients. Homozygous knockout mice for this gene exhibit a
            wide range of nervous system defects, growth retardation, metabolic
            abnormalities, and increased neonatal lethality. [provided by
            RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033112.1, AK080498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 15034149
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-709               AC126804.3         146735-147443
            710-798             AC126804.3         161043-161131
            799-1015            AC126804.3         162782-162998
            1016-1153           AC126804.3         164243-164380
            1154-1288           AC126804.3         165269-165403
            1289-1390           AC126804.3         166555-166656
            1391-1540           AC126804.3         167065-167214
            1541-1712           AC126804.3         167434-167605
            1713-6055           AC126804.3         168209-172551
FEATURES             Location/Qualifiers
     source          1..6055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.22 cM"
     gene            1..6055
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /note="beta-site APP cleaving enzyme 1"
                     /db_xref="GeneID:23821"
                     /db_xref="MGI:MGI:1346542"
     exon            1..709
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     regulatory      59..70
                     /regulatory_class="uORF"
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:15034149]"
                     /note="this uORF is predicted to encode a 3 aa peptide
                     (PMID:15034149)"
     regulatory      166..231
                     /regulatory_class="uORF"
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:15034149]"
                     /note="this uORF is predicted to encode a 21 aa peptide
                     (PMID:15034149)"
     regulatory      226..231
                     /regulatory_class="uORF"
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:15034149]"
                     /note="this uORF is predicted to encode 1 aa
                     PMID:15034149)"
     regulatory      348..371
                     /regulatory_class="uORF"
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:15034149]"
                     /note="this uORF is predicted to encode a 7 aa peptide
                     (PMID:15034149)"
     CDS             449..1954
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /EC_number="3.4.23.46"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; beta-secretase 1; asp 2; memapsin-2; aspartyl
                     protease 2; membrane-associated aspartic protease 2;
                     beta-site amyloid precursor protein cleaving enzyme 1; APP
                     beta-secretase"
                     /codon_start=1
                     /product="beta-secretase 1 isoform 1 preproprotein"
                     /protein_id="NP_035922.4"
                     /db_xref="CCDS:CCDS23135.1"
                     /db_xref="GeneID:23821"
                     /db_xref="MGI:MGI:1346542"
                     /translation="MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLP
                     RETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG
                     AAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI
                     AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA
                     GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM
                     DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG
                     TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGT
                     VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQT
                     DESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK"
     exon            710..798
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1015
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1153
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1288
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1390
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1540
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1712
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..6055
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccacaagcc tttccgcctc cccagcctgc ctaggtgctg ggagctggga gctggattat
       61 ggtggcctga gcagccgacg cagccgtagg agcccggagt ccctgtcggt ccccaagctg
      121 caaagcccgc ctggaagacc ccgaaagcta cgggctcgga tagccatgcc cgcccctccc
      181 agccccacaa ggggcccgat ccccccgctg gcggccggcg tccagatgta gctgggtccc
      241 ctggatcgcc atcgtcgtct cctctcgtgc gctacggatt tctcctgccc actctccgcc
      301 gcctggaccg ggaactgagc gaggggcctg cagactctgc agtcctgatg ccgccgaggc
      361 cgctctcctg agagaagcca ccaccaccca gacttagggg caggcaagag ggacagtcac
      421 caaccggacc acaaggcccg ggctcactat ggccccagcg ctgcactggc tcctgctatg
      481 ggtgggctcg ggaatgctgc ctgcccaggg aacccatctc ggcatccggc tgccccttcg
      541 cagcggcctg gcagggccac ccctgggcct gaggctgccc cgggagaccg acgaggaatc
      601 ggaggagcct ggccggagag gcagctttgt ggagatggtg gacaacctga ggggaaagtc
      661 cggccagggc tactatgtgg agatgaccgt aggcagcccc ccacagacgc tcaacatcct
      721 ggtggacacg ggcagtagta actttgcagt gggggctgcc ccacaccctt tcctgcatcg
      781 ctactaccag aggcagctgt ccagcacata tcgagacctc cgaaagggtg tgtatgtgcc
      841 ctacacccag ggcaagtggg agggggaact gggcaccgac ctggtgagca tccctcatgg
      901 ccccaacgtc actgtgcgtg ccaacattgc tgccatcact gaatcggaca agttcttcat
      961 caatggttcc aactgggagg gcatcctagg gctggcctat gctgagattg ccaggcccga
     1021 cgactctttg gagcccttct ttgactccct ggtgaagcag acccacattc ccaacatctt
     1081 ttccctgcag ctctgtggcg ctggcttccc cctcaaccag accgaggcac tggcctcggt
     1141 gggagggagc atgatcattg gtggtatcga ccactcgcta tacacgggca gtctctggta
     1201 cacacccatc cggcgggagt ggtattatga agtgatcatt gtacgtgtgg aaatcaatgg
     1261 tcaagatctc aagatggact gcaaggagta caactacgac aagagcattg tggacagtgg
     1321 gaccaccaac cttcgcttgc ccaagaaagt atttgaagct gccgtcaagt ccatcaaggc
     1381 agcctcctcg acggagaagt tcccggatgg cttttggcta ggggagcagc tggtgtgctg
     1441 gcaagcaggc acgacccctt ggaacatttt cccagtcatt tcactttacc tcatgggtga
     1501 agtcaccaat cagtccttcc gcatcaccat ccttcctcag caatacctac ggccggtgga
     1561 ggacgtggcc acgtcccaag acgactgtta caagttcgct gtctcacagt catccacggg
     1621 cactgttatg ggagccgtca tcatggaagg tttctatgtc gtcttcgatc gagcccgaaa
     1681 gcgaattggc tttgctgtca gcgcttgcca tgtgcacgat gagttcagga cggcggcagt
     1741 ggaaggtccg tttgttacgg cagacatgga agactgtggc tacaacattc cccagacaga
     1801 tgagtcaaca cttatgacca tagcctatgt catggcggcc atctgcgccc tcttcatgtt
     1861 gccactctgc ctcatggtat gtcagtggcg ctgcctgcgt tgcctgcgcc accagcacga
     1921 tgactttgct gatgacatct ccctgctcaa gtaaggaggc ccgtgggcag atgatggaga
     1981 cgcccctgga ccacatctgg gtggttccct ttggtcacat gagttggagc tatggatggt
     2041 acctgtggcc agagcacctc aggaccctca ccaacctgcc aatgcttctg gcgtgacaga
     2101 acagagaaat caggcaagct ggattacagg gcttgcacct gtaggacaca ggagagggaa
     2161 ggaagcagcg ttctggtggc aggaatatcc ttagacacca caaacttgag ttggaaattt
     2221 tgctgcttga agcttcagcc ctgaccctct gcccagcatc ctttagagtc tccaacctaa
     2281 agtattcttt atgtccttcc agaagtactg gcgtcatact caggctaccc ggcatgtgtc
     2341 cctgtggtac cctggcagag aaagggccaa tctcattccc tgctggccaa agtcagcaga
     2401 agaaagtgaa gtttgccagt tgctttagtg atagggactg cagactcaag cctacactgg
     2461 tacaaagact gcgtcttgag ataaacaaga acctatgcga tgcgaatgtt tatactcctg
     2521 ggggcagtca agatgaggag acaggatagg atagagacag gaaggagatg gtagcaaaac
     2581 tgggaaaggc agaactctga tcactttcta gttccaagtt tagactcatc tccaagacag
     2641 aagcccatct ggactaagag gtatcattcc ccaatgtgcc tgtggttgta gtctgaactg
     2701 aaatgaaatg ggggaaaaag ggcttattag ccaaagagct ctttttaaca ctcttagagg
     2761 aacagtgctc atgagaaaag tcccactgga cagatgaatt cctatcttgt taattctgtc
     2821 tctctctgct tcttcaacat gctaagtggc accaaaatga cccaacccca aggtcttagg
     2881 tgccctatgg gacaacagtt agaatattgt agggctaggg atggtcttcc cagcataggt
     2941 tcactccaac caaggtgcta aaaggaacag acaggagagt cctcctctct gatccacaaa
     3001 ggcagagccc tcaagattca tccagcaggg ttagggctga tgcatttgcc tctgcctgga
     3061 ttttgttttt attttctttc tttttgccca gtggtacaaa acgataagct ctttatggaa
     3121 tactgagtgg gttcattcct ctcttgccct ctccaatggc ccctctattt atctggctaa
     3181 ggaaacacca cgcattggct agtattaaac agcaactgta agatagaggg ctttctgttc
     3241 tatgtcattg ccttcagtat caaggctgcc tggagaaagg atggcagcct cagggcttcc
     3301 ttactttctt ctcctttcct gacagagcag cctttctgtc ctgctctctg ctgcccctcc
     3361 caatataatc catgggtacc caggctggtt cttgggctag gttgtggggg ccacactcac
     3421 ctcttccctg ccagttctaa cacgacagac atgaagccag tgttagtggg aagagctggg
     3481 ttttcccagg atgaccactg catcctctcc tggtacgctc tacactgctt tcaggctggg
     3541 gacctgccaa gtgtgggaca gttgatgagg aagagacatt agcagggcct ctggagttgc
     3601 tggcccagcc agctgcccac aagccataaa ccaataaaat aagaatcctg cgtcacagtt
     3661 tccagctggg tcctcttcct tgccctcgca ctggtgctgc tctggctgag taggaataca
     3721 cccacagact gccaggaaga tggagactgt ccgcttccgg ctcagaacta cagtgtaatt
     3781 aagcttccag gatcactacc atgaaaacgc cgcattctgc tttatcattt ctacccatgt
     3841 tgggaaaaac tggctttttc cccatttctt tacagggcaa aaaaaaaaaa aaaaaaaggg
     3901 agagagagag agaactcaac ctagttgtta tttaccctag taactggtgt tctatttttt
     3961 tttaaagggg gaaaatttgc atttattttt cttttgatgg ttaactcctt tgtatcataa
     4021 aattatgaac tctgatatgt aaaacagaaa aaaatcttga caacagcttc tcgcttgtaa
     4081 aaatatgtat tatacagctc tattttcaaa gtctcctgaa aaatgactga cctatctcca
     4141 ctgtatgtgg ggctttgcta ccgtctgtat gaacggaggc ccagtgggca gaggtgatac
     4201 aaacaggcat ggcagactct gagtgttttt ctgactgttt ctctgcaaag atagagccac
     4261 agtgatgagg ctccaactgt ggaggtccac tctccaaaat gctgcctttc tggggctcgc
     4321 tctgagagac agcttggccc catcattcct gctttttttc ttctctactc ttttggcttc
     4381 taagattttt ttttaaaaga aaagtagttt ttttcttact ttcttttttc ctttctgtct
     4441 tctttttgtc tgtctgtctt tctcttttct tttctttgac agcatctcat gtagatcagg
     4501 ctggcctcaa acttgtagca acgttcctgc ctttgcctcc tgagtgctag gattacaggt
     4561 gtgtgccaca actcctcctc gatagaaacc gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4621 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgatt acatgcgtgt ctgtagggga
     4681 aggggccagg aggatgagat atggtctcat gtagctcagg ctagccttga actcctgacc
     4741 ctcctgtgtg tccacctccc atatgccatg attacaggct tgtgccacta tgtttaacta
     4801 aacacaacat tctttatgct cactttcaat gtacagtttt caggtgacag tgaggtacta
     4861 catagctagt gctggatgct gcacagttga agggagagag caatcttaag acagaaaatg
     4921 aatgaatgaa tctgccacat gaaataaaca aaggaagtag acttccattt tgccaccttt
     4981 ttctgttcaa gtagtaccaa actggagaca agaagacaga agtacttcat taaccaaaga
     5041 aaggaggtca cctgacctct aaaaaggaag actcaggcca ttccccctta aagattttaa
     5101 ggtaaccctg ggaagtccac ccctaatcat gcttatcaat caacctggac aataaggcaa
     5161 gagaaaagaa ttcatccatg agctcatagg caaggcagag aaaaacaaga gaatttagtt
     5221 agctcagaaa ggacaaagtc tttgctatcc taacagaaac tgctagactc aataagcacc
     5281 cccagtccca ggatgggaaa acatcaattg tcagtagcat gttacccttc ccccagatgc
     5341 attttttctc aattaacact tgtttaattc tgaaaaaaga aggtaattaa aaccatttcc
     5401 tgtaggagta aagataaaga ttgggaaaga ctcaaggttc tcagagccac agctgtctca
     5461 gacataaaaa ccagaagaac tcagtaagtg gcggtggcaa acctatcttc ctccagatgg
     5521 gaatccacaa agcatagctt acaactgtac caccttcctt catctcactg tctccactgt
     5581 attctagaca gggaatgtat ccttcatagc gttcttgatt gataaatgaa gtccaacatc
     5641 ccacgattat tctgcaagta attttgcaca gacatctcac cccagtgcct gtctggagct
     5701 cacctaaggt caccaaatca cttggtggtg aaccaattgc cttaaccttt ggggggaggg
     5761 gatagctaga ttaggaaacc agaggaatgg aagggtgagc actttgcaag cctggctggt
     5821 cagtgcttag tggaggctaa accagtagca acaagggatg gtggcttggc ccaggggaaa
     5881 aatctgtgaa ttgtgctttt ctatctagaa agcagagtag acagaagatg gtgggagaaa
     5941 tggaacctga ttttgttgtt cttggactgt ggattttact gacataaaac agaatatcct
     6001 gtatacctga tatcaatgta taaataatga ggattaacac agtaaaatgt tcaat
//
