LOCUS       NM_001410456            5498 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus beta-site APP cleaving enzyme 1 (Bace1), transcript
            variant 4, mRNA.
ACCESSION   NM_001410456 XM_011242512
VERSION     NM_001410456.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5498)
  AUTHORS   Rajani,R.M., Ellingford,R., Hellmuth,M., Harris,S.S., Taso,O.S.,
            Graykowski,D., Lam,F.K.W., Arber,C., Fertan,E., Danial,J.S.H.,
            Swire,M., Lloyd,M., Giovannucci,T.A., Bourdenx,M., Klenerman,D.,
            Vassar,R., Wray,S., Sala Frigerio,C. and Busche,M.A.
  TITLE     Selective suppression of oligodendrocyte-derived amyloid beta
            rescues neuronal dysfunction in Alzheimer's disease
  JOURNAL   PLoS Biol 22 (7), e3002727 (2024)
   PUBMED   39042667
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5498)
  AUTHORS   Gao,L., Zhuang,Y. and Liu,Z.
  TITLE     Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting
            BACe1-Mediated Autophagy
  JOURNAL   Tissue Eng Regen Med 21 (5), 777-789 (2024)
   PUBMED   38630369
  REMARK    GeneRIF: Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting
            BACe1-Mediated Autophagy.
REFERENCE   3  (bases 1 to 5498)
  AUTHORS   Hong,J., Garfolo,R., Kabre,S., Humml,C., Velanac,V., Roue,C.,
            Beck,B., Jeanette,H., Haslam,S., Bach,M., Arora,S., Acheta,J.,
            Nave,K.A., Schwab,M.H., Jourd'heuil,D., Poitelon,Y. and Belin,S.
  TITLE     PMP2 regulates myelin thickening and ATP production during
            remyelination
  JOURNAL   Glia 72 (5), 885-898 (2024)
   PUBMED   38311982
REFERENCE   4  (bases 1 to 5498)
  AUTHORS   Jia,T., Wang,H., Chi,W., Zhou,W., Guo,L., Dai,Y., Bian,K., Sun,Z.,
            Ding,X. and Yu,Y.
  TITLE     Knockdown of BACE1 by a multistage brain-targeting polyion complex
            improved memory and learning behaviors in APP/PS1 transgenic mouse
            model
  JOURNAL   Int J Pharm 650, 123727 (2024)
   PUBMED   38142018
  REMARK    GeneRIF: Knockdown of BACE1 by a multistage brain-targeting polyion
            complex improved memory and learning behaviors in APP/PS1
            transgenic mouse model.
REFERENCE   5  (bases 1 to 5498)
  AUTHORS   Kandalepas,P.C. and Vassar,R.
  TITLE     The normal and pathologic roles of the Alzheimer's beta-secretase,
            BACE1
  JOURNAL   Curr Alzheimer Res 11 (5), 441-449 (2014)
   PUBMED   24893886
  REMARK    Review article
REFERENCE   6  (bases 1 to 5498)
  AUTHORS   De Pietri Tonelli,D., Mihailovich,M., Di Cesare,A., Codazzi,F.,
            Grohovaz,F. and Zacchetti,D.
  TITLE     Translational regulation of BACE-1 expression in neuronal and
            non-neuronal cells
  JOURNAL   Nucleic Acids Res 32 (5), 1808-1817 (2004)
   PUBMED   15034149
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5498)
  AUTHORS   Luo,Y., Bolon,B., Kahn,S., Bennett,B.D., Babu-Khan,S., Denis,P.,
            Fan,W., Kha,H., Zhang,J., Gong,Y., Martin,L., Louis,J.C., Yan,Q.,
            Richards,W.G., Citron,M. and Vassar,R.
  TITLE     Mice deficient in BACE1, the Alzheimer's beta-secretase, have
            normal phenotype and abolished beta-amyloid generation
  JOURNAL   Nat Neurosci 4 (3), 231-232 (2001)
   PUBMED   11224535
REFERENCE   8  (bases 1 to 5498)
  AUTHORS   Marcinkiewicz,M. and Seidah,N.G.
  TITLE     Coordinated expression of beta-amyloid precursor protein and the
            putative beta-secretase BACE and alpha-secretase ADAM10 in mouse
            and human brain
  JOURNAL   J Neurochem 75 (5), 2133-2143 (2000)
   PUBMED   11032903
REFERENCE   9  (bases 1 to 5498)
  AUTHORS   Yan,R., Bienkowski,M.J., Shuck,M.E., Miao,H., Tory,M.C.,
            Pauley,A.M., Brashier,J.R., Stratman,N.C., Mathews,W.R., Buhl,A.E.,
            Carter,D.B., Tomasselli,A.G., Parodi,L.A., Heinrikson,R.L. and
            Gurney,M.E.
  TITLE     Membrane-anchored aspartyl protease with Alzheimer's disease
            beta-secretase activity
  JOURNAL   Nature 402 (6761), 533-537 (1999)
   PUBMED   10591213
REFERENCE   10 (bases 1 to 5498)
  AUTHORS   Vassar,R., Bennett,B.D., Babu-Khan,S., Kahn,S., Mendiaz,E.A.,
            Denis,P., Teplow,D.B., Ross,S., Amarante,P., Loeloff,R., Luo,Y.,
            Fisher,S., Fuller,J., Edenson,S., Lile,J., Jarosinski,M.A.,
            Biere,A.L., Curran,E., Burgess,T., Louis,J.C., Collins,F.,
            Treanor,J., Rogers,G. and Citron,M.
  TITLE     Beta-secretase cleavage of Alzheimer's amyloid precursor protein by
            the transmembrane aspartic protease BACE
  JOURNAL   Science 286 (5440), 735-741 (1999)
   PUBMED   10531052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC126804.3.
            
            On Aug 8, 2022 this sequence version replaced XM_011242512.4.
            
            Summary: This gene encodes a member of the peptidase A1 family of
            aspartic proteases. Alternative splicing results in multiple
            transcript variants, at least one of which encodes a preproprotein
            that is proteolytically processed to generate the mature protease.
            This transmembrane protease catalyzes the first step in the
            formation of amyloid beta peptide from amyloid precursor protein.
            Amyloid beta peptides are the main constituent of amyloid beta
            plaques, which accumulate in the brains of human Alzheimer's
            disease patients. Homozygous knockout mice for this gene exhibit a
            wide range of nervous system defects, growth retardation, metabolic
            abnormalities, and increased neonatal lethality. [provided by
            RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.121686.1,
                                           SRR13422597.1568346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC126804.3         148046-148197
            153-241             AC126804.3         161043-161131
            242-458             AC126804.3         162782-162998
            459-596             AC126804.3         164243-164380
            597-731             AC126804.3         165269-165403
            732-833             AC126804.3         166555-166656
            834-983             AC126804.3         167065-167214
            984-1155            AC126804.3         167434-167605
            1156-5498           AC126804.3         168209-172551
FEATURES             Location/Qualifiers
     source          1..5498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.22 cM"
     gene            1..5498
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /note="beta-site APP cleaving enzyme 1"
                     /db_xref="GeneID:23821"
                     /db_xref="MGI:MGI:1346542"
     exon            1..152
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1397
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /EC_number="3.4.23.46"
                     /note="isoform 4 is encoded by transcript variant 4;
                     beta-secretase 1; asp 2; memapsin-2; aspartyl protease 2;
                     membrane-associated aspartic protease 2; beta-site amyloid
                     precursor protein cleaving enzyme 1; APP beta-secretase"
                     /codon_start=1
                     /product="beta-secretase 1 isoform 4"
                     /protein_id="NP_001397385.1"
                     /db_xref="GeneID:23821"
                     /db_xref="MGI:MGI:1346542"
                     /translation="MGTQPWEGTSPCLFPSFPTVSKLNILVDTGSSNFAVGAAPHPFL
                     HRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESD
                     KFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQT
                     EALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNY
                     DKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIF
                     PVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIM
                     EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMT
                     IAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK"
     exon            153..241
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            242..458
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            459..596
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            597..731
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            732..833
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            834..983
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1155
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..5498
                     /gene="Bace1"
                     /gene_synonym="ASP2; Bace"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacatggc cagaagagag ctgtactgag tctgagaaag ataagcctag gggagccaga
       61 aaccccttgc aagggttctg agacggatgg gcacacagcc atgggaaggg acttctccct
      121 gtcttttccc gtcttttcca acagtttcca agctcaacat cctggtggac acgggcagta
      181 gtaactttgc agtgggggct gccccacacc ctttcctgca tcgctactac cagaggcagc
      241 tgtccagcac atatcgagac ctccgaaagg gtgtgtatgt gccctacacc cagggcaagt
      301 gggaggggga actgggcacc gacctggtga gcatccctca tggccccaac gtcactgtgc
      361 gtgccaacat tgctgccatc actgaatcgg acaagttctt catcaatggt tccaactggg
      421 agggcatcct agggctggcc tatgctgaga ttgccaggcc cgacgactct ttggagccct
      481 tctttgactc cctggtgaag cagacccaca ttcccaacat cttttccctg cagctctgtg
      541 gcgctggctt ccccctcaac cagaccgagg cactggcctc ggtgggaggg agcatgatca
      601 ttggtggtat cgaccactcg ctatacacgg gcagtctctg gtacacaccc atccggcggg
      661 agtggtatta tgaagtgatc attgtacgtg tggaaatcaa tggtcaagat ctcaagatgg
      721 actgcaagga gtacaactac gacaagagca ttgtggacag tgggaccacc aaccttcgct
      781 tgcccaagaa agtatttgaa gctgccgtca agtccatcaa ggcagcctcc tcgacggaga
      841 agttcccgga tggcttttgg ctaggggagc agctggtgtg ctggcaagca ggcacgaccc
      901 cttggaacat tttcccagtc atttcacttt acctcatggg tgaagtcacc aatcagtcct
      961 tccgcatcac catccttcct cagcaatacc tacggccggt ggaggacgtg gccacgtccc
     1021 aagacgactg ttacaagttc gctgtctcac agtcatccac gggcactgtt atgggagccg
     1081 tcatcatgga aggtttctat gtcgtcttcg atcgagcccg aaagcgaatt ggctttgctg
     1141 tcagcgcttg ccatgtgcac gatgagttca ggacggcggc agtggaaggt ccgtttgtta
     1201 cggcagacat ggaagactgt ggctacaaca ttccccagac agatgagtca acacttatga
     1261 ccatagccta tgtcatggcg gccatctgcg ccctcttcat gttgccactc tgcctcatgg
     1321 tatgtcagtg gcgctgcctg cgttgcctgc gccaccagca cgatgacttt gctgatgaca
     1381 tctccctgct caagtaagga ggcccgtggg cagatgatgg agacgcccct ggaccacatc
     1441 tgggtggttc cctttggtca catgagttgg agctatggat ggtacctgtg gccagagcac
     1501 ctcaggaccc tcaccaacct gccaatgctt ctggcgtgac agaacagaga aatcaggcaa
     1561 gctggattac agggcttgca cctgtaggac acaggagagg gaaggaagca gcgttctggt
     1621 ggcaggaata tccttagaca ccacaaactt gagttggaaa ttttgctgct tgaagcttca
     1681 gccctgaccc tctgcccagc atcctttaga gtctccaacc taaagtattc tttatgtcct
     1741 tccagaagta ctggcgtcat actcaggcta cccggcatgt gtccctgtgg taccctggca
     1801 gagaaagggc caatctcatt ccctgctggc caaagtcagc agaagaaagt gaagtttgcc
     1861 agttgcttta gtgataggga ctgcagactc aagcctacac tggtacaaag actgcgtctt
     1921 gagataaaca agaacctatg cgatgcgaat gtttatactc ctgggggcag tcaagatgag
     1981 gagacaggat aggatagaga caggaaggag atggtagcaa aactgggaaa ggcagaactc
     2041 tgatcacttt ctagttccaa gtttagactc atctccaaga cagaagccca tctggactaa
     2101 gaggtatcat tccccaatgt gcctgtggtt gtagtctgaa ctgaaatgaa atgggggaaa
     2161 aagggcttat tagccaaaga gctcttttta acactcttag aggaacagtg ctcatgagaa
     2221 aagtcccact ggacagatga attcctatct tgttaattct gtctctctct gcttcttcaa
     2281 catgctaagt ggcaccaaaa tgacccaacc ccaaggtctt aggtgcccta tgggacaaca
     2341 gttagaatat tgtagggcta gggatggtct tcccagcata ggttcactcc aaccaaggtg
     2401 ctaaaaggaa cagacaggag agtcctcctc tctgatccac aaaggcagag ccctcaagat
     2461 tcatccagca gggttagggc tgatgcattt gcctctgcct ggattttgtt tttattttct
     2521 ttctttttgc ccagtggtac aaaacgataa gctctttatg gaatactgag tgggttcatt
     2581 cctctcttgc cctctccaat ggcccctcta tttatctggc taaggaaaca ccacgcattg
     2641 gctagtatta aacagcaact gtaagataga gggctttctg ttctatgtca ttgccttcag
     2701 tatcaaggct gcctggagaa aggatggcag cctcagggct tccttacttt cttctccttt
     2761 cctgacagag cagcctttct gtcctgctct ctgctgcccc tcccaatata atccatgggt
     2821 acccaggctg gttcttgggc taggttgtgg gggccacact cacctcttcc ctgccagttc
     2881 taacacgaca gacatgaagc cagtgttagt gggaagagct gggttttccc aggatgacca
     2941 ctgcatcctc tcctggtacg ctctacactg ctttcaggct ggggacctgc caagtgtggg
     3001 acagttgatg aggaagagac attagcaggg cctctggagt tgctggccca gccagctgcc
     3061 cacaagccat aaaccaataa aataagaatc ctgcgtcaca gtttccagct gggtcctctt
     3121 ccttgccctc gcactggtgc tgctctggct gagtaggaat acacccacag actgccagga
     3181 agatggagac tgtccgcttc cggctcagaa ctacagtgta attaagcttc caggatcact
     3241 accatgaaaa cgccgcattc tgctttatca tttctaccca tgttgggaaa aactggcttt
     3301 ttccccattt ctttacaggg caaaaaaaaa aaaaaaaaaa gggagagaga gagagaactc
     3361 aacctagttg ttatttaccc tagtaactgg tgttctattt ttttttaaag ggggaaaatt
     3421 tgcatttatt tttcttttga tggttaactc ctttgtatca taaaattatg aactctgata
     3481 tgtaaaacag aaaaaaatct tgacaacagc ttctcgcttg taaaaatatg tattatacag
     3541 ctctattttc aaagtctcct gaaaaatgac tgacctatct ccactgtatg tggggctttg
     3601 ctaccgtctg tatgaacgga ggcccagtgg gcagaggtga tacaaacagg catggcagac
     3661 tctgagtgtt tttctgactg tttctctgca aagatagagc cacagtgatg aggctccaac
     3721 tgtggaggtc cactctccaa aatgctgcct ttctggggct cgctctgaga gacagcttgg
     3781 ccccatcatt cctgcttttt ttcttctcta ctcttttggc ttctaagatt tttttttaaa
     3841 agaaaagtag tttttttctt actttctttt ttcctttctg tcttcttttt gtctgtctgt
     3901 ctttctcttt tcttttcttt gacagcatct catgtagatc aggctggcct caaacttgta
     3961 gcaacgttcc tgcctttgcc tcctgagtgc taggattaca ggtgtgtgcc acaactcctc
     4021 ctcgatagaa accgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     4081 tgtgtgtgtg tgtgtgtgtg attacatgcg tgtctgtagg ggaaggggcc aggaggatga
     4141 gatatggtct catgtagctc aggctagcct tgaactcctg accctcctgt gtgtccacct
     4201 cccatatgcc atgattacag gcttgtgcca ctatgtttaa ctaaacacaa cattctttat
     4261 gctcactttc aatgtacagt tttcaggtga cagtgaggta ctacatagct agtgctggat
     4321 gctgcacagt tgaagggaga gagcaatctt aagacagaaa atgaatgaat gaatctgcca
     4381 catgaaataa acaaaggaag tagacttcca ttttgccacc tttttctgtt caagtagtac
     4441 caaactggag acaagaagac agaagtactt cattaaccaa agaaaggagg tcacctgacc
     4501 tctaaaaagg aagactcagg ccattccccc ttaaagattt taaggtaacc ctgggaagtc
     4561 cacccctaat catgcttatc aatcaacctg gacaataagg caagagaaaa gaattcatcc
     4621 atgagctcat aggcaaggca gagaaaaaca agagaattta gttagctcag aaaggacaaa
     4681 gtctttgcta tcctaacaga aactgctaga ctcaataagc acccccagtc ccaggatggg
     4741 aaaacatcaa ttgtcagtag catgttaccc ttcccccaga tgcatttttt ctcaattaac
     4801 acttgtttaa ttctgaaaaa agaaggtaat taaaaccatt tcctgtagga gtaaagataa
     4861 agattgggaa agactcaagg ttctcagagc cacagctgtc tcagacataa aaaccagaag
     4921 aactcagtaa gtggcggtgg caaacctatc ttcctccaga tgggaatcca caaagcatag
     4981 cttacaactg taccaccttc cttcatctca ctgtctccac tgtattctag acagggaatg
     5041 tatccttcat agcgttcttg attgataaat gaagtccaac atcccacgat tattctgcaa
     5101 gtaattttgc acagacatct caccccagtg cctgtctgga gctcacctaa ggtcaccaaa
     5161 tcacttggtg gtgaaccaat tgccttaacc tttgggggga ggggatagct agattaggaa
     5221 accagaggaa tggaagggtg agcactttgc aagcctggct ggtcagtgct tagtggaggc
     5281 taaaccagta gcaacaaggg atggtggctt ggcccagggg aaaaatctgt gaattgtgct
     5341 tttctatcta gaaagcagag tagacagaag atggtgggag aaatggaacc tgattttgtt
     5401 gttcttggac tgtggatttt actgacataa aacagaatat cctgtatacc tgatatcaat
     5461 gtataaataa tgaggattaa cacagtaaaa tgttcaat
//
