LOCUS       NM_144541               1299 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BRISC and BRCA1 A complex member 2 (Babam2),
            transcript variant 5, mRNA.
ACCESSION   NM_144541
VERSION     NM_144541.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Jin,F., Zhu,Y., Liu,M., Wang,R., Cui,Y., Wu,Y., Liu,G., Wang,Y.,
            Wang,X. and Ren,Z.
  TITLE     Babam2 negatively regulates osteoclastogenesis by interacting with
            Hey1 to inhibit Nfatc1 transcription
  JOURNAL   Int J Biol Sci 18 (11), 4482-4496 (2022)
   PUBMED   35864959
  REMARK    GeneRIF: Babam2 negatively regulates osteoclastogenesis by
            interacting with Hey1 to inhibit Nfatc1 transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Donaghy,R., Han,X., Rozenova,K., Lv,K., Jiang,Q., Doepner,M.,
            Greenberg,R.A. and Tong,W.
  TITLE     The BRISC deubiquitinating enzyme complex limits hematopoietic stem
            cell expansion by regulating JAK2 K63-ubiquitination
  JOURNAL   Blood 133 (14), 1560-1571 (2019)
   PUBMED   30755420
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Jin,F., Wang,Y., Wang,X., Wu,Y., Wang,X., Liu,Q., Zhu,Y., Liu,E.,
            Fan,J. and Wang,Y.
  TITLE     Bre Enhances Osteoblastic Differentiation by Promoting the
            Mdm2-Mediated Degradation of p53
  JOURNAL   Stem Cells 35 (7), 1760-1772 (2017)
   PUBMED   28436570
  REMARK    GeneRIF: Bre enhances osteoblastic differentiation by promoting the
            Mdm2-mediated degradation of p53.
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Yeung,C.K., Wang,G., Yao,Y., Liang,J., Tenny Chung,C.Y., Chuai,M.,
            Lee,K.K. and Yang,X.
  TITLE     BRE modulates granulosa cell death to affect ovarian follicle
            development and atresia in the mouse
  JOURNAL   Cell Death Dis 8 (3), e2697 (2017)
   PUBMED   28333135
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1299)
  AUTHORS   Ching,A.K., Li,Q., Lim,P.L., Chan,J.Y. and Chui,Y.L.
  TITLE     Expression of a conserved mouse stress-modulating gene, Bre:
            comparison with the human ortholog
  JOURNAL   DNA Cell Biol 22 (8), 497-504 (2003)
   PUBMED   14565866
  REMARK    GeneRIF: a highly conserved gene in two species can generate
            alternative transcripts different in both of the sequence structure
            and expression pattern, as well as a similar class of transcripts
            resulting from unconventional transcript processing.
REFERENCE   7  (bases 1 to 1299)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1299)
  AUTHORS   Mallery,D.L., Vandenberg,C.J. and Hiom,K.
  TITLE     Activation of the E3 ligase function of the BRCA1/BARD1 complex by
            polyubiquitin chains
  JOURNAL   EMBO J 21 (24), 6755-6762 (2002)
   PUBMED   12485996
REFERENCE   9  (bases 1 to 1299)
  AUTHORS   Ching,A.K., Li,P.S., Li,Q., Chan,B.C., Chan,J.Y., Lim,P.L.,
            Pang,J.C. and Chui,Y.L.
  TITLE     Expression of human BRE in multiple isoforms
  JOURNAL   Biochem Biophys Res Commun 288 (3), 535-545 (2001)
   PUBMED   11676476
REFERENCE   10 (bases 1 to 1299)
  AUTHORS   Gu,C., Castellino,A., Chan,J.Y. and Chao,M.V.
  TITLE     BRE: a modulator of TNF-alpha action
  JOURNAL   FASEB J 12 (12), 1101-1108 (1998)
   PUBMED   9737713
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF440752.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF440752.1, BC061000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6 x CBA/N"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.27 cM"
     gene            1..1299
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /note="BRISC and BRCA1 A complex member 2"
                     /db_xref="GeneID:107976"
                     /db_xref="MGI:MGI:1333875"
     exon            1..28
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            29..180
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1204
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /note="isoform V is encoded by transcript variant 5;
                     BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing
                     complex subunit 45; brain and reproductive organ-expressed
                     protein"
                     /codon_start=1
                     /product="BRISC and BRCA1-A complex member 2 isoform V"
                     /protein_id="NP_653124.1"
                     /db_xref="CCDS:CCDS19188.1"
                     /db_xref="GeneID:107976"
                     /db_xref="MGI:MGI:1333875"
                     /translation="MSPEIALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGC
                     TSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALHNL
                     ASWNPSNPECLLLVVKELVQQYHQFQCGRLRESSRLMFEYQTLLEEPQYGENMEIYAG
                     KKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPK
                     LYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIA
                     AFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFT
                     NSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL"
     exon            181..257
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            258..352
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            353..547
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            548..622
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            623..732
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            733..832
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            833..903
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            904..986
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1140
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1299
                     /gene="Babam2"
                     /gene_synonym="6030405P19Rik; B830038C02Rik; Bre"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggttactg atcggactta agttccagtg gtaactcata aatcaagtta aaatgtctcc
       61 agaaattgcc ttgaaccgaa tttctccaat gctctcccca ttcatatcaa gcgtggtccg
      121 aaatgggaag gtgggactgg atgctacaaa ctgtttgaga attacggact tgaagtctgg
      181 ctgtacatca ttgactcctg gacccaactg tgaccgcttc aaactgcaca tcccgtacgc
      241 tggggagacg ttaaaatggg acataatttt caatgctcag tacccagagc tgcctcctga
      301 tttcatcttt ggagaggatg ctgagtttct gccagacccc tctgcgctgc acaaccttgc
      361 ctcctggaac ccttcaaacc ctgagtgcct gttgctcgtg gtgaaggagc tggtgcagca
      421 gtaccaccag ttccagtgcg gccgcctccg tgagagctcg cgcctcatgt ttgagtacca
      481 gacgctcctg gaagagcctc agtatggaga gaacatggaa atttatgctg gaaagaaaaa
      541 caactggact ggtgaatttt cagctcgttt tctattgaag ttaccagtag atttcagcaa
      601 cattcccaca taccttctca aggatgtaaa tgaagaccct ggagaagatg tggcccttct
      661 ttctgtcagt tttgaggata ctgaagctac ccaggtgtac cccaagttgt acttgtcacc
      721 ccgaattgag catgcactcg gaggctcctc tgctcttcac atccctgctt tccccggagg
      781 aggatgtctc attgattatg tgcctcaagt gtgccacctg ctcaccaaca aggtacagta
      841 tgtgattcaa ggctatcaca aaagaagaga gtacatcgca gctttcctca gtcactttgg
      901 cacaggtgtc gtggaatatg atgcagaagg cttcacaaaa cttactctgc tgctgatgtg
      961 gaaagacttt tgttttcttg tccacattga cctgcccctg tttttccctc gagatcagcc
     1021 tacgctcaca tttcagtcag tctatcactt taccaacagt ggacagcttt actcccaagc
     1081 acaaaaaaac tacccataca gccccagatg ggatggaaat gaaatggcca agagagcaaa
     1141 ggcttatttc aaaacctttg tccctcagtt ccaggaggcc gcatttgcca atggaaagct
     1201 ctaggaaaca ccagtgctga gaggcggcca accagactgc tcagtccaca tgcgtgtcag
     1261 cgctcgggct gcttgctgga aactgctcgg aatgtcttc
//
