LOCUS       NM_026636               1592 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BRISC and BRCA1 A complex member 1 (Babam1), mRNA.
ACCESSION   NM_026636
VERSION     NM_026636.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1592)
  AUTHORS   Donaghy,R., Han,X., Rozenova,K., Lv,K., Jiang,Q., Doepner,M.,
            Greenberg,R.A. and Tong,W.
  TITLE     The BRISC deubiquitinating enzyme complex limits hematopoietic stem
            cell expansion by regulating JAK2 K63-ubiquitination
  JOURNAL   Blood 133 (14), 1560-1571 (2019)
   PUBMED   30755420
REFERENCE   3  (bases 1 to 1592)
  AUTHORS   Jiang,Q., Paramasivam,M., Aressy,B., Wu,J., Bellani,M., Tong,W.,
            Seidman,M.M. and Greenberg,R.A.
  TITLE     MERIT40 cooperates with BRCA2 to resolve DNA interstrand
            cross-links
  JOURNAL   Genes Dev 29 (18), 1955-1968 (2015)
   PUBMED   26338419
  REMARK    GeneRIF: Merit40 mutation exacerbated ICL-induced chromosome
            instability in the context of concomitant Brca2 deficiency but not
            in conjunction with Fancd2 mutation.
REFERENCE   4  (bases 1 to 1592)
  AUTHORS   Rozenova,K., Jiang,J., Donaghy,R., Aressy,B., Greenberg,R.A. and
            Tong,W.
  TITLE     MERIT40 deficiency expands hematopoietic stem cell pools by
            regulating thrombopoietin receptor signaling
  JOURNAL   Blood 125 (11), 1730-1738 (2015)
   PUBMED   25636339
  REMARK    GeneRIF: MERIT40(-/-) hematopoietic stem cells are more resistant
            to cytoablative stress, and exhibit superior repopulating ability
            and self-renewal upon serial transplantation.
REFERENCE   5  (bases 1 to 1592)
  AUTHORS   Wang,B.
  TITLE     BRCA1 tumor suppressor network: focusing on its tail
  JOURNAL   Cell Biosci 2 (1), 6 (2012)
   PUBMED   22369660
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1592)
  AUTHORS   Patterson-Fortin,J., Shao,G., Bretscher,H., Messick,T.E. and
            Greenberg,R.A.
  TITLE     Differential regulation of JAMM domain deubiquitinating enzyme
            activity within the RAP80 complex
  JOURNAL   J Biol Chem 285 (40), 30971-30981 (2010)
   PUBMED   20656689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127416.7 and AK147083.1.
            
            On Nov 19, 2009 this sequence version replaced NM_026636.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147083.1, BC005692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC127416.7         59449-59454
            7-1369              AK147083.1         2-1364
            1370-1592           AC127416.7         67144-67366
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..1592
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /note="BRISC and BRCA1 A complex member 1"
                     /db_xref="GeneID:68251"
                     /db_xref="MGI:MGI:1915501"
     exon            1..166
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /inference="alignment:Splign:2.1.0"
     exon            167..513
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /inference="alignment:Splign:2.1.0"
     exon            514..572
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /inference="alignment:Splign:2.1.0"
     exon            573..693
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /inference="alignment:Splign:2.1.0"
     exon            694..772
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /inference="alignment:Splign:2.1.0"
     exon            773..797
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /inference="alignment:Splign:2.1.0"
     exon            798..927
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1014
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1592
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1344..1349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /note="hexamer: AATAAA"
     polyA_site      1365
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /note="major polyA site"
     polyA_site      1397
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
     polyA_site      1422
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
     regulatory      1432..1437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Babam1"
                     /gene_synonym="5430437P03Rik; Merit40"
                     /note="hexamer: AACAAA"
ORIGIN      
        1 ctcggcagcg ccgcacaaac ttccggccag gaagatggcg gcttcctaga gtcctgattg
       61 actggccgcg gtgcccaggc tacagagtgg aacctgcggc actgtgaacg cgcgtgagct
      121 ttgtgtcgcc gtggtctaac ttcgacccgg attgctgtag ctccaggcag gatcctggct
      181 tccactatcc ccccttcatc taaccactcg ggaaccatgg aggtggcaga ggcgaacagc
      241 cccacggagg aggaggaaga ggaggaagaa gaaggagagg agacgatatc agagcccagg
      301 cctcacactc gatccaatcc agagggggct gaggaccggg ccctgggagc tcaagccagt
      361 gtgggcagcc gcagcgaggg cgagggtgag gcagccactg cagatggcgg ggcagccagt
      421 gtcccaggag ccgggcctaa gccctggcaa gtaccagcat cagcatctga ggtccagatt
      481 cgaacaccaa gggtcaactg tccagagaag gtgatcatct gtctggatct ttcggaggag
      541 atgtctgtgc caaagctgga gtcctttaat ggctctagga caaacgccct gaatgtgtct
      601 cagaagatgg ttgagatgtt tgttcgcaca aagcacaaga ttgacaagag ccacgaattt
      661 gcactggttg tagtgaatga cgactccgcc tggctgtctg gcctgacctc tgacccacgt
      721 gagctctgca gctgcctgta tgacctggag acggcgtcct gctccacctt caatttggaa
      781 ggcctcttca gcctcatcca gcagaagacc gagctgccag tcacagagaa tgtgcaaacc
      841 atcccacccc cctatgttgt gcgcaccatc ctggtctaca gccgcccacc ctgccagccc
      901 cagttttccc tgactgagcc catgaagaag atgttccagt gtccctactt cttcttcgac
      961 atcgtttata tccacaatgg cactgaggag aaggaagagg atatgagctg gaaggacatg
     1021 tttgccttca tgggtagcct ggacaccaag ggcgccagct acaagtatga ggtagcactt
     1081 gctggtcctg ccctggagct gcacaattgc atggccaagt tgctggccca cccgctgcaa
     1141 agaccctgcc agacccacgc gagctacagc ctgctggagg aggacgagga ggctggagaa
     1201 gaggaagcca ctgtgtgaac tatgacatgt gacatctccg caccctccta tgaggagagc
     1261 gcaggcacac tattattggc ccatgctcaa tcccactctg tccactgtaa attcattctt
     1321 cctgggacta tttttgtcac cggaataaaa atctgaggtc cctgagccca cccttggtgt
     1381 cactttgggc tcactgagac ctgttattaa tgtcacagaa aacaggcact aaacaaagca
     1441 gtggtgtatg gcttcaggct cagctgtatc cgagtaaccc acaggctggt gttcactgcg
     1501 ctttccaaac tcctcttcat cctacagaac ccactccaga tgttctttta tccagaaagt
     1561 cctccagaaa cagggaagat ctattgaaag tg
//
