LOCUS       NM_007519               1961 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Mus musculus bile acid-Coenzyme A: amino acid N-acyltransferase
            (Baat), mRNA.
ACCESSION   NM_007519
VERSION     NM_007519.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1961)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1961)
  AUTHORS   Neugebauer,K.A., Okros,M., Guzior,D.V., Feiner,J., Chargo,N.J.,
            Rzepka,M., Schilmiller,A.L., O'Reilly,S., Jones,A.D., Watson,V.E.,
            Luyendyk,J.P., McCabe,L.R. and Quinn,R.A.
  TITLE     Baat Gene Knockout Alters Post-Natal Development, the Gut
            Microbiome, and Reveals Unusual Bile Acids in Mice
  JOURNAL   J Lipid Res 63 (12), 100297 (2022)
   PUBMED   36243101
REFERENCE   3  (bases 1 to 1961)
  AUTHORS   Alrehaili,B.D., Lee,M., Takahashi,S., Novak,R., Rimal,B.,
            Boehme,S., Trammell,S.A.J., Grevengoed,T.J., Kumar,D., Alnouti,Y.,
            Chiti,K., Wang,X., Patterson,A.D., Chiang,J.Y.L., Gonzalez,F.J. and
            Lee,Y.K.
  TITLE     Bile acid conjugation deficiency causes hypercholanemia,
            hyperphagia, islet dysfunction, and gut dysbiosis in mice
  JOURNAL   Hepatol Commun 6 (10), 2765-2780 (2022)
   PUBMED   35866568
REFERENCE   4  (bases 1 to 1961)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1961)
  AUTHORS   O'Byrne,J., Hunt,M.C., Rai,D.K., Saeki,M. and Alexson,S.E.
  TITLE     The human bile acid-CoA:amino acid N-acyltransferase functions in
            the conjugation of fatty acids to glycine
  JOURNAL   J Biol Chem 278 (36), 34237-34244 (2003)
   PUBMED   12810727
  REMARK    GeneRIF: cytosolic BACAT enzyme may play important roles in
            protection against toxicity by accumulation of unconjugated bile
            acids and non-esterified very long-chain fatty acids
REFERENCE   6  (bases 1 to 1961)
  AUTHORS   Sfakianos,M.K., Wilson,L., Sakalian,M., Falany,C.N. and Barnes,S.
  TITLE     Conserved residues in the putative catalytic triad of human bile
            acid Coenzyme A:amino acid N-acyltransferase
  JOURNAL   J Biol Chem 277 (49), 47270-47275 (2002)
   PUBMED   12239217
REFERENCE   7  (bases 1 to 1961)
  AUTHORS   Coli,R., Anderson,S.L., Volpi,S.A. and Rubin,B.Y.
  TITLE     Genomic organization and chromosomal localization of the mouse
            IKBKAP gene
  JOURNAL   Gene 279 (1), 81-89 (2001)
   PUBMED   11722848
REFERENCE   8  (bases 1 to 1961)
  AUTHORS   Contos,J.J. and Chun,J.
  TITLE     Complete cDNA sequence, genomic structure, and chromosomal
            localization of the LPA receptor gene, lpA1/vzg-1/Gpcr26
  JOURNAL   Genomics 51 (3), 364-378 (1998)
   PUBMED   9721207
REFERENCE   9  (bases 1 to 1961)
  AUTHORS   Nuglozeh,E. and Kozak,L.P.
  TITLE     Genetic mapping of the C-type natriuretic peptide receptor (Npr2)
            gene to mouse chromosome 4
  JOURNAL   Mamm Genome 8 (8), 624-625 (1997)
   PUBMED   9250880
REFERENCE   10 (bases 1 to 1961)
  AUTHORS   Falany,C.N., Fortinberry,H., Leiter,E.H. and Barnes,S.
  TITLE     Cloning, expression, and chromosomal localization of mouse liver
            bile acid CoA:amino acid N-acyltransferase
  JOURNAL   J Lipid Res 38 (6), 1139-1148 (1997)
   PUBMED   9215542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY080271.1, AK017923.1, CB947692.1, AA255212.1, BB800891.1 and
            U95215.1.
            
            On Nov 4, 2008 this sequence version replaced NM_007519.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U95215.1, AK017923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY080271.1         2-53
            53-473              AK017923.1         2-422
            474-950             AK017923.1         424-900
            951-1223            CB947692.1         276-548
            1224-1546           AA255212.1         96-418
            1547-1898           BB800891.1         12-363
            1899-1961           U95215.1           1808-1870
FEATURES             Location/Qualifiers
     source          1..1961
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.51 cM"
     gene            1..1961
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /note="bile acid-Coenzyme A: amino acid N-acyltransferase"
                     /db_xref="GeneID:12012"
                     /db_xref="MGI:MGI:106642"
     exon            1..230
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /inference="alignment:Splign:2.1.0"
     exon            231..747
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1544
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /EC_number="2.3.1.65"
                     /EC_number="3.1.2.2"
                     /EC_number="3.1.2.27"
                     /note="bile acid-Coenzyme A dehydrogenase: amino acid
                     n-acyltransferase; BACAT; glycine N-choloyltransferase;
                     long-chain fatty-acyl-CoA hydrolase; taurine
                     N-acyltransferase; choloyl-CoA hydrolase; bile acid-CoA
                     thioesterase"
                     /codon_start=1
                     /product="bile acid-CoA:amino acid N-acyltransferase"
                     /protein_id="NP_031545.2"
                     /db_xref="CCDS:CCDS18173.1"
                     /db_xref="GeneID:12012"
                     /db_xref="MGI:MGI:106642"
                     /translation="MAKLTAVPLSALVDEPVHIQVTGLAPFQVVCLQASLKDEKGNLF
                     SSQAFYRASEVGEVDLEHDPSLGGDYMGVHPMGLFWSLKPEKLLGRLIKRDVMNSPYQ
                     IHIKACHPYFPLQDIVVSPPLDSLTLERWYVAPGVKRIQVKESRIRGALFLPPGEGPF
                     PGVIDLFGGAGGLMEFRASLLASRGFATLALAYWNYDDLPSRLEKVDLEYFEEGVEFL
                     LRHPKVLGPGVGILSVCIGAEIGLSMAINLKQIRATVLINGPNFVSQSPHVYHGQVYP
                     PVPSNEEFVVTNALGLVEFYRTFQETADKDSKYCFPIEKAHGHFLFVVGEDDKNLNSK
                     VHANQAIAQLMKNGKKNWTLLSYPGAGHLIEPPYTPLCQASRMPILIPSLSWGGEVIP
                     HAAAQEHSWKEIQKFLKQHLLPDLSSQL"
     exon            748..950
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1946
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /note="hexamer: AATAAA"
     polyA_site      1791
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /note="major polyA site"
     regulatory      1928..1933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /note="hexamer: ATTAAA"
     polyA_site      1946
                     /gene="Baat"
                     /gene_synonym="BAT"
                     /note="major polyA site"
ORIGIN      
        1 agtctcttct ctgggttcag cctacttata tctggttgag gagggaaata ctaagatatt
       61 ttcctcagct ctgaccgaat agtctgcatt tttaaaaact cttccattat ctacagtgtt
      121 gtcagagcct tggtttgaga gtctctgaga agtcctgggc atctgtgctg accgacaggg
      181 cctccttctc tagagcacac cacgttcctg agggttgctg taaaactact gttttggtga
      241 aaatattcct gaagaattgt ccaagattcc ctctgcaaaa aatggccaag ctgacagctg
      301 ttcctctcag tgctcttgtt gatgagcctg tgcacatcca ggtcacaggc ctggccccct
      361 ttcaggtggt gtgccttcag gcatcactga aagatgagaa gggaaacctg tttagttctc
      421 aggccttcta cagggccagt gaagtgggtg aggtagatct ggagcatgac ccctcacttg
      481 gaggagacta tatgggggtc caccccatgg gccttttctg gtccttgaaa cctgaaaagc
      541 tattgggtag attgataaaa agagatgtga tgaatagccc ctaccaaatc cacataaaag
      601 cttgccatcc atactttcca ttacaagaca tagtcgtcag tcctcccttg gatagcctga
      661 ctctggaaag gtggtatgtg gcacctgggg tcaagaggat ccaggtaaag gaaagccgca
      721 tccggggagc cctgtttctg cctccaggag aaggtccttt tccaggggtc attgacttgt
      781 ttggaggtgc tggtggattg atggagttcc gggccagtct tctggcaagt cgtggctttg
      841 ccaccttagc tctggcttac tggaactatg atgacctgcc ttctcgactg gagaaggtag
      901 atctagaata ttttgaagaa ggtgtagagt ttctcctgag acatcctaag gtcctcggcc
      961 caggtgttgg catcctttct gtatgcattg gagcagagat tggactttct atggctatta
     1021 acctaaaaca aataagagcc actgtactta tcaatgggcc taattttgtt tctcaaagtc
     1081 cacatgtata tcatggtcag gtctacccac ctgtacccag taatgaagag tttgtagtca
     1141 ccaatgcctt gggacttgta gaattctatc gaacctttca ggaaactgca gataaggaca
     1201 gcaaatattg ttttcccatt gaaaaagctc atggacattt cctttttgtg gttggagaag
     1261 atgataaaaa tctcaacagc aaagtgcatg ctaatcaagc catagcacag ctgatgaaaa
     1321 atggaaagaa gaattggact ctgctgtctt accctggggc aggtcacctg attgagcctc
     1381 cctatacccc actgtgccaa gcctcaagga tgcccatttt gatcccaagc ctcagctggg
     1441 gaggagaggt tatcccccat gcagctgcac aggagcattc ttggaaggag atacagaaat
     1501 ttctcaagca gcatctcctt ccagatttga gcagtcagct ctgagtggac ttgattatat
     1561 tcctggaaag tggagctggg catctcctgg ccagcaccac tcctcacttc catagaggaa
     1621 tgtctttgat ctcttatctg gcaaggaagg agagtaccac aagaaaatac aggaggatgg
     1681 agagtgataa cgtcttgaat ttggaagggg aaacatgttt tccatggaat gaaatgtcat
     1741 gcagtgagag ccctatatct acatgaataa aatcgtaggc ctttcctaaa atgttcaaca
     1801 tcatagcaac tttctgttat gataattatc agggaaatta tcagtgataa accacagaat
     1861 acttttgttt ataaaagaaa catgaaaata attatatatt atcacttatt aatttcttga
     1921 aactcacatt aaatatactt agatcaaaaa aaaaaaaaaa a
//
