LOCUS       NM_178776               1141 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cDNA sequence BC049715 (BC049715), mRNA.
ACCESSION   NM_178776
VERSION     NM_178776.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1141)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1141)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049715.1 and BX638225.1.
            
            On Dec 14, 2006 this sequence version replaced NM_178776.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1120              BC049715.1         1-1120
            1121-1141           BX638225.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.72 cM"
     gene            1..1141
                     /gene="BC049715"
                     /note="cDNA sequence BC049715"
                     /db_xref="GeneID:320135"
                     /db_xref="MGI:MGI:3605234"
     exon            1..227
                     /gene="BC049715"
                     /inference="alignment:Splign:2.1.0"
     exon            228..323
                     /gene="BC049715"
                     /inference="alignment:Splign:2.1.0"
     exon            324..1138
                     /gene="BC049715"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..1091
                     /gene="BC049715"
                     /codon_start=1
                     /product="uncharacterized protein C12orf60 homolog"
                     /protein_id="NP_848891.2"
                     /db_xref="CCDS:CCDS39685.1"
                     /db_xref="GeneID:320135"
                     /db_xref="MGI:MGI:3605234"
                     /translation="MSSESEKDKERLIQAAKLFFFHIRDLVSFINRFVELFNLTMKTQ
                     ILPMNLNEESCIKDFFEQMIRNFKEMQLMVDGKHKQMQKEPLCSKVLTAMTSAVEKCA
                     TIAPHHTAEDMLRNIQTSGAALVLKTSHVLVNLETSLSLLMQFPIMGLRLSDLYREET
                     KEQSDATSDATTSEKNKSPECPKATTEETLRKLQDVLSPENAHTPVEAAADELEQFVK
                     SMEITLQVLQKSIKTMEGDIFVLTQVQGK"
     regulatory      1113..1118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BC049715"
                     /note="hexamer: AATGAA"
     polyA_site      1120
                     /gene="BC049715"
                     /note="major polyA site"
     polyA_site      1138
                     /gene="BC049715"
                     /note="major polyA site"
ORIGIN      
        1 atatagaaag ggactttgtt atgatgactt acggtctgta gtccacctcc ccaacaatgg
       61 tcagctgtga atgggaagtc caaggatcta ggagttgctc agtcccacca ggctagtaga
      121 ttccaactga tgggctggca agtaaatgca agcagaggag gaagagaaaa acttccatct
      181 tccaatgtct tatagatctc cagaagaagg tgtggttcag attaaagcag gaatatttga
      241 agacatttgc tgcgaacaag gaagcaatag cctgtgcctg ctggtctatg atgcctttac
      301 acctcagtgg ttctgacaac aggggttgaa agttgtttgt tggagaaatg tcttctgagt
      361 cagaaaagga taaagagaga ctgatccaag ctgccaaact attcttcttc cacatacgag
      421 acctggtctc cttcataaat cggttcgttg agctgtttaa cctcacgatg aagactcaga
      481 tccttcccat gaatctgaac gaagagagct gcattaaaga tttctttgaa caaatgatca
      541 gaaatttcaa agagatgcaa ctgatggtgg atggaaagca caaacaaatg cagaaggagc
      601 cgttgtgctc taaggtgctg actgctatga cctctgcagt ggagaagtgc gccaccattg
      661 ctccacacca caccgcggaa gatatgctca gaaacatcca gacatcaggt gctgccttgg
      721 tcctgaagac cagtcatgtg cttgtgaatc tagaaacttc tctctcactc ctgatgcagt
      781 tccccatcat gggtcttcga ttaagtgacc tctatagaga ggagaccaaa gagcagtcag
      841 atgccacctc agatgccacc acatctgaga aaaacaagag tccagaatgt cccaaagcca
      901 ctacagagga aaccttgagg aagctgcaag atgtgctaag tcctgagaat gcccacacgc
      961 ccgtagaagc agccgcagat gagctggaac agtttgtcaa gagtatggag ataacgttac
     1021 aggtcctcca gaaatccatc aagaccatgg aaggggatat ctttgtactt acgcaggtcc
     1081 agggcaagta gaggacaaca tgttcctttc tgaatgaaaa gcagcttgag ttctcgaaaa
     1141 a
//
