LOCUS       NM_001305431             430 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus follicular dendritic cell secreted protein (Fdcsp),
            mRNA.
ACCESSION   NM_001305431 XR_389320
VERSION     NM_001305431.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 430)
  AUTHORS   Hou,S., Landego,I., Jayachandran,N., Miller,A., Gibson,I.W.,
            Ambrose,C. and Marshall,A.J.
  TITLE     Follicular dendritic cell secreted protein FDC-SP controls IgA
            production
  JOURNAL   Mucosal Immunol 7 (4), 948-957 (2014)
   PUBMED   24399151
  REMARK    GeneRIF: Our results demonstrate a novel biological activity of
            FDC-SP in controlling B-cell IgA production and identify
            FDC-SP-deficient mice as a novel mouse model of IgAN.
REFERENCE   2  (bases 1 to 430)
  AUTHORS   Shinomura,T., Nakamura,S., Ito,K., Shirasawa,S., Hook,M. and
            Kimura,J.H.
  TITLE     Adsorption of follicular dendritic cell-secreted protein (FDC-SP)
            onto mineral deposits. Application of a new stable gene expression
            system
  JOURNAL   J Biol Chem 283 (48), 33658-33664 (2008)
   PUBMED   18806264
REFERENCE   3  (bases 1 to 430)
  AUTHORS   Al-Alwan,M., Du,Q., Hou,S., Nashed,B., Fan,Y., Yang,X. and
            Marshall,A.J.
  TITLE     Follicular dendritic cell secreted protein (FDC-SP) regulates
            germinal center and antibody responses
  JOURNAL   J Immunol 178 (12), 7859-7867 (2007)
   PUBMED   17548624
REFERENCE   4  (bases 1 to 430)
  AUTHORS   Marshall,A.J., Du,Q., Draves,K.E., Shikishima,Y., HayGlass,K.T. and
            Clark,E.A.
  TITLE     FDC-SP, a novel secreted protein expressed by follicular dendritic
            cells
  JOURNAL   J Immunol 169 (5), 2381-2389 (2002)
   PUBMED   12193705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022298.31.
            
            On Mar 13, 2015 this sequence version replaced XR_389320.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF301466.1, BC037156.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849383
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC022298.31        63045-63087
            44-103              AC022298.31        64897-64956
            104-136             AC022298.31        65879-65911
            137-343             AC022298.31        67167-67373
            344-430             AC022298.31        68351-68437
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..430
                     /gene="Fdcsp"
                     /gene_synonym="FDC-SP"
                     /note="follicular dendritic cell secreted protein"
                     /db_xref="GeneID:494497"
                     /db_xref="MGI:MGI:3512757"
     exon            1..43
                     /gene="Fdcsp"
                     /gene_synonym="FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     exon            44..103
                     /gene="Fdcsp"
                     /gene_synonym="FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..304
                     /gene="Fdcsp"
                     /gene_synonym="FDC-SP"
                     /note="follicular dendritic cell secreted peptide"
                     /codon_start=1
                     /product="follicular dendritic cell secreted peptide
                     precursor"
                     /protein_id="NP_001292360.1"
                     /db_xref="GeneID:494497"
                     /db_xref="MGI:MGI:3512757"
                     /translation="MKTLLLLAAIVAVTACLPVPKDQEREKRSASDSDSDEFPLRIPF
                     PPYGYPFGTYPPFLNQGYPWYYYYYPPFPLPFTPPPTADP"
     exon            104..136
                     /gene="Fdcsp"
                     /gene_synonym="FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     exon            137..343
                     /gene="Fdcsp"
                     /gene_synonym="FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     exon            344..430
                     /gene="Fdcsp"
                     /gene_synonym="FDC-SP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      407..412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fdcsp"
                     /gene_synonym="FDC-SP"
                     /note="hexamer: AATAAA"
     polyA_site      428
                     /gene="Fdcsp"
                     /gene_synonym="FDC-SP"
                     /note="major polyA site"
ORIGIN      
        1 cgatagcagt atcagctaga aggagcagag tggagagttt cagaacaaga tgaaaactct
       61 tctcctgctc gctgccatcg tggcagtaac tgcttgtctc cccgtgccta aggaccagga
      121 acgagaaaaa cgaagtgcca gtgacagtga cagtgatgaa ttccctttac ggattccctt
      181 tcccccatac gggtatccat ttggtacata cccaccattc ttaaatcaag gctacccgtg
      241 gtattattat tattatcctc cttttcccct gcccttcacc ccccctccaa ctgcagatcc
      301 ttaactgcaa atgaaagaaa agtcacactg tggattattt aaggttgctt tgaaattgaa
      361 tatgaaccac ttccttgaag gatcaatatt cctgttaaga gagaaaaata aaagcaattg
      421 aaatagcata
//
