LOCUS       NM_175383               2035 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus beta-1,4-glucuronyltransferase 1 (B4gat1), mRNA.
ACCESSION   NM_175383
VERSION     NM_175383.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2035)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    GeneRIF: A glucuronic acid beta1,4-xylose disaccharide synthesized
            by B4GAT1 acts as an acceptor primer that can be elongated by LARGE
            with the ligand-binding heteropolysaccharide.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2035)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2035)
  AUTHORS   Yagi,H., Nakagawa,N., Saito,T., Kiyonari,H., Abe,T., Toda,T.,
            Wu,S.W., Khoo,K.H., Oka,S. and Kato,K.
  TITLE     AGO61-dependent GlcNAc modification primes the formation of
            functional glycans on alpha-dystroglycan
  JOURNAL   Sci Rep 3, 3288 (2013)
   PUBMED   24256719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2035)
  AUTHORS   Wright,K.M., Lyon,K.A., Leung,H., Leahy,D.J., Ma,L. and Ginty,D.D.
  TITLE     Dystroglycan organizes axon guidance cue localization and axonal
            pathfinding
  JOURNAL   Neuron 76 (5), 931-944 (2012)
   PUBMED   23217742
  REMARK    GeneRIF: This study demonistrated that the axonal guidance defects
            observed in B3gnt1 mutant mice
REFERENCE   5  (bases 1 to 2035)
  AUTHORS   Arata-Kawai,H., Singer,M.S., Bistrup,A., Zante,Av., Wang,Y.Q.,
            Ito,Y., Bao,X., Hemmerich,S., Fukuda,M. and Rosen,S.D.
  TITLE     Functional contributions of N- and O-glycans to L-selectin ligands
            in murine and human lymphoid organs
  JOURNAL   Am J Pathol 178 (1), 423-433 (2011)
   PUBMED   21224079
REFERENCE   6  (bases 1 to 2035)
  AUTHORS   Hirakawa,J., Tsuboi,K., Sato,K., Kobayashi,M., Watanabe,S.,
            Takakura,A., Imai,Y., Ito,Y., Fukuda,M. and Kawashima,H.
  TITLE     Novel anti-carbohydrate antibodies reveal the cooperative function
            of sulfated N- and O-glycans in lymphocyte homing
  JOURNAL   J Biol Chem 285 (52), 40864-40878 (2010)
   PUBMED   20929857
REFERENCE   7  (bases 1 to 2035)
  AUTHORS   Biellmann,F., Henion,T.R., Burki,K. and Hennet,T.
  TITLE     Impaired sexual behavior in male mice deficient for the beta1-3
            N-acetylglucosaminyltransferase-I gene
  JOURNAL   Mol Reprod Dev 75 (5), 699-706 (2008)
   PUBMED   18008318
  REMARK    GeneRIF: Impaired sexual behavior in male mice deficient for the
            beta1-3 N-acetylglucosaminyltransferase-I gene.
REFERENCE   8  (bases 1 to 2035)
  AUTHORS   Mitoma,J., Bao,X., Petryanik,B., Schaerli,P., Gauguet,J.M.,
            Yu,S.Y., Kawashima,H., Saito,H., Ohtsubo,K., Marth,J.D., Khoo,K.H.,
            von Andrian,U.H., Lowe,J.B. and Fukuda,M.
  TITLE     Critical functions of N-glycans in L-selectin-mediated lymphocyte
            homing and recruitment
  JOURNAL   Nat Immunol 8 (4), 409-418 (2007)
   PUBMED   17334369
REFERENCE   9  (bases 1 to 2035)
  AUTHORS   Henion,T.R., Raitcheva,D., Grosholz,R., Biellmann,F., Skarnes,W.C.,
            Hennet,T. and Schwarting,G.A.
  TITLE     Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required
            for axon pathfinding by olfactory sensory neurons
  JOURNAL   J Neurosci 25 (8), 1894-1903 (2005)
   PUBMED   15728829
REFERENCE   10 (bases 1 to 2035)
  AUTHORS   Samant,R.S., Debies,M.T., Shevde,L.A., Verderame,M.F. and
            Welch,D.R.
  TITLE     Identification and characterization of the murine ortholog (brms1)
            of breast-cancer metastasis suppressor 1 (BRMS1)
  JOURNAL   Int J Cancer 97 (1), 15-20 (2002)
   PUBMED   11774238
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158899.1 and AV344651.1.
            
            On Apr 15, 2006 this sequence version replaced NM_175383.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158899.1, AK050347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2031              AK158899.1         2-2032
            2032-2035           AV344651.1         259-262
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19"
     gene            1..2035
                     /gene="B4gat1"
                     /gene_synonym="1500032M01Rik; B3gnt1; B3gnt6; BETA3GNT1;
                     iGAT; iGNT"
                     /note="beta-1,4-glucuronyltransferase 1"
                     /db_xref="GeneID:108902"
                     /db_xref="MGI:MGI:1919680"
     exon            1..1207
                     /gene="B4gat1"
                     /gene_synonym="1500032M01Rik; B3gnt1; B3gnt6; BETA3GNT1;
                     iGAT; iGNT"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1399
                     /gene="B4gat1"
                     /gene_synonym="1500032M01Rik; B3gnt1; B3gnt6; BETA3GNT1;
                     iGAT; iGNT"
                     /EC_number="2.4.1.149"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 6;
                     N-acetyllactosaminide
                     beta-1,3-N-acetylglucosaminyltransferase;
                     poly-N-acetyllactosamine extension enzyme;
                     I-beta-1,3-N-acetylglucosaminyltransferase;
                     UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 1"
                     /codon_start=1
                     /product="beta-1,4-glucuronyltransferase 1"
                     /protein_id="NP_780592.1"
                     /db_xref="CCDS:CCDS29446.1"
                     /db_xref="GeneID:108902"
                     /db_xref="MGI:MGI:1919680"
                     /translation="MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQEQ
                     YFEFFPPSPRSVDQVKSQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHAS
                     VDNLLHLSGLLERWEGPLSVSVFAATKEEAQLATVLAYALSSHCPEMRARVAMHLVCP
                     SRYEAAVPDPREPGEFALLRSCQEVFDKLARVAQPGINYALGTNTSYPNNLLRNLARE
                     EANYALVIDVDMVPSEGLWRGLREMLDQSNHWDGTALVVPAFEIRRSRRMPMNKNELV
                     QLYQVGEVRPFYYGLCTPCHAPTNYSRWVNLPEESLLRPAYVVPWRDPWEPFYVAGGK
                     VPTFDERFRQYGFNRISQACELHVAGFNFEVLNEGFLVHKGFKEALKFHPQKEAENQR
                     NKILYRQFKQELKARYPNSPHRC"
     exon            1208..2035
                     /gene="B4gat1"
                     /gene_synonym="1500032M01Rik; B3gnt1; B3gnt6; BETA3GNT1;
                     iGAT; iGNT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1822..1827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B4gat1"
                     /gene_synonym="1500032M01Rik; B3gnt1; B3gnt6; BETA3GNT1;
                     iGAT; iGNT"
                     /note="hexamer: AATAAA"
     polyA_site      1847
                     /gene="B4gat1"
                     /gene_synonym="1500032M01Rik; B3gnt1; B3gnt6; BETA3GNT1;
                     iGAT; iGNT"
                     /note="major polyA site"
     regulatory      2012..2017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B4gat1"
                     /gene_synonym="1500032M01Rik; B3gnt1; B3gnt6; BETA3GNT1;
                     iGAT; iGNT"
                     /note="hexamer: AATAAA"
     polyA_site      2032
                     /gene="B4gat1"
                     /gene_synonym="1500032M01Rik; B3gnt1; B3gnt6; BETA3GNT1;
                     iGAT; iGNT"
                     /note="major polyA site"
ORIGIN      
        1 gagcggatgg tgggaggagc tgcgcgtagg gctcggctgg cctcggctgg cctcggctgc
       61 gctcgggagg ctgcggtaaa tccgggcttg cggtggctgg cagaggctac ggcccggtgg
      121 tccctgcttc gtgccgggat ccccgagagc catgcaaatg tcctacgcca tccgatgcgc
      181 cttctaccag ctgctgctgg ccgcgctcat gttggtggca atgctgcagc tgctctacct
      241 atcgctgctc tctggactgc acggccagga ggagcaggaa cagtatttcg agttcttccc
      301 gccgtctccg cgatccgtag accaggtaaa gtctcaactc cgcaccgcac tggcctccgg
      361 aggcgttcta gatgccagcg gcgattatcg cgtctacagg ggtctattga agaccaccat
      421 ggaccccaac gatgtcatct tagctacgca tgccagtgtg gacaacctac tacacctgtc
      481 cggacttctg gagcgctggg agggtccgct gtccgtttca gtgttcgcgg ccaccaaaga
      541 ggaggcgcag ctggccacgg tgctggccta cgcgctgagt agccactgcc ccgagatgcg
      601 cgccagggtc gccatgcacc tcgtgtgccc ctcgcgctat gaggctgctg tgcccgaccc
      661 ccgagaacct ggagagtttg ccctgctgcg gtcctgccaa gaggtctttg acaagctagc
      721 cagggtggcc cagcccggga ttaattatgc actagggacc aacacctcct atcccaataa
      781 cctgttaagg aatctggctc gggaagaggc caactacgcc ctggtgattg atgtggacat
      841 ggtgcccagc gaagggctgt ggagaggcct gagggaaatg ttggatcaga gcaatcactg
      901 ggatggcaca gccctggtgg tgcctgcatt tgaaatccgc cggtcccgcc gaatgccgat
      961 gaacaagaac gagctggtgc agctctatca ggtgggcgaa gtccggccct tctattatgg
     1021 gctgtgcacg ccttgccatg cgcccaccaa ctactcccgc tgggtcaacc tgccagagga
     1081 gagcttgctg agacctgcct acgtggtgcc ctggagggac ccctgggaac cattttatgt
     1141 ggctggagga aaggtgccca catttgacga acgctttcgg cagtatggtt tcaatcgaat
     1201 cagccaggct tgtgagctgc acgtggcagg gtttaatttt gaggtgctga acgaaggttt
     1261 tctggttcat aagggattca aggaggcatt gaagttccat ccccaaaagg aggctgaaaa
     1321 ccagcgcaat aagatccttt accgccagtt caaacaggag ttgaaggcta ggtaccccaa
     1381 ctctccccac cgatgctgag tccttgtctt ccatggtctg agaattgtca gtatctggct
     1441 ccaggcctga ctggggtaag aaacatgcct ccactttaca gaggtagcta tgggtttgga
     1501 acactggact tgactatggg gtgctgggag tcaagtctca gctttaccac taactagctg
     1561 tgtggccttg agcaaatact attacttctc tgagcctccg ttacgccgtc tgtaaaaagg
     1621 gaggtgaaaa tacctacctc acagaactgt tggctcagat gagacgctgt atgtgtaaac
     1681 atcctgtaaa cttcgtacaa atgtgaagta ttattaatat tgctacagtg ttattatgat
     1741 attgttacta ttaaccatgt tgggtggata gcggcagagc aaaaagtttg aatgggctag
     1801 aggtgggaag cttgagtgtt taataaaatg aggcttttgg aaagaaagat gaaaacgtag
     1861 aatgtagtgc taagaacgtt tcccgttctc tcatgccttc gccctccgcc ctccgagatc
     1921 cctgaaggag gaaagagata aaggttaaag tcccagatct gtgccctcca gtaggttggg
     1981 ctgctcattt gccttcggat gacattatgt aaataaacga atgtcacacc cacag
//
