LOCUS       NM_146045               2317 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus beta-1,4-galactosyltransferase 7 (B4galt7), transcript
            variant 1, mRNA.
ACCESSION   NM_146045
VERSION     NM_146045.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2317)
  AUTHORS   Sun,X., Mahajan,D., Chen,B., Song,Z. and Lu,L.
  TITLE     A quantitative study of the Golgi retention of glycosyltransferases
  JOURNAL   J Cell Sci 134 (20) (2021)
   PUBMED   34533190
REFERENCE   2  (bases 1 to 2317)
  AUTHORS   Ma,H., Kim,A.S., Kafai,N.M., Earnest,J.T., Shah,A.P., Case,J.B.,
            Basore,K., Gilliland,T.C., Sun,C., Nelson,C.A., Thackray,L.B.,
            Klimstra,W.B., Fremont,D.H. and Diamond,M.S.
  TITLE     LDLRAD3 is a receptor for Venezuelan equine encephalitis virus
  JOURNAL   Nature 588 (7837), 308-314 (2020)
   PUBMED   33208938
REFERENCE   3  (bases 1 to 2317)
  AUTHORS   Rahuel-Clermont,S., Daligault,F., Piet,M.H., Gulberti,S.,
            Netter,P., Branlant,G., Magdalou,J. and Lattard,V.
  TITLE     Biochemical and thermodynamic characterization of mutated
            beta1,4-galactosyltransferase 7 involved in the progeroid form of
            the Ehlers-Danlos syndrome
  JOURNAL   Biochem J 432 (2), 303-311 (2010)
   PUBMED   20809901
REFERENCE   4  (bases 1 to 2317)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (bases 1 to 2317)
  AUTHORS   de la Cruz,L., Steffgen,K., Martin,A., McGee,C. and Hathaway,H.
  TITLE     Apoptosis and involution in the mammary gland are altered in mice
            lacking a novel receptor, beta1,4-Galactosyltransferase I
  JOURNAL   Dev Biol 272 (2), 286-309 (2004)
   PUBMED   15282149
  REMARK    GeneRIF: surface GalT I might negatively regulate mammary
            epithelial cell survival
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC055703.1, AK146855.1 and BF455923.1.
            
            On Jul 24, 2015 this sequence version replaced NM_146045.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146855.1, AK171600.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-970               BC055703.1         1-970
            971-1075            AK146855.1         803-907
            1076-1789           BC055703.1         971-1684
            1790-2043           BC055703.1         1686-1939
            2044-2317           BF455923.1         1-274               c
FEATURES             Location/Qualifiers
     source          1..2317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..2317
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /note="beta-1,4-galactosyltransferase 7"
                     /db_xref="GeneID:218271"
                     /db_xref="MGI:MGI:2384987"
     exon            1..297
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1231
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /EC_number="2.4.1.133"
                     /note="isoform 1 is encoded by transcript variant 1;
                     b4Gal-T7; beta4Gal-T7; beta-1,4-GalTase 7;
                     UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7;
                     xylosylprotein beta1,4-galactosyltransferase, polypeptide
                     7 (galactosyltransferase I);
                     UDP-galactose:beta-N-acetylglucosamine
                     beta-1,4-galactosyltransferase 7; xylosylprotein
                     4-beta-galactosyltransferase; xylosylprotein
                     beta-1,4-galactosyltransferase; UDP-galactose:beta-xylose
                     beta-1,4-galactosyltransferase; proteoglycan
                     UDP-galactose:beta-xylose beta1,4-galactosyltransferase I"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 7 isoform 1"
                     /protein_id="NP_666157.1"
                     /db_xref="CCDS:CCDS26550.1"
                     /db_xref="GeneID:218271"
                     /db_xref="MGI:MGI:2384987"
                     /translation="MLPSRRKAAQLPWEDGRARLLPGGLRRKCSIFHLFIAFLLLVFF
                     SLLWLQLSCSGDMAQVTRGQGQETSGPPRACPPEPPPEHWEEDESWGPHRLAVLVPFR
                     ERFEELLVFVPHMHRFLSRKRIQHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIA
                     MHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYQLCNGMS
                     NRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYQTFRHLHDPAWRKRDQKRIAAQKQ
                     EQFKVDREGGLNTVKYRVDSRTALSIGGAPCTVLNVMLDCDKTATPWCIFG"
     exon            298..660
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /inference="alignment:Splign:2.1.0"
     exon            661..886
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /inference="alignment:Splign:2.1.0"
     exon            887..970
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1075
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..2300
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2277..2282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /note="hexamer: AATAAA"
     polyA_site      2300
                     /gene="B4galt7"
                     /gene_synonym="XGalT-1; XGPT"
                     /note="major polyA site"
ORIGIN      
        1 agggaactcc ctttcttgtg acatccagtg ggcccttgta tgtagtgaga acctagctag
       61 gtcccgccat cggttctcca gacagcagaa ccttataagc tgtggctctg aggtgcagcc
      121 ggcccaaccg gagggacgga ctcggcggac cggggggcgg ggcgggggcg gagacgccgc
      181 gtaggctggg caggccgggc agcggggctt tgagccagag ccccatgtcc tgctgtgtcc
      241 cgccacgatg ttgccctccc ggaggaaagc ggcgcagctg ccctgggagg atggcagggc
      301 caggttgctt cctggaggcc tccgccggaa atgctccatc ttccacctct tcattgcctt
      361 tctcctgttg gtcttcttct ccctgctctg gctgcagctc agctgttctg gagatatggc
      421 ccaggtgacc aggggacaag ggcaagagac ctcgggtcca ccccgggctt gccctccaga
      481 gccgccccct gagcactggg aagaagatga gtcctggggg ccccaccgct tggcagtgct
      541 ggtgcccttt cgtgagcgct ttgaggagct gctggtcttt gtgccccaca tgcaccgctt
      601 cctaagcagg aagaggatcc agcaccacat ctatgtgctc aaccaggtgg accatttcag
      661 gttcaatcgg gcagcactca tcaatgtggg cttcctggag agcagcaaca gcacagacta
      721 catcgccatg cacgatgtgg acctgctccc tctcaatgag gagctggact atggcttccc
      781 ggaggctggg cccttccatg tggcctcccc agagctccac cctctctacc actacaagac
      841 ctatgtgggc ggcattctgc tgctgtccaa acagcactac cagctgtgca acggaatgtc
      901 caaccgcttt tggggctggg gccgagagga tgatgaattc taccggcgca tcaaaggagc
      961 tggcctccag cttttccgcc cctcgggaat cacaactggg taccagacat ttcgccactt
     1021 gcatgaccct gcctggcgga agagggacca aaaacgcatt gcggctcaaa aacaggaaca
     1081 gttcaaggtg gaccgggagg gaggcctgaa cactgtgaag taccgggtgg attcccgcac
     1141 ggcactgtct ataggagggg ccccgtgcac tgtcctcaat gtcatgctgg actgcgataa
     1201 aacagccacc ccatggtgca tatttggctg acagctaaac tgtaaggaag cttccagacc
     1261 tcagtgctgc tcaggctcag gaaacctcag gcctttggcc cagctcagga ggatgcagag
     1321 aggcctgaag gagttgccag cccatcggcg tcttcagcaa cctggccccc agagccaggc
     1381 ccaagacaga acacaggtag accctgggat gctgctgaag gtatggctct tgactgacct
     1441 tctcctcctg gcctcctgcc tgccctgctc tgcctgccct gctgtgtgtg ctgaggcctg
     1501 aggcagtgag aaggtggcca ggacggcctc agcagggaca tactgctccg ctgctcctct
     1561 ggaagaacag actcacaaag atgtagtcag aagtcatgtg accagtgtgt acagccgctg
     1621 ctactaggag gcttaggaca tcagaaggca gaacacaagc ccgggtgaag gagcggctga
     1681 tatagctgta attggtgcca ccacagcaaa accggaggaa ccagggcaca agatctcaat
     1741 tttcaaaaga aactagaatg ctggattctt ttcttttttt ttttttttta aagatttatt
     1801 attatgtatg agtacgctgt agctgtcttc agacacacca gaagagggca tcagatctca
     1861 ttgcagatgg ttgtgagcca ccatgtggtt gctgggattt gaactcggga cccttggaag
     1921 agcagtcagt gctcttaacc gctgagccat ctctccagcc ctgaatgctg gattcttaag
     1981 cagaattttt tcttttgttt ttttaaatgg cagcagttaa ctaaagcttt gaaaatctgt
     2041 ggcaggccaa acaaaatatg tttttttgtt tgtttgtttt ttgagacagg gtttctctga
     2101 tagctctggc tgtcttggaa ctcactttgt agatcaggct ggcctcgaac tcagaaattc
     2161 gcctgcctct gcctcccaag tgctgggatt aaaggcgtgt gccaccacct cctagctcaa
     2221 acaaaatgtt ttatggttca ctggtttgtc acctttggtt gaccaaaggg ggatgaaata
     2281 aaagacgatg ctctcagtta aaaaaaaaaa aaaaaaa
//
