LOCUS       NM_019737               5808 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase,
            polypeptide 6 (B4galt6), mRNA.
ACCESSION   NM_019737 XM_987129
VERSION     NM_019737.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5808)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5808)
  AUTHORS   Yoshihara,T., Satake,H., Nishie,T., Okino,N., Hatta,T., Otani,H.,
            Naruse,C., Suzuki,H., Sugihara,K., Kamimura,E., Tokuda,N.,
            Furukawa,K., Fururkawa,K., Ito,M. and Asano,M.
  TITLE     Lactosylceramide synthases encoded by B4galt5 and 6 genes are
            pivotal for neuronal generation and myelin formation in mice
  JOURNAL   PLoS Genet 14 (8), e1007545 (2018)
   PUBMED   30114188
  REMARK    GeneRIF: Lactosylceramide synthase is encoded by B4galt5 and 6
            genes in the central nervous system, and these genes are
            indispensable for neuronal maturation, perineuronal nets formation,
            and axonal and myelin formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5808)
  AUTHORS   Mayo,L., Trauger,S.A., Blain,M., Nadeau,M., Patel,B., Alvarez,J.I.,
            Mascanfroni,I.D., Yeste,A., Kivisakk,P., Kallas,K., Ellezam,B.,
            Bakshi,R., Prat,A., Antel,J.P., Weiner,H.L. and Quintana,F.J.
  TITLE     Regulation of astrocyte activation by glycolipids drives chronic
            CNS inflammation
  JOURNAL   Nat Med 20 (10), 1147-1156 (2014)
   PUBMED   25216636
  REMARK    GeneRIF: lactosylceramide (LacCer) synthesized by
            beta-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the
            central nervous system during chronic experimental autoimmune
            encephalomyelitis, a model of multiple sclerosis.
REFERENCE   4  (bases 1 to 5808)
  AUTHORS   Tokuda,N., Numata,S., Li,X., Nomura,T., Takizawa,M., Kondo,Y.,
            Yamashita,Y., Hashimoto,N., Kiyono,T., Urano,T., Furukawa,K. and
            Furukawa,K.
  TITLE     beta4GalT6 is involved in the synthesis of lactosylceramide with
            less intensity than beta4GalT5
  JOURNAL   Glycobiology 23 (10), 1175-1183 (2013)
   PUBMED   23882130
REFERENCE   5  (bases 1 to 5808)
  AUTHORS   Nicholson,T.B., Singh,A.K., Su,H., Hevi,S., Wang,J., Bajko,J.,
            Li,M., Valdez,R., Goetschkes,M., Capodieci,P., Loureiro,J.,
            Cheng,X., Li,E., Kinzel,B., Labow,M. and Chen,T.
  TITLE     A hypomorphic lsd1 allele results in heart development defects in
            mice
  JOURNAL   PLoS One 8 (4), e60913 (2013)
   PUBMED   23637775
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5808)
  AUTHORS   Ngamukote,S., Yanagisawa,M., Ariga,T., Ando,S. and Yu,R.K.
  TITLE     Developmental changes of glycosphingolipids and expression of
            glycogenes in mouse brains
  JOURNAL   J Neurochem 103 (6), 2327-2341 (2007)
   PUBMED   17883393
REFERENCE   7  (bases 1 to 5808)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   8  (bases 1 to 5808)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5808)
  AUTHORS   Nomura,T., Takizawa,M., Aoki,J., Arai,H., Inoue,K., Wakisaka,E.,
            Yoshizuka,N., Imokawa,G., Dohmae,N., Takio,K., Hattori,M. and
            Matsuo,N.
  TITLE     Purification, cDNA cloning, and expression of UDP-Gal:
            glucosylceramide beta-1,4-galactosyltransferase from rat brain
  JOURNAL   J Biol Chem 273 (22), 13570-13577 (1998)
   PUBMED   9593693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129078.6 and AF097158.1.
            
            On Feb 6, 2010 this sequence version replaced NM_019737.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF097158.1, AK164724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1052              AC129078.6         100379-101430
            1053-1938           AF097158.1         1051-1936
            1939-5808           AC129078.6         158315-162184
FEATURES             Location/Qualifiers
     source          1..5808
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.48 cM"
     gene            1..5808
                     /gene="B4galt6"
                     /note="UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase,
                     polypeptide 6"
                     /db_xref="GeneID:56386"
                     /db_xref="MGI:MGI:1928380"
     exon            1..1052
                     /gene="B4galt6"
                     /inference="alignment:Splign:2.1.0"
     CDS             938..2086
                     /gene="B4galt6"
                     /EC_number="2.4.1.274"
                     /note="UDP-Gal:glucosylceramide
                     beta-1,4-galactosyltransferase; b4Gal-T6; beta4Gal-T6;
                     beta-1,4-GalTase 6; UDP-Gal:beta-GlcNAc
                     beta-1,4-galactosyltransferase 6;
                     UDP-galactose:beta-N-acetylglucosamine
                     beta-1,4-galactosyltransferase 6; beta-1,
                     4-galactosyltransferase VI; lacCer synthase;
                     lactosylceramide synthase"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 6"
                     /protein_id="NP_062711.1"
                     /db_xref="CCDS:CCDS29086.1"
                     /db_xref="GeneID:56386"
                     /db_xref="MGI:MGI:1928380"
                     /translation="MSALKRMMRVSNRSLIAFIFFFSLSTSCLYFIYVAPGIANTYLF
                     MVQARGIMLRENVKTIGHMIRLYTNKNTTLNGTDYPEGNNTSDYLVQTTTYLPQNFTY
                     LPHLPCPEKLPYMRGFLSVNVSEISFDEVHQLFSKDSEIGPGGHWRPKDCKPRWKVAV
                     LIPFRNRHEHLPIFFLHLIPMLQKQRLEFAFYVIEQTGTQPFNRAMLFNVGFKEAMKD
                     RAWDCVIFHDVDHLPENDRNYYGCGEMPRHFAAKLDKYMYILPYKEFFGGVSGLTVEQ
                     FRKINGFPNAFWGWGGEDDDLWNRVHYAGYNVTRPEGDLGKYISIPHHHRGEVQFLGR
                     YKLLRYSKERQYIDGLNNLLYTPKILVDRLYTNISVNLMPELAPIEDY"
     exon            1053..1169
                     /gene="B4galt6"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1283
                     /gene="B4galt6"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1408
                     /gene="B4galt6"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1525
                     /gene="B4galt6"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1713
                     /gene="B4galt6"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1836
                     /gene="B4galt6"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1938
                     /gene="B4galt6"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..5808
                     /gene="B4galt6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5788..5793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B4galt6"
                     /note="hexamer: AATATA"
     polyA_site      5805
                     /gene="B4galt6"
                     /note="major polyA site"
ORIGIN      
        1 ggcgctccag gggctagggc tcttggttcc tcttctccgg gcgcagcgcc gcctggcgag
       61 ttgtggaccg gcgggcggag ccttgcaggg gtctcggggc gcacagggct gtcgggattg
      121 tcctcgtggg tgtccgcggt ccgagatcgc ctcgcgtctg tcatcttttt ccttcgccct
      181 ccgggccccg gccgtgcgca tccgccgggt agtccggggt ctgtgcgggg gcggcgccgc
      241 ctctccctcg ggctccgcgg cgggaatgcg gctgctgtgg ccggctgggc agcgggcggc
      301 ggcagcaagc ggaacccggg cgcactcgcc gctggccggg acgccgccct ggcctgcgct
      361 ccgctcccga ggccgccgtt gcgctccggg gcccggcgcg gaatgaggtg caggccgcgc
      421 gacggcgagc gccccgctcc gcggccccca ggttccccgc gaccgtccgt gcctcgcgtg
      481 ccccggtgcc cactttagag cccccgcact agcagcgttc gccaaggcac aggcccgcag
      541 agcgcacgcg acccggaccg ggtcccgatc gcggggactc gcctcttgga cgccgccccg
      601 agtgcgggga ccccggcacg ctgcagcgcg cgggccgcac tccgcatcgc cgagctccgc
      661 cagcctggcc cgtggctttg gcctccaccg agcccggtct cccggcctcc cttcacgttt
      721 ctccgcatcc ttccaacacc cttcccgctg ctccaccgcc tcccattcat tgcatccgtt
      781 tctccttccc ggctcggttc ttctccccac agcctccccg gccggacccc gccaccttct
      841 tggggttctc cgtacattca tggaagttta gggcctggac cgtggcccgg agtctggcct
      901 gagagcgcag cccgcgctac tggcagggca gaggaagatg tctgcgctca agcggatgat
      961 gcgggtctcc aatcgctctc tgattgcctt catcttcttc ttctccctct ccacgtcctg
     1021 tctctacttc atctatgtgg ctccaggcat cgccaacacg tacctcttta tggtacaagc
     1081 tagaggtatc atgctgagag agaatgtgaa aacaattgga cacatgatca ggctgtatac
     1141 caataaaaac actacgctca acggaacaga ttatcctgaa ggcaataata caagtgacta
     1201 tcttgttcaa acaacaacgt atcttccgca aaacttcacg tatttgccac acctcccctg
     1261 tccagagaag ctgccttaca tgcggggatt cctcagtgtc aatgtgagtg agatcagttt
     1321 tgatgaagtc catcagctct tctccaagga ctcagagatt gggccaggag gccactggag
     1381 gcccaaagac tgcaagccca gatggaaggt ggcagttctc atccccttcc gtaaccgcca
     1441 tgaacatctt ccgatttttt tcctgcacct gattccgatg ctccagaaac agcggctgga
     1501 atttgccttt tatgtcatcg aacagaccgg cacacaacca ttcaatcgtg cgatgctctt
     1561 taatgtgggt ttcaaagagg ccatgaaaga cagagcctgg gactgtgtga tcttccatga
     1621 tgtggatcat ctgcctgaaa atgatcggaa ctactacgga tgtggagaga tgccgcggca
     1681 ctttgcagcg aagctggaca agtacatgta cattcttccc tataaggagt tttttggtgg
     1741 ggtgagtggc ctgacggtgg agcaattcag gaagatcaac ggctttccca atgccttctg
     1801 gggatgggga ggcgaggacg atgacctttg gaacagagtt cactacgccg gctacaatgt
     1861 aacccggcca gaaggggact tgggaaaata catatctatt cctcatcacc atcgagggga
     1921 ggtacagttc ctaggacggt ataaattact tcggtattcc aaggagcggc agtacatcga
     1981 tggactgaac aatttattat acacacccaa aatactggtt gataggctgt atacaaatat
     2041 atctgtaaac ctcatgccag aattagctcc aattgaagac tattaaaaga agtcattctc
     2101 atggtggggt agaccacagt gctggatcat gaacttggct tggagtgccc tcaccgtgga
     2161 agttagagat tggggtgtat ctcagtgtcc cggtctgtaa aaagagccag caatccttaa
     2221 tgtttacagc gcgggctcca tccgtcacac tctcccactc tccccctgct gggagcgtcc
     2281 ccccatggca agcactgtag agataagaac ccattgcttg ggactggaag tgaagaaaac
     2341 tccctacaca gagaagattt ttatactgaa atctataatt taattcaaga gaatgctttt
     2401 atttccgttc aaacatattt tgtacatatg tgatgtaaat taaatgtgtt caaattgttg
     2461 gaaaacaaga tgtcacaatt ttgcatgtaa ttggttatgc cttcattgga cttttataga
     2521 cattttttta tttgcatggg gaaaaatgta aatttatgtc gccaaacaaa ggttaagcct
     2581 tgtgtcaaat gaagggactg tcagcgacag acaaagataa tatagtaacc gttctgtact
     2641 attggtgttc agctttagac cttcagcctc atggcaggag gcacggtcct ctgagggctt
     2701 cgaaggaagg aaggactcgc ataacttttc ttcctgccac gattacctgt tttgttttgt
     2761 ctattttttc ccttgcttgc agtctcatca gatcttgcca agtcaacagc catattgttt
     2821 atgcatactg catgagtatt accaagaaaa ccttcccagt tgtaaagtga cgtgctgtac
     2881 aggacttctt catgttaaat gtctctatgt acctccgcgt gtcagggatc ttgtgcctca
     2941 aaaaaacgtt cccaaggttg tgtttataca cggttgtgtt tatacacggt atatatattt
     3001 ttttcaatct cataatgaaa acattattat tcccacctta gaagaaccaa aagagggtat
     3061 cttcttttaa aaactttttt tttttgaaag aatgacttta tggaaaatcc agtagtgctt
     3121 atacagatga attatactat tagatgagag attagatgct ctatttttat gaagataaat
     3181 gcttagatta aaacaaactt caactttaat tctcagacat acatggttcc ctttcacatt
     3241 agctcgtcac tcctactgct tttttcactt ttaagaaatc tctggtgtta tccaattttt
     3301 ttttcactac aagtataatt taatgcctac caccaccacc accaccccac caccaccacc
     3361 atggtgctgg gcagtgagcc gagggcctat agacttacct tacagtcatt aattgactgt
     3421 gtggatattg tgacttctgc tcaccctcca cacacgggtg aggttttcaa tgaccagaca
     3481 acaacaaagc ccaaatagtg ttcttacttt gaaaatgatt gattataaaa attcttgaaa
     3541 aatagcctat attcacatgt aagatcttat ctcccatctt taaacaaatt tagaacaaca
     3601 tcgtctgtca agtaaaccct aagagtgaga attctggatg tgagaaagtt tgctcccctt
     3661 gtctaatgtt gagagcttag ctttcagttg tcattgtctg tcatagtttt ggtaatgctg
     3721 atgaccacaa gtcaaaccct acagtgataa ctaaaattct tgcaccggag aagacagatg
     3781 ccctgttgtg acagcaatct ctccgtgttt attcttagaa ttgcttctaa aatatttacc
     3841 tcccaacctt tttagctact caaaaaagag tgaaaaaaaa atctcaactt ctggagatga
     3901 agatttttgt atgttctcag tttatgttct gtctcctgtg gctaatgaag tgtttaattt
     3961 gaccgaatga cagcagaatg taatgttaat gttaaggcgg gtgagacagg gctctttggc
     4021 ccctccttac agtgctgtgg gaagctgtgc catgtggaat tttattggag gacacacact
     4081 tcataatgtg gcgggctgtc cacagtgggg tgccttttgc attgatactt agttcacagt
     4141 tttaggaaaa ttcagaactg gtcatctgcc ttactttctt aggttaagtc tagtattaat
     4201 atggcttccg gaattggatg taagtaattt tgctatatct tcgtgttgca tctggaatgt
     4261 cagcttgtga gaaccacctt ttctaattca gacctggaat tcttttcagt aatgaatagt
     4321 gacctgggta tgtttccatg gatgacagtt ttgcctagtt accatgacca cgtgacaata
     4381 aatctctttc ttacatatta gcacaagcag gcagtctgat agaatcaaat ctatttggtg
     4441 gctttgcact gggtgtctgt ctcccatccg ctgactggct aactgtggta tttaaaggca
     4501 ggttttgttt ttttgttttg ttttttccta aacaacttaa atcaagaaag ttgaaactta
     4561 tctgaaatta gaaagaacac cctctgggaa cttatctgtt agatgtctta gtctcaaatc
     4621 tagtgtggtc ccagctgctg ggaggtcctt gtgacattgg ggaaatgata tggtgccttt
     4681 gaactaaaga aatcgtggct gatggggaga aagttcctac attcattgat ttcccacatt
     4741 ctatctgatt ttcaataaag ttgtcattta attatttgcc aaaactaggg ttttaatgag
     4801 gtggcttcca cagccccctt tttatattta ttttcagttg taggcccttg agatggctca
     4861 gggtgtaaag gtgcctgcac caagcctgac aacctgcatt tgatccctgg gacccacact
     4921 gtagaagtag agacctcccc ttacacagta ttctcagact tccatatgtg taagcacaca
     4981 catgtacaca cacacacagc aaattaaaaa gtaaaagtta aatttctgtt tgtgtcttat
     5041 agaaaggtgt tcactaagaa aatattcatg aaatttaagt acaaaattat ctattaaaaa
     5101 ttcctatcgg ttagtcgtgg tggcacacac ctttaatccc agcactcggg aggcagaggc
     5161 aggcggatct ctgagttcga ggccagcctg gtctacagag ttagttccag gacagccaag
     5221 gctacacaga gaaaccctgt ctcaaaaacc aaaaaaaaaa aaaaaaaaaa aaaaaagaaa
     5281 aaaaaagaaa actaaaattc ctatcccagc tctccagatg cagaggcagg ttctctgagt
     5341 tcaaggccag cctggtctac agaatgaatt ccaagacagt tggggctaca cagagaaacc
     5401 ctgtttaaaa aacacaccaa aaactcctat tccaattgat actgataacc cttgtaaaag
     5461 gaaatggaag cattatcaat acaatattgt ccctttggag atccctgggg gaagcagatt
     5521 tgtgtcattg tatctgtcct gtttctttat gtacctttca gataaataac actctagatt
     5581 tcttgccttg ggtttgcaga tttgttattt gagaagcaaa atgtctcagt gttttttgga
     5641 aggtggaagt gtacttaaga ttatttatta agatatggaa gtaagtgcat tgacgtaaat
     5701 gctagtgatt tcttgctgtc tttttttttt gtcttgtttt gcttctcatg gacatgtttg
     5761 tacttttttt atcattgtct tttatgaaat ataatgttct aaagattt
//
