LOCUS       NM_019835               4205 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase,
            polypeptide 5 (B4galt5), mRNA.
ACCESSION   NM_019835
VERSION     NM_019835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4205)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4205)
  AUTHORS   Zhang,X., Cui,S., Ding,Y., Li,Y., Wu,B., Gao,J., Li,M., Xu,L. and
            Xia,H.
  TITLE     Downregulation of B4GALT5 attenuates cardiac fibrosis through
            Lumican and Akt/GSK-3beta/beta-catenin pathway
  JOURNAL   Eur J Pharmacol 963, 176263 (2024)
   PUBMED   38081351
  REMARK    GeneRIF: Downregulation of B4GALT5 attenuates cardiac fibrosis
            through Lumican and Akt/GSK-3beta/beta-catenin pathway.
REFERENCE   3  (bases 1 to 4205)
  AUTHORS   Ma,F., Zhan,Y., Bartolome-Cabrero,R., Ying,W., Asano,M., Huang,Z.,
            Xiao,C. and Gonzalez-Martin,A.
  TITLE     Analysis of a miR-148a Targetome in B Cell Central Tolerance
  JOURNAL   Front Immunol 13, 861655 (2022)
   PUBMED   35634349
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4205)
  AUTHORS   Ishii,T., Miyauchi,K., Nitta,Y., Kaneko,K., Maruyama,T. and Sato,T.
  TITLE     Mechanism for Decreased Gene Expression of
            beta4-Galactosyltransferase 5 upon Differentiation of 3T3-L1 Mouse
            Preadipocytes to Adipocytes
  JOURNAL   Biol Pharm Bull 41 (9), 1463-1470 (2018)
   PUBMED   29984736
  REMARK    GeneRIF: The expression of Beta4GalT5 gene decreases through
            reduced expression of the Sp1 gene and protein upon differentiation
            of pre-adipocytes to adipocytes.
REFERENCE   5  (bases 1 to 4205)
  AUTHORS   Yoshihara,T., Satake,H., Nishie,T., Okino,N., Hatta,T., Otani,H.,
            Naruse,C., Suzuki,H., Sugihara,K., Kamimura,E., Tokuda,N.,
            Furukawa,K., Fururkawa,K., Ito,M. and Asano,M.
  TITLE     Lactosylceramide synthases encoded by B4galt5 and 6 genes are
            pivotal for neuronal generation and myelin formation in mice
  JOURNAL   PLoS Genet 14 (8), e1007545 (2018)
   PUBMED   30114188
  REMARK    GeneRIF: Lactosylceramide synthase is encoded by B4galt5 and 6
            genes in the central nervous system, and these genes are
            indispensable for neuronal maturation, perineuronal nets formation,
            and axonal and myelin formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4205)
  AUTHORS   Kumagai,T., Tanaka,M., Yokoyama,M., Sato,T., Shinkai,T. and
            Furukawa,K.
  TITLE     Early lethality of beta-1,4-galactosyltransferase V-mutant mice by
            growth retardation
  JOURNAL   Biochem Biophys Res Commun 379 (2), 456-459 (2009)
   PUBMED   19114028
  REMARK    GeneRIF: The results indicate that the growth is delayed by one to
            one and half day in B4galt5-/- embryos when compared to B4galt5+/-
            embryos, which results in early death of the embryos by E10.5,
            probably due to hematopoietic and/or placental defects.
REFERENCE   7  (bases 1 to 4205)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 4205)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4205)
  AUTHORS   Nakamura,N., Yamakawa,N., Sato,T., Tojo,H., Tachi,C. and
            Furukawa,K.
  TITLE     Differential gene expression of beta-1,4-galactosyltransferases I,
            II and V during mouse brain development
  JOURNAL   J Neurochem 76 (1), 29-38 (2001)
   PUBMED   11145975
REFERENCE   10 (bases 1 to 4205)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134591.1, BE981379.1, AK151469.1 and AL591854.18.
            
            On Oct 13, 2006 this sequence version replaced NM_019835.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.3545948.1,
                                           SRR10662774.2256103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               CJ134591.1         2-462
            462-701             BE981379.1         332-571
            702-1844            AK151469.1         172-1314
            1845-4205           AL591854.18        175449-177809       c
FEATURES             Location/Qualifiers
     source          1..4205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.22 cM"
     gene            1..4205
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /note="UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase,
                     polypeptide 5"
                     /db_xref="GeneID:56336"
                     /db_xref="MGI:MGI:1927169"
     exon            1..261
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1313
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /EC_number="2.4.1.274"
                     /note="beta-1,4-galactosyltransferase V; b4Gal-T5;
                     beta4Gal-T5; beta-1,4-GalT II; beta-1,4-GalTase 5;
                     UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5;
                     UDP-galactose:beta-N-acetylglucosamine
                     beta-1,4-galactosyltransferase 5; lacCer synthase;
                     lactosylceramide synthase; glucosylceramide
                     beta-1,4-galactosyltransferase"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 5"
                     /protein_id="NP_062809.2"
                     /db_xref="CCDS:CCDS17098.1"
                     /db_xref="GeneID:56336"
                     /db_xref="MGI:MGI:1927169"
                     /translation="MRARRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLF
                     MVQAQGILLRDNVRTIGAQVYEQVVRSAYAKRNSSLNDSDYPLDLNHSEAFPPTTTFL
                     PEDFTYFANHPCPERLPSMKGPIDINMSEIAMDDIHELFSRDPAIKLGGHWKPADCVP
                     RWKVAILIPFRNRHEHLPVLLRHLLPMLQRQRLQFAFYVIEQVGTQPFNRAMLFNVGF
                     QEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVS
                     GLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGE
                     VQFLGRYALLRKSKERQGLDGLNNLNYSANVTYDALYKNITVNLTPELAQVTEY"
     exon            262..396
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            397..510
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            511..635
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            636..752
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            753..940
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1063
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1165
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..4205
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4185..4190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /note="hexamer: AATACA"
     polyA_site      4205
                     /gene="B4galt5"
                     /gene_synonym="9430078I07Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgtggcccg gcccgcggcg gccggcggct gaaagcggcg aggcggcggc gcgcgaagcc
       61 cggaaggcgg cggccgaggc ccaggcggcg gaccggagcg gcgggagcgg ggcccgggtt
      121 ggccctcgag cggccgccgg ctcagcatgc gcgcccgccg ggggctgctg cggctgccgc
      181 gccgctcgct gctcgccgcg ctcttcttct tctcgctgtc gtcctcgctg ctctacttcg
      241 tctatgtggc gcccggcata gtgaacacct acctcttcat ggtgcaggct cagggcatcc
      301 tactgcggga caatgtgagg accatcggtg cccaggtgta cgagcaggtg gtccgcagcg
      361 cctatgccaa gaggaacagc agcctgaatg actcagatta tcctctggac ttgaaccaca
      421 gtgaagcctt tcccccaacc acgacctttc ttcctgaaga tttcacctac tttgccaacc
      481 acccttgccc agagaggctc ccttccatga agggcccgat agatataaac atgagtgaga
      541 tcgcaatgga cgatattcat gagctgttct ccagagaccc ggccattaag ctcggagggc
      601 actggaagcc tgcagactgt gtgcctcggt ggaaggtggc tatcctcatc cccttccgga
      661 accgccatga gcacctcccg gtcctcctga gacacctgct ccccatgctt cagcgccagc
      721 gcctgcagtt cgccttctat gtgatcgagc aagttggcac ccagcccttt aaccgagcca
      781 tgcttttcaa tgttggtttt caagaagcca tgaaggactt ggattgggat tgtctgatct
      841 tccatgacgt cgatcacata cctgagagtg accgaaacta ctatggctgc gggcagatgc
      901 ccaggcactt tgcaaccaag ctggacaagt acatgtacct gctgccctac actgagtttt
      961 ttggtggcgt gagcggcctg actgtagaac agtttcggaa aatcaatggc tttcctaatg
     1021 ccttctgggg ctggggcgga gaagatgacg acttgtggaa cagggtacaa aatgcaggct
     1081 attctgtgag ccggccagaa ggggacacag gaaaatacaa gtccattcct caccaccatc
     1141 gaggagaggt ccagtttctt ggcaggtacg ctctgctgag gaagtcaaag gagcggcaag
     1201 gactggatgg cctcaacaac ctgaactact ctgcgaatgt cacgtacgac gccttgtata
     1261 aaaacataac tgtcaacttg acacccgagc tggctcaggt gactgagtac tgagatgcga
     1321 agagaagccg cactcaccta cccaccgctc ccttggacgg gctgcgaccc gccatcctgg
     1381 gggtcaacac aggaggacag aagagagtgg agcacaggac cataggggtt ccagaaaact
     1441 gtcacagagc acacgcacaa aggccttcgc tgtagggccc aacagggaca ggagacttga
     1501 ggacacctgt catcagcact ggtgtctatt ccacaagaca gatgtctgcc ctgccactcc
     1561 cttccgtccg tccctgtccg tccccccccc cccaccgccc ccaggtcctg tctcagctgc
     1621 aacccataga actgcagggc caggctaggt gccccttgga tagatgggtg gccaagcccc
     1681 ctggcctgaa ggcccgtctc tgcatctcta cagttctctt tggttttcat ttttcatttg
     1741 gcttagttta ggggtttttg tttgtttggg tttttttgtt ttgttttgtt ttgttttgtt
     1801 ttggttttgg tttgtttgtg gggttttggg gttgtttttt tttttggtgg tttttttttt
     1861 tttttttttt aaagaaaaat tttctgcttt gggtggggac tgaggacaga ggggagggac
     1921 ttggtgtgat agacatataa cagtcacttc ttgaagaagt gcagttgtaa ataagccatg
     1981 taaaatgcct ttttaaagtt taattttata gctggctcca catcaaagtg agggcctcat
     2041 atgttagatc accttgggtg gcaaacaccc cagttcccac gcagttgagt gtcatcaccc
     2101 aagtccctgt catctaggaa ggaagtggat gcagggtgga acaaagaacc tccggtcact
     2161 gtagcccctc ttctctgctc tgcccctcct ttcctgtccc ctcctttagc cccttccccc
     2221 aaggacttcc tcctggagac tcagccccta agctggaact gctgttaggg gcacagtgct
     2281 ctcccctctt acagacccag cggagccagc tgggatgtgc aggggagggg aggcaaaggc
     2341 ccagggcaca ggcttatcac tccagtatgg atggcgggag ctagagacca ggagatatga
     2401 ggccagtgtg agctgtgtca caagttccag gtcagcctgt gctgtgtagc acagtccagc
     2461 tccctacacc tcctcacaca cacagtggct gctgggtgac cgttcccttt tttctttgga
     2521 acttggccac agtttctctg ggctgtgcct gcatgaccag ctggcttcag tgatttctcc
     2581 gtttccctct ttagtttcta ggaagccact gtgctgtgct aagaagcagt tggtcaggag
     2641 ggctcagccc aggagcaggt ggccctgggg tgcatgtcag ccaggggcca gtcagcccag
     2701 cagtctcccc tgctccctga catgagttcc taaagggcac tgaaaagggc acctccttcc
     2761 tgtgtctgcc tccactgcac ccccagtccc taaagcaggg atcgtgtgtg gtgaggaacg
     2821 ctctcttctg gcctcaagct ctttgcctct ttgccttcag cacccttgat gttcatggtt
     2881 tacatgggtg ggggtgggat gtagatatgt gggggtgggg ttttgcatca cacagttggt
     2941 tctgaggaca gatgatcccc acagactgtg ggagtgattg gccaggcctt gttttttctt
     3001 gtgttttgtt ctttttgtag actagtgtgg taactaggga acagatggca ctgcagagtg
     3061 cttcccgctc atatgagaga gcaggtgtct gcccttgaga gctggtgagc cgcgtcatct
     3121 gtttgcgctg ggcaaggagc tgcaccgctg cgttgacctg ccttgtctta cggtacacac
     3181 agcaataaag cctgggttcc gcccggtctc caccctccct ccgcctccct tggttagttt
     3241 cacagtgctg gcaatgaagc ccgtggccca ccacgctagg cgagtgctct gccactgagt
     3301 cacggcccag ccctctctcc ctcattcttc tgtttccata ccaaaggcca ggagtgcttc
     3361 actgtgctgg agccatggtg tcctttggag ggacaacggt gcacgcggca tgtatcctgg
     3421 ctgaagcgct gcaatcttac actagccaca gggtactgtt ttgagccaaa ggctgatact
     3481 taattgaaga gggaaaatgc agatttgggg acaaaggtct ttttactgct caagtagggt
     3541 cgcttctgtc ctgttgcaat catgtccaag tttgttttta gtgtggactt ttgtgggcac
     3601 tgtctgtcat tggccaccca gtcacgtacc gagtgggcag tgtcacagcc aaagctacca
     3661 ctgagccaca gcgtaggtca ttgcttgaaa aaaatgacag tgacaatgga gtgtgacctt
     3721 ggtgtactgt ggcagcccag atgactgagt gctacagacg agtgaccctt agatgacctc
     3781 ctcaactgcc tgccttgtgt gtgcgcgcaa ggcccctctc tgcacagggg ttcttcgggg
     3841 gagggggtat ttgcaaaacc ttaattttgt taaaatgggg gactctgtca ggggactctg
     3901 tcatcgcttc ccttcctcag aggacagcac agagccgcgg cgtacacact gacgtaccca
     3961 ccaccaacag attgaggcac tgacgcagcc agcttagccc agcattactg tctctgttgt
     4021 gagcttgctc tttgttttaa aaggtgccag gggtacattt ttgcactgaa acctaaagat
     4081 gttttaaaaa cacttttcac agaaatagtc cttgtcatta cattgttcac tcatgtgttt
     4141 gtacattttt gtatgttaat ttatgaatga ttttttcagt aaaaaataca tattcaataa
     4201 ccaaa
//
