LOCUS       NM_019804               2314 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase,
            polypeptide 4 (B4galt4), transcript variant 2, mRNA.
ACCESSION   NM_019804
VERSION     NM_019804.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Wei,H., Naruse,C., Takakura,D., Sugihara,K., Pan,X., Ikeda,A.,
            Kawasaki,N. and Asano,M.
  TITLE     Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth
            of immunogenic tumors in mice
  JOURNAL   Front Immunol 14, 1272537 (2023)
   PUBMED   37901252
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2314)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   3  (bases 1 to 2314)
  AUTHORS   Ngamukote,S., Yanagisawa,M., Ariga,T., Ando,S. and Yu,R.K.
  TITLE     Developmental changes of glycosphingolipids and expression of
            glycogenes in mouse brains
  JOURNAL   J Neurochem 103 (6), 2327-2341 (2007)
   PUBMED   17883393
REFERENCE   4  (bases 1 to 2314)
  AUTHORS   Lo,N.W., Shaper,J.H., Pevsner,J. and Shaper,N.L.
  TITLE     The expanding beta 4-galactosyltransferase gene family: messages
            from the databanks
  JOURNAL   Glycobiology 8 (5), 517-526 (1998)
   PUBMED   9597550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY283636.1, AK050005.1 and CT009576.9.
            
            On Oct 23, 2013 this sequence version replaced NM_019804.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013492.1, AK045602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY283636.1         1-5
            6-1930              AK050005.1         2-1926
            1931-2314           CT009576.9         194483-194866
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.87 cM"
     gene            1..2314
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /note="UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase,
                     polypeptide 4"
                     /db_xref="GeneID:56375"
                     /db_xref="MGI:MGI:1928387"
     exon            1..110
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            111..508
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1290
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /EC_number="2.4.1.90"
                     /EC_number="2.4.1.275"
                     /note="beta-1,4-galactosyltransferase IV; beta-1,4-GalTase
                     4; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4;
                     UDP-galactose:beta-N-acetylglucosamine
                     beta-1,4-galactosyltransferase 4; nal synthase;
                     N-acetyllactosamine synthase; lactotriaosylceramide
                     beta-1,4-galactosyltransferase;
                     beta-N-acetylglucosaminyl-glycolipid
                     beta-1,4-galactosyltransferase"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 4"
                     /protein_id="NP_062778.2"
                     /db_xref="CCDS:CCDS28173.1"
                     /db_xref="GeneID:56375"
                     /db_xref="MGI:MGI:1928387"
                     /translation="MGCNPPYHLSYRLRLLLLFTLCLTVVGWATSNYFVGAIQVIPKA
                     KDFMASFHKVIHLGNEETLGHDGATKKPELANCPSVSPNLRGQSKLVFKPDLTLEEIE
                     AENPKVSRGRYHPEECKALQRVAILIPHRNREKHLIYLLEHLHPFLQRQQLDYGIYII
                     HQTGSKKFNRAKLLNVGYLEALKEENWDCFVFHDVDLVPENDFNLYTCGDQPKHLVVG
                     RNSTGYRLRYSKYFGGVTALSREQFLKVNGFSNNYWGWGGEDDDLRLRVELHKMKISR
                     PKPDVGKYTMIFHTRDKGNEVNMGRMKLLQQMSRVWKTDGLSSCSYRLLSVEHNPLYA
                     NITVDFWTAA"
     exon            509..741
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            742..929
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1052
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1157
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..2314
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2087..2092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /note="hexamer: AGTAAA"
     polyA_site      2109
                     /gene="B4galt4"
                     /gene_synonym="9130402O08Rik; b4Gal-T4; B4galt-IV;
                     beta4Gal-T4; beta4GalT-IV"
                     /note="major polyA site"
ORIGIN      
        1 gggctgcaga gccgcctccc ggcggcgcag gcggtccacg agcgcgatcc ccggggctgc
       61 tcctcaccac ctccccttcc ccgggcggcc tcccggtggc cgcgtccggg tgatctctgg
      121 gctagaactg ctgagcagtg gcaaacatta cctcatgagt tgccatcaga tccccggtca
      181 tactggaaaa gtacaatttg gaacctcctc actccagctg aaacagagat acagattact
      241 cacaaactaa gagacatggg ctgcaaccca ccttatcacc tctcctacag attacgattg
      301 ttgctgctct ttaccctgtg cctgacggtg gttgggtggg ccaccagcaa ctactttgtg
      361 ggtgctattc aagtgatccc caaggcaaag gacttcatgg ctagtttcca caaggtcata
      421 catttgggga atgaagaaac tctgggccat gatggggcca cgaaaaaacc agagcttgct
      481 aactgccctt cggtgtctcc aaacctcaga ggccagagca agctcgtttt taagccggac
      541 ctcacgttgg aggaaataga ggctgaaaac cccaaagtgt ccagaggccg gtatcaccct
      601 gaggaatgta aggctctgca gcgggtggcc atcctcattc cacacaggaa cagagagaag
      661 cacttgatct acctgctgga acacctgcat cccttcctgc agaggcaaca gctggactac
      721 ggcatctata tcatccacca gacgggaagt aaaaagttta accgagccaa gctcctgaac
      781 gtgggctatc tggaagctct caaggaggag aactgggact gcttcgtatt ccacgacgtg
      841 gacctggtgc ctgagaatga cttcaacctc tacacctgcg gtgatcagcc caagcacttg
      901 gtggtgggcc ggaacagcac gggctacagg ttgcgttaca gtaaatattt tgggggtgtc
      961 actgccctca gcagggaaca gtttctcaag gtgaatggat tctctaacaa ctactgggga
     1021 tggggaggag aagacgatga cctcagactc agggttgagc tccataaaat gaaaatatcc
     1081 cggcccaagc ccgacgtggg caaatacacc atgatcttcc acaccagaga caaaggcaac
     1141 gaggtgaaca tgggccgaat gaagctgttg caacagatgt cccgggtctg gaaaacagat
     1201 ggcttatcga gttgttctta cagattactc tctgtggagc acaacccttt atatgccaac
     1261 atcacagtgg atttctggac tgctgcgtga cccggagctt ttgatgacac tcaggactga
     1321 tgatttgact gtaataattt tggcctagag acttccatag tagcacaacg ttaagaactt
     1381 gttccaacta attattaggc tgaaattttt ccattttctc agcagagctc ttggttatgt
     1441 agaatgtaga accatagtaa caagacagct tttcttggtt gttttgaatc atggctgtga
     1501 agtgttgtaa cacacgtact tgaaggacta aagatgagag gatgtgatga agtcaccttg
     1561 cggtctgtat ccttacagga ttcacttcag caatgtacca tgtgatcaaa aagcggagaa
     1621 caaaatcccc aagcatctta gagaaccatc taagacagaa aggtactaag atatgtttct
     1681 gtaactcagt gtatcctata tggccatctg cgaagtggtg gattccagat tcgaagaaag
     1741 ccatagaaga ggggagcaaa gtcaagaatc agatgccaca aacacgaccg taaagagctg
     1801 gctaaggaca gagtgtggag tgaactggca gcggtccccg tgctggctgc tgccaccaat
     1861 cttctgtggt ggatgccgcc tcatcagaaa taccttccag cctgtggcca cccgaccctg
     1921 aatgtaccca gcctcttgag aggctcttgc cagtaataac ccaccagaga acacactgtc
     1981 tattagtttt taaagcattt ttataaaatg attttgtaca tgtagggtat gaatgagcag
     2041 tttataagcc acgtgatgac tgataatgtc tatagagtat ctctgtagta aaatatgaaa
     2101 aaacttccag ttcttggtct tgttttttta ctattaattt agaccaatga tatattcatt
     2161 tcagtacctg taattttaaa cgtcttgaaa acagaagagt ggactagaga gatgcacagc
     2221 agttaagaac aggtagagat gattggatgg atacatacat aaaatacata cccacataca
     2281 taaaataata ataaataaat cttttaaaga aaat
//
