LOCUS       NM_022305               3962 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase,
            polypeptide 1 (B4galt1), transcript variant 1, mRNA.
ACCESSION   NM_022305
VERSION     NM_022305.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3962)
  AUTHORS   Ma,Y., Liu,C., Ren,L., Li,J., Xu,Y., Liang,J. and Wang,P.
  TITLE     beta-1,4-Galactosyltransferase 1 protects against cerebral ischemia
            injury in mice by suppressing ferroptosis via the TAZ/Nrf2/HO-1
            signaling pathway
  JOURNAL   CNS Neurosci Ther 30 (9), e70030 (2024)
   PUBMED   39233353
  REMARK    GeneRIF: beta-1,4-Galactosyltransferase 1 protects against cerebral
            ischemia injury in mice by suppressing ferroptosis via the
            TAZ/Nrf2/HO-1 signaling pathway.
REFERENCE   2  (bases 1 to 3962)
  AUTHORS   Wei,H., Naruse,C., Takakura,D., Sugihara,K., Pan,X., Ikeda,A.,
            Kawasaki,N. and Asano,M.
  TITLE     Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth
            of immunogenic tumors in mice
  JOURNAL   Front Immunol 14, 1272537 (2023)
   PUBMED   37901252
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3962)
  AUTHORS   Wang,H., Wang,W., Wang,J., Zhang,L., Luo,Y. and Tang,X.
  TITLE     MicroRNA-15a/beta1,4-GalT-I axis contributes to cartilage
            degeneration via NF-kappaB signaling in osteoarthritis
  JOURNAL   Clinics (Sao Paulo) 78, 100254 (2023)
   PUBMED   37478628
  REMARK    GeneRIF: MicroRNA-15a/beta1,4-GalT-I axis contributes to cartilage
            degeneration via NF-kappaB signaling in osteoarthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3962)
  AUTHORS   Rodeheffer,C. and Shur,B.D.
  TITLE     Targeted mutations in beta1,4-galactosyltransferase I reveal its
            multiple cellular functions
  JOURNAL   Biochim Biophys Acta 1573 (3), 258-270 (2002)
   PUBMED   12417408
  REMARK    Review article
REFERENCE   5  (bases 1 to 3962)
  AUTHORS   Harduin-Lepers,A., Shaper,N.L., Mahoney,J.A. and Shaper,J.H.
  TITLE     Murine beta 1,4-galactosyltransferase: round spermatid transcripts
            are characterized by an extended 5'-untranslated region
  JOURNAL   Glycobiology 2 (4), 361-368 (1992)
   PUBMED   1384819
REFERENCE   6  (bases 1 to 3962)
  AUTHORS   Shaper,N.L., Wright,W.W. and Shaper,J.H.
  TITLE     Murine beta 1,4-galactosyltransferase: both the amounts and
            structure of the mRNA are regulated during spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 791-795 (1990)
   PUBMED   1689054
REFERENCE   7  (bases 1 to 3962)
  AUTHORS   Hollis,G.F., Douglas,J.G., Shaper,N.L., Shaper,J.H.,
            Stafford-Hollis,J.M., Evans,R.J. and Kirsch,I.R.
  TITLE     Genomic structure of murine beta-1,4-galactosyltransferase
  JOURNAL   Biochem Biophys Res Commun 162 (3), 1069-1075 (1989)
   PUBMED   2504153
REFERENCE   8  (bases 1 to 3962)
  AUTHORS   Shaper,J.H., Hollis,G.F. and Shaper,N.L.
  TITLE     Evidence for two forms of murine beta-1,4-galactosyltransferase
            based on cloning studies
  JOURNAL   Biochimie 70 (11), 1683-1688 (1988)
   PUBMED   3149531
REFERENCE   9  (bases 1 to 3962)
  AUTHORS   Nakazawa,K., Ando,T., Kimura,T. and Narimatsu,H.
  TITLE     Cloning and sequencing of a full-length cDNA of mouse
            N-acetylglucosamine (beta 1-4)galactosyltransferase
  JOURNAL   J Biochem 104 (2), 165-168 (1988)
   PUBMED   3141392
REFERENCE   10 (bases 1 to 3962)
  AUTHORS   Shaper,N.L., Hollis,G.F., Douglas,J.G., Kirsch,I.R. and Shaper,J.H.
  TITLE     Characterization of the full length cDNA for murine
            beta-1,4-galactosyltransferase. Novel features at the 5'-end
            predict two translational start sites at two in-frame AUGs
  JOURNAL   J Biol Chem 263 (21), 10420-10428 (1988)
   PUBMED   3134348
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL833775.7 and AEKQ02033059.1.
            
            On Jul 30, 2020 this sequence version replaced NM_022305.5.
            
            Summary: This gene encodes two distinct enzyme isoforms, a long
            membrane-bound form and a short soluble form. These alternate
            isoforms are thought to be produced through alternative nested
            transcription initiation and different in-frame start codon usage.
            These enzymes catalyze the transfer of galactose to acceptor
            sugars, such as N-acetylglucosamine and glucose. The long form of
            this enzyme is localized to the trans-Golgi membrane and is
            involved in glycoconjugate biosynthesis. The short form functions
            in lactose biosynthesis though formation of a heterodimer with
            alpha-lactalbumin. [provided by RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053006.1, D00314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-594               AL833775.7         165251-165844       c
            595-830             AL833775.7         135299-135534       c
            831-1018            AL833775.7         124545-124732       c
            1019-1141           AL833775.7         121539-121661       c
            1142-1246           AL833775.7         119593-119697       c
            1247-3453           AL833775.7         116971-119177       c
            3454-3654           AEKQ02033059.1     5525-5725           c
            3655-3962           AL833775.7         116462-116769       c
FEATURES             Location/Qualifiers
     source          1..3962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 20.46 cM"
     gene            1..3962
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /note="UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase,
                     polypeptide 1"
                     /db_xref="GeneID:14595"
                     /db_xref="MGI:MGI:95705"
     exon            1..594
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1379
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /EC_number="2.4.1.22"
                     /EC_number="2.4.1.90"
                     /EC_number="2.4.1.38"
                     /EC_number="2.4.1.275"
                     /note="long form; isoform 1 is encoded by transcript
                     variant 1; beta-1,4-galactosyltransferase 1;
                     beta-1,4-GalTase 1; UDP-galactose:beta-N-acetylglucosamine
                     beta-1,4-galactosyltransferase 1; glycoprotein
                     galactosyltransferase beta 1, 4; galactosyltransferase 2
                     beta 1, 4; b1,4-Galactosyltransferase I; nal synthase;
                     lactose synthase A protein; N-acetyllactosamine synthase;
                     beta-N-acetylglucosaminyl-glycolipid
                     beta-1,4-galactosyltransferase;
                     beta-N-acetylglucosaminylglycopeptide
                     beta-1,4-galactosyltransferase; neolactotriaosylceramide
                     beta-1,4-galactosyltransferase"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 1 isoform 1"
                     /protein_id="NP_071641.1"
                     /db_xref="CCDS:CCDS18051.1"
                     /db_xref="GeneID:14595"
                     /db_xref="MGI:MGI:95705"
                     /translation="MRFREQFLGGSAAMPGATLQRACRLLVAVCALHLGVTLVYYLSG
                     RDLSRLPQLVGVSSTLQGGTNGAAASKQPPGEQRPRGARPPPPLGVSPKPRPGLDSSP
                     GAASGPGLKSNLSSLPVPTTTGLLSLPACPEESPLLVGPMLIDFNIAVDLELLAKKNP
                     EIKTGGRYSPKDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQA
                     GDTMFNRAKLLNIGFQEALKDYDYNCFVFSDVDLIPMDDRNAYRCFSQPRHISVAMDK
                     FGFSLPYVQYFGGVSALSKQQFLAINGFPNNYWGWGGEDDDIFNRLVHKGMSISRPNA
                     VVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMRFDGLNSLTYKVLDVQRYPLYTQIT
                     VDIGTPR"
     exon            595..830
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1018
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1141
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1246
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..3962
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3940..3945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /note="hexamer: AATAAA"
     polyA_site      3962
                     /gene="B4galt1"
                     /gene_synonym="4-GalT; 4-GalT1; B-1; b4Gal-T1; beta-1;
                     beta4Gal-T1; GalT; Ggtb; Ggtb2"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgcgg ccaggggtgt cggctttccg ccgcaggcgg ccggtgctgc gctaggtcct
       61 agccccctcc ccccggcccc tccttcgatc gctgtggtcg ggtagcgcct ggcgggcggc
      121 ctgcgggcgg gccgtcctct cagccgtagc ccaccccctc ttaaagccgc ggcgggaaga
      181 tgaggtttcg tgagcagttc ctgggcggca gcgccgcgat gccgggcgcg accctgcagc
      241 gggcctgccg cctgctcgtg gccgtctgcg cgctgcacct cggcgtcacc ctcgtctatt
      301 acctctctgg ccgcgatctg agccgcctgc cccagttggt cggagtctcc tctacactgc
      361 agggcggcac gaacggcgcc gcagccagca agcagccccc aggagagcag cggccgcggg
      421 gtgcgcggcc gccgcctcct ttaggcgtct ccccgaagcc tcgcccgggt ctcgactcca
      481 gccctggtgc agcttctggc cccggcttga agagcaactt gtcttcgttg ccagtgccca
      541 ccaccactgg actgttgtcg ctgccagctt gccctgagga gtccccgctg ctcgttggcc
      601 ccatgctgat tgactttaat attgctgtgg atctggagct tttggcaaag aagaacccag
      661 agataaagac gggcggccgt tactccccca aggactgtgt ctctcctcac aaggtggcca
      721 tcatcatccc attccgtaac cggcaggagc atctcaaata ctggctgtat tatttgcatc
      781 ccatccttca gcgccagcaa ctcgactatg gcatctacgt catcaatcag gctggagaca
      841 ccatgttcaa tcgagctaag ctgctcaata ttggctttca agaggccttg aaggactatg
      901 attacaactg ctttgtgttc agtgatgtgg acctcattcc gatggacgac cgtaatgcct
      961 acaggtgttt ttcgcagcca cggcacattt ctgttgcaat ggacaagttc gggtttagcc
     1021 tgccatatgt tcagtatttt ggaggtgtct ctgctctcag taaacaacag tttcttgcca
     1081 tcaatggatt ccctaataat tattggggtt ggggaggaga agatgacgac atttttaaca
     1141 gattagttca taaaggcatg tctatatcac gtccaaatgc tgtagtaggg aggtgtcgaa
     1201 tgatccggca ttcaagagac aagaaaaatg agcccaatcc tcagaggttt gaccggatcg
     1261 cacatacaaa ggaaacgatg cgcttcgatg gtttgaactc acttacctac aaggtgttgg
     1321 atgtacagag atacccgtta tatacccaaa tcacagtgga catcgggaca ccgagatagc
     1381 atttttagta ccaataagag acctgagaat ggccggagac ctcagatatg tgtctctgcc
     1441 agttgactgg gctggtccct ctcatttgta cagtctgaat gacagttctt cttatcattc
     1501 agacgtccct ccagatgccc agggtgagtg taacatttac ccacaacctg gctcggcact
     1561 ggatgaaatt ctacaaggtg agtggagtgt aaaactggtc agcccttgga gagacttctt
     1621 ggttgtgtca cccccaaaga gtcagaactg tacacagttc aaaacttagt gactgtgggt
     1681 cacattccca ctgttgaaac tgctaaattg tgacctgggg aaggactttg ctttagtcgg
     1741 tgatgttcgt acttggtgac aaattgagac tgctgctgga ttcagattga caagattttc
     1801 ttggattttt tttttatacg aaaatcaaaa tttcaatcag tctcgtgctc tgtcccttta
     1861 catcggtatg cgactattac aatcactgtg tgtgtgtctt ttcttagcaa aggcgtttta
     1921 aaacttgagc ctggaccttg gggtcctgta gtgtgtggat tccaaggcct tgccctcaga
     1981 gcaggggcct gggcactctc actcacgtgg cctgtctcca gatccctgtc tgatttctga
     2041 atgtaaagag gctttttgtt ttgtttttgt ttttgttttt agaagcagtt cgtagtattt
     2101 gaaagaataa atcaagtttt gattatgcta taggttgatt tttgtgttga tccaaatcag
     2161 aatagctatt gagtgtttaa gtcatgactt tatttttctg ggcatgctat ataaacttga
     2221 atttcctatg tatttttatt gtggtatttt aaatgtgggg gaagggattg ggtatttttt
     2281 aggggaaaaa aaataatgta tgctgtagtg gtcaaaggag ctctgattga gctggcaggc
     2341 caggttttgt aaagagcaaa attactttca ggtcccttgt tgagggaaca ggtcagcgtt
     2401 atcctgccag acatctgggt caggaacttg ggagacaaca tctgcttacc tggcagaact
     2461 ccccactcca ctcccccagg tgggctgggt ggaaggaccc tcagccacca agaactgacg
     2521 ccctcatggc cctagactat ggggttgaaa actcatagca gtcaggtttg tttaccatct
     2581 ctccgagcct ccaccacact ccctgaccca cccaacgtct ccagttctta ttgttctcct
     2641 tccttccttc tttcctttcc cttctcacct ctttgcctcc ttccctaaaa ttcgctgtgg
     2701 ccctcggggt cagactgttc attctccagc atgattgtgc cttttaatta gaggtctaga
     2761 aagttcacct gaacccacac ccccttcttc ctgagaattc tggtgcctct aaagcccctc
     2821 cttgccactc agggttttag tgggtgctcc cactgctcag tgtacccatg agctgtcgtc
     2881 attcacagag ccctgtgcca ggccgtgttc tgtgcctgcc tgcggtgatg tagccagaag
     2941 cacgtactca ggtcatcaag ccgagagggc gtcaaagagg aagcctgggc tgggatcctt
     3001 aggctcagct gtctgtctaa tcccagagct aagccctttc tgcttcgggc agcctggact
     3061 ccagccctga gtatagaggc ggtgtggatg gctggccctc atcctacctg tgtctttatt
     3121 gctttgatca ccacagtctc taacttgctg ctttctccag aagccttttt atgtatgggt
     3181 tagaaactct tttttcccta gtcagagcag ccaggctgta caaaatctgt gctctctcgg
     3241 ttccccatgc ctctagaagg ccgttaaaac caagactgga tgcactgaga ggagtctttt
     3301 tttttttttt tttttttttc tgtcccaaga tcctgacttt tccaaagtgc cttaaaagaa
     3361 gggagacaga ctcattgagt gtgttgcttc tttctctcct aaagcaaacc tctgcctttt
     3421 ctctatgctg ttcgtgttgg gttttgttca tgtcagatac gtggttcatt ctcaggacca
     3481 agggaaactg tcttgcctgt cctcctatct cctccctttc agcatccttt ggggaacctc
     3541 cagcccaagg caccgttagg cttgggcatt agcctggccc aagagatgcc actggggact
     3601 agaggacaga aggggacgtt cccttcacct gggaattctc accctggtgt caacatgctg
     3661 tgcctttctc tttctctatt tttgttggtg acctggatag tgtggccttt gggacagatc
     3721 agaggcacag gaaagcaaag gaaatgtgcc accctttagc ctggcagggt ctccctgccc
     3781 actgggctgt tccagacctg tgatactgtg tttgtatgtt gatatcccat gtgtacaaat
     3841 gtgtttacca ttggggctgg gggtgggtgg ctgtctctga ccttggcatt cagaacagac
     3901 atctgtattt ttgcctttga aatgcagtaa tataacgtga ataaatgacc ttatctttgt
     3961 aa
//
