LOCUS       NM_177897               3682 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus beta-1,4-N-acetyl-galactosaminyl transferase 4
            (B4galnt4), mRNA.
ACCESSION   NM_177897 XM_355977
VERSION     NM_177897.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3682)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   2  (bases 1 to 3682)
  AUTHORS   Fiete,D., Beranek,M. and Baenziger,J.U.
  TITLE     Peptide-specific transfer of N-acetylgalactosamine to O-linked
            glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl
            transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4
  JOURNAL   J Biol Chem 287 (34), 29204-29212 (2012)
   PUBMED   22722940
  REMARK    GeneRIF: Peptide-specific transfer of N-acetylgalactosamine to
            O-linked glycans by the glycosyltransferases
            beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and
            beta4GalNAc-T4.
REFERENCE   3  (bases 1 to 3682)
  AUTHORS   Fiete,D., Beranek,M. and Baenziger,J.U.
  TITLE     Molecular basis for protein-specific transfer of
            N-acetylgalactosamine to N-linked glycans by the
            glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3
            (beta4GalNAc-T3) and beta4GalNAc-T4
  JOURNAL   J Biol Chem 287 (34), 29194-29203 (2012)
   PUBMED   22722937
  REMARK    GeneRIF: Molecular basis for protein-specific transfer of
            N-acetylgalactosamine to N-linked glycans by the
            glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3
            (beta4GalNAc-T3) and beta4GalNAc-T4.
REFERENCE   4  (bases 1 to 3682)
  AUTHORS   Gotoh,M., Sato,T., Kiyohara,K., Kameyama,A., Kikuchi,N., Kwon,Y.D.,
            Ishizuka,Y., Iwai,T., Nakanishi,H. and Narimatsu,H.
  TITLE     Molecular cloning and characterization of
            beta1,4-N-acetylgalactosaminyltransferases IV synthesizing
            N,N'-diacetyllactosediamine
  JOURNAL   FEBS Lett 562 (1-3), 134-140 (2004)
   PUBMED   15044014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109272.20.
            
            On Feb 13, 2019 this sequence version replaced NM_177897.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB114827.1, SRR11927937.3511107.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-447               AC109272.20        71811-72257         c
            448-551             AC109272.20        69295-69398         c
            552-647             AC109272.20        68862-68957         c
            648-743             AC109272.20        68680-68775         c
            744-834             AC109272.20        68504-68594         c
            835-935             AC109272.20        68328-68428         c
            936-1003            AC109272.20        68114-68181         c
            1004-1082           AC109272.20        67830-67908         c
            1083-1149           AC109272.20        66237-66303         c
            1150-1284           AC109272.20        65991-66125         c
            1285-1394           AC109272.20        65799-65908         c
            1395-1495           AC109272.20        65615-65715         c
            1496-1596           AC109272.20        65435-65535         c
            1597-2485           AC109272.20        64474-65362         c
            2486-2769           AC109272.20        62541-62824         c
            2770-2923           AC109272.20        62294-62447         c
            2924-2996           AC109272.20        62121-62193         c
            2997-3150           AC109272.20        61874-62027         c
            3151-3277           AC109272.20        61472-61598         c
            3278-3682           AC109272.20        60835-61239         c
FEATURES             Location/Qualifiers
     source          1..3682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.32 cM"
     gene            1..3682
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /note="beta-1,4-N-acetyl-galactosaminyl transferase 4"
                     /db_xref="GeneID:330671"
                     /db_xref="MGI:MGI:2652891"
     exon            1..447
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..3401
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /EC_number="2.4.1.244"
                     /note="beta
                     1,4-N-acetylgalactosaminyltransferase-transferase 4;
                     beta4GalNAc-T4; beta-1,4-N-acetylgalactosaminyltransferase
                     IV; beta1,4-N-acetylgalactosaminyltransferase IV"
                     /codon_start=1
                     /product="N-acetyl-beta-glucosaminyl-glycoprotein
                     4-beta-N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_808565.2"
                     /db_xref="CCDS:CCDS21998.1"
                     /db_xref="GeneID:330671"
                     /db_xref="MGI:MGI:2652891"
                     /translation="MPWFPVKKVRKQMKLLLLLLLLTCAAWLTYVHRSLVRPGRALRQ
                     RLGYGRDGEKLTGVTDSRGVRVPSSTQRSEDSSESHEEEQAPEGRGPNMLFPGGPRKP
                     PPLNLTHQTPPWREEFKGQVNLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVTKLAVS
                     PKWKNYGLRIFGFIHPARDGDIQFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEW
                     TAPGEFTKFSSQVSKPRRLMASRRYYFELLHKQDDKGSDHVEVGWRAFLPGLKFEIID
                     SAHISLYTDESSLKMDHVAHVPQSPASHIGGFPPQGEPSADMLHPDPRDTFFLTPRME
                     PLSLENVLEPCAYAPTYILKDFPIARYQGLQFVYLSFIYPNDHTRLTHMETDNKCFYR
                     ESPLYLERFGFYKYMKMDKEEGEEDEEEEVQRRAFLFLNPDDFLDEEDEQDLLDSLEP
                     TDASVQQSHRTPTPAASTGTTASPTPPTTSPLDEQTLRHSRALNWAPRPLPLFLGRAP
                     PPRTVEKSPSKVYVTRVRPGQRASPRALRDSPWPPFPGVFLRPKPLPRVQLRVPPHPP
                     RTQGYRTSGPKVTELKPPVRAQTSQGGREGQLHGQGLMVPTVDLNSSVETQPVTSFLS
                     LSQVSRPQLPGEGEEGEEDGAPGDEATSEDSEEEEEPAAGRPLGRWREDAINWQRTFS
                     VGAMDFELLRSDWNDLRCNVSGNLQLPEAEAVDVVAQYMERLNAKHGGRFSLLRIVNV
                     EKRRDSARGSRFLLELELQERGGSRQRLSEYVFLRLPGARVGDEDGESPEPPPAASIH
                     PDSRPELCRPLHLAWRQDVMVHFIVPVKNQARWVVQFLADMTALHVHTGDSYFNIILV
                     DFESEDMDVERALRAAQLPRYQYLKRTGNFERSAGLQTGVDAVEDPSSIVFLCDLHIH
                     FPPNILDSIRKHCVEGKLAFAPVVMRLGCGSSPWDPHGYWEVNGFGLFGIYKSDFDRV
                     GGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRHFYHHYHSKRGMWATRSRKGAR
                     AQRS"
     exon            448..551
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..647
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..743
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..834
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..935
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1003
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1082
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1149
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1284
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1394
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1495
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1596
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..2485
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2769
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2923
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..2996
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3150
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3277
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3682
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /note="hexamer: AATGAA"
     polyA_site      3682
                     /gene="B4galnt4"
                     /gene_synonym="beta4GalNAcT4; Gm1095; NGalNAc-T1"
                     /note="major polyA site"
ORIGIN      
        1 cccgtttcac gctgggtagc accgcagcgt ggatgctgct cggtcccgcg gcgtccagag
       61 gagcgtgagc agccgggagg ggcgggcggg ggagcgcctc aaggagccgc tcccgccgcc
      121 caccccgacc gcggcctgag cagcccggga gtagtggccg aatcccgtag tccccgcagc
      181 ggacaaagga ccatgcggtg ctgcaggcgc taagcgcagc agggtgggcc gggggatgtg
      241 gggcggggca ggcggggccg gggggccgca gcgacgcccc tgattgtggc gccgcgatgc
      301 cgtggttccc ggtgaagaag gtccgcaagc agatgaagct gctgctgctg ttgctgctgc
      361 tcacctgcgc cgcgtggctc acgtatgtgc accggagcct ggtgcgcccg ggccgcgcgc
      421 tacgccagcg gctgggctac gggcgagatg gggagaagct gaccggtgtg accgatagcc
      481 gcggagtccg agtgccatcg tccacacaga ggtcggagga ctcgagtgaa agtcatgaag
      541 aggagcaggc gcccgagggg cggggcccaa acatgctgtt tcctggagga cctaggaagc
      601 cacccccact gaacctcacc caccagacac ccccatggcg ggaagagttc aaaggacagg
      661 tgaacctgca cgtgtttgag gactggtgtg gaggtgctgt gggccacctg agacggaatc
      721 tgcacttccc actctttcct cacactcgta ctacggtgac aaagttagct gtgtccccta
      781 agtggaagaa ctatggactc cggatttttg gcttcatcca cccagccaga gatggagaca
      841 tccagttctc tgtggcttcg gatgacaact ctgagttctg gctgagtttg gatgagagcc
      901 cagcagccgc ccagcttgta gcctttgtgg gcaagactgg ctccgagtgg accgcacctg
      961 gagaattcac caagttcagc tcccaggtgt ctaagccacg tcggctcatg gcctcccgga
     1021 gatactactt tgaactgctc cacaagcaag atgacaaggg ttcagaccat gtggaagtgg
     1081 gttggcgagc tttcctgcct ggtctgaagt tcgagatcat tgattctgct cacatttccc
     1141 tgtacacaga tgagtcatct ctgaagatgg accatgtggc ccatgtgcct cagtctccag
     1201 ccagccacat aggaggattc ccgccgcagg gggaacccag cgccgacatg ctgcacccag
     1261 accccaggga taccttcttc ctcactcctc ggatggaacc tttgagcctg gagaatgttc
     1321 tggagccctg tgcctatgcc cccacctata tcctcaagga tttccccata gccagatacc
     1381 aaggactaca gtttgtgtac ctgtccttca tctaccccaa tgaccatacc cgtctcactc
     1441 acatggagac agacaacaag tgcttctacc gtgagtcccc actatacctg gaaaggtttg
     1501 ggttctataa atacatgaaa atggacaagg aggagggaga ggaagatgag gaggaagaag
     1561 ttcagcgtag agccttcctc ttcctcaacc cagatgactt cctggatgag gaggatgagc
     1621 aggatctgtt agacagcctg gagcccaccg atgcatctgt acagcagagc cacaggaccc
     1681 ccaccccagc agcctccact ggaacgacag ccagcccgac cccacctaca actagtcctc
     1741 tggacgagca gaccctcaga cactcccggg cactgaattg ggccccacgc cccctgcccc
     1801 tcttcttggg gcgagctcca cctccccgaa ctgtggagaa gtcgccttca aaggtgtacg
     1861 tgaccagggt ccgacctgga cagcgggctt ccccgagggc attgcgagac tcaccctggc
     1921 cacccttccc tggcgtcttc ctgcgcccca agcctctgcc cagagtacag ctgcgggtac
     1981 ccccacatcc acctcggacc cagggctata ggaccagtgg ccccaaggtc acagaactaa
     2041 agcccccagt cagggcccag accagccagg gaggccggga gggccagtta catggacagg
     2101 gactcatggt gcccacagtg gacttgaact cctcagtgga aacacagcct gtgacttcct
     2161 tcctgagctt gtctcaggta tccaggccac agctgccagg agagggtgaa gaaggggagg
     2221 aggatggggc cccaggtgat gaggccacat cagaagacag tgaggaagag gaggagccgg
     2281 ccgctgggcg gcccctgggt cgctggcggg aggatgccat caactggcag cgcacgttca
     2341 gcgtgggcgc catggacttc gagctcctgc gctctgactg gaacgacctg cgctgtaacg
     2401 tatccgggaa cctgcaactt cctgaggccg aagcggtgga tgtagtggct cagtacatgg
     2461 agcggctaaa tgcaaagcat ggcgggcgct tctcgcttct acgcatcgtg aacgtggaga
     2521 agcgccgcga ctctgcacgc gggagccgct tcctcctgga actggaattg caagagcgcg
     2581 gagggagccg ccagcgccta tccgaatacg tcttcctgcg gttgcccgga gcccgcgttg
     2641 gggacgaaga tggagaaagt cccgagccgc ctccagccgc ctcgatccac ccagacagtc
     2701 gcccagagct ctgccggcct ttgcatctgg cctggcgtca ggatgtcatg gttcatttca
     2761 ttgtaccagt gaagaatcag gcgcgctggg tagtgcagtt cctggcagat atgaccgcgc
     2821 tgcatgtgca tacgggggac tcgtacttca acatcatctt ggtggacttt gagagcgagg
     2881 acatggatgt ggagcgggcc ctgcgtgcgg ctcagctacc tcggtaccag tacttgaaac
     2941 gaactggaaa cttcgagcgc tctgcaggcc tgcaaactgg agtggatgcc gtggaggacc
     3001 ccagcagcat cgttttcctc tgtgacctgc acatccactt cccacctaat atcctggaca
     3061 gcatccgcaa gcattgcgtg gagggcaagc tggccttcgc ccctgtggtc atgcgtctgg
     3121 gctgtggaag ctcaccgtgg gacccacatg gttactggga agtgaatgga tttggcctct
     3181 ttgggatcta caaatcagac tttgacagag taggaggcat gaacactgag gagttccgtg
     3241 accagtgggg aggcgaggac tgggaacttc ttgacagggt cctgcaggca gggctggagg
     3301 tggagaggct tcgactgcga cacttctacc accactatca ctcgaagcga ggcatgtggg
     3361 ccacacgcag ccgcaaaggt gcccgcgcac agcgatcctg aagacctagc tgccctctgg
     3421 gccaccgggt cttggtgcag caggtagaag ctgcgtcctg agcttgattc aggctctgcc
     3481 accacctgtg ctggtcccta aaagcctcct ctgggactgc agataggtgg cgctcgtggc
     3541 agggcaggca ccttggtccc cacaccccct gatgatttct gtgaaatttt ccgtagcgac
     3601 gacattgttt tcagaattta caagagttct gtctgttctg ttttttattc agaatgaaat
     3661 gaaatatttt ttttagttct ga
//
