LOCUS       NM_008080               2492 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus beta-1,4-N-acetyl-galactosaminyl transferase 1
            (B4galnt1), transcript variant 1, mRNA.
ACCESSION   NM_008080
VERSION     NM_008080.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2492)
  AUTHORS   Furukawa,K., Takamiya,K., Ohmi,Y., Bhuiyan,R.H., Tajima,O. and
            Furukawa,K.
  TITLE     Disordered testosterone transport in mice lacking the ganglioside
            GM2/GD2 synthase gene
  JOURNAL   FEBS Open Bio 13 (9), 1615-1624 (2023)
   PUBMED   36999634
  REMARK    GeneRIF: Disordered testosterone transport in mice lacking the
            ganglioside GM2/GD2 synthase gene.
            Review article
REFERENCE   2  (bases 1 to 2492)
  AUTHORS   Arends,M., Weber,M., Papan,C., Damm,M., Surma,M.A., Spiegel,C.,
            Djannatian,M., Li,S., Connell,L., Johannes,L., Schifferer,M.,
            Klose,C. and Simons,M.
  TITLE     Ganglioside lipidomics of CNS myelination using direct infusion
            shotgun mass spectrometry
  JOURNAL   iScience 25 (11), 105323 (2022)
   PUBMED   36310581
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2492)
  AUTHORS   Sasaki,E., Hamamura,K., Mishima,Y., Furukawa,K., Nagao,M., Kato,H.,
            Hamajima,K., Sato,T., Miyazawa,K., Goto,S. and Togari,A.
  TITLE     Attenuation of Bone Formation through a Decrease in Osteoblasts in
            Mutant Mice Lacking the GM2/GD2 Synthase Gene
  JOURNAL   Int J Mol Sci 23 (16), 9044 (2022)
   PUBMED   36012308
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2492)
  AUTHORS   Suzuki,M., Nagane,M., Kato,K., Yamauchi,A., Shimizu,T.,
            Yamashita,H., Aihara,N., Kamiie,J., Kawashima,N., Naito,S. and
            Yamashita,T.
  TITLE     Endothelial ganglioside GM3 regulates angiogenesis in solid tumors
  JOURNAL   Biochem Biophys Res Commun 569, 10-16 (2021)
   PUBMED   34216992
REFERENCE   5  (bases 1 to 2492)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2492)
  AUTHORS   Sango,K., Johnson,O.N., Kozak,C.A. and Proia,R.L.
  TITLE     beta-1,4-N-Acetylgalactosaminyltransferase involved in ganglioside
            synthesis: cDNA sequence, expression, and chromosome mapping of the
            mouse gene
  JOURNAL   Genomics 27 (2), 362-365 (1995)
   PUBMED   7558008
REFERENCE   7  (bases 1 to 2492)
  AUTHORS   Sokoloff,D. and Hechtman,P.
  TITLE     Genetic control of ganglioside biosynthesis in mice
  JOURNAL   Biochem Genet 26 (9-10), 631-644 (1988)
   PUBMED   3149468
REFERENCE   8  (bases 1 to 2492)
  AUTHORS   Hashimoto,Y., Abe,M., Kiuchi,Y., Suzuki,A. and Yamakawa,T.
  TITLE     Genetically regulated expression of UDP-N-acetylgalactosamine:
            GM3(NeuGc) N-acetylgalactosaminyltransferase [EC 2.4.1.92] activity
            in mouse liver
  JOURNAL   J Biochem 95 (6), 1543-1549 (1984)
   PUBMED   6432773
REFERENCE   9  (bases 1 to 2492)
  AUTHORS   Suzuki,A., Hashimoto,Y., Abe,M., Kiuchi,Y. and Yamakawa,T.
  TITLE     Genetic regulation of GM2 (NeuGc) expression in liver of mouse
  JOURNAL   Adv Exp Med Biol 174, 263-272 (1984)
   PUBMED   6430047
REFERENCE   10 (bases 1 to 2492)
  AUTHORS   Hashimoto,Y., Otsuka,H., Sudo,K., Suzuki,K., Suzuki,A. and
            Yamakawa,T.
  TITLE     Genetic regulation of GM2 expression in liver of mouse
  JOURNAL   J Biochem 93 (3), 895-901 (1983)
   PUBMED   6874670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144852.3, AK144484.1 and BE996315.1.
            
            [WARNING] On Mar 13, 2024 this sequence was replaced by
            NM_008080.6.
            
            On Sep 21, 2011 this sequence version replaced NM_008080.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144484.1, BC057199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC144852.3         142846-142880       c
            36-2463             AK144484.1         2-2429
            2464-2492           BE996315.1         1-29                c
FEATURES             Location/Qualifiers
     source          1..2492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..2492
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /note="beta-1,4-N-acetyl-galactosaminyl transferase 1"
                     /db_xref="GeneID:14421"
                     /db_xref="MGI:MGI:1342057"
     exon            1..364
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..583
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..1967
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /EC_number="2.4.1.92"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-1,4 N-acetylgalactosaminyltransferase 1;
                     (N-acetylneuraminyl)-galactosylglucosylceramide;
                     UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-
                     galactosylglucosylceramide-beta-1,
                     4-N-acetylgalactosaminyltransferase; beta1,4GalNAC-T;
                     GM2/GD2 synthase"
                     /codon_start=1
                     /product="beta-1,4 N-acetylgalactosaminyltransferase 1
                     isoform 1"
                     /protein_id="NP_032106.1"
                     /db_xref="CCDS:CCDS24230.1"
                     /db_xref="GeneID:14421"
                     /db_xref="MGI:MGI:1342057"
                     /translation="MRLDRRALYALVLLLACASLGLLYSSTRNAPSLPNPLALWSPPQ
                     GPPRLDLLDLAPEPRYAHIPVRIKEQVVGLLAQNNCSCESKGGSLPLPFLRQVRAVDL
                     TKAFDAEELRAVSVAREQEYQAFLARSRSLADQLLIAPANSPLQYPLQGVEVQPLRSI
                     LVPGLSLQEASVQEIYQVNLSASLGTWDVAGEVTGVTLTGEGQPDLTLASPVLDKLNR
                     QLQLVTYSSRSYQANTADTVRFSTKGHEVAFTILVRHPPNPRLYPPSSLPQGAEYNIS
                     ALVTIATKTFLRYDRLRTLIASIRRFYPTVTIVIADDSDKPERISDPHVEHYFMPFGK
                     GWFAGRNLAVSQVTTKYVLWVDDDFVFTARTRLEKLVDVLEKTPLDLVGGAVREISGY
                     ATTYRQLLSVEPGAPGLGNCFRQKQGFHHELVGFPSCVVTDGVVNFFLARTDKVRQVG
                     FDPRLNRVAHLEFFLDGLGFLRVGSCSDVVVDHASKVKLPWTAKDPGAETYARYRYPG
                     SLDQSQVAKHRLLFFKHRLQCMTAE"
     exon            584..748
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..855
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..896
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1077
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1176
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1367
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1508
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1749
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2474
                     /gene="B4galnt1"
                     /gene_synonym="4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T;
                     GalNAcT; Ggm-2; Ggm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagccag cccgggagcg gcgctgcgct gcggtgtgag agccgggcgg aggcctgagc
       61 cctcggctgc ctgggagcgc gacgcggtgc cagggcttcc ccgctttgtc gctggggctg
      121 gggcgcggcg gatttacgat ccagttcacc ccggcaggaa acgttcagaa ccacccccgc
      181 gctgcggtct acaaagcccc ggagtccgca ggcgggagga gtcggatccc cgacactgtc
      241 gggctccctc ccgcccagct cccgcatcag gccgtcgccg gcctcatgag gaccccccgg
      301 ccggggcgga gaaccgggca ctgcccggac cgcgatcctg ccgcggcctt agaacgttag
      361 acaggatgcg gctagaccgc cgggccctct atgcgctagt cttgctgctc gcctgcgcct
      421 cgctgggtct cctgtactcc agcacccgaa acgcgccaag tctcccgaac cctctggcat
      481 tgtggtcgcc cccacaaggt cccccgagac tcgatctgct agaccttgcc cctgagcctc
      541 gctacgcaca catcccggtc aggatcaagg agcaagtggt ggggctgctg gctcagaaca
      601 actgcagttg tgaatccaag ggaggaagcc ttcccttgcc ctttctgaga caggttcggg
      661 cggttgacct cactaaagcc tttgacgctg aggagctgag ggctgtttct gtcgccaggg
      721 agcaggaata ccaggccttc cttgcaagga gccggtccct ggctgaccag ctgctgatag
      781 ctcccgccaa ctccccctta cagtaccccc tgcagggtgt ggaggttcag cccctcagga
      841 gcatcctggt gccagggcta agtctgcagg aagcttctgt ccaggagata taccaggtga
      901 acctgagtgc ttctctaggc acctgggacg tggcagggga agtaacagga gtgactctca
      961 cgggagaggg gcaaccggat ctcacccttg ccagcccagt tctggataaa ctcaaccggc
     1021 agctgcaact ggtgacttac agcagccgga gctaccaggc caacacagca gacacagtcc
     1081 ggttctccac caagggacat gaagttgcct tcaccatcct cgtaagacac cctcccaacc
     1141 cccggctgta cccaccatca tccctacccc aaggagccga gtacaacatc agtgctctgg
     1201 ttaccattgc caccaagact tttcttcgtt atgatcgact acggacactc attgccagca
     1261 tccgacgctt ttaccctacg gtcaccatag tcatcgctga cgacagtgac aaaccggagc
     1321 gcattagcga cccacacgtg gagcactact tcatgccctt cggcaagggt tggttcgcag
     1381 gtcggaacct ggcggtgtcc caagtaacca ccaaatacgt gctgtgggtg gacgacgact
     1441 ttgtcttcac ggcgcgcacg cggctggaga agcttgtgga cgtgctcgag aagacgcccc
     1501 tggacctggt agggggcgcg gtgcgggaga tctcgggcta cgctaccacc taccggcagc
     1561 tgctgagtgt ggagccgggc gccccaggcc ttgggaactg cttccggcaa aagcagggct
     1621 tccaccacga gctcgttggc ttcccaagtt gtgtggtcac agacggcgtg gtcaacttct
     1681 tcctggcgcg cacagacaaa gtgcgccaag tgggctttga cccacgcctc aaccgggtgg
     1741 cacatctgga attcttcctg gatggacttg gtttccttcg tgttggctcc tgctctgatg
     1801 ttgttgtgga tcatgcatcg aaggtgaagc tgccgtggac agcaaaagac ccaggagctg
     1861 aaacttatgc ccgttaccgg tacccgggat cactggacca aagtcaagtg gccaaacatc
     1921 gcctactctt cttcaaacac cggctacagt gcatgaccgc cgagtgacgt ctgatttggg
     1981 ccttcacact gtcaggctgg gcctgcctcc ttgttccttc caggattatc caccaccacc
     2041 tccatccctg tgcaccccac tgatgaacac cctggcttcc cgatcctctc caccaatctg
     2101 attcctaaca ggggcttgtc ctggtgacac ccttcctttc tgtgagcgac cagaggcccg
     2161 atggagccat atcctcttcc ccccacagcc agtgccaagt cctcccacaa ccccattcct
     2221 atggggcagg aaatggggag gttcactttc caagtgccaa agagcccaga aggactctaa
     2281 gaccctcaag tggaaacact ctcacctccc gaggtgggca gggaaactcc caatttgcaa
     2341 ccccagggac atgcacccca ccccagctct ggatccagca ccgtgtgtac cggctcccac
     2401 atacccccac agaaagcact gtgactgtag ttctgtgggg ctggtgaaca cacggtgaaa
     2461 gccattttta cttgaaaaaa aaaaaaaaaa aa
//
