LOCUS       NM_177083               2441 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus triggering receptor expressed on myeloid cells-like 6
            (Trem6l), transcript variant 1, mRNA.
ACCESSION   NM_177083
VERSION     NM_177083.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2441)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2441)
  AUTHORS   Kasamatsu,J., Deng,M., Azuma,M., Funami,K., Shime,H., Oshiumi,H.,
            Matsumoto,M., Kasahara,M. and Seya,T.
  TITLE     Double-stranded RNA analog and type I interferon regulate
            expression of Trem paired receptors in murine myeloid cells
  JOURNAL   BMC Immunol 17 (1), 9 (2016)
   PUBMED   27141827
  REMARK    GeneRIF: this study shows that that a set of Trem receptors are
            up-regulated in response to viral RNA to regulate myeloid cell
            activation through modulation of DAP12-associated Trem4 and
            ITIM-containing Treml6
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166164.2.
            
            On Mar 23, 2023 this sequence version replaced NM_177083.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133242.1, AK155881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC166164.2         111428-111714       c
            288-599             AC166164.2         110871-111182       c
            600-663             AC166164.2         108699-108762       c
            664-791             AC166164.2         106808-106935       c
            792-850             AC166164.2         105444-105502       c
            851-2441            AC166164.2         102386-103976       c
FEATURES             Location/Qualifiers
     source          1..2441
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..2441
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /note="triggering receptor expressed on myeloid cells-like
                     6"
                     /db_xref="GeneID:320148"
                     /db_xref="MGI:MGI:2443478"
     exon            1..287
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1099
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; triggering receptor expressed on myeloid
                     cells-like 6b"
                     /codon_start=1
                     /product="trem-like transcript 6 protein isoform 1
                     precursor"
                     /protein_id="NP_796057.1"
                     /db_xref="CCDS:CCDS28864.1"
                     /db_xref="GeneID:320148"
                     /db_xref="MGI:MGI:2443478"
                     /translation="MAWEPTYLLSPVLLLLLASGSWTQKPELLRAQEGETVSLTCWYD
                     SLYHSDEKIWCKQIDNLCYLFVSKSAEKPRFLIQQSSRFNFFTVTMTKLKMSDSGIYH
                     CGIAVNTRIIYLRSIHLVVSKASSTTTWRTTTLASTHSPVTNRSFPDSPMWKAIVAGV
                     VVAVLLLLTFVILVILYLRKARRKALNVQNQCHPIYEDFSDQKEETTSFNQQTHSSED
                     TGTICYASLIHLNRVNPQDSIYSNTQPYPKPSPDPLLTVEYASISRNRLGSSKPDYPR
                     GEDQQLRAELPGQ"
     exon            288..599
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /inference="alignment:Splign:2.1.0"
     exon            600..663
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /inference="alignment:Splign:2.1.0"
     exon            664..791
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /inference="alignment:Splign:2.1.0"
     exon            792..850
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /inference="alignment:Splign:2.1.0"
     exon            851..2441
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2424..2429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /note="hexamer: AATAAA"
     polyA_site      2441
                     /gene="Trem6l"
                     /gene_synonym="B430306N03Rik; Treml6"
                     /note="major polyA site"
ORIGIN      
        1 agagtctctg agagctttca tctagttcag agcagggctg tagctggagg atccacagga
       61 ctgcacaggc cttgcccagc ttctctctca tccacagagg tctctgcctt ccttagcagc
      121 tcctgcagaa ctggctgtgg tggctcctga atcctgccca gggttgctct tctctcttca
      181 gagcgcccct cctttcttgc tcaacatcac agctcaggag gactcagtga tggcctggga
      241 gcccacatac ctgctctccc cagtgctgct gctgctcctg gcctcaggct cctggacaca
      301 gaaaccagag ttacttcgag cacaggaggg tgagactgtt tctttgacat gctggtatga
      361 ttcgctctac cactccgatg agaagatctg gtgtaagcaa atagacaact tgtgttacct
      421 cttcgtcagc aaaagtgccg agaagccaag attcctcatc cagcagtctt ctcgcttcaa
      481 cttcttcact gtcaccatga ctaagctcaa gatgagtgac tcgggcatct atcactgtgg
      541 gatcgctgta aataccagga taatttatct cagaagtatt cacctggtgg tgtcaaaagc
      601 ttcatccaca accacctgga ggacaacaac cctggcctct acccacagcc ccgtcactaa
      661 cagaagcttt ccagatagcc cgatgtggaa ggccatcgtt gctggggtgg tcgtggctgt
      721 tctgctactg ctcacattcg tcatccttgt gatcctgtac ctgaggaaag ctcgaagaaa
      781 ggccctgaac gttcagaacc aatgtcaccc tatctatgaa gacttttcag accagaagga
      841 ggagaccact agcttcaatc agcagaccca ctccagtgag gacactggga ccatctgcta
      901 tgcctctctc atccacctaa accgtgtaaa ccctcaggac tccatctaca gcaacaccca
      961 gccctacccg aagccctctc ctgacccact tctgactgtg gaatatgcca gcatctctag
     1021 aaacagactc ggctcttcca agccagatta cccaagaggt gaagaccagc aactgagggc
     1081 tgagctccca gggcagtgag catgtaggta caacgctact gtccctgtgg aggggcaact
     1141 tcctacacag agttaagatg gcctcagatg acagaggaca cactttcttc aaggaaggtg
     1201 actgaaagtg ccatccagaa ggactctgga gccctgttct cacccttctg gaggcctagg
     1261 accaatgctg ctaacacatt ctgtgtggaa gagagatggg tcggcgcctc tgagtgacct
     1321 taacctccct tccttgtgtg accaccactt ccttcccccc tggttcatga aatcgaagcc
     1381 ggttgcacaa gttcctcagg aactttaggc agaactatga cattctgccc aacccccaat
     1441 ccctcccaca ccagcctgac ccttgtttct aaaaccatcc tgctcaggga actctggtga
     1501 ccttgctagg atgaatacta agatgtaggc ggtgatcttc tgaggtattt ccaaccatgt
     1561 caaaagtggg aacttcctta ccatagccag ccacacatct ctgtcagaac acctgggctc
     1621 cccggccttc tagaggacta gcattcactc tgcaaactgt gtctacctgt accacctaag
     1681 accacacgct ccttccaggg tcctagcact gaagatgctg ttcctggacg cggactgctc
     1741 acccctatga ggcagaccct tgggggggat ggggtcccta tgaggcagac ccccggggag
     1801 cagggagatg cagctacaga gaaggaaggg atgctgtgag tgtggccctg ttcctgagca
     1861 ctctgcctca ccctgcctgc ccatgccctc ctcctatgat gcagatttgc ctgggggaga
     1921 caggatgctt accacctcca gcctcacacc caactccatc tcgctcctgg gttattggtc
     1981 tctgctcctg atttcagttg acctgtggtc cttcgtgcct cctaactgca gccgtgctct
     2041 tgggccatgc ttcagtcaac accgtctcct ggaagcctgc tttctattgt acattccttg
     2101 aattgctctt cttggctatg gctcatcctg aaggttgggc ttctcatgag ctgtcaaaac
     2161 ccaaaagggt ttttcagact ggagctcctg gtgctgacta agcagtattc gctgggtcag
     2221 tatcaataga tacttaggac tcccaggacc tacactcaag cttgaggaca agagagattg
     2281 attgtaggat gtagttggga atacttataa tgtgtccctt tgcctctata tggatgaaga
     2341 gcctaaacgc tcctatttac atgcattcct ccattttaca gatggagata tactgaggca
     2401 cggggagact tggtctcaca ggtaataaac ggtaaattgc c
//
