LOCUS       NM_145222               2608 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 7 (B3gnt7), mRNA.
ACCESSION   NM_145222
VERSION     NM_145222.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2608)
  AUTHORS   Wang,T., Sun,H., Zhang,M., Shen,P. and Li,Y.
  TITLE     B3GNT7 regulates mucin O-glycosylation to alleviate colonic
            inflammation
  JOURNAL   BMC Gastroenterol 24 (1), 202 (2024)
   PUBMED   38886669
  REMARK    GeneRIF: B3GNT7 regulates mucin O-glycosylation to alleviate
            colonic inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2608)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2608)
  AUTHORS   Littlechild,S.L., Young,R.D., Caterson,B., Yoshida,H., Yamazaki,M.,
            Sakimura,K., Quantock,A.J. and Akama,T.O.
  TITLE     Keratan Sulfate Phenotype in the
            beta-1,3-N-Acetylglucosaminyltransferase-7-Null Mouse Cornea
  JOURNAL   Invest Ophthalmol Vis Sci 59 (3), 1641-1651 (2018)
   PUBMED   29625490
REFERENCE   4  (bases 1 to 2608)
  AUTHORS   Cunningham,T.J., Colas,A. and Duester,G.
  TITLE     Early molecular events during retinoic acid induced differentiation
            of neuromesodermal progenitors
  JOURNAL   Biol Open 5 (12), 1821-1833 (2016)
   PUBMED   27793834
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2608)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2608)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2608)
  AUTHORS   de Ledesma,A.M., Desai,A.N., Bolivar,V.J., Symula,D.J. and
            Flaherty,L.
  TITLE     Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1:
            Congenic strains and candidate gene identification studies
  JOURNAL   Mamm Genome 17 (2), 111-118 (2006)
   PUBMED   16465591
REFERENCE   8  (bases 1 to 2608)
  AUTHORS   Kataoka,K. and Huh,N.H.
  TITLE     A novel beta1,3-N-acetylglucosaminyltransferase involved in
            invasion of cancer cells as assayed in vitro
  JOURNAL   Biochem Biophys Res Commun 294 (4), 843-848 (2002)
   PUBMED   12061784
  REMARK    GeneRIF: beta3GnT7 may play a role in preventing cells from
            migrating out of the original tissues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB591167.2, AK131975.1, AV456413.1 and BX521960.1.
            
            On Apr 25, 2009 this sequence version replaced NM_145222.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031187.1, AK131975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               BB591167.2         1-209
            210-1190            AK131975.1         1-981
            1191-1484           AV456413.1         189-482
            1485-2583           AK131975.1         1276-2374
            2584-2608           BX521960.1         224-248
FEATURES             Location/Qualifiers
     source          1..2608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.94 cM"
     gene            1..2608
                     /gene="B3gnt7"
                     /gene_synonym="beta-3GnT7; C330001H22Rik"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 7"
                     /db_xref="GeneID:227327"
                     /db_xref="MGI:MGI:2384394"
     exon            1..334
                     /gene="B3gnt7"
                     /gene_synonym="beta-3GnT7; C330001H22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1517
                     /gene="B3gnt7"
                     /gene_synonym="beta-3GnT7; C330001H22Rik"
                     /note="BGnT-7; beta3Gn-T7; beta-1,3-Gn-T7;
                     beta-1,3-N-acetylglucosaminyltransferase 7"
                     /codon_start=1
                     /product="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 7"
                     /protein_id="NP_660257.2"
                     /db_xref="CCDS:CCDS35645.1"
                     /db_xref="GeneID:227327"
                     /db_xref="MGI:MGI:2384394"
                     /translation="MSLWKKTLYKSVCLALALLVAVTVFQRSVTPGQFLQDPLPPTPG
                     PAKTGNLVNPNSFWKSSKDVAAPTPTVPRGPQVWDVITTNCSININLTHQPWFQSLEP
                     HFRQFLAYRHCRYFPMLLNHPEKCAGDVYMLVVVKSVITQHDRREVIRQTWGHEWESA
                     GLGRGAVRTLFLLGTASKQEERTHYQQLLAYEDRLYADILQWDFLDSFFNLTLKEIHF
                     LKWLDIYCPNVPFVFKGDDDVFVNPTNLLEFLSDRQPQENLFVGDVLKHARPIRKKDN
                     KYYIPAVMYGKATYPPYAGGGGFLMSGSLARQLHHACDTLELFPIDDVFLGMCLEVLG
                     VKPTGHEGFKTFGISRVRSSRMNKEPCFYRAMLVVHKLLPAELLAMWDLVHSNLTCSV
                     KFQVL"
     exon            335..2595
                     /gene="B3gnt7"
                     /gene_synonym="beta-3GnT7; C330001H22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2564..2569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gnt7"
                     /gene_synonym="beta-3GnT7; C330001H22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2585
                     /gene="B3gnt7"
                     /gene_synonym="beta-3GnT7; C330001H22Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgaaggccc agcagcgggg aagtcgccgc ctcaggatgt tggcgatctt caaggtctct
       61 gagattctgg ctcttccctt cgcgttcccg tggggcgtgc ctctgaggtg gccagggctg
      121 aacggagttg ctgtccccac agtgagccgg ggcacaaagg gttaacctac ctgggccacc
      181 gcccctgagg cccctcctcc agccgcaggg aaaaaaagaa agtctcagcg ggggtgcggc
      241 tcggcctcgt cccgctgtcc ccagccgcgg cgctcagagc tgtgatccgt gcgccccgct
      301 cagctgccct ggaccgggcc gccatgtctc tgtggaagaa aaccctctac aagagtgtat
      361 gcctggctct ggccctcctt gtggctgtca ccgttttcca gcgcagtgtg acccctggtc
      421 aattccttca ggatccttta ccgcccacgc cggggccagc caaaactgga aatctggtca
      481 accccaacag cttctggaag agttcaaagg atgtagcggc tcccactccc acagttcctc
      541 ggggacccca ggtctgggat gtgatcacca ctaactgctc tatcaacatc aacctgaccc
      601 atcagccctg gttccagagt ctggagccac acttccgaca gtttctagcc tatcggcatt
      661 gccggtattt ccccatgttg ctgaaccacc cagagaagtg tgctggcgat gtctatatgc
      721 tggtggttgt caagtcggtc atcacacagc atgaccgccg agaggtcatt cgtcagacct
      781 ggggccacga atgggagtca gcgggtttgg gcaggggtgc agtgcggact ctcttcctgc
      841 tcggcacggc ctccaagcaa gaggagcgaa cccactatca gcagctgctg gcctacgagg
      901 accgtctcta tgctgacatc ctacagtggg atttccttga cagcttcttc aacctgaccc
      961 tcaaggagat ccacttcctc aagtggctcg acatttactg tcccaacgtc cccttcgttt
     1021 tcaaaggtga tgatgatgtc tttgtcaacc ccaccaacct gctcgagttt ctgtctgacc
     1081 ggcagcccca ggaaaaccta tttgtaggtg atgttctgaa acatgctcgg cccatccgca
     1141 aaaaagataa caaatactac atcccagccg tcatgtatgg taaggccacc tacccgccct
     1201 atgctggtgg agggggtttc ctcatgtctg gcagcttagc tcggcaactc caccatgcct
     1261 gtgacacact ggaactcttc cctattgatg atgtcttcct gggcatgtgc ttggaggtgc
     1321 tgggagtgaa gcccacaggc cacgagggct tcaagacctt tggcatctct cgggtccgaa
     1381 gcagccggat gaacaaggaa ccgtgcttct accgggccat gcttgtggta cacaagttgc
     1441 tccctgccga gctgctggcc atgtgggatc tggtgcatag caatcttacc tgttctgtca
     1501 agttccaggt gctctaatgt tgctgagcca ccagtgcgtt tgtcctcggg ggatacatgg
     1561 cattgtcttt ggtcccctgc aggaggtgaa gggtttgggc cctctgtgcc cctaggtgtg
     1621 gtgaggtaca gagatccaga gagggactcc cagaaattcc cagaaagagg tccaggaata
     1681 gccagaactt ccctgactgg aggtcatccg agaacctgga tctctcctat cttgggcctc
     1741 tagcctgacc tctctagcct ggtaggaggc cctggtggac tctaaaggaa catttgctca
     1801 ggtacctgag ctagacctgg ccccaatggg tctgtggctg cttcttgtcc tcacagggaa
     1861 gcccccttcc tgtgaaatgc ctctggctcc ctgagggtca agcagccttt gtgggagctc
     1921 aggcctgtgc aggtccacag gtgtcccctg gcccacattg ctggacctcc taagatagga
     1981 gctctctctc cataggccct cagcacagcc ccaggcttgc ctggagtcag ctgccgaggc
     2041 atggctcctg gctctgactt ctcttgtcca gaagcctgac tggccgctct gactacctca
     2101 gcactcctct aaacctcagt gtgggctagt gccccacctt atgcccctga cacagagcaa
     2161 aatagcagtg ctcctgcacc ctgcccaccc cacccccacc cccacaaggc acagtgatcc
     2221 ttgagcatag tccaagccaa gtctcacctt tggcacctca ccaatactga ctccctggcc
     2281 agaaactggc cggatgggcc ctagatgtag acattcttct attactgtga aattttattt
     2341 atgaagaatt ggaaggaggc cttgggaggt gtacctcttt cctgtacact ttccttcagc
     2401 agctagcatc tttaccactc accccctgcc tttcaagccc tcccccactg acacccctac
     2461 ttttctgggg cctgcccaga tattttcccc tgtgaaagaa taccacctcc cacctctggc
     2521 tggggtcacc tggaaaagat ggaggcatct tctctatttt ctcaataaaa caactggttg
     2581 ttgaaggtgt ctgaaaaaaa aaaaaaaa
//
