LOCUS       NM_001081167            2367 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 6 (B3gnt6), mRNA.
ACCESSION   NM_001081167 XM_195661
VERSION     NM_001081167.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Coletto,E., Savva,G.M., Latousakis,D., Pontifex,M., Crost,E.H.,
            Vaux,L., Telatin,A., Bergstrom,K., Vauzour,D. and Juge,N.
  TITLE     Role of mucin glycosylation in the gut microbiota-brain axis of
            core 3 O-glycan deficient mice
  JOURNAL   Sci Rep 13 (1), 13982 (2023)
   PUBMED   37634035
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2367)
  AUTHORS   Stahl,M., Tremblay,S., Montero,M., Vogl,W., Xia,L., Jacobson,K.,
            Menendez,A. and Vallance,B.A.
  TITLE     The Muc2 mucin coats murine Paneth cell granules and facilitates
            their content release and dispersion
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 315 (2), G195-G205 (2018)
   PUBMED   29698056
REFERENCE   3  (bases 1 to 2367)
  AUTHORS   Leclaire,C., Lecointe,K., Gunning,P.A., Tribolo,S., Kavanaugh,D.W.,
            Wittmann,A., Latousakis,D., MacKenzie,D.A., Kawasaki,N. and Juge,N.
  TITLE     Molecular basis for intestinal mucin recognition by galectin-3 and
            C-type lectins
  JOURNAL   FASEB J 32 (6), 3301-3320 (2018)
   PUBMED   29401627
REFERENCE   4  (bases 1 to 2367)
  AUTHORS   Gao,N., Bergstrom,K., Fu,J., Xie,B., Chen,W. and Xia,L.
  TITLE     Loss of intestinal O-glycans promotes spontaneous duodenal tumors
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 311 (1), G74-G83 (2016)
   PUBMED   27229122
REFERENCE   5  (bases 1 to 2367)
  AUTHORS   Zarepour,M., Bhullar,K., Montero,M., Ma,C., Huang,T., Velcich,A.,
            Xia,L. and Vallance,B.A.
  TITLE     The mucin Muc2 limits pathogen burdens and epithelial barrier
            dysfunction during Salmonella enterica serovar Typhimurium colitis
  JOURNAL   Infect Immun 81 (10), 3672-3683 (2013)
   PUBMED   23876803
REFERENCE   6  (bases 1 to 2367)
  AUTHORS   Ahmed,I., Roy,B., Chandrakesan,P., Venugopal,A., Xia,L., Jensen,R.,
            Anant,S. and Umar,S.
  TITLE     Evidence of functional cross talk between the Notch and NF-kappaB
            pathways in nonneoplastic hyperproliferating colonic epithelium
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 304 (4), G356-G370 (2013)
   PUBMED   23203159
REFERENCE   7  (bases 1 to 2367)
  AUTHORS   Ahmed,I., Chandrakesan,P., Tawfik,O., Xia,L., Anant,S. and Umar,S.
  TITLE     Critical roles of Notch and Wnt/beta-catenin pathways in the
            regulation of hyperplasia and/or colitis in response to bacterial
            infection
  JOURNAL   Infect Immun 80 (9), 3107-3121 (2012)
   PUBMED   22710872
REFERENCE   8  (bases 1 to 2367)
  AUTHORS   Thomsson,K.A., Holmen-Larsson,J.M., Angstrom,J., Johansson,M.E.,
            Xia,L. and Hansson,G.C.
  TITLE     Detailed O-glycomics of the Muc2 mucin from colon of wild-type,
            core 1- and core 3-transferase-deficient mice highlights
            differences compared with human MUC2
  JOURNAL   Glycobiology 22 (8), 1128-1139 (2012)
   PUBMED   22581805
REFERENCE   9  (bases 1 to 2367)
  AUTHORS   An,G., Wei,B., Xia,B., McDaniel,J.M., Ju,T., Cummings,R.D.,
            Braun,J. and Xia,L.
  TITLE     Increased susceptibility to colitis and colorectal tumors in mice
            lacking core 3-derived O-glycans
  JOURNAL   J Exp Med 204 (6), 1417-1429 (2007)
   PUBMED   17517967
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC119880.11.
            
            On Feb 6, 2007 this sequence version replaced XM_195661.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039789.1, BG867793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC119880.11        84226-84255
            31-2367             AC119880.11        88950-91286
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.63 cM"
     gene            1..2367
                     /gene="B3gnt6"
                     /gene_synonym="Core-3; Core3"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 6"
                     /db_xref="GeneID:272411"
                     /db_xref="MGI:MGI:3039603"
     exon            1..30
                     /gene="B3gnt6"
                     /gene_synonym="Core-3; Core3"
                     /inference="alignment:Splign:2.1.0"
     exon            31..2367
                     /gene="B3gnt6"
                     /gene_synonym="Core-3; Core3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1206
                     /gene="B3gnt6"
                     /gene_synonym="Core-3; Core3"
                     /EC_number="2.4.1.147"
                     /note="BGnT-6; beta3Gn-T6; beta-1,3-Gn-T6; core 3
                     synthase; beta-1,3-N-acetylglucosaminyltransferase 6"
                     /codon_start=1
                     /product="acetylgalactosaminyl-O-glycosyl-glycoprotein
                     beta-1,3-N-acetylglucosaminyltransferase"
                     /protein_id="NP_001074636.1"
                     /db_xref="CCDS:CCDS40027.1"
                     /db_xref="GeneID:272411"
                     /db_xref="MGI:MGI:3039603"
                     /translation="MALPSSRRFKSPTTLAFFLVGVTLVVLNQWFLQEHRQEKAKGPV
                     ATRRSLAAVVQRSPLFQVPPCVANASANLLTGFQLLPARIQDFLRYRHCRRFPQLWDA
                     PPKCAGPRGVFLLLAVKSSPAHYERRELIRRTWGQERSYSGRQVLRLFLVGTSPPEEA
                     AREPQLADLLSLEAREYGDVLQWDFSDTFLNLTLKHLHLLDWTAEHCPGVSFLLSCDD
                     DVFVHTANVLSFLEVQSPEHHLFTGQLMVGSVPVRESGSKYFVPPQIFPGVAYPAYCS
                     GGGFLLSRYTVRNLRSAAHHVPLFPIDDAYMGMCLQQAGLAPSSHQGIRPFGVQLPNV
                     QRLSLDPCMYRELLLVHRFAPYEMLLMWKALHNPALHCSHKQVAGSPTAGEQNPDAH"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gnt6"
                     /gene_synonym="Core-3; Core3"
                     /note="hexamer: AATAAA"
     polyA_site      2361
                     /gene="B3gnt6"
                     /gene_synonym="Core-3; Core3"
                     /note="major polyA site"
ORIGIN      
        1 ggccagattc tcctctctca aacgcacaag atggctttgc ccagcagccg caggttcaag
       61 agtcccacga cactggcttt ctttctagtg ggtgtgactt tagtggtgct gaatcagtgg
      121 ttcctccagg aacacaggca ggagaaagcc aagggtcctg tggccactcg ccggtctttg
      181 gcagctgtgg tacagcgttc gccgctcttc caggtgcccc cctgcgtggc caacgcctcc
      241 gcgaacctcc tgactggctt ccagctgctg cctgctagga tccaagactt cctgcgctac
      301 cgccactgcc gccgctttcc gcaactgtgg gacgcgccgc ccaagtgcgc gggcccccgc
      361 ggcgtcttct tgctgctggc cgtgaagtcg tcgcctgcgc actacgagcg gcgcgagctg
      421 atccggcgca cgtggggcca ggagcgcagc tacagcggcc ggcaggtgct tcgcctcttc
      481 ctggtgggga cctcccctcc cgaggaggcg gctcgcgagc ctcagctggc cgatctgctg
      541 agcctggagg cgcgcgagta cggcgatgtg ctgcagtggg acttcagtga caccttcctc
      601 aacctcacac tcaagcacct gcacctgctg gactggacag cggagcactg cccgggcgtg
      661 agcttcctgc tcagctgcga cgacgacgtc ttcgtgcaca cggccaacgt actgagcttc
      721 ctagaggtgc agtcgcccga gcaccacctc ttcaccgggc agctcatggt tggttctgtg
      781 cctgttcgcg aaagcgggag caagtacttc gtgcccccac agatcttccc gggcgtagcc
      841 taccctgcgt actgcagcgg cggcggcttc cttctgtccc gctacacagt ccgcaacctg
      901 cgcagcgcgg cacaccacgt cccgctcttc cccatcgacg atgcctacat gggcatgtgt
      961 ctgcagcagg ccggcctggc gcccagcagc caccagggca tccggccctt cggcgtgcag
     1021 ctgcccaatg tgcagcgctt atccttggat ccctgcatgt accgcgagct gctgctggtg
     1081 caccgcttcg cgccttatga gatgctgctc atgtggaagg cgctgcacaa cccagcgctg
     1141 cactgtagcc acaaacaggt tgcaggatct cccacggccg gagaacagaa ccccgatgca
     1201 cactgatgtc cccttgagga cggatctgga aacacatgtt cctgacctca acttcagggg
     1261 ttctggttct attgctcaag agtggcttca aacatgtagg tggcgttttt cttgttttaa
     1321 gccgactcca aggcctctgg gctggggcta tctatctgtt catcctcaca cagcagcctt
     1381 tcagggcatc tgtcttctat cttccattct tcgtgggcag caagagaggc atggcggcca
     1441 agatcaatgt cagctttcaa gtgcagcgct gttcagaggt cagtttacat tcagaactaa
     1501 aggggtgtct ggcagcctcg cttctaccat gctccagggc tcttgtgaag tcagtaaaaa
     1561 gcaaaggccc ttaagggcag cagagggaag accttcacag ccatttttct gtagcactgt
     1621 gaagtcccag tagctacagc cttgcctccc cagtgcttta ggaagtgcac gtttgagtgg
     1681 acagtggcca tctgtgagaa cattatatta gtttcctgtt gctgctataa caaatcttca
     1741 ttaactctcg aagcctagga acaagcccgc gtatcctgta gttctccgac aacacaggtc
     1801 tcaccaccgg gttaatgtca agatgctggt aaaactgctt tctttcctag tattctatgg
     1861 gggagaaccc ccccccattc cctagcttct agagggagag gttcttcacc ttcaaaacca
     1921 gaaattgcta catttcccta cagccaaatc tctctctgac tcttcttttt cctccatcct
     1981 caactctcct tccctggagt taaaacctgg gtccacctga cagtccagac ttagcttccc
     2041 gtctgtttgt ggagacagac tcaggtagcc caggctgccc tgaaactttg tagtcaagca
     2101 tcatcctgaa ttccggaacc tcctgccttc acctccccaa gggtggactg tagatttgtc
     2161 tccatgccca gctaatctct tcatgttgta aagccagatc actaggtata ttattgatca
     2221 tcatgtcgtt cacatgtaac ctaatttagt cacaggtttc agagatcagg gtgtggacat
     2281 ctttggagga ccattggttc tgtcttccat gatgccacac ataaatgtgt gagataaacg
     2341 ataataaatg aaggaaatga acacatg
//
