LOCUS       NM_016888               2699 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 2 (B3gnt2), transcript
            variant 1, mRNA.
ACCESSION   NM_016888
VERSION     NM_016888.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Mkhikian,H., Mortales,C.L., Zhou,R.W., Khachikyan,K., Wu,G.,
            Haslam,S.M., Kavarian,P., Dell,A. and Demetriou,M.
  TITLE     Golgi self-correction generates bioequivalent glycans to preserve
            cellular homeostasis
  JOURNAL   Elife 5, e14814 (2016)
   PUBMED   27269286
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 2699)
  AUTHORS   Henion,T.R. and Schwarting,G.A.
  TITLE     N-linked polylactosamine glycan synthesis is regulated by
            co-expression of beta3GnT2 and GCNT2
  JOURNAL   J Cell Physiol 229 (4), 471-478 (2014)
   PUBMED   24105809
  REMARK    GeneRIF: These data clearly suggest that GCNT2 functions in vivo
            together with beta3GnT2 to determine poly-N-acetyllactosamine (PLN)
            levels in olfactory neurons by regulating beta1,6-branches that
            promote PLN extension.
REFERENCE   4  (bases 1 to 2699)
  AUTHORS   Henion,T.R., Madany,P.A., Faden,A.A. and Schwarting,G.A.
  TITLE     beta3GnT2 null mice exhibit defective accessory olfactory bulb
            innervation
  JOURNAL   Mol Cell Neurosci 52, 73-86 (2013)
   PUBMED   23006775
  REMARK    GeneRIF: These results identify a novel function for beta3GnT2
            glycosylation in maintaining expression of layer-specific
            vomeronasal receptors
REFERENCE   5  (bases 1 to 2699)
  AUTHORS   Knott,T.K., Madany,P.A., Faden,A.A., Xu,M., Strotmann,J.,
            Henion,T.R. and Schwarting,G.A.
  TITLE     Olfactory discrimination largely persists in mice with defects in
            odorant receptor expression and axon guidance
  JOURNAL   Neural Dev 7, 17 (2012)
   PUBMED   22559903
  REMARK    GeneRIF: Beta3GnT2(-/-) mice exhibit a relatively small deficit in
            their ability to discriminate divergent odors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2699)
  AUTHORS   Henion,T.R., Raitcheva,D., Grosholz,R., Biellmann,F., Skarnes,W.C.,
            Hennet,T. and Schwarting,G.A.
  TITLE     Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required
            for axon pathfinding by olfactory sensory neurons
  JOURNAL   J Neurosci 25 (8), 1894-1903 (2005)
   PUBMED   15728829
REFERENCE   7  (bases 1 to 2699)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2699)
  AUTHORS   Cole,S.E., Mao,M.S., Johnston,S.H. and Vogt,T.F.
  TITLE     Identification, expression analysis, and mapping of B3galt6, a
            putative galactosyl transferase gene with similarity to Drosophila
            brainiac
  JOURNAL   Mamm Genome 12 (2), 177-179 (2001)
   PUBMED   11210191
REFERENCE   9  (bases 1 to 2699)
  AUTHORS   Egan,S., Cohen,B., Sarkar,M., Ying,Y., Cohen,S., Singh,N., Wang,W.,
            Flock,G., Goh,T. and Schachter,H.
  TITLE     Molecular cloning and expression analysis of a mouse
            UDP-GlcNAc:Gal(beta1-4)Glc(NAc)-R
            beta1,3-N-acetylglucosaminyltransferase homologous to Drosophila
            melanogaster Brainiac and the beta1,3-galactosyltransferase family
  JOURNAL   Glycoconj J 17 (12), 867-875 (2000)
   PUBMED   11511811
REFERENCE   10 (bases 1 to 2699)
  AUTHORS   Zhou,D., Dinter,A., Gutierrez Gallego,R., Kamerling,J.P.,
            Vliegenthart,J.F., Berger,E.G. and Hennet,T.
  TITLE     A beta-1,3-N-acetylglucosaminyltransferase with
            poly-N-acetyllactosamine synthase activity is structurally related
            to beta-1,3-galactosyltransferases
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 406-411 (1999)
   PUBMED   9892646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772364.21.
            
            On Dec 15, 2009 this sequence version replaced NM_016888.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160088.1, AY043479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AL772364.21        93547-93788         c
            243-2699            AL772364.21        68792-71248         c
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.22 cM"
     gene            1..2699
                     /gene="B3gnt2"
                     /gene_synonym="B3Galt6; B3gnt1; Beta3gnt; BGnT-1; BGnT-2;
                     BGnT1; BGnT2"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 2"
                     /db_xref="GeneID:53625"
                     /db_xref="MGI:MGI:1889505"
     exon            1..242
                     /gene="B3gnt2"
                     /gene_synonym="B3Galt6; B3gnt1; Beta3gnt; BGnT-1; BGnT-2;
                     BGnT1; BGnT2"
                     /inference="alignment:Splign:2.1.0"
     exon            243..2699
                     /gene="B3gnt2"
                     /gene_synonym="B3Galt6; B3gnt1; Beta3gnt; BGnT-1; BGnT-2;
                     BGnT1; BGnT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2551..2556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gnt2"
                     /gene_synonym="B3Galt6; B3gnt1; Beta3gnt; BGnT-1; BGnT-2;
                     BGnT1; BGnT2"
                     /note="hexamer: AATAAA"
     polyA_site      2575
                     /gene="B3gnt2"
                     /gene_synonym="B3Galt6; B3gnt1; Beta3gnt; BGnT-1; BGnT-2;
                     BGnT1; BGnT2"
                     /note="major polyA site"
     regulatory      2666..2671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gnt2"
                     /gene_synonym="B3Galt6; B3gnt1; Beta3gnt; BGnT-1; BGnT-2;
                     BGnT1; BGnT2"
                     /note="hexamer: AATAAA"
     polyA_site      2698
                     /gene="B3gnt2"
                     /gene_synonym="B3Galt6; B3gnt1; Beta3gnt; BGnT-1; BGnT-2;
                     BGnT1; BGnT2"
                     /note="major polyA site"
ORIGIN      
        1 ggcagggggc ggcggtgcca ggagccgggg ccgagagtaa ggctcagcgg ccgccgcggc
       61 aacaagtgct ggagctgagg cgagccggag ccgcccagac cccgccgggc cgcccgtccg
      121 cgcattgcgc atggagcgag agcggcggcg gtcgcggggc tgagccgcaa gagcggctgg
      181 gacgtggatg cggccgcggt cttccgcccc gccccgccga gctggaggtg tccctagaca
      241 aggtatgaga gatgagtgtg gggcgtcgaa gagtcaagtt gctgggcatc ctgatgatgg
      301 caaatgtctt catttatttg attgtggaag tctccaaaaa cagtagccaa gacaaaaatg
      361 gaaagggagg agtaataatc ccgaaagaga agttctggaa gccacccagc actccccggg
      421 catactggaa cagggaacag gagaagctga acaggtggta caatcccatc ttgaacaggg
      481 tggccaatca gacaggggag ctagccacat ctccaaacac aagtcacctg agctattgtg
      541 aaccagactc gacggtcatg acagctgtga cagattttaa taatctgccg gacagattta
      601 aagactttct cttgtatttg agatgccgga attactcgct gcttatagat caaccgaaga
      661 aatgtgcaaa gaagcccttc ttactattgg cgataaagtc cctcattcca cattttgcca
      721 gaaggcaagc aattcgggag tcttggggcc gagaaaccaa cgtagggaac cagacagtag
      781 tgagggtctt cctgttgggc aagacacccc cagaggacaa ccaccctgac ctttcggaca
      841 tgcttaagtt tgagagtgac aagcaccagg acatcctcat gtggaactat agagacacat
      901 tcttcaacct gtccctgaag gaagtgctgt ttcttaggtg ggtgagcact tcctgtccag
      961 acgcagagtt tgtcttcaag ggcgatgatg acgtgtttgt gaacacccat cacatcctta
     1021 attacttgaa tagcttatcc aagagcaaag ccaaagactt gttcataggt gacgtgatcc
     1081 acaatgctgg gcctcaccgg gataagaaac tgaagtacta catcccagaa gtcttctaca
     1141 ccggcgtcta cccaccgtat gccgggggtg gtggattcct gtactccggc ccccttgcct
     1201 tgaggctgta cagtgcgact agccgggtcc atctctaccc tattgatgat gtttatacgg
     1261 gaatgtgcct tcagaaactg ggccttgttc cagagaagca caaaggcttc aggacatttg
     1321 atattgaaga gaaaaataag aaaaatattt gttcctatat agacctaatg ttagtacata
     1381 gcagaaaacc tcaagagatg attgatatct ggtctcagtt gcaaagtcct aatttaaaat
     1441 gctgaaatag acatgagctg catttcacag aaaggcctag cctgactagt tcccatggtg
     1501 tgctctcaca ataggtgagt tctgtgtgag gctattagcc ttcatgagca ggtagcccct
     1561 gggctcccaa gccctcagtc cttcccttgc cttgtgaaga gggaaggctg aagacagctc
     1621 agcatggcag ggtgagtggt tatgaccctt cctctggctg ccggtcctca gtttctaatt
     1681 tgttttcttt ctcctccaca attatgtatg tatgtgtgta tatatgtgtg tgtgtacata
     1741 catacatata tatatatgta ggacacaacc tggtggcttt gtgaaatgga attctatgta
     1801 ttttcataag attttgaaag ttgtctagaa agtagactga tgtcaatctc ccgtcaccca
     1861 gcagtattgt ccttgttact agaaaccgtt acttccttta tgcaaggaaa gccacgcagt
     1921 gcgtgtagtt catcttgtca gggcttatgg ccatgaggac agaggggatt ttctttttac
     1981 ttgtgtttgg tttcctgggt ggcatcatgg tagttaacct atttttagta tttgaagatc
     2041 atgagtgtga ttccctaatg gccaactgga gactgagtag cccgacagcc atgggtctgt
     2101 gagtgttcag agactgggaa gcattcgcca cttctgagct ttggacgtga ttagtcagtt
     2161 aaaaccccaa gattctattc ttgccatatt atcacgtatt ccttagataa aattctgggt
     2221 agtgacactt ccctgtctca gtgtagaagt gcctgtgctt ttatttattg ttcagatcaa
     2281 acaccaaaac attttcttaa aaaatatttt gtgtaatatt ttatttgtat acagtgtttg
     2341 tgaaatattt aactagagca tgatatttta ttttttctca tttttaattc tttgagaatt
     2401 tcatacaatg tgttttgatt gtattcacct ccccatctcc tcccagatcc agcatgatgt
     2461 tttaaatgtt aagctgtaac atgttagata aagttaactc ttatttttga attttaaaat
     2521 ttggatgggg gggtatgaac tgctagagaa aataaagttc tgccaaaata ttgcatatac
     2581 tagtatcttg taacatgctt tcttgaaata tttttgtgct ttagagggtt ctcacctgtg
     2641 ctacagggga ctgggaaaaa gtggaaataa agtgattgta ttttttaatc atcacgtat
//
