LOCUS       NM_024256               1599 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus beta-1,3-glucuronyltransferase 3 (B3gat3), mRNA.
ACCESSION   NM_024256
VERSION     NM_024256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Rios,J.J., Denton,K., Russell,J., Kozlitina,J., Ferreira,C.R.,
            Lewanda,A.F., Mayfield,J.E., Moresco,E., Ludwig,S., Tang,M., Li,X.,
            Lyon,S., Khanshour,A., Paria,N., Khalid,A., Li,Y., Xie,X.,
            Feng,J.Q., Xu,Q., Lu,Y., Hammer,R.E., Wise,C.A. and Beutler,B.
  TITLE     Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice
  JOURNAL   J Bone Miner Res 36 (8), 1548-1565 (2021)
   PUBMED   33905568
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Kouno,T., Kizuka,Y., Nakagawa,N., Yoshihara,T., Asano,M. and Oka,S.
  TITLE     Specific enzyme complex of beta-1,4-galactosyltransferase-II and
            glucuronyltransferase-P facilitates biosynthesis of N-linked human
            natural killer-1 (HNK-1) carbohydrate
  JOURNAL   J Biol Chem 286 (36), 31337-31346 (2011)
   PUBMED   21771787
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Baasanjav,S., Al-Gazali,L., Hashiguchi,T., Mizumoto,S., Fischer,B.,
            Horn,D., Seelow,D., Ali,B.R., Aziz,S.A., Langer,R., Saleh,A.A.,
            Becker,C., Nurnberg,G., Cantagrel,V., Gleeson,J.G., Gomez,D.,
            Michel,J.B., Stricker,S., Lindner,T.H., Nurnberg,P., Sugahara,K.,
            Mundlos,S. and Hoffmann,K.
  TITLE     Faulty initiation of proteoglycan synthesis causes cardiac and
            joint defects
  JOURNAL   Am J Hum Genet 89 (1), 15-27 (2011)
   PUBMED   21763480
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Izumikawa,T., Kanagawa,N., Watamoto,Y., Okada,M., Saeki,M.,
            Sakano,M., Sugahara,K., Sugihara,K., Asano,M. and Kitagawa,H.
  TITLE     Impairment of embryonic cell division and glycosaminoglycan
            biosynthesis in glucuronyltransferase-I-deficient mice
  JOURNAL   J Biol Chem 285 (16), 12190-12196 (2010)
   PUBMED   20164174
  REMARK    GeneRIF: mice with a deletion of GlcAT-I showed remarkable
            reduction of the synthesis of chondroitin sulfate and heparan
            sulfate and embryonic lethality before the 8-cell stage because of
            failed cytokinesis
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Izumikawa,T. and Kitagawa,H.
  TITLE     Mice deficient in glucuronyltransferase-I
  JOURNAL   Prog Mol Biol Transl Sci 93, 19-34 (2010)
   PUBMED   20807639
  REMARK    Review article
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 1599)
  AUTHORS   Bengtsson,T., Camper,L., Schneller,M. and Lundgren-Akerlund,E.
  TITLE     Characterization of the mouse integrin subunit alpha10 gene and
            comparison with its human homologue. Genomic structure, chromosomal
            localization and identification of splice variants
  JOURNAL   Matrix Biol 20 (8), 565-576 (2001)
   PUBMED   11731273
REFERENCE   8  (bases 1 to 1599)
  AUTHORS   Kitagawa,H., Tone,Y., Tamura,J., Neumann,K.W., Ogawa,T., Oka,S.,
            Kawasaki,T. and Sugahara,K.
  TITLE     Molecular cloning and expression of glucuronyltransferase I
            involved in the biosynthesis of the glycosaminoglycan-protein
            linkage region of proteoglycans
  JOURNAL   J Biol Chem 273 (12), 6615-6618 (1998)
   PUBMED   9506957
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC004038.1.
            
            On Jun 19, 2003 this sequence version replaced NM_024256.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004038.1, AK144402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.03 cM"
     gene            1..1599
                     /gene="B3gat3"
                     /gene_synonym="2810405M13Rik"
                     /note="beta-1,3-glucuronyltransferase 3"
                     /db_xref="GeneID:72727"
                     /db_xref="MGI:MGI:1919977"
     exon            1..256
                     /gene="B3gat3"
                     /gene_synonym="2810405M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            257..431
                     /gene="B3gat3"
                     /gene_synonym="2810405M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            432..792
                     /gene="B3gat3"
                     /gene_synonym="2810405M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1083
                     /gene="B3gat3"
                     /gene_synonym="2810405M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1584
                     /gene="B3gat3"
                     /gene_synonym="2810405M13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1564..1569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gat3"
                     /gene_synonym="2810405M13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1584
                     /gene="B3gat3"
                     /gene_synonym="2810405M13Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaagtggtcc caggtgtcgc tcagagtccc gcgttcccgg gaactagtaa gggagcctgg
       61 ggaaggcggg gcgcggcccg ggcggccggg gcggggccgg cgggagggcg gagggccggg
      121 cggacctgtc cctgccggtc ccggtggacc ccgcctgccc cggtggcacc ggccatgaag
      181 ctgaagctga agaacgtgtt tcttgcctac ttcctggtgt cgatcgccgg cctcctctac
      241 gctctggtgc agctcggcca gccttgcgac tgcctccctc cgcttcgagc tgcagctgag
      301 cagcttcggc agaaggacct gaggatatcc cagttgcaag ctgatctccg tcgcccaccc
      361 cctgtcccag cccagccccc tgaacctgag gccctgccta ctatctatgt cattaccccc
      421 acctacgcca ggctggtaca aaaggcagag ctggttcggc tgtcccagac cctgagcttg
      481 gtgccccgtc tacactggct gctagtggag gacgctgaga gccctacccc gctggtctcg
      541 gggctgttgg ccgcctctgg tctcctcttt acacacctgg ctgtccttac ccccaaggct
      601 caacggctta gggaaggtga gccaggctgg gtccggcccc gaggagtgga acagcgcaat
      661 aaggccctcg actggctccg aggaaaaggg ggtgctgttg ggggggagaa ggatccaccg
      721 ccaccaggga cccaaggagt cgtgtatttt gctgacgatg acaacaccta cagccgggag
      781 ctctttaagg agatgcgttg gactcgcggt gtctcagtgt ggcctgtggg gctggtgggt
      841 ggcctgcgat ttgaaggtcc tcaggtacag gatggccgcg ttgtgggttt ccacacagca
      901 tgggaaccca acaggccctt tcccttggac atggcgggat ttgcggttgc cctgcccttg
      961 ctattggcta agcccaatgc ccagtttgat gctactgcac cccggggcca cctggaaagt
     1021 agtctcctga gccaccttgt agatcccaag gacctggagc cacgggctgc caattgtact
     1081 caggtactgg tatggcacac ccggacagag aaacctaaga tgaagcagga ggagcagcta
     1141 caacggcagg gccagggctc agacccagcc attgaggtgt gatggcaacc tcaccctgac
     1201 ttctacctta ttttaggcac ataccttgtg ggactgggct ccaggccagc ccaggatgtg
     1261 gttttttttt taaagacctg acccctgaga accagaggca gcccctccaa ccacagggtg
     1321 tgtcccagtt gcttccctcc cttcccccag cctgccatgt ggcactgccc acatgttggg
     1381 gacaagcagc ttctctagtg agccagatca gccccatctg gggcggagca ggacagatgg
     1441 actcagaaag gagggtagct gtgggaaaag ggtaacttat tggggacaag catgcagtgg
     1501 ggggctagag gagctgggct ggaccctccc cacctgagca tgcgatcccc ttcctacctc
     1561 tagaataaag aatctcaacc cggaaaaaaa aaaaaaaaa
//
