LOCUS       NM_172124               4367 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus beta-1,3-glucuronyltransferase 2 (B3gat2), mRNA.
ACCESSION   NM_172124 XM_914839
VERSION     NM_172124.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4367)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4367)
  AUTHORS   Nakamura,A., Morise,J., Yabuno-Nakagawa,K., Hashimoto,Y.,
            Takematsu,H. and Oka,S.
  TITLE     Site-specific HNK-1 epitope on alternatively spliced fibronectin
            type-III repeats in tenascin-C promotes neurite outgrowth of
            hippocampal neurons through contactin-1
  JOURNAL   PLoS One 14 (1), e0210193 (2019)
   PUBMED   30629639
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4367)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4367)
  AUTHORS   Yabuno,K., Morise,J., Kizuka,Y., Hashii,N., Kawasaki,N.,
            Takahashi,S., Miyata,S., Izumikawa,T., Kitagawa,H., Takematsu,H.
            and Oka,S.
  TITLE     A Sulfated Glycosaminoglycan Linkage Region is a Novel Type of
            Human Natural Killer-1 (HNK-1) Epitope Expressed on Aggrecan in
            Perineuronal Nets
  JOURNAL   PLoS One 10 (12), e0144560 (2015)
   PUBMED   26659409
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4367)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 4367)
  AUTHORS   Ngamukote,S., Yanagisawa,M., Ariga,T., Ando,S. and Yu,R.K.
  TITLE     Developmental changes of glycosphingolipids and expression of
            glycogenes in mouse brains
  JOURNAL   J Neurochem 103 (6), 2327-2341 (2007)
   PUBMED   17883393
REFERENCE   7  (bases 1 to 4367)
  AUTHORS   Inoue,M., Kato,K., Matsuhashi,H., Kizuka,Y., Kawasaki,T. and Oka,S.
  TITLE     Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and
            their target substrate, the HNK-1 carbohydrate epitope in the adult
            mouse brain with or without a targeted deletion of the GlcAT-P gene
  JOURNAL   Brain Res 1179, 1-15 (2007)
   PUBMED   17935701
  REMARK    GeneRIF: moderate expression of GlcAT-S were seen in neuronal cells
            of several nuclei of limbic-related regions
REFERENCE   8  (bases 1 to 4367)
  AUTHORS   Imiya,K., Ishizaki,T., Seiki,T., Saito,F., Inazawa,J., Oka,S. and
            Kawasaki,T.
  TITLE     cDNA cloning, genomic structure and chromosomal mapping of the
            mouse glucuronyltransferase-S involved in the biosynthesis of the
            HNK-1 carbohydrate epitope
  JOURNAL   Gene 296 (1-2), 29-36 (2002)
   PUBMED   12383500
REFERENCE   9  (bases 1 to 4367)
  AUTHORS   Yamamoto,S., Oka,S., Saito-Ohara,F., Inazawa,J. and Kawasaki,T.
  TITLE     Molecular cloning and genomic analysis of mouse
            glucuronyltransferase involved in biosynthesis of the HNK-1 epitope
  JOURNAL   J Biochem 131 (3), 337-347 (2002)
   PUBMED   11872162
REFERENCE   10 (bases 1 to 4367)
  AUTHORS   Shimoda,Y., Tajima,Y., Nagase,T., Harii,K., Osumi,N. and Sanai,Y.
  TITLE     Cloning and expression of a novel galactoside beta1,
            3-glucuronyltransferase involved in the biosynthesis of HNK-1
            epitope
  JOURNAL   J Biol Chem 274 (24), 17115-17122 (1999)
   PUBMED   10358066
  REMARK    Erratum:[J Biol Chem 1999 Jul 23;274(30):21490]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052640.1 and BC058082.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_914839.1, NM_172124.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056368.1, AK220433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AK052640.1         1-108
            109-4367            BC058082.1         1-4259
FEATURES             Location/Qualifiers
     source          1..4367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 9.75 cM"
     gene            1..4367
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /note="beta-1,3-glucuronyltransferase 2"
                     /db_xref="GeneID:280645"
                     /db_xref="MGI:MGI:2389490"
     exon            1..1303
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /inference="alignment:Splign:2.1.0"
     CDS             710..1684
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /EC_number="2.4.1.135"
                     /note="galactosylgalactosylxylosylprotein
                     3-beta-glucuronosyltransferase 2;
                     UDP-glucuronosyltransferase-S; glcAT-D;
                     glucuronosyltransferase S"
                     /codon_start=1
                     /product="galactosylgalactosylxylosylprotein
                     3-beta-glucuronosyltransferase 2 precursor"
                     /protein_id="NP_742122.2"
                     /db_xref="CCDS:CCDS14850.1"
                     /db_xref="GeneID:280645"
                     /db_xref="MGI:MGI:2389490"
                     /translation="MKSALCSRFFILLPWILIVIIMLDVDPRRPAPQLTSRPYFSPHA
                     VGCGGSRVPLRRSSPGRDAAEKRNESRPQLQPEPRLPTIYAITPTYSRPVQKAELTRL
                     ANTFRQVAQLHWILVEDRATRSELVSSFLARAGLPNTHLHVPTPRRYKRPWLPRATEQ
                     RNAGLAWLRQRHQHQSAQPGVLFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRY
                     ERPLVKNGKVVGWYTGWREDRPFAIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESD
                     FLKQITTVEELEPKASNCTKVLVWHTRTEKVNLANEPKYHLDTVNIEV"
     exon            1304..1448
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1597
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..4362
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2099..2104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /note="hexamer: AATAAA"
     regulatory      2112..2117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /note="hexamer: AATAAA"
     polyA_site      2119
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /note="major polyA site"
     polyA_site      2133
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /note="hexamer: AATAAA"
     polyA_site      2478
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
                     /note="hexamer: AATAAA"
     polyA_site      2672
                     /gene="B3gat2"
                     /gene_synonym="GlcAT-S; Glcats"
ORIGIN      
        1 ttcccaccgg agcactagga ggacgcccga gtctgcagcg cccccgcccc ctcgcttttt
       61 ctttctttcc ctgctttggg atcttgctgt ctggagccgg gagaggttcc gagaaggaga
      121 gagcggcaca ggtttctgcc gcggcgctcg aacgggagct tagggacgca gcatcctcgg
      181 tgtccacccg ggatcgcagc tgcaccggcc gacatgtgac ggaggaaagc cctcagcatt
      241 cccggcaacc gccttcaaag gggtcccgga acgctcgccc aggccagcag ctggatcctc
      301 ttagccctca gcgacgcggg acaggagcgg caaggtacaa cgcctggtac gttccaggct
      361 cgcactcggg aaaagagcgc agcggggacc gccgcctggc ttgcactcgg cacaactccg
      421 ggacctgcgg agtgcggctg gaccgtgtcc agattcccgc cgacttcatc cagagtgacc
      481 caagacccta gccggtcctc ctgcaccccc tggagttcta gcttgccctg catctgcgcc
      541 gaccccacaa cgcccaggtc cccgcaacgc cccagtccgg aaggggagcg cgcttgcggc
      601 ttctccctga ttgcagacgc tgccgctgtc ctaactgcac acagaggtcc cctacccgga
      661 gcctagtcct tgcagggggt ggtgtccgag acgctgggga gcgcgcacca tgaagtccgc
      721 gctgtgcagc cgcttcttca tcctcctgcc ctggatcctg attgtcatca tcatgttgga
      781 cgtggacccc cgcaggcccg cgccccaact cacttcccgt ccctacttct ctccccatgc
      841 agtgggctgc gggggctccc gagtcccgct ccgacggagt agccccgggc gtgacgctgc
      901 cgagaagcgg aacgagtctc ggcctcagct gcagccggag ccgcgcttgc ccaccatcta
      961 tgccatcaca cccacctaca gtcgcccggt gcagaaagcc gagctcactc gcctggccaa
     1021 caccttccgc caggtggcgc agttgcactg gatcctggtg gaggaccggg cgacgcgcag
     1081 cgagctggtg agcagcttcc tagctcgggc cggcctgccc aacacgcacc tgcatgtgcc
     1141 cacgccgcgg cgctacaagc gaccgtggct gccgcgcgcc accgaacagc gcaacgcggg
     1201 cctcgcctgg ctgcgccaga ggcatcagca tcagagcgcg caacccggcg tgctcttctt
     1261 cgccgacgat gacaacacgt acagtctgga gctcttccag gagatgagga ccactcgcaa
     1321 ggtttctgtc tggcctgtgg gactagttgg tgggcgacgc tatgaacgtc cgttggtaaa
     1381 aaatggcaaa gttgttggct ggtacaccgg atggagagaa gacaggcctt ttgccattga
     1441 catggctggg tttgctgtga gtctgcaagt catcttgtcc aatccgaaag ctgtatttaa
     1501 gcgccgtgga tcccagccag ggatgcaaga atctgacttt ctaaagcaga taacaacagt
     1561 tgaagaactg gaaccaaaag ctagtaactg caccaaggtt ctcgtgtggc acactcggac
     1621 agagaaggtc aatctagcca atgagccaaa gtatcacctg gacacagtga acattgaggt
     1681 gtagccgcca ggaccagcag gtgaggacag gaagtctgga gcgtgggctg ctgcccattc
     1741 aggtactgtt cctttgcctt cagcctttcc ttaccgccga tggacggccg tttcgacagc
     1801 tacctggatg ctacaaaatg tgttgtcttc atttgtctgc atgtgttttc tgaactggaa
     1861 gagttttgta gagtgaagcc acatgtcact gaaaaggaca acgaagtatc tcacactgct
     1921 ccctccctcc ctccctccct ccctccatcc ctccctccca caagccatct caatactgct
     1981 agaatgacag gttttagaag ctgatgagga gtactctgtc aattaaatat tcccagttaa
     2041 attcttggct tcacaacatg aactatttgg aaagctgatg gcagtgtaca ctgtaggaaa
     2101 taaaacccac aaataaaaag gtgtgtggat tcatctgttt aatataggga aataacattt
     2161 tgtcaatact aggcaccata aaatgtaaac acaattactg tcataaacct ggatatacct
     2221 tcaaggatta aaagtggctt tgttttagtt accctgtgtg catatagtgc agaaaaaggt
     2281 cttcatatta gcactatgta catgagaaga ggcccacatt acaagaggca atggaaattt
     2341 gaattctgaa accttcattg agttttacag tagcatccag gtttatctcc gttcactaac
     2401 cacgttccct gttaagcaca tcataacaac agcacagtgg agtgagtgat gaataaaaga
     2461 atttgataca ctagaaaaca gtgctcagtg atacatttac attctattta tatgattaaa
     2521 catttgatca tacagtacct ttctacagga ttactggcta atttgggggt ggggtttata
     2581 ctgttagagg tattactaac atgataacta cttcccttat atgcaaacgt tagagctata
     2641 attttgcaaa taaaactgat tatgcaagtt aactgagcag cttcccaatg tggcttagga
     2701 catcatgggg agtatgagca aagctgccct ccacacagat ggtttctcaa cctgctttca
     2761 catccaattt aatcagcaca gaccaacacg gtcaatcagg tcattcttaa tgtgagcaaa
     2821 tgggggaaag aaaaaatacg ttatgtacat gaataaatgg gaactagatg cctttgcagc
     2881 gaggaatgtt ggggtcggtt ctggatggaa ctctgtgaca gcttcttact tccacagctg
     2941 tgtgctcagc gtctgccccg atgagcttcc agaccaccct gctgtcgtgc tgggaggctg
     3001 gccaaaacct gcactagcgt tagcactact gaggttcatg gcagccatct gctgattcat
     3061 ctgcgaaaca caaaaggctt ggtttacaag gaggaccctc ttttcactcc tgactcctta
     3121 gctacagcca gacacttcat cagatgtgaa aattagtcca gacactggat gtggactaca
     3181 ctgaagtctt tctactgaaa tcagttactt ttttcttact tttttctgag ttaggtgtta
     3241 cttataaagt aatccataat tagttcactt tctagattaa ccacaactga aaacacatca
     3301 aagtaatctt tgagtttata tctgagacca tcactcttct gtgactccaa gactgagaca
     3361 ttttagaaag taaaacatct aaaattaccc taacatttac aaaatactca tacctctcta
     3421 ttaacatcct aaatgacctt aatatacttc ctaaacatta aaaaggtcat atagcatatg
     3481 ttttaggttt atgttataat aacataaaca gctaaaatta aatttcatta tatgctatac
     3541 aataaacaac tacatgtact tttctttcag gctaaaatcc agtatattta tcaggctctt
     3601 agcacagtag ttctcccact acccagtttg gtgacggaac aagagatgca ggatttacct
     3661 aaaatagttt caaacctatg ttcaacatta tctgtgttct ttgtgcaaat tttttttaaa
     3721 acccaagaca taataagcac acatgtgtct acagacaggt agcttccatc ttcccttctg
     3781 ctcactcttg tggccttgct gttcttcact ggctctcctg tactctaacc tgagtcatgt
     3841 gagcctgagc atcctggtca cagaaaagct gttcctagta tctgacatca ttcccgaggt
     3901 ttccaatgca taagcagtgt gtacgtatat acctataaac cgcagctgtc acagcacacg
     3961 agcatttgta agatacacgg tgattctgtg aatgttagtt agcagacatt gttctgaagg
     4021 taaactaggg gtcttagtgg tcctggttcc tgtgagatgc tcggtggacc atcatgcagg
     4081 aatgggaatg ggaccatgag cactaagtca aagcctctga tgtggggtaa cagcagaaat
     4141 gttactctaa cctaagccag acagacatgg aatttatcag tgaatacctg agggaagcag
     4201 ggtttacatt ctcaccatgg ggattcctga gccaatggat gttcctcata catcaacagg
     4261 cagtaaccac atgacagcgg cagccttgat ccctcataaa actgtgcttt gaaaatatga
     4321 agctggattt ctatctcact gataagaatt aataaaaaaa aaaaaaa
//
