LOCUS       NM_001310766            3721 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus beta-1,3-glucuronyltransferase 1 (B3gat1), transcript
            variant 1, mRNA.
ACCESSION   NM_001310766 XM_006510673
VERSION     NM_001310766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3721)
  AUTHORS   Trimarco,J.D., Nelson,S.L., Chaparian,R.R., Wells,A.I.,
            Murray,N.B., Azadi,P., Coyne,C.B. and Heaton,N.S.
  TITLE     Cellular glycan modification by B3GAT1 broadly restricts influenza
            virus infection
  JOURNAL   Nat Commun 13 (1), 6456 (2022)
   PUBMED   36309510
  REMARK    GeneRIF: Cellular glycan modification by B3GAT1 broadly restricts
            influenza virus infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3721)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3721)
  AUTHORS   Doyle,D.Z., Lam,M.M., Qalieh,A., Qalieh,Y., Sorel,A., Funk,O.H. and
            Kwan,K.Y.
  TITLE     Chromatin remodeler Arid1a regulates subplate neuron identity and
            wiring of cortical connectivity
  JOURNAL   Proc Natl Acad Sci U S A 118 (21) (2021)
   PUBMED   34011608
REFERENCE   4  (bases 1 to 3721)
  AUTHORS   Nakamura,A., Morise,J., Yabuno-Nakagawa,K., Hashimoto,Y.,
            Takematsu,H. and Oka,S.
  TITLE     Site-specific HNK-1 epitope on alternatively spliced fibronectin
            type-III repeats in tenascin-C promotes neurite outgrowth of
            hippocampal neurons through contactin-1
  JOURNAL   PLoS One 14 (1), e0210193 (2019)
   PUBMED   30629639
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3721)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3721)
  AUTHORS   Yamamoto,S., Oka,S., Inoue,M., Shimuta,M., Manabe,T., Takahashi,H.,
            Miyamoto,M., Asano,M., Sakagami,J., Sudo,K., Iwakura,Y., Ono,K. and
            Kawasaki,T.
  TITLE     Mice deficient in nervous system-specific carbohydrate epitope
            HNK-1 exhibit impaired synaptic plasticity and spatial learning
  JOURNAL   J Biol Chem 277 (30), 27227-27231 (2002)
   PUBMED   12032138
  REMARK    GeneRIF: HNK-1 deficient mice exhibit impaired synaptic plasticity
            and spatial learning.  (HNK-1, CD57)
REFERENCE   7  (bases 1 to 3721)
  AUTHORS   Yamamoto,S., Oka,S., Saito-Ohara,F., Inazawa,J. and Kawasaki,T.
  TITLE     Molecular cloning and genomic analysis of mouse
            glucuronyltransferase involved in biosynthesis of the HNK-1 epitope
  JOURNAL   J Biochem 131 (3), 337-347 (2002)
   PUBMED   11872162
  REMARK    GeneRIF: A 207 bp fragment of the 5'-upstream region of mouse
            GlcAT-P gene acts as a strong promoter in PC-12 cells, which
            express the HNK-1 epitope.
REFERENCE   8  (bases 1 to 3721)
  AUTHORS   Malissard,M., Dinter,A., Berger,E.G. and Hennet,T.
  TITLE     Functional assignment of motifs conserved in beta
            1,3-glycosyltransferases
  JOURNAL   Eur J Biochem 269 (1), 233-239 (2002)
   PUBMED   11784317
REFERENCE   9  (bases 1 to 3721)
  AUTHORS   Jonker,L. and Arthur,H.M.
  TITLE     Endoglin expression in early development is associated with
            vasculogenesis and angiogenesis
  JOURNAL   Mech Dev 110 (1-2), 193-196 (2002)
   PUBMED   11744382
REFERENCE   10 (bases 1 to 3721)
  AUTHORS   Zhang,J., Hagopian-Donaldson,S., Serbedzija,G., Elsemore,J.,
            Plehn-Dujowich,D., McMahon,A.P., Flavell,R.A. and Williams,T.
  TITLE     Neural tube, skeletal and body wall defects in mice lacking
            transcription factor AP-2
  JOURNAL   Nature 381 (6579), 238-241 (1996)
   PUBMED   8622766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082739.1, AK044599.1, BC034655.1 and BY626420.1.
            
            On Jul 18, 2015 this sequence version replaced XM_006510673.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220561.1, AK082739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-748               AK082739.1         2-749
            749-749             AK044599.1         734-734
            750-2688            AK082739.1         751-2689
            2689-3709           BC034655.1         2406-3426
            3710-3721           BY626420.1         393-404
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 11.49 cM"
     gene            1..3721
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /note="beta-1,3-glucuronyltransferase 1"
                     /db_xref="GeneID:76898"
                     /db_xref="MGI:MGI:1924148"
     exon            1..370
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..465
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..1505
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /EC_number="2.4.1.135"
                     /note="isoform 1 is encoded by transcript variant 1;
                     galactosylgalactosylxylosylprotein
                     3-beta-glucuronosyltransferase 1; glcUAT-P;
                     UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase;
                     glucuronosyltransferase P"
                     /codon_start=1
                     /product="galactosylgalactosylxylosylprotein
                     3-beta-glucuronosyltransferase 1 isoform 1"
                     /protein_id="NP_001297695.1"
                     /db_xref="CCDS:CCDS80970.1"
                     /db_xref="GeneID:76898"
                     /db_xref="MGI:MGI:1924148"
                     /translation="MGNEELWVQPALEMPKRRDILAIVLIVLPWTLLITVWHQSSLAP
                     LLAVHKDEGSDPRHEAPPGADPREYCMSDRDIVEVVRTEYVYTRPPPWSDTLPTIHVV
                     TPTYSRPVQKAELTRMANTLLHVPNLHWLVVEDAPRRTPLTARLLRDTGLNYTHLHVE
                     TPRNYKLRGDARDPRIPRGTMQRNLALRWLRETFPRNSTQPGVVYFADDDNTYSLELF
                     EEMRSTRRVSVWPVAFVGGLRYEAPRVNGAGKVVGWKTVFDPHRPFAIDMAGFAVNLR
                     LILQRSQAYFKLRGVKGGYQESSLLRELVTLNDLEPKAANCTKILVWHTRTEKPVLVN
                     EGKKGFTDPSVEI"
     exon            466..612
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..1121
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1418
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1519
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..3721
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3680..3685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /note="hexamer: ATTAAA"
     polyA_site      3713
                     /gene="B3gat1"
                     /gene_synonym="0710007K08Rik; GlcAT-P; Glcatp; Hnk1"
                     /note="major polyA site"
ORIGIN      
        1 acgcgctggc ccgctcggct gggctccggc cgcgcgccca gccatcccgg cccggccggc
       61 ccgcgcgtcg cctcttgggg ctccgatcgc cgccccgcgc ctcgccaccc gcgccctcct
      121 gcgcgctcca gggttctggc cgctgcctgg ctgagcccag aagcagcggg gccgtgatag
      181 cgggccggcc ggggctgcgg acgagtgggc ccgcggctat gaagtggccc ccgagggcac
      241 ggaaccggag aacgcctcga gagagaagcg cgcgcatcgc agggcagcag ccttgggtcg
      301 ctggggccag ggtataggac tgccacccgc tatggactgc gccagggacg atatggactc
      361 gctgccgcag gtatcaactt ctgaaggctc ctgaccttgc cctggactac tgccccttcg
      421 cagactccca tcaggctgga ctctgccaac ttgcttccgc aatgggtaat gaggagctgt
      481 gggtgcagcc agccttggag atgccgaaga gacgggacat ccttgcgatt gtcctcatcg
      541 tgcttccctg gacactgctc atcaccgtct ggcaccagag cagcctcgca cctctgcttg
      601 ctgtgcacaa ggatgaggga agtgaccccc gccatgaggc accacctggt gcggacccta
      661 gggagtactg catgtccgac cgtgacatcg tggaagtggt gcgcacagag tacgtgtaca
      721 cgaggccgcc accctggtcc gacacgctgc ccaccatcca tgtggtgacg cccacctaca
      781 gtagaccggt gcagaaggca gagctgacgc gaatggccaa cacactactg catgtgccca
      841 accttcactg gctagtggtg gaggatgctc cacgcaggac gcccctcacc gcgcgcttgc
      901 tgcgcgacac tggcctcaac tacacacacc tgcacgtaga gacaccacgc aactataagc
      961 tgcgaggtga tgcccgagac cctcgcatcc cacgtggcac catgcagcgc aacctggcac
     1021 tgcgctggct gcgggagacc ttcccacgga actctactca gccaggcgta gtgtacttcg
     1081 cggatgatga caacacgtac agtctggagc tctttgaaga gatgcgcagc acaagaaggg
     1141 tgtccgtgtg gcctgtggcc tttgttggtg gccttcggta tgaggcccca cgggtgaatg
     1201 gggcagggaa agtggttggc tggaagacag tcttcgaccc ccaccggccc tttgcaatag
     1261 acatggctgg atttgctgtc aacctccggc tcatcttgca gcgaagtcaa gcctacttta
     1321 agctacgtgg tgtgaaggga ggctaccagg aaagcagtct ccttcgagaa cttgtcaccc
     1381 tcaatgacct ggagcccaag gcagcaaact gtaccaagat cttggtctgg catacacgaa
     1441 cagagaagcc agtgctggtc aatgagggga agaagggctt caccgacccc tcagtggaga
     1501 tctgaaacta aagatgcagg aacctccttc tcagaccctg atcttggcct gccatcctct
     1561 cccatggctg atagtcactc tgaggcagac tccagaggaa caactcttat gtattccgag
     1621 ggcttccaag agagcccagc ttgatgtcag gataaaagac agagaattta agcacagaat
     1681 cccagacctg tggtcctcta cagcaacatg gccaggggct taaaagacca gagagctggg
     1741 gattccggtt gccagccaag cctgtgctcg gcacatctcc ttggaagctt cctacattga
     1801 tggggctgtg tgagcagggg accctgcctt ggagtgatac tggggtgagg gaggtcagaa
     1861 aaccctactg tggagtgcag catggctctc catggctccc tgctcttggg cctagcatga
     1921 ctatacagca tgtgcccagc caggacattc tgaagaccag agagcagcct ggggcatgaa
     1981 gatgccccaa cactcctctt tcacacctgc tcttcctcag agctgctccc aaatcagaaa
     2041 tacctctggc tctcctctgg ttcatgttta caggacataa ggctgtcttg gatcccacct
     2101 ggcaccctac cctgcattgg gggagcctgg gccttcctac agctccccct gtacctcagg
     2161 ctgtaggaga acaaagccct ttcccatgtc cctcaagcct cctgcgccag aatcggcaag
     2221 gtggtgggct tagagccagc acaggtcata gatcgacctg gattaagaac caagtcaccc
     2281 cagtgtcccc actgcctctc cagtacccct gggctgcaat gccccttgct gggtttggac
     2341 tgaggagaca attgccctct tcctgaaacc cctaagaatc acagatctcg gggcgcagat
     2401 aacaataata aagaggcaga gctcttcctg aaaaaatgtg agacccagca atcccagtcc
     2461 tttcctgagc cgattctgtg agggctgcat tagaatgggc tcaaggtcaa gagcaggaaa
     2521 tgtctacaca ctgagaggaa gggcgacctg agcacatact gctttagaaa tcactctgtc
     2581 tcacacaaaa tgggaaagct tgcaaagcca acccgcctcg tgcccactgc cccttctcca
     2641 ccccggacag aacagtatgc tcacgctgtt gcacctaccc agccgcccaa aagaaccatc
     2701 tgcctgggtg ttcagcatct gagaggcccc tggtcctggc tacatggggc cctctggtgg
     2761 taatctcact ccagctccta caagttggaa gcacaatttt cctcccaagt gggggaaagg
     2821 aaagggcgca agcccactga agaggcgttt attttttaac tgctaacagc tccccccacc
     2881 ccgcaccttc ccccagttcc ccctcccccc gcgctccatt aaaactcata ggacaggccc
     2941 gggagtcatt ccgaatccac tctcgggtgg atgagactca gtccacacat ctaactttca
     3001 gagaatagca tcagctgcct atgttgaaat gaatttaact tctcacagtc ttcaggacac
     3061 cacctgatgg gatcagaccc cacagccccc tgtaggacat ctccccctag ccatttatac
     3121 tttggatatt gttttggaaa tttactcctt ggcatcaaat gagaggcacc gggaatttat
     3181 ccgatgggtg aatttatgtc tgggcaccct actgctcatt catagaaact gtcagtgaat
     3241 gccaaggtca aacgggctgc taaggctgcc ttcttagcca aactcagtgc tctttttagg
     3301 aaactgaaaa aaaacaaaac aaaacaaaac aaaaatgggg atttttactt ttcacgtttt
     3361 ggcagatgct acttcagttg ttttcatgta atgtcctccc ttcactgcat gtgtatttat
     3421 ttaaaattat aaccctggtg gactgcggcc ttcatctctg ttgggaatga gtttgttgca
     3481 aatcagaact gggtccatga tgacaacttt ccctccaaac ccaggctgca accccgctcc
     3541 ctcgatggaa agccccacca cagaagagtt aagccagggg ttcaggagca ccatgggcaa
     3601 aggctggtgt gagggtgggg cccaagctgc tgcgccatct ggtctgtttt tatttaactg
     3661 tatttaattt gttttcaaaa ttaaaagtca aatatggttt ttaacagttg taatcctctt
     3721 c
//
