LOCUS       NM_019420               1599 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase,
            polypeptide 4 (B3galt4), mRNA.
ACCESSION   NM_019420 XM_905652
VERSION     NM_019420.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Sha,Y.L., Liu,Y., Yang,J.X., Wang,Y.Y., Gong,B.C., Jin,Y., Qu,T.Y.,
            Xia,F.T., Han,L. and Zhao,Q.
  TITLE     B3GALT4 remodels the tumor microenvironment through GD2-mediated
            lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in
            neuroblastoma
  JOURNAL   J Exp Clin Cancer Res 41 (1), 314 (2022)
   PUBMED   36284313
  REMARK    GeneRIF: B3GALT4 remodels the tumor microenvironment through
            GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis
            in neuroblastoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Ngamukote,S., Yanagisawa,M., Ariga,T., Ando,S. and Yu,R.K.
  TITLE     Developmental changes of glycosphingolipids and expression of
            glycogenes in mouse brains
  JOURNAL   J Neurochem 103 (6), 2327-2341 (2007)
   PUBMED   17883393
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Raimondi,L.P., Daniotti,J.L. and Maccioni,H.J.
  TITLE     ETS-1 transcription factor activates the expression of mouse
            UDP-Gal:GA2/GM2/GD2/GT2 galactosyltransferase gene
  JOURNAL   FEBS Lett 576 (3), 487-491 (2004)
   PUBMED   15498585
  REMARK    GeneRIF: activation of a fragment of 211 bp around the
            transcription initiation site of the mouse Gal-T2 promoter.
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   7  (bases 1 to 1599)
  AUTHORS   Daniotti,J.L., Martina,J.A., Zurita,A.R. and Maccioni,H.J.
  TITLE     Mouse beta 1,3-galactosyltransferase (GA1/GM1/GD1b synthase):
            protein characterization, tissue expression, and developmental
            regulation in neural retina
  JOURNAL   J Neurosci Res 58 (2), 318-327 (1999)
   PUBMED   10502288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY348346.1 and AF082504.1.
            
            On Dec 11, 2007 this sequence version replaced NM_019420.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY348346.1         1-22
            23-1599             AF082504.1         16-1592
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1599
                     /gene="B3galt4"
                     /gene_synonym="Gal-T2; Galt2"
                     /note="UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase,
                     polypeptide 4"
                     /db_xref="GeneID:54218"
                     /db_xref="MGI:MGI:1859517"
     exon            1..1577
                     /gene="B3galt4"
                     /gene_synonym="Gal-T2; Galt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1342
                     /gene="B3galt4"
                     /gene_synonym="Gal-T2; Galt2"
                     /EC_number="2.4.1.62"
                     /note="beta-1,3-galactosyltransferase 4; b3Gal-T4;
                     beta3GalT4; beta3Gal-T4; beta-1,3-GalTase 4; ganglioside
                     galactosyltransferase;
                     UDP-galactose:beta-N-acetyl-galactosamine-beta-1,
                     3-galactosyltransferase; UDP-Gal:betaGlcNAc beta
                     13-galactosyltransferase polypeptide 4"
                     /codon_start=1
                     /product="beta-1,3-galactosyltransferase 4 precursor"
                     /protein_id="NP_062293.1"
                     /db_xref="CCDS:CCDS28638.1"
                     /db_xref="GeneID:54218"
                     /db_xref="MGI:MGI:1859517"
                     /translation="MPLSLFRRVLLAVLLLVIIWTLFGPSGLGEELLSLSLASLLPAP
                     ASPGPPLALPRLLISNSHACGGSGPPPFLLILVCTAPEHLNQRNAIRASWGAIREARG
                     FRVQTLFLLGKPRRQQLADLSSESAAHRDILQASFQDSYRNLTLKTLSGLNWVNKYCP
                     MARYILKTDDDVYVNVPELVSELIQRGGPSEQWQKGKEAQEETTAIHEEHRGQAVPLL
                     YLGRVHWRVRPTRTPESRHHVSEELWPENWGPFPPYASGTGYVLSISAVQLILKVASR
                     APPLPLEDVFVGVSARRGGLAPTHCVKLAGATHYPLDRCCYGKFLLTSHKVDPWQMQE
                     AWKLVSGMNGERTAPFCSWLQGFLGTLRCRFIAWFSS"
ORIGIN      
        1 gatggagcgg agttccgcgt gcacgctagc tagggaaacg aagccttccg gggccagctg
       61 tggtgggcca gggccgcatt gcacgacagc atctggagaa cagcatctgt gatgcgccag
      121 agccccgcgc atgggtcacc gcgtctcctc agcagcagct ggttaaagcc gtcctcccac
      181 ctccccacgc tctaacagct gtgcccacag gtctctgcgg cacgccatgc ccctcagcct
      241 cttccggcgc gtcctcctgg cggtcctact actggtgatc atctggaccc tgtttggacc
      301 ttcaggcttg ggggaggagc tgctgagcct gtccctggca tccctgctgc cggccccagc
      361 ctcgccagga ccgcccctcg ccctgccccg cctcttgatt tctaactctc atgcctgtgg
      421 tggctccgga ccccctccct tcctgctcat cctggtgtgt acggccccgg agcacctgaa
      481 ccagagaaac gccattcggg catcttgggg tgccatccgc gaagcccggg gtttcagagt
      541 gcagacgctc ttcctcctgg gaaaacctag aagacagcag cttgctgacc tgtcctcaga
      601 gtcagcagca cacagggata tcttgcaggc ctccttccag gattcctacc gcaacctcac
      661 cctcaagacc ctcagtggac tgaactgggt gaacaaatac tgtcctatgg cccgctacat
      721 cctcaagacg gatgatgacg tgtatgtcaa cgtcccagag ctggtgtcag agctgataca
      781 aagagggggg ccttcggagc aatggcagaa gggcaaagag gcccaggaag agacaacagc
      841 tatccatgaa gagcacagag gccaggcagt gccccttctg tatttaggca gggtgcactg
      901 gagggtgaga cccactcgga caccagagtc ccggcaccat gtgtcagaag aactgtggcc
      961 ggaaaactgg ggtccttttc caccctatgc ctcgggcaca ggatatgtac tgtccatctc
     1021 tgctgtgcag ctcatcctga aggtggccag ccgggcccca cctctacctc tagaggatgt
     1081 ctttgtggga gtaagtgcaa ggcgaggggg ccttgccccc acacactgtg tcaaattggc
     1141 tggtgctacc cactacccct tggatcggtg ctgttacggg aagttcctgc tgacatccca
     1201 caaggtggat ccctggcaaa tgcaggaagc ttggaagctg gtgagcggca tgaatgggga
     1261 gaggactgca cccttttgct cctggctcca gggatttctg ggtaccttga ggtgccggtt
     1321 catagcctgg ttcagtagct gagaacccac agaaaacagc acctcagaga cctttcccca
     1381 aagttggtgc agaggctgca gatccctgtg gtgatctagt tcctccattt tctcacagca
     1441 aactctgaag ctgcaaccaa ccaagtttac caagataaac ttgggccctg gcctgccagc
     1501 tccggggagg gataaagcca agggcgggaa ggggactcac aagcagggac aagggtccaa
     1561 taaacatgtc tctctacaaa aaaaaaaaaa aaaaaaaaa
//
