LOCUS       NM_020025               4578 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase,
            polypeptide 2 (B3galt2), mRNA.
ACCESSION   NM_020025
VERSION     NM_020025.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4578)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4578)
  AUTHORS   Chen,X., Wang,P., Ren,L., Deng,X., Yin,X., Zhang,L., Li,Q., Bai,L.,
            Li,X., Wang,P. and Bi,J.
  TITLE     Effects of the genetic knockout of the
            beta-1,3-galactosyltransferase 2 on spatial learning and neurons in
            the adult mouse hippocampus and somatosensory cortex
  JOURNAL   Neuroreport 34 (1), 46-55 (2023)
   PUBMED   36504040
  REMARK    GeneRIF: Effects of the genetic knockout of the
            beta-1,3-galactosyltransferase 2 on spatial learning and neurons in
            the adult mouse hippocampus and somatosensory cortex.
REFERENCE   3  (bases 1 to 4578)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4578)
  AUTHORS   Jia,M., Yang,X., Yang,T., Deng,X., Liang,J., Bi,J. and Wang,P.
  TITLE     beta-1, 3-galactosyltransferase 2 deficiency exacerbates brain
            injury after transient focal cerebral ischemia in mice
  JOURNAL   Brain Res Bull 169, 104-111 (2021)
   PUBMED   33482286
  REMARK    GeneRIF: beta-1, 3-galactosyltransferase 2 deficiency exacerbates
            brain injury after transient focal cerebral ischemia in mice.
REFERENCE   5  (bases 1 to 4578)
  AUTHORS   Yang,X., Liang,J., Jia,M., Yang,T., Deng,X., Wang,P., Ren,L.,
            Gao,S., Zuo,Z., Pei,D., Bi,J. and Wang,P.
  TITLE     beta-1, 3-galactosyltransferase 2 ameliorates focal ischemic
            cerebral injury by maintaining blood-brain barrier integrity
  JOURNAL   Neurochem Int 144, 104976 (2021)
   PUBMED   33524473
  REMARK    GeneRIF: beta-1, 3-galactosyltransferase 2 ameliorates focal
            ischemic cerebral injury by maintaining blood-brain barrier
            integrity.
REFERENCE   6  (bases 1 to 4578)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4578)
  AUTHORS   Kim,S.K., Avila,J.J. and Massett,M.P.
  TITLE     Strain survey and genetic analysis of vasoreactivity in mouse aorta
  JOURNAL   Physiol Genomics 48 (11), 861-873 (2016)
   PUBMED   27764765
REFERENCE   8  (bases 1 to 4578)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   9  (bases 1 to 4578)
  AUTHORS   Zhu,D., Shen,A., Wang,Y., Gu,X. and Gu,J.
  TITLE     Developmental regulation of beta-1,3-galactosyltransferase-1 gene
            expression in mouse brain
  JOURNAL   FEBS Lett 538 (1-3), 163-167 (2003)
   PUBMED   12633872
REFERENCE   10 (bases 1 to 4578)
  AUTHORS   Hennet,T., Dinter,A., Kuhnert,P., Mattu,T.S., Rudd,P.M. and
            Berger,E.G.
  TITLE     Genomic cloning and expression of three murine UDP-galactose:
            beta-N-acetylglucosamine beta1,3-galactosyltransferase genes
  JOURNAL   J Biol Chem 273 (1), 58-65 (1998)
   PUBMED   9417047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036141.1, AK034371.1, AK038860.1 and BB370382.2.
            
            On Sep 14, 2007 this sequence version replaced NM_020025.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB628870.1, SRR1660821.194515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2530              AK036141.1         3-2532
            2531-3902           AK034371.1         2487-3858
            3903-4428           AK038860.1         977-1502
            4429-4471           AK034371.1         4385-4427
            4472-4474           AK038860.1         1546-1548
            4475-4578           BB370382.2         588-691
FEATURES             Location/Qualifiers
     source          1..4578
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.52 cM"
     gene            1..4578
                     /gene="B3galt2"
                     /note="UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase,
                     polypeptide 2"
                     /db_xref="GeneID:26878"
                     /db_xref="MGI:MGI:1349461"
     exon            1..646
                     /gene="B3galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..4578
                     /gene="B3galt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             769..2037
                     /gene="B3galt2"
                     /EC_number="2.4.1.86"
                     /note="beta3GalT2; beta3Gal-T2; beta-1,3-GalTase 2;
                     UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase-II"
                     /codon_start=1
                     /product="beta-1,3-galactosyltransferase 2"
                     /protein_id="NP_064409.3"
                     /db_xref="CCDS:CCDS15342.1"
                     /db_xref="GeneID:26878"
                     /db_xref="MGI:MGI:1349461"
                     /translation="MLQWRRRHCCFAKMTWSPKRSLLRTPLTGVLSLVFLFAMFLFFN
                     HHDWLPGRPGFKENPVTYTFRGFRSTKSETNHSSLRTIWKEVAPQTLRPHTASNSSNT
                     ELSPQGVTGLQNTLSANGSIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAE
                     PGQIEARRAIRQTWGNETLAPGIQIIRVFLLGISIKLNGYLQHAIQEESRQYHDIIQQ
                     EYLDTYYNLTIKTLMGMNWVATYCPHTPYVMKTDSDMFVNTEYLIHKLLKPDLPPRHN
                     YFTGYLMRGYAPNRNKDSKWYMPPDLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGI
                     RRLHLEDVYVGICLAKLRVDPVPPPNEFVFNHWRVSYSSCKYSHLITSHQFQPSELIK
                     YWNHLQQNKHNACANAAKEKAGRYRHRKLH"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3galt2"
                     /note="hexamer: ATTAAA"
     polyA_site      2735
                     /gene="B3galt2"
                     /note="major polyA site"
     regulatory      3347..3352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3galt2"
                     /note="hexamer: AATAAA"
     polyA_site      3374
                     /gene="B3galt2"
                     /note="major polyA site"
     regulatory      4468..4473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3galt2"
                     /note="hexamer: AATGAA"
     polyA_site      4489
                     /gene="B3galt2"
                     /note="major polyA site"
ORIGIN      
        1 gttaaattct gctctgtcag agacagcatc tgtcaagccc acatttaaac tgctgcctgc
       61 ctgtgcagca cggaagaacg gtgcatttca cattacagac caaaacccca ggaaaacagc
      121 tcaaaaatcc ttcctgcagc tgccaggcaa ccacgacgga gaaaggcaaa gccttttttt
      181 ttcccccaat gcaactgaaa cactaaacca cagctctgct gcttaacatt gcagctcagc
      241 gctattacta gaaatatgga tactgagaag agaatacagc actgcattgt ccagccggga
      301 atacagcaga tgtaaagagc ttcaatgcat caactgtcgg aaagagtcaa ctgtgcacca
      361 aatacaacag acagctacag ctcttttgtt tagtgaaaga gagaaaatga aagaaaggaa
      421 aaatctctga agactataag atatagacat atgaacaaga agggtaactt gaagacaccc
      481 cgacagatgg acactttgga tactgtgaaa agcaatcaca ggaggcagac tgttggggga
      541 tgtgcgcatg ttcgatagca tcgttttttg ctgaagtgat ggcgtgccaa aagtattttc
      601 agtagacata atcctctcca tctaatggtc tgaccaagaa agaaagaatg acatcgaggg
      661 acatgtacct gaaccagaag acgatgaatc aagcgcagta ttgactgagg acggaacaac
      721 agtgtttttg gccacagaca tccattactg ctactggata cttacaacat gcttcagtgg
      781 agaagacgac actgctgctt tgcaaaaatg acctggagcc ctaagaggtc tctgctccgg
      841 actcccctta cgggtgtgct ttctctagtg tttctctttg ctatgttctt gtttttcaat
      901 catcatgact ggttaccagg tagaccagga ttcaaagaaa atcctgtgac atacactttc
      961 cgaggatttc gttctacaaa aagtgagaca aaccatagct cccttcggac catctggaaa
     1021 gaagtagctc ctcagactct gaggcctcac acagcaagca actccagtaa caccgagcta
     1081 tcaccacagg gagtcacagg gctgcagaac actctcagtg ccaatggcag catttataat
     1141 gaaaaaggaa ctggacatcc aaactcttac catttcaaat atattatcaa tgagcctgaa
     1201 aaatgccaag agaaaagtcc atttttaata ctattaatag ctgcagaacc tggacaaatc
     1261 gaagcaagaa gagctatacg gcaaacttgg ggcaatgaaa ctttggcacc tggcatccaa
     1321 atcatacggg tttttttgtt gggcataagt attaagctaa atggctatct tcaacatgca
     1381 attcaagaag aaagcagaca gtatcatgat ataattcagc aggaatattt agatacatac
     1441 tataatctga ccattaaaac actaatgggt atgaactggg ttgcaacata ctgtccacat
     1501 actccctatg ttatgaaaac ggacagtgac atgtttgtca acacagaata cttaatacac
     1561 aagttactaa agccagacct gcctcctaga cataactatt ttactggcta tctaatgaga
     1621 ggatatgcac cgaacagaaa caaagacagt aagtggtaca tgccaccaga cctttaccca
     1681 agtgagcgct accctgtctt ctgctcagga actggttatg tgttttctgg ggatctggca
     1741 gagaagatat ttaaggtttc tttaggtatc cgtcgtttgc acttggaaga tgtatatgta
     1801 gggatctgtc ttgccaagtt gagagttgat cctgtgcccc ctcccaatga gttcgtgttc
     1861 aatcactggc gagtttctta ttcaagctgt aaatacagcc acctaattac ctctcatcag
     1921 ttccaaccta gtgaactgat aaaatactgg aaccatttac aacaaaataa gcacaacgcc
     1981 tgtgccaatg cagcaaagga aaaggcaggc aggtatcgac accgcaaact acactagaag
     2041 actatttttg ttcaaatgtg gagtctgtaa atattgctta aagcatgtat agttaaaaac
     2101 ttgattatat acataggaca agttttagtt caactcatca cataaaggaa ttcaaagcta
     2161 ttttttaaat tttctgaata agataattca tacaattgca aattatgaca aaaaggtatc
     2221 ccaaaagagt ctatttaaat aactgttatg aggagattct ctatattaac atgcaataat
     2281 aagcatgcat acataaatgg ttcaagactt acattaggga ccaatacaat gtatctgcat
     2341 acattttcta tataaatctt aagaaatgaa gacagtaaaa agattcctag atttactttt
     2401 gatttcatca tataactaaa tgtaaataag acagtactat tgattttaaa ggaactttgt
     2461 aattgtgcaa tgaacaagtt ttctgacctg actcagttgc aataagattt agttaagtta
     2521 ttccataaac tcatttatag cattcaggtg tttgagcaat gcaattctca ttcaagaata
     2581 tacttttaaa aataatttat aattatttta atttctttta ttaatactta tctatactgg
     2641 gaaaattatt ttgacatgat gtgataaatg tgaaaaatta atgtgtctca ggctcaagtt
     2701 tttataaaat gaattattaa aggtatcaaa atagataaat tttgcttcct cattggtatt
     2761 aagggtcaag accatatttc aatggatttt gcctttaaaa tattacactc ttggggagtg
     2821 cttttatctt caactatacc tgacttaaag tatgtcttta aaatagaatc atattcctct
     2881 agctgaaata caagtagtaa cataacagca caggggtaat gtgtggtctt aaataaggaa
     2941 gaaaaaaagg aatacaaata gtcatttcat tcaatctatt ttaaagttgt atatctgcca
     3001 aacagcgaga tataggaaaa gcttatattc tgagagcagt gtacgtcaga caacatttaa
     3061 tcattttatg gcacttattt ctttctctca gtgtcaagtt tataaacctt ctgtttttaa
     3121 tttggtagat gacaaatatt cgcatcacca attcaaaacc atttagagaa tggtggggag
     3181 aaagctacat atgtttgata atcatttgct tttagagtgg acaatatact taatgcactt
     3241 taaccaaggt actattggtt tttaaaaggt aaacaacaaa gccctgaact gaatgctata
     3301 caaatgttct catatttcat ttggccctat catgaattgt aacatcaata aacacaagcc
     3361 cagtaacttt gaaacagtgt atcctatgta tatttataaa ttttaattga gtcagaatat
     3421 cttctatcag aattctaata ttcgttttta tcactaaatc tagtatgaaa ggctaaattg
     3481 acagacacac aaaaagcttt atttattagt aatacagagt tctacttata ttaaatgtat
     3541 agctcatttt ttaaataaga agcctaagta ttctattcca caccaaatgg ttatgaataa
     3601 tcagctataa aacatatcca gctcttagct aatgtttttt taatttattc tatgtaattg
     3661 tagtgaacag aattgcctca caaaaagaca tacacagagg ataacaccaa accacaccag
     3721 tgatcaaaga cagagagaga ccctgacagt gtactgagtc tctctgattt ataccacaaa
     3781 ggtttaaaat gaaaatggga actatgtatg tttgtgagcg ttcctgcaca agtatgtaaa
     3841 caaaaagaga gctcctaagt gatatttaaa aactataata gtataggatt actgggatta
     3901 aaatactgac ttaaaaaaca cagagttctt aaaaatactt aagtgcttac taaaattatt
     3961 tccattaatt tgaaaaaata atttaatcat ggtctgagtc ctcagagagc attaaaccag
     4021 tcaagttatt aatgtcaaaa gtctgtactt ttgactttgg gagaacacac gctagcatag
     4081 cttcagcact tggaaaataa ggcaggaaga aagagagttc aaggcaattt taggttaaac
     4141 aataaaatcc taagaaaacc atcaaacctt actttaaaat aaaaattcta ttgttaattt
     4201 atttttacat ttaattttca ataatataaa tgctaacttt ataagctgct atataatgtc
     4261 tcaccagttg ttaattatat cttgtttata taaaattttt gtatgtaaga aatgtttgaa
     4321 aatgactata ttatattgat ttgaccaaaa gaaagtttac agaatcaact gtataacact
     4381 aaactcaaag tgttaataga catttcaaaa ggaaaatgca aacttcagta tttacaacat
     4441 tagtttgttt gaaataaaat tagaagtaat gaaatcttca acaactaaat aatttgcatt
     4501 tccttaatgt ctttcatgca taaaaatata agcacataca cctaattgga actttttaaa
     4561 tacctgattc tcccccct
//
