LOCUS       NM_009735                858 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus beta-2 microglobulin (B2m), mRNA.
ACCESSION   NM_009735
VERSION     NM_009735.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 858)
  AUTHORS   Al-Omari,A.A., Cook,K.W., Symonds,P., Skinner,A., Wright,A.,
            Zhu,Y., Coble,V.L., Mohammed,O.J., Choudhury,R.H., Uddin,N.,
            Ranglani,P., Parry,A., Adams,S.E., Lynn,G.M., Durrant,L.G. and
            Brentville,V.A.
  TITLE     Modi-2 a vaccine stimulating CD4 responses to homocitrullinated
            self epitopes as therapy for solid cancers
  JOURNAL   NPJ Vaccines 9 (1), 236 (2024)
   PUBMED   39604380
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Callahan,J.W., Morales,J.C., Atherton,J.F., Wang,D., Kostic,S. and
            Bevan,M.D.
  TITLE     Movement-related increases in subthalamic activity optimize
            locomotion
  JOURNAL   Cell Rep 43 (8), 114495 (2024)
   PUBMED   39068661
REFERENCE   4  (bases 1 to 858)
  AUTHORS   Specht,C.A., Wang,R., Oliveira,L.V.N., Hester,M.M., Gomez,C.,
            Mou,Z., Carlson,D., Lee,C.K., Hole,C.R., Lam,W.C., Upadhya,R.,
            Lodge,J.K. and Levitz,S.M.
  TITLE     Immunological correlates of protection mediated by a whole
            organism, Cryptococcus neoformans, vaccine deficient in chitosan
  JOURNAL   mBio 15 (8), e0174624 (2024)
   PUBMED   38980038
REFERENCE   5  (bases 1 to 858)
  AUTHORS   Sung,C.Y.W., Hayase,N., Yuen,P.S.T., Lee,J., Fernandez,K., Hu,X.,
            Cheng,H., Star,R.A., Warchol,M.E. and Cunningham,L.L.
  TITLE     Macrophage depletion protects against cisplatin-induced ototoxicity
            and nephrotoxicity
  JOURNAL   Sci Adv 10 (30), eadk9878 (2024)
   PUBMED   39047106
REFERENCE   6  (bases 1 to 858)
  AUTHORS   White,R.A., Peters,L.L., Adkison,L.R., Korsgren,C., Cohen,C.M. and
            Lux,S.E.
  TITLE     The murine pallid mutation is a platelet storage pool disease
            associated with the protein 4.2 (pallidin) gene
  JOURNAL   Nat Genet 2 (1), 80-83 (1992)
   PUBMED   1284644
REFERENCE   7  (bases 1 to 858)
  AUTHORS   Fremont,D.H., Matsumura,M., Stura,E.A., Peterson,P.A. and
            Wilson,I.A.
  TITLE     Crystal structures of two viral peptides in complex with murine MHC
            class I H-2Kb
  JOURNAL   Science 257 (5072), 919-927 (1992)
   PUBMED   1323877
REFERENCE   8  (bases 1 to 858)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   9  (bases 1 to 858)
  AUTHORS   Correa,I., Bix,M., Liao,N.S., Zijlstra,M., Jaenisch,R. and
            Raulet,D.
  TITLE     Most gamma delta T cells develop normally in beta
            2-microglobulin-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 89 (2), 653-657 (1992)
   PUBMED   1346234
REFERENCE   10 (bases 1 to 858)
  AUTHORS   Appella,E., Tanigaki,N., Natori,T. and Pressman,D.
  TITLE     Partial amino acid sequence of mouse beta2-microglobulin
  JOURNAL   Biochem Biophys Res Commun 70 (2), 425-430 (1976)
   PUBMED   59595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019389.1.
            
            On Apr 9, 2007 this sequence version replaced NM_009735.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019389.1, AK020632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-858               AK019389.1         4-861
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.55 cM"
     gene            1..858
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /note="beta-2 microglobulin"
                     /db_xref="GeneID:12010"
                     /db_xref="MGI:MGI:88127"
     exon            1..118
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..411
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /codon_start=1
                     /product="beta-2-microglobulin precursor"
                     /protein_id="NP_033865.2"
                     /db_xref="CCDS:CCDS16654.1"
                     /db_xref="GeneID:12010"
                     /db_xref="MGI:MGI:88127"
                     /translation="MARSVTLVFLVLVSLTGLYAIQKTPQIQVYSRHPPENGKPNILN
                     CYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRV
                     KHASMAEPKTVYWDRDM"
     exon            119..397
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /inference="alignment:Splign:2.1.0"
     exon            398..426
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /inference="alignment:Splign:2.1.0"
     exon            427..858
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      595..600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /note="hexamer: AATAAA"
     polyA_site      613
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /note="major polyA site"
     regulatory      631..636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /note="hexamer: AATATA"
     polyA_site      668
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
                     /note="major polyA site"
     polyA_site      844
                     /gene="B2m"
                     /gene_synonym="beta2-m; beta2m; Ly-m11"
ORIGIN      
        1 tttcagtggc tgctactcgg cgcttcagtc gcggtcgctt cagtcgtcag catggctcgc
       61 tcggtgaccc tggtctttct ggtgcttgtc tcactgaccg gcctgtatgc tatccagaaa
      121 acccctcaaa ttcaagtata ctcacgccac ccaccggaga atgggaagcc gaacatactg
      181 aactgctacg taacacagtt ccacccgcct cacattgaaa tccaaatgct gaagaacggg
      241 aaaaaaattc ctaaagtaga gatgtcagat atgtccttca gcaaggactg gtctttctat
      301 atcctggctc acactgaatt cacccccact gagactgata catacgcctg cagagttaag
      361 catgccagta tggccgagcc caagaccgtc tactgggatc gagacatgtg atcaagcatc
      421 atgatgctct gaagattcat ttgaacctgc ttaattacaa atccagtttc taatatgcta
      481 tacaatttat gcacgcagaa agaaatagca atgtacacat caccttcttt atatcttact
      541 ttaaatattt tatgcatgtt ttcaaaaaat tggaaatatc ctagatagct gagcaataaa
      601 tcttcaataa gtattttgat cagaataata aatataattt taagaacaat agttgatcat
      661 atgccaaacc ctctgtactt ctcattactt ggatgcagtt actcatcttt ggtctatcac
      721 aacataagtg acatactttc cttttggtaa agcaaagagg cctaattgaa gtctgtcact
      781 gtgcccaatg cttagcaatt ctcaccccca accctgtggc tacttctgct tttgttactt
      841 ttactaaaaa taaaaaac
//
