LOCUS       NM_009465               5084 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus AXL receptor tyrosine kinase (Axl), transcript variant
            1, mRNA.
ACCESSION   NM_009465
VERSION     NM_009465.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5084)
  AUTHORS   Schott,C., Germain,A., Lacombe,J., Pata,M., Faubert,D., Boulais,J.,
            Carmeliet,P., Cote,J.F. and Ferron,M.
  TITLE     GAS6 and AXL Promote Insulin Resistance by Rewiring Insulin
            Signaling and Increasing Insulin Receptor Trafficking to Endosomes
  JOURNAL   Diabetes 73 (10), 1648-1661 (2024)
   PUBMED   39046834
  REMARK    GeneRIF: GAS6 and AXL Promote Insulin Resistance by Rewiring
            Insulin Signaling and Increasing Insulin Receptor Trafficking to
            Endosomes.
REFERENCE   2  (bases 1 to 5084)
  AUTHORS   Diawara,M. and Martin,L.J.
  TITLE     The transcription factors NR5A1 and JUNB cooperate to activate the
            Axl promoter in mouse Sertoli cell lines
  JOURNAL   Mol Biol Rep 51 (1), 982 (2024)
   PUBMED   39271559
  REMARK    GeneRIF: The transcription factors NR5A1 and JUNB cooperate to
            activate the Axl promoter in mouse Sertoli cell lines.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5084)
  AUTHORS   Guimaraes-Pinto,K., Leandro,M., Correa,A., Maia,E.P., Rodrigues,L.,
            da Costa,A.L.A., Rafael Machado Ferreira,J., Claudio-Etienne,E.,
            Siebenlist,U., He,J., Rigoni,T.D.S., Ferreira,T.P.T.,
            Jannini-Sa,Y.A.P., Matos-Guedes,H.L., Costa-da-Silva,A.C.,
            Lopes,M.F., Silva,P.M.R., Kelsall,B.L. and Filardy,A.A.
  TITLE     Differential regulation of lung homeostasis and silicosis by the
            TAM receptors MerTk and Axl
  JOURNAL   Front Immunol 15, 1380628 (2024)
   PUBMED   38774866
  REMARK    GeneRIF: Differential regulation of lung homeostasis and silicosis
            by the TAM receptors MerTk and Axl.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5084)
  AUTHORS   Cheng,M., Chen,S., Li,K., Wang,G., Xiong,G., Ling,R., Zhang,C.,
            Zhang,Z., Han,H., Chen,Z., Wang,X., Liang,Y., Tian,G., Zhou,R.,
            Zhu,Y., Ma,J., Liu,J., Lin,S., Xu,H., Chen,D., Li,Y. and Peng,L.
  TITLE     CD276-dependent efferocytosis by tumor-associated macrophages
            promotes immune evasion in bladder cancer
  JOURNAL   Nat Commun 15 (1), 2818 (2024)
   PUBMED   38561369
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5084)
  AUTHORS   Mohammadzadeh,P., Roueinfar,M. and Amberg,G.C.
  TITLE     AXL receptor tyrosine kinase modulates gonadotropin-releasing
            hormone receptor signaling
  JOURNAL   Cell Commun Signal 21 (1), 284 (2023)
   PUBMED   37828510
  REMARK    GeneRIF: AXL receptor tyrosine kinase modulates
            gonadotropin-releasing hormone receptor signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5084)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   7  (bases 1 to 5084)
  AUTHORS   Faust,M., Ebensperger,C., Schulz,A.S., Schleithoff,L.,
            Hameister,H., Bartram,C.R. and Janssen,J.W.
  TITLE     The murine ufo receptor: molecular cloning, chromosomal
            localization and in situ expression analysis
  JOURNAL   Oncogene 7 (7), 1287-1293 (1992)
   PUBMED   1320243
REFERENCE   8  (bases 1 to 5084)
  AUTHORS   Janssen,J.W., Schulz,A.S., Steenvoorden,A.C., Schmidberger,M.,
            Strehl,S., Ambros,P.F. and Bartram,C.R.
  TITLE     A novel putative tyrosine kinase receptor with oncogenic potential
  JOURNAL   Oncogene 6 (11), 2113-2120 (1991)
   PUBMED   1834974
REFERENCE   9  (bases 1 to 5084)
  AUTHORS   Rescigno,J., Mansukhani,A. and Basilico,C.
  TITLE     A putative receptor tyrosine kinase with unique structural topology
  JOURNAL   Oncogene 6 (10), 1909-1913 (1991)
   PUBMED   1840679
REFERENCE   10 (bases 1 to 5084)
  AUTHORS   O'Bryan,J.P., Frye,R.A., Cogswell,P.C., Neubauer,A., Kitch,B.,
            Prokop,C., Espinosa,R. 3rd, Le Beau,M.M., Earp,H.S. and Liu,E.T.
  TITLE     axl, a transforming gene isolated from primary human myeloid
            leukemia cells, encodes a novel receptor tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (10), 5016-5031 (1991)
   PUBMED   1656220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119211.8, AK033237.1, BC050914.1 and AC162614.2.
            
            On Jul 17, 2010 this sequence version replaced NM_009465.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046618.1, X63535.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC119211.8         96496-96528         c
            34-192              AK033237.1         3-161
            193-4159            BC050914.1         1-3967
            4160-5084           AC162614.2         16307-17231
FEATURES             Location/Qualifiers
     source          1..5084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 14.02 cM"
     gene            1..5084
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /note="AXL receptor tyrosine kinase"
                     /db_xref="GeneID:26362"
                     /db_xref="MGI:MGI:1347244"
     exon            1..319
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2922
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tyrosine-protein kinase receptor UFO;
                     adhesion-related kinase; ufo oncogene homolog"
                     /codon_start=1
                     /product="tyrosine-protein kinase receptor UFO isoform 1
                     precursor"
                     /protein_id="NP_033491.2"
                     /db_xref="CCDS:CCDS20996.1"
                     /db_xref="GeneID:26362"
                     /db_xref="MGI:MGI:1347244"
                     /translation="MGRVPLAWWLALCCWGCAAHKDTQTEAGSPFVGNPGNITGARGL
                     TGTLRCELQVQGEPPEVVWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQ
                     LSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPP
                     EPVTLLWLQDAVPLAPVTGHSSQHSLQTPGLNKTSSFSCEAHNAKGVTTSRTATITVL
                     PQRPHHLHVVSRQPTELEVAWTPGLSGIYPLTHCNLQAVLSDDGVGIWLGKSDPPEDP
                     LTLQVSVPPHQLRLEKLLPHTPYHIRISCSSSQGPSPWTHWLPVETTEGVPLGPPENV
                     SAMRNGSQVLVRWQEPRVPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRP
                     VANLTVSVTAYTSAGDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPRAFSWPWWYVLLG
                     ALVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLN
                     SLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIA
                     ICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHS
                     FLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCV
                     ADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRG
                     QTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDLE
                     NTLKALPPAQEPDEILYVNMDEGGSHLEPRGAAGGADPPTQPDPKDSCSCLTAADVHS
                     AGRYVLCPSTAPGPTLSADRGCPAPPGQEDGA"
     exon            320..545
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            546..646
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            647..823
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            824..904
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1020
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1231
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1371
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1522
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1549
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1682
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1774
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1870
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1948
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2041
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2163
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2273
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2433
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2570
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..5084
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3938..3943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /note="hexamer: ATTAAA"
     polyA_site      3955
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
     regulatory      4289..4294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /note="hexamer: CATAAA"
     polyA_site      4311
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /note="major polyA site"
     regulatory      4475..4480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
                     /note="hexamer: AATAAA"
     polyA_site      4503
                     /gene="Axl"
                     /gene_synonym="Ark; Tyro7; Ufo"
ORIGIN      
        1 agagggggag ccaggggcgg ggaaagaagt ctgggagtga gagaatgagg cagggtagcc
       61 gggaaggcgg ctagctgcgg aggagttgag ccagccgagg ggctcccgct gtgccaggcg
      121 ggcagtgcca aatcccagga gcccaggggt ggggggaggg ccggggacaa cccggccctg
      181 ccccctttcc tagcgaggtg cccatcaact tcggaagaaa gtttggcatc aatctgagct
      241 gttggtgtct ggaggatggg cagggtcccg ctggcctggt ggttggcgct gtgctgctgg
      301 gggtgtgcag cccataagga cacacagacc gaggctggca gcccgtttgt ggggaaccca
      361 gggaatatca caggtgccag aggactcacg gggacacttc ggtgtgagct ccaggttcag
      421 ggggaacccc ctgaggtggt gtggcttcga gatggacaga tcctagaact ggctgataac
      481 acccagaccc aggtgcctct gggcgaagac tggcaagatg aatggaaagt tgtcagtcag
      541 ctcagaatct cagccctgca actttcagat gcaggggagt accagtgtat ggtgcatcta
      601 gaaggacgga cctttgtgtc tcagccgggc tttgtagggc tggaaggtct cccgtacttc
      661 ctggaggagc ctgaggacaa agctgtgcct gccaacaccc ctttcaacct aagctgccag
      721 gcccagggac ccccggaacc cgtgacccta ctctggcttc aagatgctgt ccccctggcc
      781 ccagtcacag gacacagctc ccagcacagt ctgcaaactc caggcctgaa caagacatct
      841 tctttctcat gtgaagccca caatgccaag ggagtcacca cctcccgcac agccaccatc
      901 acagtgctcc cccagaggcc tcaccatctc cacgtggttt ccagacaacc tacggagcta
      961 gaggtagctt ggacccctgg cctgagtggc atctacccgc tcacccactg caacctgcag
     1021 gccgtgctgt cagacgatgg ggtgggtatc tggctgggaa agtcagatcc tcctgaagac
     1081 cccctcacct tgcaagtatc agtgcccccc caccagcttc ggctggaaaa gctccttcct
     1141 cacaccccgt atcacatccg gatatcctgc agcagcagcc agggcccctc accttggacc
     1201 cactggcttc ctgtggagac cacagaggga gtgcccttgg gtccccctga gaacgttagc
     1261 gccatgcgga atgggagcca ggtcctcgtg cgttggcagg agccaagggt gcccctgcaa
     1321 ggcaccctgt tagggtaccg gctggcatat cgaggccagg acacccccga ggtacttatg
     1381 gatatagggc taactcgaga ggtgaccttg gaactgcggg gggacaggcc tgtggctaac
     1441 ctgactgtgt ctgtgacagc ctatacctcg gctggggatg ggccctggag ccttcctgtg
     1501 cccctagagc cctggcgccc agggcaagga cagccactcc accatctggt gagtgaaccc
     1561 ccacctcgcg ccttctcgtg gccttggtgg tatgtactgc tgggagcact tgtggctgcc
     1621 gcctgcgtcc tcatcttggc cctgttcctt gtccatcgga ggaagaagga gactcgatat
     1681 ggggaggtgt ttgagccaac cgtggaaaga ggtgaactgg tagtcaggta ccgtgtccga
     1741 aagtcctaca gccggcggac cactgaagcc accttgaaca gtctgggcat cagtgaagag
     1801 ctgaaggaga aactacgaga cgtcatggta gatcggcata aggtggcctt ggggaagacc
     1861 ctgggagaag gagaatttgg cgctgtgatg gaaggtcagc tcaatcagga tgactccatc
     1921 ctcaaggtcg ctgtgaagac catgaaaatt gccatctgca caagatcaga gctggaggat
     1981 ttcctgagtg aagctgtctg catgaaggaa tttgaccacc ccaacgtcat gaggctcatt
     2041 ggcgtctgtt ttcagggctc tgacagagag ggtttcccag aacctgtggt catcttgcct
     2101 ttcatgaaac acggagacct acacagtttc ctcctgtact cccggctcgg ggaccagcca
     2161 gtgttcctgc ccactcagat gctagtgaag ttcatggccg acattgccag tggtatggag
     2221 tacctgagta ccaagagatt catacatcgg gacctggctg ccaggaactg catgctgaat
     2281 gagaacatgt ccgtgtgtgt ggcagacttc gggctctcca agaagatcta caacggggat
     2341 tactaccgcc aagggcgcat tgccaagatg ccagtcaagt ggattgctat tgagagtctg
     2401 gcagatcggg tctacaccag caagagcgat gtgtggtcct tcggtgtgac aatgtgggag
     2461 atcgccaccc gaggccaaac tccctatcca ggggtggaga acagtgagat ttacgactac
     2521 ctgcgtcaag gaaatcggct gaaacagcct gtggactgtc tggacggcct gtatgccctg
     2581 atgtctcggt gctgggaact gaaccctcga gaccggccaa gttttgcgga gctccgggaa
     2641 gacttggaga acacactgaa ggctctgccc cctgctcagg agccagatga aatcctctat
     2701 gtcaacatgg atgagggcgg aagccacctt gaaccccgtg gggctgctgg aggagctgac
     2761 cccccaaccc aacctgatcc taaggattcc tgtagctgtc tcactgcagc tgacgtccac
     2821 tcagctggac gctatgtcct ttgtccttct acagccccag gacccactct gtctgctgac
     2881 agaggctgcc cagcacctcc agggcaggag gacggagcct gagacaatct tccacctggg
     2941 acatcctctc aggacccaag ctaggcactg ccactggggg aaagctcacc cccccactcc
     3001 gtcactccag gccttctccc cagatgcaga atggccttcc ctcccttctc agatgcagtc
     3061 catgccttat gcaccctatc cataacagtt tcaagggatc gtctcacatc ttccatccca
     3121 gcgttctaga ttttaaggtt tgagtttaga gttcaaagtt ctcaaagatg atgagtcttt
     3181 ggaccgagat gcttgtttct aggtctgcag cgctgttgct atagacaggc ccactgctcg
     3241 aaggctctga gattctatgg ctctagattt ttctggctct ataattcgtg gcaatgctcc
     3301 catggtttta ggttgcacga ctctgagatt ccaggaccta aggcttctag actttatttt
     3361 tctggagcca ggggtcctgt cagtggaaga ttgtagattt ttaaattcta aagattctag
     3421 gcatgaaggt tctaaggcat actgcttctc cagtttaaca gtttagggct catgttggaa
     3481 tactccagat cataatgttt caaactttta ttttttttaa tttctaagac cccagtgatg
     3541 gtcaactaca gattctgaag ccttatgacc atagattctt ttatataaaa atcctgtatc
     3601 tcaaggaaat atgattctag actctgaaat tccaaagctt taagagtctc cagatggagt
     3661 ttctaagcta tgatgtggtg ataatctaaa gtttagtcca aggttctaga ttcctaagct
     3721 tccacgtcat ctgctcccag gattccagat tattaaactc taaaactcta atgttggcct
     3781 gatcttcgtc tcaggccctg taggatgctg tgggtcctca gcatctaagt cacaagaggc
     3841 tccagttaac gaggactaat gagacaccaa agttctaacc acttctaatg ctggacacct
     3901 ctaggttcta tgctgctttt tgcctttcta gcacataatt aaatgcccaa gaatacatat
     3961 gtctaaagat cttaaatctc taagcactat ggagccaatg ttttgagtgt ctgagattct
     4021 aaaggtccac agtctagagt attaggtacg actccaaggg tgggcgcttg tagccatcct
     4081 aagtcctttc cctccttaag cacctatgct cctcctctcc ttgtgtgggg tacaccccac
     4141 cttaagcctg tgcgatgcac tgggaatgcc tgctttcctc caagggatgg gtcatctccc
     4201 ctcatttggg gccatgttgc cccttgagcc agtcccctat gcctgttctg aagtgtggac
     4261 tctggtgcct ccagagaggc tcagatcaca taaaactttt gtcagtcact attctgtctc
     4321 ttgtgtccat tcaactgtgc tacgtcccct ctccctagag attcggtttc cccactgtga
     4381 gaagaaaggc tcctgtaatc ccaacacctg agcggcaaga ggatggaaag ttagttgcag
     4441 gccatcgtgg cttacctaga gggaccctga cctcaataaa aagaataaga agagtttgag
     4501 ggacacatgg gaatgttttc attagtgaga gtagacatga accatgcaca tagacaaata
     4561 tatacaacca aggaaagtca gactctcaga aagccctgag gaatactccc tctctgtcag
     4621 agagagagag agagagagag agagagagac agagagagag agccagacag agagagcgag
     4681 ccagacagag agagagagag agggatggag ggagagagcg atccccgaca gggtcttaca
     4741 caaacattcc aaagtaacag acatgtgaat tagtgcacat gctcaggcaa acctagccac
     4801 aaatgcaaag gcccagttat gcactcacag taacagaaac atataaaccc acacttgtaa
     4861 atctgcaaac atcagcaggc aggtactcac cagcaatagg aagaaccttt agtaacagac
     4921 acagaacaag cattacacac actcaagaat ccaacatggt gcacataatc ccggcgcttg
     4981 agaggtataa gcagaaagat caagacttca aggttgacct tgatttcaca gagagatgca
     5041 ggccagcctg ggctacatga gactgtctta ataaagaaga aaat
//
