LOCUS       NM_001417411            4408 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus axin 2 (Axin2), transcript variant 2, mRNA.
ACCESSION   NM_001417411 XM_006532057
VERSION     NM_001417411.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4408)
  AUTHORS   Zhu,X., Xu,M., Portal,C., Lin,Y., Ferdinand,A., Peng,T.,
            Morrisey,E.E., Dlugosz,A.A., Castellano,J.M., Lee,V., Seykora,J.T.,
            Wong,S.Y., Iomini,C. and Millar,S.E.
  TITLE     Identification of Meibomian gland stem cell populations and
            mechanisms of aging
  JOURNAL   Nat Commun 16 (1), 1663 (2025)
   PUBMED   39955307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4408)
  AUTHORS   Leybova,L., Biswas,A., Sharan,R., Trejo,B.M., Kim,K.,
            Soto-Muniz,Y., Jones,R.A., Phillips,B.K. and Devenport,D.
  TITLE     Radially patterned morphogenesis of murine hair follicle placodes
            ensures robust epithelial budding
  JOURNAL   Dev Cell 59 (24), 3272-3289 (2024)
   PUBMED   39413781
REFERENCE   3  (bases 1 to 4408)
  AUTHORS   Oh,S.A., Jeon,J., Je,S.Y., Kim,S., Jung,J. and Ko,H.W.
  TITLE     TMEM132A regulates Wnt/beta-catenin signaling through stabilizing
            LRP6 during mouse embryonic development
  JOURNAL   Cell Commun Signal 22 (1), 482 (2024)
   PUBMED   39385148
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4408)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   5  (bases 1 to 4408)
  AUTHORS   Padmanabhan,A., de Soysa,T.Y., Pelonero,A., Sapp,V., Shah,P.P.,
            Wang,Q., Li,L., Lee,C.Y., Sadagopan,N., Nishino,T., Ye,L., Yang,R.,
            Karnay,A., Poleshko,A., Bolar,N., Linares-Saldana,R., Ranade,S.S.,
            Alexanian,M., Morton,S.U., Jain,M., Haldar,S.M., Srivastava,D. and
            Jain,R.
  TITLE     A genome-wide CRISPR screen identifies BRD4 as a regulator of
            cardiomyocyte differentiation
  JOURNAL   Nat Cardiovasc Res 3 (3), 317-331 (2024)
   PUBMED   39196112
REFERENCE   6  (bases 1 to 4408)
  AUTHORS   Mao,J., Wang,J., Liu,B., Pan,W., Farr,G.H. 3rd, Flynn,C., Yuan,H.,
            Takada,S., Kimelman,D., Li,L. and Wu,D.
  TITLE     Low-density lipoprotein receptor-related protein-5 binds to Axin
            and regulates the canonical Wnt signaling pathway
  JOURNAL   Mol Cell 7 (4), 801-809 (2001)
   PUBMED   11336703
REFERENCE   7  (bases 1 to 4408)
  AUTHORS   Mai,M., Qian,C., Yokomizo,A., Smith,D.I. and Liu,W.
  TITLE     Cloning of the human homolog of conductin (AXIN2), a gene mapping
            to chromosome 17q23-q24
  JOURNAL   Genomics 55 (3), 341-344 (1999)
   PUBMED   10049590
REFERENCE   8  (bases 1 to 4408)
  AUTHORS   Hart,M.J., de los Santos,R., Albert,I.N., Rubinfeld,B. and
            Polakis,P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
REFERENCE   9  (bases 1 to 4408)
  AUTHORS   Behrens,J., Jerchow,B.A., Wurtele,M., Grimm,J., Asbrand,C.,
            Wirtz,R., Kuhl,M., Wedlich,D. and Birchmeier,W.
  TITLE     Functional interaction of an axin homolog, conductin, with
            beta-catenin, APC, and GSK3beta
  JOURNAL   Science 280 (5363), 596-599 (1998)
   PUBMED   9554852
REFERENCE   10 (bases 1 to 4408)
  AUTHORS   Sanz,L., Moscat,J. and Diaz-Meco,M.T.
  TITLE     Molecular characterization of a novel transcription factor that
            controls stromelysin expression
  JOURNAL   Mol Cell Biol 15 (6), 3164-3170 (1995)
   PUBMED   7760812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662893.12.
            
            On Mar 4, 2023 this sequence version replaced XM_006532057.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.21658.1,
                                           SRR17784647.233955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               AL662893.12        159593-159953
            362-1312            AL662893.12        161912-162862
            1313-1453           AL662893.12        170199-170339
            1454-1556           AL662893.12        178072-178174
            1557-1697           AL662893.12        180663-180803
            1698-2203           AL662893.12        180951-181456
            2204-2398           AL662893.12        181695-181889
            2399-2629           AL662893.12        182416-182646
            2630-2725           AL662893.12        183270-183365
            2726-2893           AL662893.12        184640-184807
            2894-4408           AL662893.12        188029-189543
FEATURES             Location/Qualifiers
     source          1..4408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 71.83 cM"
     gene            1..4408
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /note="axin 2"
                     /db_xref="GeneID:12006"
                     /db_xref="MGI:MGI:1270862"
     exon            1..361
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     exon            362..1312
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     CDS             498..3020
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /note="axin-like protein; axis inhibition protein 2"
                     /codon_start=1
                     /product="axin-2"
                     /protein_id="NP_001404340.1"
                     /db_xref="GeneID:12006"
                     /db_xref="MGI:MGI:1270862"
                     /translation="MSSAVLVTLLPDPSSSFREDAPRPPVPGEEGETPPCQPSVGKVQ
                     STKPMPVSSNARRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLERE
                     KCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSVVSKQLKPATKTYIRDG
                     IKKQQIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYLEYVRSGGENTAYMSNGGLGSL
                     KVLCGYLPTLNEEEEWTCADLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKR
                     SDPVNPYHVGSGYVFAPATSANDSELSSDALTDDSMSMTDSSVDGVPPYRMGSKKQLQ
                     REMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHSLE
                     ERLQQIREDEEKEGSEQALSSRDGAPVQHPLALLPSGSYEEDPQTILDDHLSRVLKTP
                     GCQSPGVGRYSPRSRSPDHHHQHHHHQQCHTLLPTGGKLPPVAACPLLGGKSFLTKQT
                     TKHVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYSKCKSHPKAPEPLPGE
                     QFCGSRGGTLPKRNAKGTEPGLALSARDGGMSSAAGAPQLPGEEGDRSQDVWQWMLES
                     ERQSKSKPHSAQSIRKSYPLESACAAPGERVSRHHLLGASGHSRSVARAHPFTQDPAM
                     PPLTPPNTLAQLEEACRRLAEVSKPQKQRCCVASQQRDRNHSAAGQAGASPFANPSLA
                     PEDHKEPKKLASVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNY
                     RYYFKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID"
     exon            1313..1453
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1556
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1697
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..2203
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2398
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2629
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2725
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2893
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..4408
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4385..4390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /note="hexamer: ATTAAA"
     polyA_site      4408
                     /gene="Axin2"
                     /gene_synonym="Axi1; Axil; Conductin"
                     /note="major polyA site"
ORIGIN      
        1 agcgcccgga ggacatttgg tgcgcctagt gactgctgga aacaggacct gggttgaaag
       61 ccggccgggc gggggccggg ggcggccgcg gtgggggcgg aggcccactc ggatcttttg
      121 cataaaaggg gcagcggggc gcacgatccc cccccccaaa aaaaacccgg cgcagacctc
      181 gggatcgttg ttttccgtgc accccctcct ccgcctccgc gagactcctc atgttcccca
      241 cgcccgggcg ggcccggggg ggccccgggg cagcctctgc gagtccagcg ggggacccgg
      301 gcaggggctc tgcccgcggc gcctgcgagg tctccgcaag gagtgcgcca gcggatcaat
      361 gagaggaggc tcacatgagc ccctgctgac ttaagagaga ccaagccgat tgctgagagg
      421 aactggaaga agaaaaagga ggaggaggga aaaaaagcaa aacaaaatcc aaactcagtg
      481 agacgctctc cctcaccatg agtagcgccg tgttagtgac tctccttcca gatcccagca
      541 gcagcttccg cgaggatgct ccgcggcccc cggttccggg agaagaaggg gagaccccac
      601 cgtgtcagcc tagtgtgggc aaggtccagt ccaccaaacc tatgcccgtt tcctctaatg
      661 ctaggcggaa tgaagatgga ctgggggagc ccgaggggcg ggcctccccc gattcccctt
      721 tgaccaggtg gaccaagtct ttacactcct tgttgggtga ccaggatggt gcatacctct
      781 tccggacttt cctggagagg gagaaatgtg tggatacgct ggacttctgg tttgcttgta
      841 atgggttcag gcagatgaac ctgaaggata ccaaaacttt gcgagtggcc aaagcaatct
      901 ataagaggta cattgagaac aacagcgttg tctccaagca gctgaagccc gccaccaaga
      961 cctacatacg agatggcatc aagaagcaac agatcggctc ggtcatgttt gaccaggcac
     1021 agaccgagat ccaggcagtg atggaggaaa atgcctacca ggtgttcttg acttctgaca
     1081 tttacctgga atatgtgagg agtggggggg aaaacacagc ttacatgagt aacgggggac
     1141 tggggagcct aaaggtctta tgtggctacc tccccacctt gaatgaagaa gaggagtgga
     1201 cgtgtgccga cctcaagtgc aaactctcac ccaccgtggt tggcttgtcc agcaaaactc
     1261 ttcgggccac cgcgagtgtg agatccacgg aaacagctga aaacggattc aggtccttca
     1321 agagaagcga cccagtcaat ccttatcacg taggttccgg ctatgtcttt gcaccagcca
     1381 ccagcgccaa cgacagcgag ttatccagcg acgcactgac cgacgattcc atgtccatga
     1441 cggacagtag cgtagatgga gtccctcctt accgcatggg gagtaagaaa cagctccaga
     1501 gagagatgca tcgcagtgtg aaggccaatg gccaagtgtc tctacctcat tttccgagaa
     1561 cccaccgcct gcccaaggag atgacgcctg tggaacctgc tgccttcgcc gccgagctca
     1621 tctccaggct ggagaaactg aaactggagc tggaaagccg ccatagtctg gaggagcggc
     1681 tgcagcagat ccgggaggat gaagaaaagg aggggtctga gcaggccctg agctcacggg
     1741 atggagcacc ggtccagcac cccctggccc tcctaccctc cggcagctat gaagaggacc
     1801 cacaaaccat tttggacgac cacctctcca gggtcctcaa gacccccggc tgtcaatccc
     1861 ctggtgtggg tcgctatagc ccacggtccc gctcccccga ccaccaccac cagcaccacc
     1921 accatcagca gtgtcatacc cttcttccga ctgggggcaa gctgcccccc gtggctgctt
     1981 gccccctcct tggaggcaag agcttcctga ccaaacagac gacgaagcac gttcaccacc
     2041 actacatcca ccaccacgct gtccccaaga ccaaggagga gatcgaggca gaagccacac
     2101 agagagtccg ctgcctctgt cctgggggaa cagattatta ttgctactcc aaatgcaaaa
     2161 gccacccaaa ggctccagag cccctgcctg gggagcagtt ttgtggcagc agaggtggta
     2221 ccttgccaaa acggaatgca aagggcaccg aaccgggtct tgcactgtcg gccagggatg
     2281 gagggatgtc cagtgcagcg ggggcccccc agcttcctgg ggaagaagga gaccggtcac
     2341 aggatgtctg gcagtggatg ttagagagtg agcggcagag caagtccaag ccccatagtg
     2401 cccaaagcat aagaaagagc tacccattgg agtctgcctg tgcggcccca ggagaacgag
     2461 tcagccggca ccatctgttg ggggccagcg gacactcccg ctcggtggcc cgggctcacc
     2521 catttaccca ggaccctgca atgcctcccc ttaccccacc caacactttg gcacagctag
     2581 aggaagcctg ccgcaggctg gcagaggtgt cgaagcccca gaagcagcgg tgctgcgtgg
     2641 ccagtcagca gagggacagg aaccactcgg ctgctggtca ggcaggagcc tcacccttcg
     2701 ccaacccaag cctggctcca gaagatcaca aagagccaaa gaaactggca agtgtccacg
     2761 cgctccaggc cagtgagctg gttgtcacct actttttctg tggagaagaa attccataca
     2821 ggaggatgct gaaggctcaa agcttgaccc tgggccactt caaggagcag ctcagcaaaa
     2881 agggaaatta caggtattat ttcaagaagg cgagtgacga atttgcctgc ggagcagttt
     2941 ttgaggagat ctgggacgac gagacagtgc tccccatgta cgaaggcagg atcctgggca
     3001 aagtggagag gatcgactga gccttggcct cctcggcgtg caacctgggc aagcacctcg
     3061 gcgtgcacca tggagccgaa gcccagagac cctgtctcag gcctacgcaa cagccacgaa
     3121 atattctgaa ggaaaatgaa accaattaag aagacaaagc ctagggaggg actggcgcct
     3181 gggccttcag gagggcgggg gtagttgatc ttcagtctcc aggagcctgg gtaccgagat
     3241 gagaaaagcc tgaactattt attcaaaaca tgaccactct gggctataga agatgctgag
     3301 tgtgtttgag agactgacat acataataga tgacttccta gggttctgaa attcatagac
     3361 taagagaaaa ctgtgtatag cttgcccgaa caggagtcct tactgatatt tattgaacag
     3421 tcgattcccc tacccgccct ccctaccccc agcccccagt ttatgctgct ttaaacctgg
     3481 aagtgggagt gagaagtttg gattgctgtc cacgcttagg agccaagccg ggaatgcatt
     3541 aatcatttct tcgttaacag aggaatctgc tctgcatggc atttctccaa gtgaagacag
     3601 gcttcttttt ttttttttta aatggtgccc gccccaccca tcgacacatg cagaaatggg
     3661 tcacccccac cccaccccac cccccgccat gctgctctgc ttgtcacaga cgtcctgtgg
     3721 gttggttgtg acagcatctt caccactttg gggaccatcc agagtggggg agtgggggag
     3781 acttcaccct ggagccaaag gctacaccgt acgtgtagtc ccagagcccg tcacagccct
     3841 tgtggttcaa gcttcttctg cctctttagg aagtgagggt ttcttgttct cctttaaaaa
     3901 tcagtctcta gactacggcc atcaggaatc taccctcgcc cacctgaccc tgcgaggaca
     3961 cgggcaccca gcagcacctc tcctctgtta ccttcccctt ggcgatcgct cgggtttgtg
     4021 ttaagttaat ctgtatgtcc tgtctgccag cgttccctgt actataggcc tgtgtatagt
     4081 gtagggcaga gcgttgaccc actggctagt gcttgacttg ggaatcagga cagtacctgt
     4141 acaggcacgg ggacccgctc cgtccgtgcg ccgccctata ttgagggctc cagctctccc
     4201 ttggtttttg aaaggggttt atgtataaat atattttatg cctttttatt acaagtcttg
     4261 ttactcaatg acttttgtca tggcagtttg ttctacttta gactgtaaat tatgcattat
     4321 aaagagttca tttaaagaaa actacttggt acaataatta ttgtaattaa gagatgtagc
     4381 ctttattaaa attttatatt tttcaaaa
//
