LOCUS       NM_009733               3776 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus axin 1 (Axin1), transcript variant 2, mRNA.
ACCESSION   NM_009733 XM_128515
VERSION     NM_009733.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3776)
  AUTHORS   Li,M., Wang,Y., Wei,X., Cai,W.F., Wu,J., Zhu,M., Wang,Y., Liu,Y.H.,
            Xiong,J., Qu,Q., Chen,Y., Tian,X., Yao,L., Xie,R., Li,X., Chen,S.,
            Huang,X., Zhang,C., Xie,C., Wu,Y., Xu,Z., Zhang,B., Jiang,B.,
            Wang,Z.C., Li,Q., Li,G., Lin,S.Y., Yu,L., Piao,H.L., Deng,X.,
            Han,J., Zhang,C.S. and Lin,S.C.
  TITLE     AMPK targets PDZD8 to trigger carbon source shift from glucose to
            glutamine
  JOURNAL   Cell Res 34 (10), 683-706 (2024)
   PUBMED   38898113
REFERENCE   2  (bases 1 to 3776)
  AUTHORS   Li,Z., Zhao,J., Wu,Y., Fan,S., Yuan,H., Xia,J., Hu,L., Yang,J.,
            Liu,J., Wu,X., Lin,R. and Yang,L.
  TITLE     TRAF2 decrease promotes the TGF-beta-mTORC1 signal in MAFLD-HCC
            through enhancing AXIN1-mediated Smad7 degradation
  JOURNAL   FASEB J 38 (4), e23491 (2024)
   PUBMED   38363556
  REMARK    GeneRIF: TRAF2 decrease promotes the TGF-beta-mTORC1 signal in
            MAFLD-HCC through enhancing AXIN1-mediated Smad7 degradation.
REFERENCE   3  (bases 1 to 3776)
  AUTHORS   Garrett,S., Asada,M.C. and Sun,J.
  TITLE     Axin1's mystique in manipulating microbiome amidst colitis
  JOURNAL   Gut Microbes 15 (2), 2286674 (2023)
   PUBMED   38010886
  REMARK    GeneRIF: Axin1's mystique in manipulating microbiome amidst
            colitis.
REFERENCE   4  (bases 1 to 3776)
  AUTHORS   Schaeffer,S., Gupta,B., Calatayud,A.L., Calderaro,J., Caruso,S.,
            Hirsch,T.Z., Pelletier,L., Zucman-Rossi,J. and Rebouissou,S.
  TITLE     RSK2 inactivation cooperates with AXIN1 inactivation or
            beta-catenin activation to promote hepatocarcinogenesis
  JOURNAL   J Hepatol 79 (3), 704-716 (2023)
   PUBMED   37201672
  REMARK    GeneRIF: RSK2 inactivation cooperates with AXIN1 inactivation or
            beta-catenin activation to promote hepatocarcinogenesis.
REFERENCE   5  (bases 1 to 3776)
  AUTHORS   Xie,R., Yi,D., Zeng,D., Jie,Q., Kang,Q., Zhang,Z., Zhang,Z.,
            Xiao,G., Chen,L., Tong,L. and Chen,D.
  TITLE     Specific deletion of Axin1 leads to activation of beta-catenin/BMP
            signaling resulting in fibular hemimelia phenotype in mice
  JOURNAL   Elife 11, e80013 (2022)
   PUBMED   36541713
  REMARK    GeneRIF: Specific deletion of Axin1 leads to activation of
            beta-catenin/BMP signaling resulting in fibular hemimelia phenotype
            in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3776)
  AUTHORS   Ebersole,T., Lai,F. and Artzt,K.
  TITLE     New molecular markers for the distal end of the t-complex and their
            relationships to mutations affecting mouse development
  JOURNAL   Genetics 131 (1), 175-182 (1992)
   PUBMED   1350556
REFERENCE   7  (bases 1 to 3776)
  AUTHORS   Ruvinsky,A.O. and Agulnik,A.I.
  TITLE     Gametic imprinting and the manifestation of the fused gene in the
            house mouse
  JOURNAL   Dev Genet 11 (4), 263-269 (1990)
   PUBMED   2090373
REFERENCE   8  (bases 1 to 3776)
  AUTHORS   Lyon,M.F. and Bechtol,K.B.
  TITLE     Derivation of mutant t-haplotypes of the mouse by presumed
            duplication or deletion
  JOURNAL   Genet Res 30 (1), 63-76 (1977)
   PUBMED   924142
REFERENCE   9  (bases 1 to 3776)
  AUTHORS   Key,M. and Hollander,W.F.
  TITLE     Thin fur, a recessive mutant on chromosome 17 of the mouse
  JOURNAL   J Hered 63 (2), 97-98 (1972)
   PUBMED   5031320
REFERENCE   10 (bases 1 to 3776)
  AUTHORS   Deol,M.S.
  TITLE     The probable mode of gene action in the circling mutants of the
            mouse
  JOURNAL   Genet Res 7 (3), 363-371 (1966)
   PUBMED   5940872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140047.8 and AC126438.3.
            
            On Apr 16, 2021 this sequence version replaced NM_009733.2.
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            exon in the 3' coding region compared to variant 1, resulting in a
            longer protein (isoform 2) compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011544.1, AF009011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               AC140047.8         158325-158678
            355-1313            AC140047.8         162255-163213
            1314-1454           AC126438.3         131472-131612       c
            1455-1551           AC126438.3         122666-122762       c
            1552-1689           AC126438.3         120938-121075       c
            1690-2207           AC126438.3         117031-117548       c
            2208-2378           AC126438.3         116508-116678       c
            2379-2624           AC126438.3         115021-115266       c
            2625-2732           AC126438.3         112629-112736       c
            2733-2900           AC126438.3         111146-111313       c
            2901-3776           AC126438.3         109442-110317       c
FEATURES             Location/Qualifiers
     source          1..3776
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.07 cM"
     gene            1..3776
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /note="axin 1"
                     /db_xref="GeneID:12005"
                     /db_xref="MGI:MGI:1096327"
     exon            1..354
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     exon            355..1313
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..3027
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein Fused; axis inhibition protein 1"
                     /codon_start=1
                     /product="axin-1 isoform 2"
                     /protein_id="NP_033863.3"
                     /db_xref="CCDS:CCDS28547.2"
                     /db_xref="GeneID:12005"
                     /db_xref="MGI:MGI:1096327"
                     /translation="MNVQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSF
                     CSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPYLRWAESLHSLLDDQDGISLF
                     RTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNGIVSRQT
                     KPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRTGSESP
                     KVCSDQSSGSGTGKGMSGYLPTLNEDEEWKCDQDADEDDGRDPLPPSRLTQKLLLETA
                     APRAPSSRRYNEGRELRYGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADTLS
                     LTDSSVDGIPPYRIRKQHRREMQESIQVNGRVPLPHIPRTYRMPKEIRVEPQKFAEEL
                     IHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGEMPSGPMASHKLPSVPAWHHFPPRY
                     VDMGCSGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSGHVAKTAVLGGTA
                     SGHGKHVPKLGLKLDTAGLHHHRHVHHHVHHNSARPKEQMEAEVARRVQSSFSWGPET
                     HGHAKPRSYSENAGTTLSAGDLAFGGKTSAPSKRNTKKAESGKNANAEVPSTTEDAEK
                     NQKIMQWIIEGEKEISRHRKAGHGSSGLRKQQAHESSRPLSIERPGAVHPWVSAQLRN
                     SVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRANKLPSKQRYVQAVMQRGR
                     TCVRPACAPVLSVVPAVSDLELSETETKSQRKAGGGSAPPCDSIVVAYYFCGEPIPYR
                     TLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKII
                     GKVEKVD"
     exon            1314..1454
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1551
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1689
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..2207
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2378
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2624
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2732
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2900
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3776
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3754..3759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /note="hexamer: AATAAA"
     polyA_site      3776
                     /gene="Axin1"
                     /gene_synonym="Axin; Fu; fused; Kb; Ki; kinky; knobbly"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggc ggcgccggcg ggggcgctca ggcctgggct tcagggctct gggctcaggc
       61 tcccggctca gggaagcgct tgcggccgcc gccgcaggag cctgctgggg tcgggctgga
      121 gcctggttcc agagagggct ggtgagagtg agcagccggt tttggcggcg ctctgcggcc
      181 tgccttgcgc cgcctccggg ccacgggtcg ccgagccgcc gccgccgccg cgatgggggc
      241 cccccagggc cgcgcccccg ccgtggcccg cccgctgagc cgccgctgag cgcatgggcc
      301 tcgccgggcc gggagccagg ccccgggccg cgcctccaca gccgccgcgc gctggagaga
      361 ttgattccct tgggagctgt aagtactgag gtattagggt gcagcgctca ttgttcactg
      421 atgcagagtc ccaaaatgaa tgtccaggag cagggtttcc ccttggacct cggagcaagt
      481 ttcaccgaag atgccccccg gcccccagtg cctggagaag agggagaact ggtatctact
      541 gattcgaggc ctgtcaacca cagtttctgt tctgggaaag gtaccagcat taaaagtgag
      601 acctcaacag ccaccccaag acgttcagat ctggatctgg gatatgagcc cgagggcagt
      661 gcctccccca ccccaccata tttgaggtgg gctgagtcac tgcattcctt actggatgac
      721 caagatggga tcagcctgtt caggactttc ctgaagcagg agggctgtgc tgacctgctg
      781 gacttctggt ttgcctgcag tggcttcagg aagcttgagc cctgtgactc aaatgaggaa
      841 aagaggctga agctggcaag agccatctac cgaaagtaca tcctggatag caatggcatt
      901 gtgtccagac aaaccaagcc agccactaag agcttcataa aggactgtgt catgaagcag
      961 cagatagatc ctgccatgtt tgaccaggca cagacagaaa tccagtccac catggaggag
     1021 aatacctacc cttcctttct taagtctgac atttatttgg agtacacaag gacaggctca
     1081 gagagtccga aggtctgcag tgaccagagc tcagggtctg gaacagggaa gggcatgtct
     1141 ggatacctgc ccactttgaa tgaggatgaa gaatggaaat gtgaccaaga tgcagatgag
     1201 gatgatggcc gagaccctct cccccccagc aggctcaccc agaagctgct attggagact
     1261 gctgccccga gggccccctc aagtagacgg tacaacgaag gcagagagct caggtatgga
     1321 tcttggaggg agcccgtcaa cccctactac gtcaactctg gctatgccct ggccccagcc
     1381 accagtgcca atgacagtga gcagcagagc ctgtccagtg atgctgacac gctatccctt
     1441 acggacagta gtgtggatgg aatcccccca tacaggatcc gtaagcagca ccgaagggag
     1501 atgcaggaga gtatccaagt caatgggcgg gtacctctac ctcacattcc tcgcacttac
     1561 cgaatgccaa aggagatccg ggtagagcca cagaaatttg ctgaagagct tattcaccgt
     1621 ctagaggctg tccagcgcac tcgagaggct gaagaaaagt tggaggaacg gctgaagcgt
     1681 gtacgcatgg aggaagaagg ggaggatggt gaaatgcctt ctggccccat ggcaagtcac
     1741 aagctgcctt ctgtcccagc ttggcaccat ttcccacccc gctatgtgga tatgggctgc
     1801 tctggactgc gggatgccca tgaggagaat cctgagagca tcctggatga gcacgtgcaa
     1861 agggtcatga ggacacctgg ctgccagtca cctggcccag gccaccgctc tcctgacagt
     1921 gggcatgtgg ctaagactgc agtgctaggg ggtacagcct ccgggcatgg gaagcatgtt
     1981 cctaagttag ggttgaagct ggatacagct ggcctgcacc atcatagaca tgtccaccac
     2041 catgttcacc ataattcagc tagacctaag gagcaaatgg aggctgaagt tgcccgcagg
     2101 gtccagagca gcttctcgtg gggcccagaa acacatggtc atgccaagcc ccggagctat
     2161 tccgagaacg caggcaccac cctcagtgct ggggatttgg cctttggtgg taaaactagt
     2221 gcaccttcca aaagaaacac caagaaggct gaatctggga agaatgccaa tgctgaggta
     2281 cccagtacca cagaggacgc tgagaagaac cagaagatca tgcagtggat cattgaggga
     2341 gagaaggaga tcagtagaca ccggaaggca ggccatgggt cttctgggtt gaggaagcag
     2401 caggcccatg aaagctccag gcccttgtcc atcgagcgtc ctggggccgt gcacccctgg
     2461 gtcagcgctc agcttcggaa ttctgtccag ccttctcatc ttttcatcca agatcccaca
     2521 atgccaccca atccagcccc taatcccctg acccagctgg aagaggcccg caggcgtttg
     2581 gaagaagaag aaaagagagc aaacaaactg ccctccaagc agaggtatgt gcaggcagtc
     2641 atgcagcggg gacgcacctg tgtcaggcca gcttgtgcac cggtgctgag tgtggtacca
     2701 gccgtgtcgg acttggaact ctccgagaca gagacaaaat cacaaagaaa ggcaggtggc
     2761 gggagtgcac caccatgtga cagcattgtt gtggcctact atttctgtgg ggaacccatc
     2821 ccctaccgga ccctggtgag gggccgtgct gtcaccctgg gccagttcaa ggagctgcta
     2881 accaagaagg ggagctacag atactacttt aagaaagtga gtgatgagtt tgactgtggt
     2941 gtggtatttg aggaagtacg ggaggatgag gccgtcttgc ctgtctttga agaaaagatc
     3001 atcggcaagg tggaaaaggt ggactgagca ctgggcagca cacccggagc acaccatcac
     3061 tactgtgcac tgtcatcagt caggtggaca gccttgtcct caggagcctg gtgtggggaa
     3121 caacacaaga ttgtgtcatg agctcttcta tcggggtgag gctggggacc ttaggtgtct
     3181 gccagcctct gtccctctgg ctttgggaaa gtgggggtgg ggggtcgtcc tactgagtgg
     3241 ttccttgggt ttctctgttt tgctgttcaa gaggaaagtt ccacttacca ccacattacc
     3301 ccctgaagca ataccaggag ccatctcatg accctcagca gctcttgctt ctgaatccag
     3361 tctgacctag ggatactttg ccctgggctt gtatcccact gtcctcttct ctctctctgg
     3421 gacctatcca ctgcacctgg ttgggctcag gtccaggagc aggggatcct gtgggggcct
     3481 ctatatattg tacatgtcac tgagtgcctt caacatagct gtctcttgcc tgccactgtg
     3541 tgaatctggc agctgagtat ctcaggcccc tttgcctgtc tctagccacc agcttggttc
     3601 agcaggaggg ggggcggtgt gtctggtccc ttccaagtgt ccgtgtaaat atgtacattt
     3661 ctcaggccag ggccagcagg gggataccct gagcccattt ttcatgcaat gacttgtaca
     3721 attatctttt caaaggtact tggataataa tgaaataaaa acgtttttga accttc
//
