LOCUS       NM_019404               1812 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus arginine vasopressin receptor 2 (Avpr2), transcript
            variant 1, mRNA.
ACCESSION   NM_019404
VERSION     NM_019404.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Jang,H.J., Park,H.J., Choi,H.S., Jung,H.J. and Kwon,T.H.
  TITLE     Genome-Engineered mpkCCDc14 Cells as a New Resource for Studying
            AQP2
  JOURNAL   Int J Mol Sci 24 (2), 1684 (2023)
   PUBMED   36675199
  REMARK    GeneRIF: Genome-Engineered mpkCCDc14 Cells as a New Resource for
            Studying AQP2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Jamadar,A., Dwivedi,N., Mathew,S., Calvet,J.P., Thomas,S.M. and
            Rao,R.
  TITLE     Vasopressin Receptor Type-2 Mediated Signaling in Renal Cell
            Carcinoma Stimulates Stromal Fibroblast Activation
  JOURNAL   Int J Mol Sci 23 (14), 7601 (2022)
   PUBMED   35886951
  REMARK    GeneRIF: Vasopressin Receptor Type-2 Mediated Signaling in Renal
            Cell Carcinoma Stimulates Stromal Fibroblast Activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Schmid,T., Boehm,U. and Braun,T.
  TITLE     GnRH neurogenesis depends on embryonic pheromone receptor
            expression
  JOURNAL   Mol Cell Endocrinol 518, 111030 (2020)
   PUBMED   32931849
REFERENCE   4  (bases 1 to 1812)
  AUTHORS   Sakai,K., Yamazaki,O., Ishizawa,K., Tamura,Y., Wang,Q., Ueno,M.,
            Hayama,Y., Fujigaki,Y. and Shibata,S.
  TITLE     Upregulation of renal Na-K-2Cl cotransporter 2 in obese diabetes
            mellitus via a vasopressin receptor 2-dependent pathway
  JOURNAL   Biochem Biophys Res Commun 524 (3), 710-715 (2020)
   PUBMED   32035616
  REMARK    GeneRIF: Upregulation of renal Na-K-2Cl cotransporter 2 in obese
            diabetes mellitus via a vasopressin receptor 2-dependent pathway.
REFERENCE   5  (bases 1 to 1812)
  AUTHORS   Wang,F., Xu,C., Luo,R., Peng,K., Ramkumar,N., Xie,S., Lu,X.,
            Zhao,L., Zuo,C.J., Kohan,D.E. and Yang,T.
  TITLE     Site-1 protease-derived soluble (pro)renin receptor targets
            vasopressin receptor 2 to enhance urine concentrating capability
  JOURNAL   JCI Insight 4 (7), 124174 (2019)
   PUBMED   30944256
  REMARK    GeneRIF: Site-1 protease-derived (S1P-derived) soluble (pro)renin
            receptor (sPRR) participates in regulation of fluid homeostasis via
            targeting V2R. PF-429242 (S1P inhibitor) treatment or renal
            tubule-specific deletion of S1P impaired mice urine concentrating
            capability, which was rescued by sPRR-His. S1P-derived sPRR exerts
            a key role in determining renal V2R expression and, thus, urine
            concentrating capability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1812)
  AUTHORS   Yun,J., Schoneberg,T., Liu,J., Schulz,A., Ecelbarger,C.A.,
            Promeneur,D., Nielsen,S., Sheng,H., Grinberg,A., Deng,C. and
            Wess,J.
  TITLE     Generation and phenotype of mice harboring a nonsense mutation in
            the V2 vasopressin receptor gene
  JOURNAL   J Clin Invest 106 (11), 1361-1371 (2000)
   PUBMED   11104789
REFERENCE   7  (bases 1 to 1812)
  AUTHORS   Gattone,V.H. 2nd, Maser,R.L., Tian,C., Rosenberg,J.M. and
            Branden,M.G.
  TITLE     Developmental expression of urine concentration-associated genes
            and their altered expression in murine infantile-type polycystic
            kidney disease
  JOURNAL   Dev Genet 24 (3-4), 309-318 (1999)
   PUBMED   10322639
REFERENCE   8  (bases 1 to 1812)
  AUTHORS   Arend,L.J., Smart,A. and Briggs,J.P.
  TITLE     Metanephric rat-mouse chimeras to study cell lineage of the nephron
  JOURNAL   Dev Genet 24 (3-4), 230-240 (1999)
   PUBMED   10322631
REFERENCE   9  (bases 1 to 1812)
  AUTHORS   Frattini,A., Chatterjee,A., Faranda,S., Sacco,M.G., Villa,A.,
            Herman,G.E. and Vezzoni,P.
  TITLE     The chromosome localization and the HCF repeats of the human host
            cell factor gene (HCFC1) are conserved in the mouse homologue
  JOURNAL   Genomics 32 (2), 277-280 (1996)
   PUBMED   8833156
REFERENCE   10 (bases 1 to 1812)
  AUTHORS   Faust,C.J., Gonzales,J.C., Seibold,A., Birnbaumer,M. and
            Herman,G.E.
  TITLE     Comparative mapping on the mouse and human X chromosomes of a human
            cDNA clone encoding the vasopressin renal-type receptor (AVP2R)
  JOURNAL   Genomics 15 (2), 439-441 (1993)
   PUBMED   8449515
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL672002.14 and BC104729.1.
            
            On Jan 26, 2013 this sequence version replaced NM_019404.1.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor 1 family and the vasopressin/oxytocin receptor subfamily.
            The encoded protein is an arginine vasopressin receptor which, when
            stimulated, activates the Gs protein/adenylyl cyclase signaling
            cascade and is involved in water and electrolyte homeostasis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ310753.1, BC105662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL672002.14        10443-10450
            9-1571              BC104729.1         1-1563
            1572-1812           AL672002.14        12529-12769
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.46 cM"
     gene            1..1812
                     /gene="Avpr2"
                     /gene_synonym="ADHR; DI1; DIR; ND1; V2R; VPV2R"
                     /note="arginine vasopressin receptor 2"
                     /db_xref="GeneID:12000"
                     /db_xref="MGI:MGI:88123"
     exon            1..167
                     /gene="Avpr2"
                     /gene_synonym="ADHR; DI1; DIR; ND1; V2R; VPV2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1258
                     /gene="Avpr2"
                     /gene_synonym="ADHR; DI1; DIR; ND1; V2R; VPV2R"
                     /note="isoform a is encoded by transcript variant 1;
                     vasopressin V2 receptor; antidiuretic hormone receptor;
                     renal-type arginine vasopressin receptor; nephrogenic
                     diabetes insipidus"
                     /codon_start=1
                     /product="vasopressin V2 receptor isoform a"
                     /protein_id="NP_062277.1"
                     /db_xref="CCDS:CCDS30216.1"
                     /db_xref="GeneID:12000"
                     /db_xref="MGI:MGI:88123"
                     /translation="MILVSTTSAVPGALSSPSSPSNSSQEELLDDRDPLLVRAELALL
                     STIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDAT
                     DRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPV
                     LVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPA
                     LGIAACQVLIFREIHASLVPGPSERAGRRRRGHRTGSPSEGAHVSAAMAKTVRMTLVI
                     VIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSS
                     ELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS"
     exon            168..1052
                     /gene="Avpr2"
                     /gene_synonym="ADHR; DI1; DIR; ND1; V2R; VPV2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1812
                     /gene="Avpr2"
                     /gene_synonym="ADHR; DI1; DIR; ND1; V2R; VPV2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Avpr2"
                     /gene_synonym="ADHR; DI1; DIR; ND1; V2R; VPV2R"
                     /note="hexamer: AATAAA"
     polyA_site      1812
                     /gene="Avpr2"
                     /gene_synonym="ADHR; DI1; DIR; ND1; V2R; VPV2R"
                     /note="major polyA site"
ORIGIN      
        1 tgtgaacaca cctacggaaa ggcatctgcc tcctggcacc tctatctggt gcagtgaccc
       61 tgggcagtgg gactggcccc ttgagtggag actaagttgg cctcctgtga caggtgtgcc
      121 gctcatcatc agccaccaca ccatgatcct ggtgtctacc acgtctgcag tgcctggggc
      181 cctttcgtcc cctagctctc ccagcaacag cagccaggag gagctactgg atgaccgaga
      241 cccgctgtta gtccgggctg aactggccct gctatctaca atttttgtgg ctgtggcctt
      301 gagcaatggc ctagtgcttg gggccctaat acgacggggt cggcgtggac gctgggcacc
      361 catgcacgtc ttcatcagtc atttgtgcct agctgacctg gctgtggctc tgtttcaagt
      421 gctgccccag ctggcttggg atgccaccga ccgcttccat ggccctgatg ccttgtgtcg
      481 ggccgtcaag tacctgcaga tggtgggcat gtatgcctct tcctacatga tcctggccat
      541 gacactagac cgccatcgcg ccatctgccg ccctatgctg gcataccgcc atggaggtgg
      601 ggctcgctgg aacaggccag tgctggtggc ctgggccttc tcactccttc tcagcctgcc
      661 tcagctcttc atctttgctc aacgtgatgt gggaaatggc agtggggtat ttgattgctg
      721 ggcccgattt gcagagccat ggggccttcg tgcctatgtc acctggatcg ccttgatggt
      781 gtttgtggca cctgccctag gcattgctgc ctgccaggtt cttatcttcc gggagataca
      841 tgccagtctg gtgccagggc catctgaaag ggcagggagg cgccgcagag gacaccggac
      901 aggaagtccc agcgagggag cccatgtatc agcagccatg gccaagaccg tgaggatgac
      961 actggtgatt gtgattgtct acgtgctgtg ctgggcaccc ttcttccttg tgcagctgtg
     1021 ggcagcgtgg gatccagaag ctcctctgga aagacccccc tttgtgttgc tcatgctgct
     1081 ggctagcctt aacagctgta ccaacccctg gatctatgct tccttcagta gcagtgtctc
     1141 ctcggagttg cgtagcctgc tttgctgtgc tcagaggcac accacacaca gcctgggtcc
     1201 tcaagatgag tcctgtgcca cagccagctc ctctctgatg aaggatacac cctcctgagt
     1261 agctactggg ctctttctat tcaaaaaccc attgtagctt agctgactat ctagggttgg
     1321 ccctgggagt accaagaaag ggtaccttgg ttatccttgg tcctccctag gtgacattgt
     1381 ccccaggtat acaagaagga agggtgtaaa gaaaccttaa cattggctcc tttgttgcca
     1441 gacatgggaa gcaactggga cagatgcctc aaggtctagg aggagaatag gcaacagagg
     1501 cacttgggct tcccattctg gcaagtactc tgcaggtgag gaagactccc agggagctgg
     1561 aagaaggacc aggataggac caatagacct tcctgtcatt cctccctctg tctgtctccc
     1621 taataaaagt tgcagttcat tttccacatg gaaaaaattt ccttggacca ggtatatggt
     1681 gggcacagaa gctgaaatac aaagattcgc acacccatag acatacctat gttcaggaat
     1741 ctgtgatata agcaaccaag actgtatttt tgagagcagg tccccaggtg aaaataaaca
     1801 gctccatgtc aa
//
