LOCUS       NM_016847               2671 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus arginine vasopressin receptor 1A (Avpr1a), mRNA.
ACCESSION   NM_016847
VERSION     NM_016847.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Kader,L., Willits,A.B., Meriano,S., Christianson,J.A., La,J.H.,
            Feng,B., Knight,B., Kosova,G., Deberry,J.J., Coates,M.D.,
            Hyams,J.S., Baumbauer,K.M. and Young,E.E.
  TITLE     Identification of Arginine-Vasopressin Receptor 1a (Avpr1a/Avpr1a)
            as a Novel Candidate Gene for Chronic Visceral Pain Sheds Light on
            the Potential Role of Enteric Neurons in the Development of
            Visceral Hypersensitivity
  JOURNAL   J Pain 25 (9), 104572 (2024)
   PUBMED   38768798
  REMARK    GeneRIF: Identification of Arginine-Vasopressin Receptor 1a
            (Avpr1a/Avpr1a) as a Novel Candidate Gene for Chronic Visceral Pain
            Sheds Light on the Potential Role of Enteric Neurons in the
            Development of Visceral Hypersensitivity.
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Hayashi,H., Shimizu,K., Nakamura,K., Nishimori,K. and Kondo,Y.
  TITLE     The bilevel chamber revealed differential involvement of
            vasopressin and oxytocin receptors in female mouse sexual behavior
  JOURNAL   PLoS One 19 (6), e0304703 (2024)
   PUBMED   38900750
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Yamaguchi,Y., Maekawa,Y., Kabashima,K., Mizuno,T., Tainaka,M.,
            Suzuki,T., Dojo,K., Tominaga,T., Kuroiwa,S., Masubuchi,S., Doi,M.,
            Tominaga,K., Kobayashi,K., Yamagata,S., Itoi,K., Abe,M.,
            Schwartz,W.J., Sakimura,K. and Okamura,H.
  TITLE     An intact pituitary vasopressin system is critical for building a
            robust circadian clock in the suprachiasmatic nucleus
  JOURNAL   Proc Natl Acad Sci U S A 120 (43), e2308489120 (2023)
   PUBMED   37844254
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Tsuchiya,H., Fujinoki,M., Azuma,M. and Koshimizu,T.A.
  TITLE     Vasopressin V1a receptor and oxytocin receptor regulate murine
            sperm motility differently
  JOURNAL   Life Sci Alliance 6 (4), e202201488 (2023)
   PUBMED   36650057
  REMARK    GeneRIF: Vasopressin V1a receptor and oxytocin receptor regulate
            murine sperm motility differently.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2671)
  AUTHORS   Bielsky,I.F., Hu,S.B., Szegda,K.L., Westphal,H. and Young,L.J.
  TITLE     Profound impairment in social recognition and reduction in
            anxiety-like behavior in vasopressin V1a receptor knockout mice
  JOURNAL   Neuropsychopharmacology 29 (3), 483-493 (2004)
   PUBMED   14647484
REFERENCE   7  (bases 1 to 2671)
  AUTHORS   Hu,S.B., Zhao,Z.S., Yhap,C., Grinberg,A., Huang,S.P., Westphal,H.
            and Gold,P.
  TITLE     Vasopressin receptor 1a-mediated negative regulation of B cell
            receptor signaling
  JOURNAL   J Neuroimmunol 135 (1-2), 72-81 (2003)
   PUBMED   12576226
  REMARK    GeneRIF: Vasopressin receptor 1a-mediated negative regulation of B
            cell receptor signaling.
REFERENCE   8  (bases 1 to 2671)
  AUTHORS   Hollon,T.R., Bek,M.J., Lachowicz,J.E., Ariano,M.A., Mezey,E.,
            Ramachandran,R., Wersinger,S.R., Soares-da-Silva,P., Liu,Z.F.,
            Grinberg,A., Drago,J., Young,W.S. 3rd, Westphal,H., Jose,P.A. and
            Sibley,D.R.
  TITLE     Mice lacking D5 dopamine receptors have increased sympathetic tone
            and are hypertensive
  JOURNAL   J Neurosci 22 (24), 10801-10810 (2002)
   PUBMED   12486173
REFERENCE   9  (bases 1 to 2671)
  AUTHORS   Wesley,V.J., Hawtin,S.R., Howard,H.C. and Wheatley,M.
  TITLE     Agonist-specific, high-affinity binding epitopes are contributed by
            an arginine in the N-terminus of the human oxytocin receptor
  JOURNAL   Biochemistry 41 (16), 5086-5092 (2002)
   PUBMED   11955056
REFERENCE   10 (bases 1 to 2671)
  AUTHORS   Kikuchi,S., Tanoue,A., Goda,N., Matsuo,N. and Tsujimoto,G.
  TITLE     Structure and sequence of the mouse V1a and V1b vasopressin
            receptor genes
  JOURNAL   Jpn J Pharmacol 81 (4), 388-392 (1999)
   PUBMED   10669045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D49730.1.
            
            On Jul 23, 2003 this sequence version replaced NM_016847.1.
            
            Summary: This gene encodes a receptor for arginine vasopressin, a
            neurohypophyseal hormone involved in diuresis inhibition, smooth
            muscle contraction, liver glycogenolysis stimulation and regulation
            of adrenocorticotropic hormone release from the pituitary. This
            receptor represents one of three G protein-coupled arginine
            vasopressin receptors which functions through a
            phosphotidylinositol-calcium second messenger system in vascular
            and hepatic tissues [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49730.1, BC024149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 70.36 cM"
     gene            1..2671
                     /gene="Avpr1a"
                     /gene_synonym="AVPR; Avpr1; V1a; V1aR"
                     /note="arginine vasopressin receptor 1A"
                     /db_xref="GeneID:54140"
                     /db_xref="MGI:MGI:1859216"
     exon            1..1291
                     /gene="Avpr1a"
                     /gene_synonym="AVPR; Avpr1; V1a; V1aR"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..1578
                     /gene="Avpr1a"
                     /gene_synonym="AVPR; Avpr1; V1a; V1aR"
                     /note="V1a arginine vasopressin receptor;
                     vascular/hepatic-type arginine vasopressin receptor;
                     antidiuretic hormone receptor 1a; AVPR V1a"
                     /codon_start=1
                     /product="vasopressin V1a receptor"
                     /protein_id="NP_058543.2"
                     /db_xref="CCDS:CCDS24215.1"
                     /db_xref="GeneID:54140"
                     /db_xref="MGI:MGI:1859216"
                     /translation="MSFPRGSHDLPAGNSSPWWPLTTEGANSSREAAGLGEGGSPPGD
                     VRNEELAKLEVTVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAF
                     FQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTL
                     QQPARRSRLMIAASWGLSFVLSIPQYFIFSVIEFEVNNGTKAQDCWATFIPPWGTRAY
                     VTWMTSGVFVVPVIILGTCYGFICYHIWRNVRGKTASRQSKGGKGSGEAAGPFHKGLL
                     VTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWTPFFIVQMWSVWDTNFVWTDSENPS
                     TTITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCQSIAQKFAKDDSDSMSRRQTS
                     YSNNRSPTNSTGTWKDSPKSSKSIRFIPVST"
     exon            1292..2671
                     /gene="Avpr1a"
                     /gene_synonym="AVPR; Avpr1; V1a; V1aR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1980
                     /gene="Avpr1a"
                     /gene_synonym="AVPR; Avpr1; V1a; V1aR"
                     /note="major polyA site"
     regulatory      2618..2623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Avpr1a"
                     /gene_synonym="AVPR; Avpr1; V1a; V1aR"
                     /note="hexamer: ATTAAA"
     polyA_site      2637
                     /gene="Avpr1a"
                     /gene_synonym="AVPR; Avpr1; V1a; V1aR"
                     /note="major polyA site"
ORIGIN      
        1 gacttggagg ggttgggtgt aggggacagt ctccagccac taagatgaga aggagcgcat
       61 cctgaggcag cctaagactg ctttgggagc agggagagtc cgctcccttg cctcggacaa
      121 gccggagcag ggacacgcaa gaacatccca tccaaaacca ctctgagcgc gcgtgggatt
      181 gcgcagcgaa gagagcgagg taaggaagga cggtgcgcag aacttaggac gcgggtcttc
      241 gggtcctccg tggagaagag gaagcagccc acgaggaaca gggttccccg gctctgtgcc
      301 gacagcatga gtttcccgcg aggctcccac gatctgcccg cgggcaactc cagcccgtgg
      361 tggcctctga ccaccgaggg cgccaacagc agccgggaag cagctgggct cggggaaggc
      421 ggcagcccgc cgggggacgt acgcaacgag gagctggcga agctggaggt taccgtgctg
      481 gcggtgattt tcgtggtggc cgtgctgggt aatagcagtg tgctgctggc gctgcatcgc
      541 acgccacgca agacatcccg catgcatctc ttcatccgac acctcagcct ggcagacctg
      601 gcggtcgcct tcttccaagt gttaccacag ctgtgctggg acatcaccta ccgcttccgc
      661 gggccggact ggctgtgccg ggtggtgaag cacttgcagg tgtttgccat gttcgcatct
      721 tcctacatgc tggtggtgat gacggctgac cgctacatcg ccgtgtgcca cccgctcaag
      781 accctgcagc agcccgcgcg ccgctcgcgc ctcatgatcg ccgcctcttg ggggctgagt
      841 ttcgttctga gcataccaca gtactttatc ttctctgtga tcgaatttga ggtgaacaat
      901 ggcaccaaag cccaagattg ctgggctacc ttcatcccgc cctggggtac ccgtgcctac
      961 gtgacctgga tgaccagcgg ggtcttcgtg gtacccgtga tcatcttggg tacctgctat
     1021 ggcttcatct gttaccacat ctggcgcaat gtccgaggga agacagcatc gcgacagagc
     1081 aaaggcggca agggctctgg ggaagccgcg ggtcccttcc acaaggggct tctggtcacg
     1141 ccttgtgtca gcagcgtgaa gagcatttcc cgtgccaaga tccgcacagt gaagatgacc
     1201 tttgtgattg taagcgccta catcctctgc tggacacctt tcttcatcgt ccagatgtgg
     1261 tcagtctggg ataccaattt cgtttggacc gattccgaaa acccttccac cacgatcacg
     1321 gcgttactgg cttccttgaa cagctgctgc aacccgtgga tctacatgtt ttttagtggt
     1381 catctcctac aagattgtgt ccagagcttc ccatgctgcc aaagcatagc gcagaaattc
     1441 gccaaggatg actcggatag catgagccgg agacagacat cttattctaa caaccgaagc
     1501 ccaacaaaca gcactgggac gtggaaggat tcacctaaat cttcaaagtc catcagattt
     1561 atccctgtct ccacttgagc cgcatatcca cgcagccaga ctcttggacg gggcttgtgt
     1621 gtccagctag agagcttaag agtaaatatg tttatgtgac atagacataa atcaactcag
     1681 tgtatacatt gtttctacaa cttggtgtat acattgtttc tacaattcag tgtatacatt
     1741 gtttctagct gtgtttttcc cattgctgtg accaaaacct gaattctttt gcatagcata
     1801 ttaatgaaaa tgtaccacat gggaaatgta taggcctggt tcgtaagcat actgacttta
     1861 tattttgtgg ttgatttttt tttattgtat ttttatgtct aatgtgaggc ttggattggt
     1921 ttaagtcatg tgataagcac tgttgtttct acacaaagtg aactggtccg tgattgaaaa
     1981 cccagtgttg ctgtcaatct gtgtgtcata aaatgtcagc aagaggtaga gaggagttgg
     2041 gttgagggtg ggaaggaggt agcttggtac ctggctgccc ttccttcaga gtcctgacac
     2101 tctattagca ctgaaaatca tgctcaccaa cagacagaag gtttgagaat gttttaggac
     2161 aataatttgt atgggggggg ggtgccacac tttatagagg cataagagaa aagatttcta
     2221 cagacattct ttgggatatt ttaaacatcc atggaccagc accataaggt agtctgtgct
     2281 acaccagatg ttaacactta gtacctagtc ggtgaatcca gattcagaga ttctaagtct
     2341 cctagataac tccagacata agatactcaa aacatgttga tttaaatcag tttatttatt
     2401 tcttcacatt tcccatccac acagcagggc cagaacacag agggtgaaga catgtggaga
     2461 aacgggagac agacagaaag agaggggggt ctgagccttg tgtctgttcc ttcatgaatg
     2521 tatgattttc agaaagatac ttaaaaatat ttaaagcctt ggtttcttgg ctgtacaatg
     2581 ggcttggtaa cactcacctc acagggttgt tgtgaagatt aaataatgtt aaatgtgtga
     2641 agagttattt ttaaaaaaaa tgtaaagtgc t
//
