LOCUS       NP_058543                423 aa            linear   ROD 12-DEC-2024
DEFINITION  vasopressin V1a receptor [Mus musculus].
ACCESSION   NP_058543
VERSION     NP_058543.2
DBSOURCE    REFSEQ: accession NM_016847.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 423)
  AUTHORS   Kader,L., Willits,A.B., Meriano,S., Christianson,J.A., La,J.H.,
            Feng,B., Knight,B., Kosova,G., Deberry,J.J., Coates,M.D.,
            Hyams,J.S., Baumbauer,K.M. and Young,E.E.
  TITLE     Identification of Arginine-Vasopressin Receptor 1a (Avpr1a/Avpr1a)
            as a Novel Candidate Gene for Chronic Visceral Pain Sheds Light on
            the Potential Role of Enteric Neurons in the Development of
            Visceral Hypersensitivity
  JOURNAL   J Pain 25 (9), 104572 (2024)
   PUBMED   38768798
  REMARK    GeneRIF: Identification of Arginine-Vasopressin Receptor 1a
            (Avpr1a/Avpr1a) as a Novel Candidate Gene for Chronic Visceral Pain
            Sheds Light on the Potential Role of Enteric Neurons in the
            Development of Visceral Hypersensitivity.
REFERENCE   2  (residues 1 to 423)
  AUTHORS   Hayashi,H., Shimizu,K., Nakamura,K., Nishimori,K. and Kondo,Y.
  TITLE     The bilevel chamber revealed differential involvement of
            vasopressin and oxytocin receptors in female mouse sexual behavior
  JOURNAL   PLoS One 19 (6), e0304703 (2024)
   PUBMED   38900750
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 423)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 423)
  AUTHORS   Yamaguchi,Y., Maekawa,Y., Kabashima,K., Mizuno,T., Tainaka,M.,
            Suzuki,T., Dojo,K., Tominaga,T., Kuroiwa,S., Masubuchi,S., Doi,M.,
            Tominaga,K., Kobayashi,K., Yamagata,S., Itoi,K., Abe,M.,
            Schwartz,W.J., Sakimura,K. and Okamura,H.
  TITLE     An intact pituitary vasopressin system is critical for building a
            robust circadian clock in the suprachiasmatic nucleus
  JOURNAL   Proc Natl Acad Sci U S A 120 (43), e2308489120 (2023)
   PUBMED   37844254
REFERENCE   5  (residues 1 to 423)
  AUTHORS   Tsuchiya,H., Fujinoki,M., Azuma,M. and Koshimizu,T.A.
  TITLE     Vasopressin V1a receptor and oxytocin receptor regulate murine
            sperm motility differently
  JOURNAL   Life Sci Alliance 6 (4), e202201488 (2023)
   PUBMED   36650057
  REMARK    GeneRIF: Vasopressin V1a receptor and oxytocin receptor regulate
            murine sperm motility differently.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 423)
  AUTHORS   Bielsky,I.F., Hu,S.B., Szegda,K.L., Westphal,H. and Young,L.J.
  TITLE     Profound impairment in social recognition and reduction in
            anxiety-like behavior in vasopressin V1a receptor knockout mice
  JOURNAL   Neuropsychopharmacology 29 (3), 483-493 (2004)
   PUBMED   14647484
REFERENCE   7  (residues 1 to 423)
  AUTHORS   Hu,S.B., Zhao,Z.S., Yhap,C., Grinberg,A., Huang,S.P., Westphal,H.
            and Gold,P.
  TITLE     Vasopressin receptor 1a-mediated negative regulation of B cell
            receptor signaling
  JOURNAL   J Neuroimmunol 135 (1-2), 72-81 (2003)
   PUBMED   12576226
  REMARK    GeneRIF: Vasopressin receptor 1a-mediated negative regulation of B
            cell receptor signaling.
REFERENCE   8  (residues 1 to 423)
  AUTHORS   Hollon,T.R., Bek,M.J., Lachowicz,J.E., Ariano,M.A., Mezey,E.,
            Ramachandran,R., Wersinger,S.R., Soares-da-Silva,P., Liu,Z.F.,
            Grinberg,A., Drago,J., Young,W.S. 3rd, Westphal,H., Jose,P.A. and
            Sibley,D.R.
  TITLE     Mice lacking D5 dopamine receptors have increased sympathetic tone
            and are hypertensive
  JOURNAL   J Neurosci 22 (24), 10801-10810 (2002)
   PUBMED   12486173
REFERENCE   9  (residues 1 to 423)
  AUTHORS   Wesley,V.J., Hawtin,S.R., Howard,H.C. and Wheatley,M.
  TITLE     Agonist-specific, high-affinity binding epitopes are contributed by
            an arginine in the N-terminus of the human oxytocin receptor
  JOURNAL   Biochemistry 41 (16), 5086-5092 (2002)
   PUBMED   11955056
REFERENCE   10 (residues 1 to 423)
  AUTHORS   Kikuchi,S., Tanoue,A., Goda,N., Matsuo,N. and Tsujimoto,G.
  TITLE     Structure and sequence of the mouse V1a and V1b vasopressin
            receptor genes
  JOURNAL   Jpn J Pharmacol 81 (4), 388-392 (1999)
   PUBMED   10669045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D49730.1.
            
            On Jul 23, 2003 this sequence version replaced NP_058543.1.
            
            Summary: This gene encodes a receptor for arginine vasopressin, a
            neurohypophyseal hormone involved in diuresis inhibition, smooth
            muscle contraction, liver glycogenolysis stimulation and regulation
            of adrenocorticotropic hormone release from the pituitary. This
            receptor represents one of three G protein-coupled arginine
            vasopressin receptors which functions through a
            phosphotidylinositol-calcium second messenger system in vascular
            and hepatic tissues [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49730.1, BC024149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 70.36 cM"
     Protein         1..423
                     /product="vasopressin V1a receptor"
                     /note="V1a arginine vasopressin receptor;
                     vascular/hepatic-type arginine vasopressin receptor;
                     antidiuretic hormone receptor 1a; AVPR V1a"
                     /calculated_mol_wt=47051
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62463.1)"
     Site            27
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62463.1)"
     Region          52..364
                     /region_name="7tmA_V1aR"
                     /note="vasopressin receptor subtype 1A, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; cd15385"
                     /db_xref="CDD:320507"
     Region          53..79
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320507"
     Site            53..76
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62463.1)"
     Region          86..113
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320507"
     Site            89..110
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62463.1)"
     Site            order(109,112..113,124..129,131..132,135,179,181..185,215,
                     218..220,222..224,226..227,309,312..313,315..316,319,
                     331..332,334..336,339,342..343)
                     /site_type="other"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:320507"
     Region          124..154
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320507"
     Site            126..147
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62463.1)"
     Region          166..187
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320507"
     Site            169..190
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62463.1)"
     Site            198
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62463.1)"
     Region          215..244
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320507"
     Site            221..241
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62463.1)"
     Region          289..319
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320507"
     Site            299..318
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62463.1)"
     Region          332..357
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320507"
     Site            337..356
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62463.1)"
     Region          377..423
                     /region_name="V1R_C"
                     /note="Vasopressin V1 receptor, C-terminal; pfam08983"
                     /db_xref="CDD:430355"
     Region          382..423
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62463.1)"
     Site            409
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q62463.1)"
     CDS             1..423
                     /gene="Avpr1a"
                     /gene_synonym="AVPR; Avpr1; V1a; V1aR"
                     /coded_by="NM_016847.2:307..1578"
                     /db_xref="CCDS:CCDS24215.1"
                     /db_xref="GeneID:54140"
                     /db_xref="MGI:MGI:1859216"
ORIGIN      
        1 msfprgshdl pagnsspwwp ltteganssr eaaglgeggs ppgdvrneel aklevtvlav
       61 ifvvavlgns svllalhrtp rktsrmhlfi rhlsladlav affqvlpqlc wdityrfrgp
      121 dwlcrvvkhl qvfamfassy mlvvmtadry iavchplktl qqparrsrlm iaaswglsfv
      181 lsipqyfifs viefevnngt kaqdcwatfi ppwgtrayvt wmtsgvfvvp viilgtcygf
      241 icyhiwrnvr gktasrqskg gkgsgeaagp fhkgllvtpc vssvksisra kirtvkmtfv
      301 ivsayilcwt pffivqmwsv wdtnfvwtds enpsttital laslnsccnp wiymffsghl
      361 lqdcvqsfpc cqsiaqkfak ddsdsmsrrq tsysnnrspt nstgtwkdsp kssksirfip
      421 vst
//
