LOCUS       NM_009732                631 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus arginine vasopressin (Avp), mRNA.
ACCESSION   NM_009732
VERSION     NM_009732.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 631)
  AUTHORS   Borie,A.M., Dromard,Y., Chakraborty,P., Fontanaud,P., Andre,E.M.,
            Francois,A., Colson,P., Muscatelli,F., Guillon,G., Desarmenien,M.G.
            and Jeanneteau,F.
  TITLE     Neuropeptide therapeutics to repress lateral septum neurons that
            disable sociability in an autism mouse model
  JOURNAL   Cell Rep Med 5 (11), 101781 (2024)
   PUBMED   39423809
REFERENCE   2  (bases 1 to 631)
  AUTHORS   Zuchowski,Y., Carty,J.S., Trapani,J.B., Watts,J.A., Bock,F.,
            Zhang,M., Terker,A.S., Zent,R., Delpire,E., Harris,R.C. and
            Arroyo,J.P.
  TITLE     Kidney collecting duct-derived vasopressin is not essential for
            appropriate concentration or dilution of urine
  JOURNAL   Am J Physiol Renal Physiol 326 (6), F1091-F1100 (2024)
   PUBMED   38695074
REFERENCE   3  (bases 1 to 631)
  AUTHORS   Wu,Z., Jiang,H., Yin,Q., Zhang,Z. and Chen,X.
  TITLE     Arginine vasopressin induces ferroptosis to promote heart failure
            via activation of the V1aR/CaN/NFATC3 pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (3), 474-481 (2024)
   PUBMED   38247327
  REMARK    GeneRIF: Arginine vasopressin induces ferroptosis to promote heart
            failure via activation of the V1aR/CaN/NFATC3 pathway.
REFERENCE   4  (bases 1 to 631)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 631)
  AUTHORS   Hirayama,M., Mure,L.S., Le,H.D. and Panda,S.
  TITLE     Neuronal reprogramming of mouse and human fibroblasts using
            transcription factors involved in suprachiasmatic nucleus
            development
  JOURNAL   iScience 27 (3), 109051 (2024)
   PUBMED   38384840
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 631)
  AUTHORS   Schonemann,M.D., Ryan,A.K., McEvilly,R.J., O'Connell,S.M.,
            Arias,C.A., Kalla,K.A., Li,P., Sawchenko,P.E. and Rosenfeld,M.G.
  TITLE     Development and survival of the endocrine hypothalamus and
            posterior pituitary gland requires the neuronal POU domain factor
            Brn-2
  JOURNAL   Genes Dev 9 (24), 3122-3135 (1995)
   PUBMED   8543156
REFERENCE   7  (bases 1 to 631)
  AUTHORS   Haas,S., Steplewski,A., Siracusa,L.D., Amini,S. and Khalili,K.
  TITLE     Identification of a sequence-specific single-stranded DNA binding
            protein that suppresses transcription of the mouse myelin basic
            protein gene
  JOURNAL   J Biol Chem 270 (21), 12503-12510 (1995)
   PUBMED   7539003
REFERENCE   8  (bases 1 to 631)
  AUTHORS   Muglia,L., Jacobson,L., Dikkes,P. and Majzoub,J.A.
  TITLE     Corticotropin-releasing hormone deficiency reveals major fetal but
            not adult glucocorticoid need
  JOURNAL   Nature 373 (6513), 427-432 (1995)
   PUBMED   7830793
REFERENCE   9  (bases 1 to 631)
  AUTHORS   Marini,J.C., Nelson,K.K., Battey,J. and Siracusa,L.D.
  TITLE     The pituitary hormones arginine vasopressin-neurophysin II and
            oxytocin-neurophysin I show close linkage with interleukin-1 on
            mouse chromosome 2
  JOURNAL   Genomics 15 (1), 200-202 (1993)
   PUBMED   8432536
REFERENCE   10 (bases 1 to 631)
  AUTHORS   Hara,Y., Battey,J. and Gainer,H.
  TITLE     Structure of mouse vasopressin and oxytocin genes
  JOURNAL   Brain Res Mol Brain Res 8 (4), 319-324 (1990)
   PUBMED   2176709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731707.12, AK138179.1 and
            BC051997.1.
            
            On Aug 5, 2015 this sequence version replaced NM_009732.1.
            
            Summary: This gene encodes a member of the vasopressin/oxytocin
            family and preproprotein that is proteolytically processed to
            generate multiple protein products. These products include the
            neuropeptide hormone arginine vasopressin, and two other peptides,
            neurophysin 2 and copeptin. Arginine vasopressin binds to
            vasopressin receptors and functions as a vasopressor, to constrict
            blood vessels and increase blood pressure, and as an antidiuretic,
            to reduce the production of urine. Neurophysin 2 functions as a
            carrier protein in the transport of arginine vasopressin. This gene
            is present in a gene cluster with the related gene oxytocin on
            chromosome 2. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051997.1, CJ057117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL731707.12        129835-129849       c
            16-610              AK138179.1         2-596
            611-631             BC051997.1         577-597
FEATURES             Location/Qualifiers
     source          1..631
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     gene            1..631
                     /gene="Avp"
                     /gene_synonym="Vp; Vsp"
                     /note="arginine vasopressin"
                     /db_xref="GeneID:11998"
                     /db_xref="MGI:MGI:88121"
     exon            1..179
                     /gene="Avp"
                     /gene_synonym="Vp; Vsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..554
                     /gene="Avp"
                     /gene_synonym="Vp; Vsp"
                     /note="vasopressin-neurophysin 2-copeptin; AVP-NPII;
                     pre-pro-arginine-vasopressin-neurophysin II; prepro-AVP-NP
                     II"
                     /codon_start=1
                     /product="vasopressin-neurophysin 2-copeptin
                     preproprotein"
                     /protein_id="NP_033862.1"
                     /db_xref="CCDS:CCDS16746.1"
                     /db_xref="GeneID:11998"
                     /db_xref="MGI:MGI:88121"
                     /translation="MLARMLNTTLSACFLSLLAFSSACYFQNCPRGGKRAISDMELRQ
                     CLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRC
                     AAVGICCSDESCVAEPECHDGFFRLTRAREPSNATQLDGPARALLLRLVQLAGTRESV
                     DSAKPRVY"
     exon            180..381
                     /gene="Avp"
                     /gene_synonym="Vp; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            382..611
                     /gene="Avp"
                     /gene_synonym="Vp; Vsp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      591..596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Avp"
                     /gene_synonym="Vp; Vsp"
                     /note="hexamer: AATAAA"
     polyA_site      611
                     /gene="Avp"
                     /gene_synonym="Vp; Vsp"
                     /note="major polyA site"
ORIGIN      
        1 ccagcccgcc aaggcagcag agcctgagct gcacacagtg cccacctatg ctcgccagga
       61 tgctcaacac tacgctctcc gcttgtttcc tgagcctgct ggccttctcc tccgcctgct
      121 acttccagaa ctgcccaaga ggcggcaaga gggccatctc tgacatggag ctgagacagt
      181 gtctcccctg cggcccgggc ggcaaaggac gctgcttcgg accaagcatc tgctgcgcgg
      241 acgagctggg ctgcttcgtg ggcaccgccg aggcgctgcg ctgccaggag gagaactacc
      301 tgccctcgcc ctgccagtcc ggccagaagc cctgcgggag cgggggccgc tgcgccgccg
      361 tgggcatctg ctgcagcgac gagagctgcg tggccgagcc cgagtgccac gacggttttt
      421 tccgcctcac ccgcgctcgg gagccaagca acgccacaca gctggacggc cctgctcggg
      481 cgctgctgct aaggctggta cagctggctg ggacacggga gtccgtggat tctgccaagc
      541 cccgggtcta ctgagccatc gcccccacgc ctcgccccta cagcatggaa aataaacttt
      601 taaaaactgc aaaaaaaaaa aaaaaaaaaa a
//
