LOCUS       NM_001402490            3141 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus advillin (Avil), transcript variant 2, mRNA.
ACCESSION   NM_001402490
VERSION     NM_001402490.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3141)
  AUTHORS   Huey,E.L., Turecek,J., Delisle,M.M., Mazor,O., Romero,G.E., Dua,M.,
            Sarafis,Z.K., Hobble,A., Booth,K.T., Goodrich,L.V., Corey,D.P. and
            Ginty,D.D.
  TITLE     The auditory midbrain mediates tactile vibration sensing
  JOURNAL   Cell 188 (1), 104-120 (2025)
   PUBMED   39701100
REFERENCE   2  (bases 1 to 3141)
  AUTHORS   Kang,H.J., Krumm,B.E., Tassou,A., Geron,M., DiBerto,J.F.,
            Kapolka,N.J., Gumpper,R.H., Sakamoto,K., Dewran Kocak,D.,
            Olsen,R.H.J., Huang,X.P., Zhang,S., Huang,K.L., Zaidi,S.A.,
            Nguyen,M.T., Jo,M.J., Katritch,V., Fay,J.F., Scherrer,G. and
            Roth,B.L.
  TITLE     Structure-guided design of a peripherally restricted chemogenetic
            system
  JOURNAL   Cell 187 (26), 7433-7449 (2024)
   PUBMED   39631393
REFERENCE   3  (bases 1 to 3141)
  AUTHORS   Xia,H., Jerde,T.J. and Fehrenbacher,J.C.
  TITLE     Sensory innervation in the prostate and a role for calcitonin
            gene-related peptide in prostatic epithelial proliferation
  JOURNAL   Front Mol Neurosci 17, 1497735 (2024)
   PUBMED   39744541
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3141)
  AUTHORS   Yin,G., Duan,K., Dong,D., Du,F., Guo,C., Zhang,C., Liu,X., Sun,Y.,
            Huang,T., Cui,G. and Cheng,L.
  TITLE     Central control of opioid-induced mechanical hypersensitivity and
            tolerance in mice
  JOURNAL   Neuron 112 (23), 3897-3923 (2024)
   PUBMED   39406237
REFERENCE   5  (bases 1 to 3141)
  AUTHORS   Melton,A.J., Palfini,V.L., Ogawa,Y., Oses Prieto,J.A.,
            Vainshtein,A., Burlingame,A.L., Peles,E. and Rasband,M.N.
  TITLE     TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not
            Axon Specification or Axon Initial Segment Formation
  JOURNAL   J Neurosci 44 (42), e0976242024 (2024)
   PUBMED   39251352
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3141)
  AUTHORS   Buch,T., Heppner,F.L., Tertilt,C., Heinen,T.J., Kremer,M.,
            Wunderlich,F.T., Jung,S. and Waisman,A.
  TITLE     A Cre-inducible diphtheria toxin receptor mediates cell lineage
            ablation after toxin administration
  JOURNAL   Nat Methods 2 (6), 419-426 (2005)
   PUBMED   15908920
REFERENCE   7  (bases 1 to 3141)
  AUTHORS   Shibata,M., Ishii,J., Koizumi,H., Shibata,N., Dohmae,N., Takio,K.,
            Adachi,H., Tsujimoto,M. and Arai,H.
  TITLE     Type F scavenger receptor SREC-I interacts with advillin, a member
            of the gelsolin/villin family, and induces neurite-like outgrowth
  JOURNAL   J Biol Chem 279 (38), 40084-40090 (2004)
   PUBMED   15247299
  REMARK    GeneRIF: interaction of SREC-I and advillin are involved in the
            development of dorsal root ganglion neurons by inducing the
            described morphological changes.
REFERENCE   8  (bases 1 to 3141)
  AUTHORS   Kwiatkowski,D.J.
  TITLE     Functions of gelsolin: motility, signaling, apoptosis, cancer
  JOURNAL   Curr Opin Cell Biol 11 (1), 103-108 (1999)
   PUBMED   10047530
  REMARK    Review article
REFERENCE   9  (bases 1 to 3141)
  AUTHORS   Marks,P.W., Arai,M., Bandura,J.L. and Kwiatkowski,D.J.
  TITLE     Advillin (p92): a new member of the gelsolin/villin family of actin
            regulatory proteins
  JOURNAL   J Cell Sci 111 (Pt 15), 2129-2136 (1998)
   PUBMED   9664034
REFERENCE   10 (bases 1 to 3141)
  AUTHORS   Wang,X.Z., Kuroda,M., Sok,J., Batchvarova,N., Kimmel,R., Chung,P.,
            Zinszner,H. and Ron,D.
  TITLE     Identification of novel stress-induced genes downstream of chop
  JOURNAL   EMBO J 17 (13), 3619-3630 (1998)
   PUBMED   9649432
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134329.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995047.1095093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC134329.3         84165-84257         c
            94-237              AC134329.3         81848-81991         c
            238-322             AC134329.3         81546-81630         c
            323-397             AC134329.3         80225-80299         c
            398-594             AC134329.3         78305-78501         c
            595-703             AC134329.3         77347-77455         c
            704-814             AC134329.3         77146-77256         c
            815-1017            AC134329.3         76662-76864         c
            1018-1096           AC134329.3         76155-76233         c
            1097-1195           AC134329.3         75937-76035         c
            1196-1349           AC134329.3         75114-75267         c
            1350-1450           AC134329.3         74919-75019         c
            1451-1588           AC134329.3         74337-74474         c
            1589-1747           AC134329.3         73937-74095         c
            1748-1927           AC134329.3         73118-73297         c
            1928-2073           AC134329.3         71343-71488         c
            2074-2218           AC134329.3         70753-70897         c
            2219-2407           AC134329.3         68498-68686         c
            2408-2476           AC134329.3         67964-68032         c
            2477-2602           AC134329.3         66485-66610         c
            2603-3141           AC134329.3         64008-64546         c
FEATURES             Location/Qualifiers
     source          1..3141
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.48 cM"
     gene            1..3141
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /note="advillin"
                     /db_xref="GeneID:11567"
                     /db_xref="MGI:MGI:1333798"
     exon            1..93
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            94..237
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            238..322
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2716
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /note="p92; actin-binding protein DOC6"
                     /codon_start=1
                     /product="advillin"
                     /protein_id="NP_001389419.1"
                     /db_xref="GeneID:11567"
                     /db_xref="MGI:MGI:1333798"
                     /translation="MSLSSAFRAVSNDPRIITWRIEKMELALVPLSAHGNFYEGDCYI
                     VLSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESD
                     TFRGYFKQGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIQATEVEMSWDSFNRG
                     DVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPG
                     LMTVLQDTLGRRSMIKPAVSDEIMDQQQKSSIMLYHVSDTAGQLSVTEVATRPLVQDL
                     LNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGA
                     ESAMFKQLFQKWSVKDQTTGLGKIFSTGKIAKIFQDKFDVSLLHTKPEVAAQERMVDD
                     GKGQVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPHYILYIWQGRHASR
                     DELAASAYRAVEVDQQFDGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNEEP
                     DPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAM
                     AKELVDLLCDGNADTVAEGQEPPEFWDLLGGKTAYANDKRLQQETLDVQVRLFECSNK
                     TGRFLVTEVTDFTQEDLSPGDVMLLDTWDQVFLWIGAEANATEKKGALSTAQEYLVTH
                     PSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITA
                     DMKNATLYLNPSDGEPKYYPVEVLLKGQNQELPEDVDPAKKENYLSEQDFVSVFGITR
                     GQFTALPGWKQLQLKKERGLF"
     exon            323..397
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            398..594
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            595..703
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            704..814
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1017
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1096
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1195
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1349
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1450
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1588
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1747
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1927
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2073
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2218
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2407
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2476
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2602
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..3141
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3119..3124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /note="hexamer: AATAAA"
     polyA_site      3141
                     /gene="Avil"
                     /gene_synonym="Advil; DOC6"
                     /note="major polyA site"
ORIGIN      
        1 attgctgaaa caggcttcag gacgggctgc tttgggagac ctcatcagta cttcacctgc
       61 tgctttgccg gacttcggag gacagagggt cagagagatg gcacatactg gcccagcacc
      121 tacttctggt gactcacgac cgcctgtcac tccagctcca cagaatttaa cacaccaaca
      181 tgcatgtatg ttttaaagga aatgtgtcat ccctatggcc cagagctctt gaccaagttc
      241 caggaagaca gccactatgt ctctgagcag tgccttcagg gctgtgagca acgacccccg
      301 gatcatcaca tggagaattg agaaaatgga gctggcgctg gtgcccctga gtgctcacgg
      361 caacttctac gagggagact gctacatcgt cctctcgacc cggagagtgg gcagccttct
      421 ctcccagaac atccactttt ggatcgggaa ggactcctcc caggacgagc agagctgcgc
      481 ggccatctat accacacagc tggatgacta cctgggaggc agcccggtgc agcaccgtga
      541 ggtccagtac cacgagtccg acaccttccg tggctacttc aagcagggca tcatctataa
      601 aaaggggggt gtggcctctg ggatgaagca cgtggagacc aacacctatg atgtgaagag
      661 gctgctacac gtaaagggga aaagaaacat ccaagccacg gaggtggaaa tgagctggga
      721 cagctttaac cgaggcgatg tcttcctgct ggaccttggg atggtcatca tccagtggaa
      781 tggcccggag agcaacagtg gggaacgtct caaggctatg cttctggcaa aggacattcg
      841 ggacagggag cgagggggcc gtgctgaaat tggggtgatt gagggagaca aggaggcggc
      901 cagcccaggg ctgatgacag tcctccagga tacccttggt cgacgctcca tgataaagcc
      961 tgcagtttct gatgagatca tggaccaaca acagaaatca agtatcatgt tatatcatgt
     1021 ctccgacaca gctgggcagc tgtcagtcac agaggtggca acaaggcccc tggtccagga
     1081 cctactgaac cacgatgact gctacatcct ggaccaaagt ggcaccaaga tctacgtgtg
     1141 gaaaggcaaa ggagccacca aggttgagaa acaggcggcc atgtccaaag ccctggattt
     1201 catcaagatg aagggatacc ccagcagcac caacgtggag accgtcaacg atggcgcaga
     1261 gtcggccatg ttcaaacagt tgttccagaa atggtcggtg aaggaccaga ccacgggctt
     1321 ggggaaaata ttcagcactg gtaaaatcgc taaaatcttc caggacaagt tcgatgtgtc
     1381 tctgctacac accaagccag aagtggctgc acaggagaga atggtggacg acggcaaagg
     1441 ccaggttgag gtctggagaa ttgagaacct ggagctggtc cccgtggaat accagtggca
     1501 tggcttcttc tacgggggag actgctatct ggttctctac acgtacgatg tgaacgggaa
     1561 accccattac atcttgtaca tctggcaggg ccgccacgca tcccgggatg agctggcagc
     1621 ctcagcctat cgggcagtgg aggtggatca gcagtttgat ggagcccctg tgcaggtccg
     1681 ggttagcatg gggaaggagc cacgccactt catggccatc ttcaaaggaa agctggttat
     1741 ctacgagggc gggacttcca ggaagggaaa cgaggagccg gaccctccag taaggctctt
     1801 ccagatccac gggaacgaca aatccaacac caaagcagtg gaggtctcgg cctctgcttc
     1861 ctcgctcaac tccaacgacg tctttctgct gcggactcag gcagagcact acctgtggta
     1921 cggcaagggg tctagtgggg acgagcgggc gatggctaag gagctggtcg accttctctg
     1981 tgatggcaat gcggacactg tggctgaggg ccaggagcca cctgagttct gggaccttct
     2041 gggaggaaaa acagcctacg ctaatgacaa aaggctgcag caagaaaccc tggacgtcca
     2101 ggtccggctc tttgagtgtt ccaataagac tggccgcttc cttgttacgg aggtcacgga
     2161 cttcacccag gaggacctga gcccaggtga tgtgatgctt ctggacacct gggaccaggt
     2221 gttcttgtgg ataggagcgg aggccaatgc cacggagaag aagggggccc tctcgacggc
     2281 tcaggagtac ctggtcacac atcctagtgg ccgagacccc gacacaccga ttctgatcat
     2341 caaacagggc tttgagcccc ccaccttcac aggctggttc ctggcatggg accctcacat
     2401 ttggagcgaa ggaaaatcat atgagcagct aaagaacgag ctgggagatg caactgccat
     2461 tgtgcgaatc accgctgaca tgaagaacgc aacactttac ctgaatccta gtgacggtga
     2521 gccaaagtac tacccggtgg aagttctgct gaaaggtcag aaccaggagc tgcctgagga
     2581 tgtggacccc gccaaaaagg agaactacct ctcggaacaa gactttgtat ctgtgtttgg
     2641 catcacgaga gggcagttca ctgctctgcc tggctggaaa cagctccagc tgaagaaaga
     2701 aaggggcctt ttctagagaa ggcgtgtgtc tgctgcccgg ccacaggaga gagcaaacta
     2761 gcagtgccaa catcagcaaa gagttcacct accaactgag cccgacacgc ggctgcttta
     2821 gatacgaccc atctcaggat ggctgactgc ctttcgaagt catccttgca ttccttgtgg
     2881 ctgtccatta gatgctgaca gcttgccttt tggctttggt ggttttttag ccgaagctgt
     2941 agcagagagc gtgaaggcag aaagagctag aaactaagct tatttaatgc atcaggaccc
     3001 acatctgctt ccaactacac cctgcaatcc ccaaagcact agagtgacca cacactccct
     3061 gcaggccagg ctccaaacgc ccaggtctac catgtgccac agcatgttca actttacaaa
     3121 taaagaggcc atgtgactat g
//
