LOCUS       NM_028844               1442 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus apoptosis, caspase activation inhibitor (Aven),
            transcript variant 1, mRNA.
ACCESSION   NM_028844
VERSION     NM_028844.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   Yu,P., Song,S., Zhang,X., Cui,S., Wei,G., Huang,Z., Zeng,L., Ni,T.
            and Sun,A.
  TITLE     Downregulation of apoptotic repressor AVEN exacerbates cardiac
            injury after myocardial infarction
  JOURNAL   Proc Natl Acad Sci U S A 120 (42), e2302482120 (2023)
   PUBMED   37816050
  REMARK    GeneRIF: Downregulation of apoptotic repressor AVEN exacerbates
            cardiac injury after myocardial infarction.
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Wu,Y., Dong,J., Feng,S., Zhao,Q., Duan,P., Xiong,M., Wen,Y., Lv,C.,
            Wang,X. and Yuan,S.
  TITLE     Maternal UHRF1 Is Essential for Transcription Landscapes and
            Repression of Repetitive Elements During the Maternal-to-Zygotic
            Transition
  JOURNAL   Front Cell Dev Biol 8, 610773 (2021)
   PUBMED   33634103
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1442)
  AUTHORS   Borrelli,A., Schiattarella,A., Mancini,R., Morrica,B.,
            Cerciello,V., Mormile,M., d'Alesio,V., Bottalico,L., Morelli,F.,
            D'Armiento,M., D'Armiento,F.P. and Mancini,A.
  TITLE     A recombinant MnSOD is radioprotective for normal cells and
            radiosensitizing for tumor cells
  JOURNAL   Free Radic Biol Med 46 (1), 110-116 (2009)
   PUBMED   18996183
  REMARK    GeneRIF: activated in irradiated tissues protected from radiodamage
            by treatment with recombinant superoxide dismutase (MnSOD)
REFERENCE   5  (bases 1 to 1442)
  AUTHORS   Weber,M.J.
  TITLE     Mammalian small nucleolar RNAs are mobile genetic elements
  JOURNAL   PLoS Genet 2 (12), e205 (2006)
   PUBMED   17154719
  REMARK    Erratum:[PLoS Genet. 2007 Feb;3(2):e36]
REFERENCE   6  (bases 1 to 1442)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 1442)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 1442)
  AUTHORS   Ina,S., Tsunekawa,N., Nakamura,A. and Noce,T.
  TITLE     Expression of the mouse Aven gene during spermatogenesis, analyzed
            by subtraction screening using Mvh-knockout mice
  JOURNAL   Gene Expr Patterns 3 (5), 635-638 (2003)
   PUBMED   12971998
  REMARK    GeneRIF: One of the cDNA clones obtained by selective PCR
            subtraction cloning matched two cDNA sequences in the mouse testis
            cDNA database, and was highly homologous to Aven, a human gene
            regulating cell death.
REFERENCE   9  (bases 1 to 1442)
  AUTHORS   Chau,B.N., Cheng,E.H., Kerr,D.A. and Hardwick,J.M.
  TITLE     Aven, a novel inhibitor of caspase activation, binds Bcl-xL and
            Apaf-1
  JOURNAL   Mol Cell 6 (1), 31-40 (2000)
   PUBMED   10949025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731840.17 and AL691423.14.
            
            On Jan 10, 2022 this sequence version replaced NM_028844.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006808.1, SRR11927938.4056371.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AL731840.17        27925-28209
            286-463             AL731840.17        49438-49615
            464-534             AL691423.14        100321-100391
            535-630             AL691423.14        102915-103010
            631-967             AL691423.14        104906-105242
            968-1442            AL691423.14        105945-106419
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.04 cM"
     gene            1..1442
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /note="apoptosis, caspase activation inhibitor"
                     /db_xref="GeneID:74268"
                     /db_xref="MGI:MGI:1921518"
     exon            1..285
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1083
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     death regulator Aven"
                     /codon_start=1
                     /product="cell death regulator Aven isoform 1"
                     /protein_id="NP_083120.2"
                     /db_xref="CCDS:CCDS16557.1"
                     /db_xref="GeneID:74268"
                     /db_xref="MGI:MGI:1921518"
                     /translation="MQAERGARGGRGRRGGRERPGGDREPVGAATALARGGCGDGGGR
                     RGRGRGFRRGRGGGGLRGGRWEPGGRGGGASTRVEEDSDSETYGEENDEQGNFSRRKI
                     VSNWDRYQDTEKEVNGESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDGETSCPKQ
                     NSALYVDSESLVRALEQLPLAVRLNVASELIQTTIPLELPQVKPRRNDDGKELGMHLR
                     GPISELRSAAGACPRSLGRGSLRQSPLEGLQKAPTPTQSVADHLEEELDMLLHLDAPV
                     QEEGNISPDQTSRDQEPEKDGQVAQEETGPEKPSVTREKNVEPEQPSTSKNVTEEELE
                     DWLDSMIS"
     exon            286..463
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /inference="alignment:Splign:2.1.0"
     exon            464..534
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /inference="alignment:Splign:2.1.0"
     exon            535..630
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /inference="alignment:Splign:2.1.0"
     exon            631..967
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1442
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1423..1428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /note="hexamer: AATAAA"
     polyA_site      1442
                     /gene="Aven"
                     /gene_synonym="1700013A01Rik; 1700056A21Rik; mAven-L;
                     mAven-S"
                     /note="major polyA site"
ORIGIN      
        1 ggtggggcct gcgctctccg cggcggctcg cgcgttctgc tcgccggcgg cctcatgcag
       61 gctgagcgcg gggctagggg cggccgcggg cggcggggag gccgggagcg gcccggaggg
      121 gaccgagagc cggtcggggc agcgacggcg ctggcgagag gaggctgcgg ggacggaggc
      181 ggccggcggg gccgaggccg gggcttccgc cgaggccgag gaggtggcgg cctgcgaggc
      241 ggccgctggg agcctggagg ccggggcggc ggagccagca ctcgggtgga agaagacagc
      301 gattcagaga cctatggaga agagaatgat gagcaaggaa atttttctag aagaaagatt
      361 gtctccaact gggatcgcta tcaagatact gaaaaggagg tcaatggtga aagtggagaa
      421 tctcagcggg gcacagactt cagtgtcctc ctgagctctg caggggactc cttttcacag
      481 ttccgatttg ctgaggagaa agaatgggat ggtgaaactt catgtccaaa acagaattca
      541 gcactctacg tggacagtga gtcactggtt cgagcccttg agcagctgcc tcttgcagtc
      601 cggcttaatg ttgcttcaga attgatccag accacaattc ctttagaact tccacaggtg
      661 aaaccaagga gaaacgatga tggcaaggag ctgggcatgc atttaagggg acccatctct
      721 gagctcagat ctgctgctgg tgcttgcccc aggtctctgg gcagaggcag tctaaggcaa
      781 agccctttag aaggtttgca gaaagcacct accccaacac agtcagtggc agaccacctg
      841 gaagaagaac tagatatgtt gctgcattta gatgcacctg tgcaagagga aggcaatatc
      901 tctccagacc agacatctcg ggaccaggaa ccagaaaaag atgggcaggt agcccaggag
      961 gaaacaggtc ctgaaaaacc ttctgtgacc agagagaaga atgtggaacc tgagcagcca
     1021 agcacatcga agaatgtcac cgaggaagag ctggaggact ggctggacag catgatttcc
     1081 tgaagcgggg tcaaggggga agagtgcctg aagcaaatgc tggttgcctt ctgtgtaatg
     1141 agcccgtctt gtgaggacgg gctcgtttac cagctacccc atgctaacac gtcctgttat
     1201 gcttacagca gccaacacct acctctgtgt ttgatggcat ctgaatatat gtatgaggct
     1261 tgtttgaggc ttcatttctg ttgttatctg gcttagtcat ctaatagatt tcattaagga
     1321 caggggatgt cacagctaca ttttgaacct ccttcctgtc aacatttaca gcataacagg
     1381 tggtatttaa gggaattagt ctcaaggcat gaagttggtc aaaataaaca ccttctggtc
     1441 ta
//
