LOCUS       NM_001363480            7291 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus autism susceptibility candidate 2 (Auts2), mRNA.
ACCESSION   NM_001363480 NM_177047
VERSION     NM_001363480.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7291)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7291)
  AUTHORS   Song,Y., Seward,C.H., Chen,C.Y., LeBlanc,A., Leddy,A.M. and
            Stubbs,L.
  TITLE     Isolated loss of the AUTS2 long isoform, brain-wide or targeted to
            Calbindin-lineage cells, generates a specific suite of brain,
            behavioral, and molecular pathologies
  JOURNAL   Genetics 226 (1) (2024)
   PUBMED   37816306
REFERENCE   3  (bases 1 to 7291)
  AUTHORS   Liu,M., Chen,Y., Sun,M., Du,Y., Bai,Y., Lei,G., Zhang,C., Zhang,M.,
            Zhang,Y., Xi,C., Ma,Y. and Wang,G.
  TITLE     Auts2 regulated autism-like behavior, glucose metabolism and
            oxidative stress in mice
  JOURNAL   Exp Neurol 361, 114298 (2023)
   PUBMED   36525998
  REMARK    GeneRIF: Auts2 regulated autism-like behavior, glucose metabolism
            and oxidative stress in mice.
REFERENCE   4  (bases 1 to 7291)
  AUTHORS   Li,J., Sun,X., You,Y., Li,Q., Wei,C., Zhao,L., Sun,M., Meng,H.,
            Zhang,T., Yue,W., Wang,L. and Zhang,D.
  TITLE     Auts2 deletion involves in DG hypoplasia and social recognition
            deficit: The developmental and neural circuit mechanisms
  JOURNAL   Sci Adv 8 (9), eabk1238 (2022)
   PUBMED   35235353
  REMARK    GeneRIF: Auts2 deletion involves in DG hypoplasia and social
            recognition deficit: The developmental and neural circuit
            mechanisms.
REFERENCE   5  (bases 1 to 7291)
  AUTHORS   Li,Z., Wang,T., Xin,C., Song,Y., Kong,J., Xu,J., Liu,Q., Teng,Y.,
            Hou,N., Cheng,X., Yang,G., Liu,W., Zhou,B., Zhang,Y., Yang,X. and
            Wang,J.
  TITLE     Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting
            Proteostasis
  JOURNAL   Int J Biol Sci 18 (5), 2018-2031 (2022)
   PUBMED   35342336
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7291)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 7291)
  AUTHORS   Srinivasan,K., Leone,D.P., Bateson,R.K., Dobreva,G., Kohwi,Y.,
            Kohwi-Shigematsu,T., Grosschedl,R. and McConnell,S.K.
  TITLE     A network of genetic repression and derepression specifies
            projection fates in the developing neocortex
  JOURNAL   Proc Natl Acad Sci U S A 109 (47), 19071-19078 (2012)
   PUBMED   23144223
REFERENCE   8  (bases 1 to 7291)
  AUTHORS   O'Leary,J. and Osborne,L.R.
  TITLE     Global analysis of gene expression in the developing brain of
            Gtf2ird1 knockout mice
  JOURNAL   PLoS One 6 (8), e23868 (2011)
   PUBMED   21909369
REFERENCE   9  (bases 1 to 7291)
  AUTHORS   Bedogni,F., Hodge,R.D., Elsen,G.E., Nelson,B.R., Daza,R.A.,
            Beyer,R.P., Bammler,T.K., Rubenstein,J.L. and Hevner,R.F.
  TITLE     Tbr1 regulates regional and laminar identity of postmitotic neurons
            in developing neocortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (29), 13129-13134 (2010)
   PUBMED   20615956
REFERENCE   10 (bases 1 to 7291)
  AUTHORS   Bedogni,F., Hodge,R.D., Nelson,B.R., Frederick,E.A., Shiba,N.,
            Daza,R.A. and Hevner,R.F.
  TITLE     Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein
            expressed in developing brain regions implicated in autism
            neuropathology
  JOURNAL   Gene Expr Patterns 10 (1), 9-15 (2010)
   PUBMED   19948250
  REMARK    GeneRIF: Autism susceptibility candidate 2 (Auts2) encodes a
            nuclear protein expressed in developing brain regions implicated in
            autism neuropathology.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB658109.1, BB621504.1, AK052418.1, BC096021.1, BC058110.1,
            AK147478.1 and CV557700.1.
            
            On May 24, 2018 this sequence version replaced NM_177047.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147478.1, BC096021.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               BB658109.1         1-498
            499-849             BB621504.1         77-427
            850-1211            AK052418.1         35-396
            1212-5321           BC096021.1         334-4443
            5322-6845           BC058110.1         2021-3544
            6846-7135           AK147478.1         6971-7260
            7136-7169           CV557700.1         124-157
            7170-7291           CV557700.1         159-280
FEATURES             Location/Qualifiers
     source          1..7291
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 70.66 cM"
     gene            1..7291
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /note="autism susceptibility candidate 2"
                     /db_xref="GeneID:319974"
                     /db_xref="MGI:MGI:1919847"
     exon            1..1706
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             1398..5183
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /codon_start=1
                     /product="autism susceptibility gene 2 protein homolog"
                     /protein_id="NP_001350409.1"
                     /db_xref="GeneID:319974"
                     /db_xref="MGI:MGI:1919847"
                     /translation="MDGPTRGHGLRKKRRSRSQRDRERRSRAGLGTGAAGGIGAGRTR
                     APSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEAL
                     EKDVAVKPQERAEKRQTPLTKKKREALTNGLSFHSKKSRLSHSHHYSSDRENDRNLCQ
                     HLGKRKKMPKGLRQLKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTG
                     YFCDSDSDQEEKASDASSEKLFNTVLVNKDPELGVGALPEHNQDAGPIVPKISGLERS
                     QEKSQDCCKEPVFEPVVLKDPHPQLPQLPSQAQAEPQLQIPSPGPDLVPRTEAPPQFP
                     PPSTQPAQGPPEAQLQPAPLPQVQQRPPRPQSPSHLLQQTLPPVQSHPSSQSLSQPLS
                     AYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPP
                     AHSHHPNMFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSAD
                     RGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKY
                     PTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVP
                     HTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLK
                     PEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHL
                     EPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRT
                     PPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSP
                     APPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKES
                     HLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYE
                     NPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGV
                     TGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHR
                     RDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHE
                     RGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAG
                     HQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR"
     exon            1707..1919
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2021
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2057
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2087
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2139
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2611
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2862
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3083
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3128
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3224
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3296
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3326
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3398
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3540
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3618
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3702
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3925
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..7286
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7268..7273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      7286
                     /gene="Auts2"
                     /gene_synonym="2700063G02Rik; A730011F23Rik;
                     D830032G16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gctgtgtgag cgaggcgggc ggaggatgag gccgtgcccg ggctctggct gcagccgccc
       61 ggggacacgc cgtgcaccct cgggctccgg gctccggcgg cggcggctga ggcagcgtta
      121 gctgagagcg agcgagcgag tgagcgagag agcgagcggc atctcgcagc gcttcttcct
      181 caggcggggc gacgcgaaaa agaagaagaa gaagaagaag acgaagaaga ggcggcggcg
      241 ccaccacacc ggtgtatctc gggttggaga ctgctctttg ctttcctcgt tgactgactc
      301 accccctccc cctttataat tttatcttaa atttttttgg aagaagggtg acctctggaa
      361 ctgggggtgg ggggagatct acaatttgtg tgtgtgcgtg cgtgcatgtg tatgtgagga
      421 gggggtcggt ggcacgcgcc aggctttgca attcttctct tctttcatct ttttctcctc
      481 ctccccccct tgaagaccga aaaaaaaaaa tcccacaact gcttcagcgt cctcctcctt
      541 cccttcctcc tttcctcggg caacctctgt ctccgcttgt gattgcgtgg ttatgctccc
      601 ctctctgggg ggtctcgccc ctctcagctc gctctccagc cctggcttcc cttggatgca
      661 tttcttaaaa aaagactggg agcccgggag tgagtttttc tgcgaggcga gtgtgtgaga
      721 gaggcggagg tgtggggtgt tttcctgcac gagggggcgg gtgaagttca ttgccaccca
      781 cccctcactt caccgtgacc ttttcggacc tcgggctttt ttttttttaa aattttttgg
      841 ggggtctcta gagaaaggga gaagcaaggc gatttcagtg gtggggagag agcatggccg
      901 cggggagggc ttccccagtc tcttgatcaa agcattccgc tattctgatt tattgcctgc
      961 ttggtgagtt atttttttcc ccctttcctc tgtaaaggag acctgtgtgt tcagccatta
     1021 ctttgctcgg cgctgttcgc aggcatctcc gaccctcggt gcagagggga gccccacact
     1081 tcgccctctc gcttccccgt ccctccctcc ccgtctcccc gccccttccc ccttttttct
     1141 ttctcttttc ccccctgccc tcccttcttg ttcttcttcg gattcttttt tttttttttt
     1201 tttttatttc tcccagccgc tttctccccc gcgcccttcc tcgcggcggg agggaaaagc
     1261 ccgtgcagga ggaagggggg ctcggtgtca attttttttt tcttcttggg gtgtgtgtgt
     1321 gtgtgtgtgg ccgcggcccg agcctgtggc gcgcgggtag gtgaacgggg aagatccccg
     1381 gcgcggttaa aagaaccatg gatggcccga cgcggggaca tggactccgg aaaaagcgga
     1441 ggtctcgatc acagcgagac cgggagagac gctcccgggc cgggttagga accggtgcgg
     1501 cgggtggtat aggagccggc cggacccggg ctccctcgct ggcttcatcg tcgggctccg
     1561 acaaggaaga caatggaaag cccccatcct ccgccccgtc ccggcccaga cccccgcgga
     1621 ggaagcgcag agagtccacc tcagccgaag aggacatcat tgatggattt gccatgacca
     1681 gctttgttac ttttgaagcg ctggagaaag atgtagcagt taagccgcag gaacgtgcgg
     1741 agaaacgaca gactcccctg accaagaaaa aacgagaagc tcttaccaat ggtttgtctt
     1801 ttcactcaaa gaagagccgg ctcagccact cacaccacta cagctcagat cgagagaatg
     1861 accgcaatct ctgccagcac cttgggaaga gaaagaagat gcctaaggga ctcagacagc
     1921 tcaagccagg acagaacagc tgcagggaca gtgacagcga aagcgctagc ggagaatcca
     1981 agggcttcca gcggagcagc tctcgggaga ggctcagtga tagttcagct ccttccagct
     2041 tggggacagg ctacttctgc gacagtgaca gcgaccagga agagaaggct tcagatgcta
     2101 gctctgaaaa actcttcaac actgttcttg taaacaaaga tccagagtta ggtgttggcg
     2161 cactacctga acacaaccaa gatgcgggac caattgtccc caagatctcg ggtctagaga
     2221 gaagccagga gaagagccag gactgttgca aagagcccgt cttcgaaccc gtggtgctca
     2281 aagacccaca tcctcagctc cctcagctac catcccaggc ccaggccgaa cctcagcttc
     2341 agattccatc tccaggccca gacttggtac cgcgcactga agctccgccc cagtttcctc
     2401 ctccaagtac acagccagcc caaggacccc cagaagccca gctgcagcct gccccgctgc
     2461 ctcaggtgca gcagcggcca ccccggcccc agtcccccag ccacctgctc cagcagactc
     2521 ttccgcctgt gcagtcacat ccctcctccc agagcctctc acagccactg tcggcctaca
     2581 acagcagtag cctgagcctc aacagcttaa gcagcagaag cagtaccccg gcaaaaaccc
     2641 agcccgcccc tcctcacatc tcccaccacc cgtccgcctc tcccttcccc ctctccctgc
     2701 ccaaccacag ccctctgcac agcttcacac ccaccctcca gccccctgcc cactcacatc
     2761 accccaatat gttcgcccct cccactgctc tgcctcctcc cccgccgctg acgtctggaa
     2821 gtctgcaggt gccagggcat cccgcaggga gcacgtactc agaacaagat atcctgaggc
     2881 aggaactgaa cacgcgtttc ctggcctctc agagtgccga ccgaggggcc tccctgggcc
     2941 ctccacccta cctgcggacc gagttccatc agcaccagca tcagcaccag cacacccatc
     3001 agcacacgca ccagcatacc ttcacaccgt tcccccacgc catcccgccc actgccatca
     3061 tgccgacgcc agcacctccc atgtttgaca aataccccac caaagttgac ccattctacc
     3121 ggcatagtct cttccactcc tatcctcctg cggtctcggg tatacccccc atgatcccac
     3181 ccacgggccc tttcgggtca ctccaaggag cattccagcc gaagacatcc aaccctatcg
     3241 acgtggctgc ccggcctgga acagtcccac atactctgct ccagaaggac ccaaggttga
     3301 cagatccttt cagacctatg ctaaggaaac caggaaagtg gtgcgccatg catgtgcata
     3361 tcgcctggca gatttatcac catcaacaaa aagtcaagaa acagatgcag tcagacccac
     3421 acaagctgga ctttgggctg aagcctgagt tcctgagccg tcctccaggc cctagtctct
     3481 tcggagccat ccatcacccc cacgatctgg cacgaccttc cactttattc tctgccgctg
     3541 gtgctgcaca tcctactggg accccttttg ggccaccacc tcatcacagt aactttctca
     3601 accctgccgc tcacctagag ccttttaacc ggccgtctac gttcacgggc ctcgctgcag
     3661 ttggtggcaa tgccttcggg ggacttggaa acccttcagt tacacccaac tcagtgttcg
     3721 gccacaagga tagccccagt gtgcagaact ttagcaatcc tcacgaaccc tggaaccggc
     3781 tgcaccgaac gcctccgtcg ttcccgaccc ctccgccctg gctgaagcca ggggaattgg
     3841 agcgcagtgc gtccgctgca gcccatgaca gagatagaga tgtagataaa cgagactcct
     3901 ccgttagtaa agatgacaag gaaagggaaa gcgttgagaa aagacacccc agccatcctt
     3961 ccccagcacc tcccgtcccg gtgagcgccc tgggccataa ccgcagctcc accgatccga
     4021 cgaccagggg tcatttgaat actgaggctc gtgagaaaga taaaccaaaa gagaaggaga
     4081 gagaccactc gggatcccga aaggacctga ccaccgaaga gcacaaagcc aaggaaagcc
     4141 atctgcccga gagagatggg cacagccacg agggacgtgc agcaggcgag gaacccaagc
     4201 agctgtcccg ggtgccatcg ccctacgtga ggacaccagg cgtggatagc accaggccta
     4261 acagcacctc tagtcgggaa gccgagccac gcaagggtga gccggcctac gagaacccca
     4321 agaagaacgc cgaggtcaag gtcaaagagg aacgcaagga agatcacgac ctacctactg
     4381 aggcccccca ggcccacagg acctcagagg cacctccgcc cagctcctca gccagtgcca
     4441 gcgtgcaccc agggcctctg gcatccatgc ccatgaccgt gggagtgact ggcatccatg
     4501 ccatgaacag tatcggtagt ctggacagga cacgtatggt gaccccattt atgggcctca
     4561 gtccgatccc aggaggagag cgtttcccat acccctcttt ccactgggac cctatgcggg
     4621 accccttgag ggatccttac cgtgacttgg acatgcaccg aagagaccct ctgggcaggg
     4681 actttctgct caggaatgac cccctgcacc ggctctccac accccggttg tatgaagccg
     4741 accgatcgtt ccgggacagg gagcctcatg attacagcca ccaccaccac caccaccatc
     4801 acccgctggc cgtggaccct cgacgggagc acgaacgagg aggacacctg gatgaacgcg
     4861 agcggctgca cgtgcttcgg gaggactatg agcacccgcg gttgcaccct gtgcaccccg
     4921 cttctctaga tggacacctc ccacacccga gcctgctcac accaggcctg cctagtatgc
     4981 actaccctcg catcagccct actgcgggcc accagaatgg actgcttaac aagaccccgc
     5041 ccactgcggc gcttagcgcc ccacctccgc tcatctccac attggggggc cgcccgggat
     5101 ccccccggag gactacgcct ctgtcggctg aaatccgaga gaggccaccg tcccacacac
     5161 tgaaggacat tgaagctcgg taagccagga ggacaaggca gacctcggag tgggggagga
     5221 atccccaggg aacccccccc ccagactcaa gagacaactc ccgcacccct aaacttgaga
     5281 ggtgcagagc tccaactctt cccctggaaa aaaaaaaaaa aggacagaca ctctgtttgg
     5341 atgttgaaat gtttttgtat attaatgttg gaatttttca gaccttttag ccaggtcttg
     5401 tttgttctta catttcttta ctttttttgt tgttgttcct tgcctaaaac tttgatctga
     5461 accaaaacgg tgaaggtact gacacacagg gatctgatga tcacaggggg cggggcgggg
     5521 gacatctatc catcacccag agctgtctcg gaggaggagg ctttgtacat aaagtgtaaa
     5581 aagagattgc ttcgtgagct gacggttcat atatgcaaaa gagaaagaca aaagctttac
     5641 ttgtacagat gtaaataggt aaagagtaag taacataata cataaatact tcctcaaatg
     5701 tgctatttac aagtctaata tcagtgaacc cggccctcgg aggaggaggc cgcgttccca
     5761 tctgctaaac ccttcaacta tgcaatgaac acgagggctt ttccccgaag cccggttaac
     5821 tcaaaggagc cttttcaaat ccatttacaa catacttaag gtcatatttt ccctgaacaa
     5881 gcgcttacct gagatgttac acaactgctt tccttttggt ttggtttttg tttttcaaat
     5941 gaagaaacac ctttcttttt ttcttttctt ttttcttttc ttattttaat ctgaaaccca
     6001 ggctggaact ttgcgtctga agttgctgct tgtggtcttc tggggagaaa tggggaaagg
     6061 tccaccccct agaaagtgta gctaagaacc ggaagtagct ttgcccaggg aagatgggat
     6121 tgctctgcca ataatcaggg gcaggtgggc tgtgtctgcc agcacaaacc ggtcaccaga
     6181 atttctggtc acctttgatg gcgtaatgtt gcaggcaact tcaagtgggc accgtgcctc
     6241 cgcagcaacc catgtcctgg ctcatgacac ggaggacaca cttcctcgtt ccacagtatg
     6301 atttaaggac actcacacgg gtcctgaaag aaagctgtct gggttttctc aggcgttgga
     6361 tacattgcca cagtaactga agaaggtacc cggagcccag tgtgaatcgt ttatattcca
     6421 ataagaaatg ggaaacctgg gcagagctga gctgagcagg tagatctagt aagagccatc
     6481 agaaattacc gagggcgaaa gaaggcagag agagagagag agagagagag agagagagag
     6541 agagagagag agaacatgca tgcacgcgct cttgtgtgca cttgtgtgtg tgtgtgtgtg
     6601 tgttgtattt tcttcagtct taatgtcttc atgacacttt tataaggaca ttaaccctct
     6661 tgtctacata tttggagaga atatgacttt actagccgag aaaatacact atatcttgtc
     6721 tactggcctg taaaatacat gtaagaaata aaaattagcc ccatttggtc ctctagtata
     6781 ttaaagtgct atctgacatt gttatcctgt tttttgtttt gttttatttt caaaaaaaaa
     6841 aaaaagtgta aactacagac cattgtttct aaaagcagag agatctattt tagtagtcaa
     6901 cagaaggttt agttgtgaat tccgattttg tggacaccag atgtgtgcgg tgttttgttt
     6961 tctttctttc gttttaattt tttttttttt aagacaacaa ctaaaaagaa aaaaaaaatc
     7021 ccaaggattc tgtgcactgg aactgtagtg gtagggtctc agcattgtaa agagattgtt
     7081 cttgtacagg ccttttggct gtttctcttg tatgtaaaaa aaagaaaaaa aaaaaagaaa
     7141 aagaaaaaaa aaaaagaaag aaaaaaaaag tcctttccag atcctactcg aacaggaagg
     7201 gaagcaacgg aatcttcagc atgtgtcatt ggaggagcct tcttgtgtaa tgtaaatgtg
     7261 ccatgttatt aaaaaatgtg aaccaaaaaa a
//
