LOCUS       NM_001080966            1331 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus aurora kinase C (Aurkc), transcript variant 2, mRNA.
ACCESSION   NM_001080966
VERSION     NM_001080966.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1331)
  AUTHORS   Kratka,C., Drutovic,D., Blengini,C.S. and Schindler,K.
  TITLE     Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal
            passenger complex isoforms in mouse oocytes
  JOURNAL   BMC Res Notes 15 (1), 96 (2022)
   PUBMED   35255953
  REMARK    GeneRIF: Using ZINC08918027 inhibitor to determine Aurora
            kinase-chromosomal passenger complex isoforms in mouse oocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1331)
  AUTHORS   Aboelenain,M. and Schindler,K.
  TITLE     Aurora kinase B inhibits aurora kinase A to control maternal mRNA
            translation in mouse oocytes
  JOURNAL   Development 148 (21) (2021)
   PUBMED   34636397
REFERENCE   3  (bases 1 to 1331)
  AUTHORS   Wellard,S.R., Schindler,K. and Jordan,P.W.
  TITLE     Aurora B and C kinases regulate chromosome desynapsis and
            segregation during mouse and human spermatogenesis
  JOURNAL   J Cell Sci 133 (23) (2020)
   PUBMED   33172986
  REMARK    GeneRIF: Aurora B and C kinases regulate chromosome desynapsis and
            segregation during mouse and human spermatogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1331)
  AUTHORS   Nguyen,A.L., Drutovic,D., Vazquez,B.N., El Yakoubi,W.,
            Gentilello,A.S., Malumbres,M., Solc,P. and Schindler,K.
  TITLE     Genetic Interactions between the Aurora Kinases Reveal New
            Requirements for AURKB and AURKC during Oocyte Meiosis
  JOURNAL   Curr Biol 28 (21), 3458-3468 (2018)
   PUBMED   30415701
  REMARK    GeneRIF: in the absence of AURKC, AURKA localizes to chromosomes in
            a CPC-dependent manner. These data suggest that AURKC prevents
            AURKA from localizing to chromosomes by competing for CPC binding.
            This competition is important for adequate spindle length to
            support meiosis I. There is also a unique requirement for AURKB to
            negatively regulate AURKC to prevent aneuploidy.
REFERENCE   5  (bases 1 to 1331)
  AUTHORS   Balboula,A.Z., Blengini,C.S., Gentilello,A.S., Takahashi,M. and
            Schindler,K.
  TITLE     Maternal RNA regulates Aurora C kinase during mouse oocyte
            maturation in a translation-independent fashion
  JOURNAL   Biol Reprod 96 (6), 1197-1209 (2017)
   PUBMED   28575288
  REMARK    GeneRIF: findings demonstrate that maternal RNAs regulate AURKC
            localization and activity in mouse oocytes
REFERENCE   6  (bases 1 to 1331)
  AUTHORS   Furuta,T., Baillie,D.L. and Schumacher,J.M.
  TITLE     Caenorhabditis elegans Aurora A kinase AIR-1 is required for
            postembryonic cell divisions and germline development
  JOURNAL   Genesis 34 (4), 244-250 (2002)
   PUBMED   12434334
REFERENCE   7  (bases 1 to 1331)
  AUTHORS   Kim,J., Bergmann,A., Wehri,E., Lu,X. and Stubbs,L.
  TITLE     Imprinting and evolution of two Kruppel-type zinc-finger genes,
            ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain
  JOURNAL   Genomics 77 (1-2), 91-98 (2001)
   PUBMED   11543637
REFERENCE   8  (bases 1 to 1331)
  AUTHORS   Tang,C.J., Chuang,C.K., Hu,H.M. and Tang,T.K.
  TITLE     The zinc finger domain of Tzfp binds to the tbs motif located at
            the upstream flanking region of the Aie1 (aurora-C) kinase gene
  JOURNAL   J Biol Chem 276 (22), 19631-19639 (2001)
   PUBMED   11279021
REFERENCE   9  (bases 1 to 1331)
  AUTHORS   Hu,H.M., Chuang,C.K., Lee,M.J., Tseng,T.C. and Tang,T.K.
  TITLE     Genomic organization, expression, and chromosome localization of a
            third aurora-related kinase gene, Aie1
  JOURNAL   DNA Cell Biol 19 (11), 679-688 (2000)
   PUBMED   11098217
REFERENCE   10 (bases 1 to 1331)
  AUTHORS   Tseng,T.C., Chen,S.H., Hsu,Y.P. and Tang,T.K.
  TITLE     Protein kinase profile of sperm and eggs: cloning and
            characterization of two novel testis-specific protein kinases
            (AIE1, AIE2) related to yeast and fly chromosome segregation
            regulators
  JOURNAL   DNA Cell Biol 17 (10), 823-833 (1998)
   PUBMED   9809744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152418.5.
            
            On Dec 23, 2022 this sequence version replaced NM_001080966.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064780.1, SRR5189685.73694.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               AC152418.5         87127-87469
            344-377             AC152418.5         87903-87936
            378-569             AC152418.5         88154-88345
            570-708             AC152418.5         89149-89287
            709-857             AC152418.5         91614-91762
            858-1032            AC152418.5         93992-94166
            1033-1331           AC152418.5         94428-94726
FEATURES             Location/Qualifiers
     source          1..1331
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 4.06 cM"
     gene            1..1331
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /note="aurora kinase C"
                     /db_xref="GeneID:20871"
                     /db_xref="MGI:MGI:1321119"
     exon            1..343
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /inference="alignment:Splign:2.1.0"
     exon            344..377
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1185
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase 13; aurora 3;
                     aurora-related kinase 3; aurora/IPL1-related kinase 3;
                     aurora/Ipl1/Eg2 protein 1; serine/threonine-protein kinase
                     aurora-C; serine/threonine kinase 13 (aurora/IPL-like);
                     aurora B"
                     /codon_start=1
                     /product="aurora kinase C"
                     /protein_id="NP_001074435.1"
                     /db_xref="CCDS:CCDS85211.1"
                     /db_xref="GeneID:20871"
                     /db_xref="MGI:MGI:1321119"
                     /translation="MEPSTSTRKHFTINDFEIGRPLGRGKFGRVYLARLKENHFIVAL
                     KVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYNYFYDDTRIYLILEYAPGGELY
                     KELQRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKPENLLLGLNGEVKISDFGW
                     SVHTPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGKPPFESSTSS
                     ETYRRIRQVDFKFPSSVPAGAQDLISKLLRYHPSERLSLAQVLKHPWVREHSRRVLPC
                     "
     exon            378..569
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /inference="alignment:Splign:2.1.0"
     exon            570..708
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /inference="alignment:Splign:2.1.0"
     exon            709..857
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1032
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1331
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /note="hexamer: ATTAAA"
     polyA_site      1331
                     /gene="Aurkc"
                     /gene_synonym="AIE1; AIK3; ARK-3; IAK3; Stk13"
                     /note="major polyA site"
ORIGIN      
        1 ctcttgagtg cggcagtgct agtggattac cagtgtgtgt gtcccgtgtg tccctgggtg
       61 ggtgagacat tccgggcggt tggggaggct ggagtcagag cgttacccgc ctaccctttt
      121 ccaggatcta agcaactagc aggacttcaa cttgccctca cctctttaga gttcagggaa
      181 gagtcacctc cttcgggctg ggcttcacac acaagtaaga ggtaggaaaa cccggaccga
      241 ctccaaagtg gtggcacgta tgagaaagat ccctgcaagc aggaggatga ggcagcagga
      301 tggggacagt tagaggtcac tgggatccgc agccaggggt tcgctactgg ccagatggag
      361 cccagcacct caaccaggaa gcatttcacc atcaatgact ttgaaatcgg gcgtcctctg
      421 ggcaggggga aatttgggcg tgtgtacttg gctcggctca aggaaaatca tttcatcgtg
      481 gccctgaagg tcctcttcaa gtctgagata gagaaggagg gattggagca ccaacttcgc
      541 agggaagtgg agatccaggc acacctacaa caccggaaca tccttcgcct gtacaactac
      601 ttctatgatg acactcggat atacttaatt ctggagtatg ctccaggagg agagctctat
      661 aaggagcttc agagacatca gaagttggac cagcagcgta cagccacgat aatacaggag
      721 ttgtcagatg ccctgaccta ctgccatgag aagaaggtga ttcacaggga catcaagcca
      781 gagaatctcc tgctgggcct caatggtgag gtgaagatct cagactttgg gtggtctgtg
      841 cataccccct ctctcaggag aaagacaatg tgtgggactc tggactactt gcccccggaa
      901 atgatagcgc agaaaccgta caatgagatg gttgatctgt ggtgcattgg ggtgctctgc
      961 tatgagctgc tggtggggaa gccacccttt gagagcagca cctccagtga gacatacaga
     1021 cgcatccgcc aggtggattt taagtttcct tcatcagtac ctgcaggagc ccaggacttg
     1081 atctccaagc ttcttaggta ccatccttca gagcggctga gcctggccca ggtcctgaag
     1141 cacccctggg tcagggaaca ctctcgaagg gtgcttcctt gctagttcag gggtcttcct
     1201 gagccctgtc catctctatc cctatgtatt tcttcaggaa ggtctccagg ctctgtttgt
     1261 tagtgcatgt ggttcgcttg ttttctcttt tatgaagtga tgttaattaa aactgattat
     1321 tttagcatca a
//
