LOCUS       NM_011496               1981 bp    mRNA    linear   ROD 06-SEP-2023
DEFINITION  Mus musculus aurora kinase B (Aurkb), mRNA.
ACCESSION   NM_011496 XM_181344
VERSION     NM_011496.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1981)
  AUTHORS   Boogerd CJ, Perini I, Kyriakopoulou E, Han SJ, La P, van der Swaan
            B, Berkhout JB, Versteeg D, Monshouwer-Kloots J and van Rooij E.
  TITLE     Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP
            inhibition during cardiac maturation
  JOURNAL   Nat Commun 14 (1), 4716 (2023)
   PUBMED   37543677
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1981)
  AUTHORS   Wang Y, Elsherbiny A, Kessler L, Cordero J, Shi H, Serke H,
            Lityagina O, Trogisch FA, Mohammadi MM, El-Battrawy I, Backs J,
            Wieland T, Heineke J and Dobreva G.
  TITLE     Lamin A/C-dependent chromatin architecture safeguards naive
            pluripotency to prevent aberrant cardiovascular cell fate and
            function
  JOURNAL   Nat Commun 13 (1), 6663 (2022)
   PUBMED   36333314
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1981)
  AUTHORS   Berenguer I, Lopez-Jimenez P, Mena I, Viera A, Page J,
            Gonzalez-Martinez J, Maestre C, Malumbres M, Suja JA and Gomez R.
  TITLE     Haspin participates in AURKB recruitment to centromeres and
            contributes to chromosome congression in male mouse meiosis
  JOURNAL   J Cell Sci 135 (13) (2022)
   PUBMED   35694956
  REMARK    GeneRIF: Haspin participates in AURKB recruitment to centromeres
            and contributes to chromosome congression in male mouse meiosis.
REFERENCE   4  (bases 1 to 1981)
  AUTHORS   Gan P, Wang Z, Morales MG, Zhang Y, Bassel-Duby R, Liu N and Olson
            EN.
  TITLE     RBPMS is an RNA-binding protein that mediates cardiomyocyte
            binucleation and cardiovascular development
  JOURNAL   Dev Cell 57 (8), 959-973 (2022)
   PUBMED   35472321
REFERENCE   5  (bases 1 to 1981)
  AUTHORS   Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu
            T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G,
            Minichiello L and Kwon C.
  TITLE     Heart neurons use clock genes to control myocyte proliferation
  JOURNAL   Sci Adv 7 (49), eabh4181 (2021)
   PUBMED   34851661
REFERENCE   6  (bases 1 to 1981)
  AUTHORS   Giet R and Prigent C.
  TITLE     Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic
            serine-threonine kinases
  JOURNAL   J Cell Sci 112 (Pt 21), 3591-3601 (1999)
   PUBMED   10523496
  REMARK    Review article
REFERENCE   7  (bases 1 to 1981)
  AUTHORS   Shindo M, Nakano H, Kuroyanagi H, Shirasawa T, Mihara M, Gilbert
            DJ, Jenkins NA, Copeland NG, Yagita H and Okumura K.
  TITLE     cDNA cloning, expression, subcellular localization, and chromosomal
            assignment of mammalian aurora homologues, aurora-related kinase
            (ARK) 1 and 2
  JOURNAL   Biochem Biophys Res Commun 244 (1), 285-292 (1998)
   PUBMED   9514916
REFERENCE   8  (bases 1 to 1981)
  AUTHORS   Gopalan G, Gilbert DJ, Copeland NG, Jenkins NA and Donovan PJ.
  TITLE     Chromosome localization of two new mammalian kinases related to
            yeast and fly chromosome segregation-regulators
  JOURNAL   Mamm Genome 9 (1), 86-87 (1998)
   PUBMED   9434955
REFERENCE   9  (bases 1 to 1981)
  AUTHORS   Kimura M, Matsuda Y, Yoshioka T, Sumi N and Okano Y.
  TITLE     Identification and characterization of STK12/Aik2: a human gene
            related to aurora of Drosophila and yeast IPL1
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 147-152 (1998)
   PUBMED   9858806
REFERENCE   10 (bases 1 to 1981)
  AUTHORS   Niwa H, Abe K, Kunisada T and Yamamura K.
  TITLE     Cell-cycle-dependent expression of the STK-1 gene encoding a novel
            murine putative protein kinase
  JOURNAL   Gene 169 (2), 197-201 (1996)
   PUBMED   8647446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY005259.1, AK075951.1 and
            CO040997.1.
            
            [WARNING] On Nov 16, 2023 this sequence was replaced by
            NM_011496.3.
            
            On Sep 17, 2015 this sequence version replaced NM_011496.1.
            
            Summary: This gene encodes a member of the aurora kinase subfamily
            of serine/threonine kinases. The genes encoding the other two
            members of this subfamily are located on chromosomes 2 and 7. These
            kinases participate in the regulation of alignment and segregation
            of chromosomes during mitosis and meiosis through association with
            microtubules. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003261.1, AK132006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY005259.1         2-42
            42-1963             AK075951.1         2-1923
            1964-1981           CO040997.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1981
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.32 cM"
     gene            1..1981
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /note="aurora kinase B"
                     /db_xref="GeneID:20877"
                     /db_xref="MGI:MGI:107168"
     exon            1..372
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1362
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 12; aurora-related kinase
                     2; serine/threonine-protein kinase 12; ARK-2; aurora 1;
                     aurora/IPL1-related kinase 2; serine/threonine-protein
                     kinase 5; serine/threonine-protein kinase aurora-B; aurora
                     B; serine/threonine kinase 5; aurora- and IPL1-like
                     midbody-associated protein 1"
                     /codon_start=1
                     /product="aurora kinase B"
                     /protein_id="NP_035626.1"
                     /db_xref="CCDS:CCDS24877.1"
                     /db_xref="GeneID:20877"
                     /db_xref="MGI:MGI:107168"
                     /translation="MAQKENAYPWPYGSKTSQSGLNTLSQRVLRKEPATTSALALVNR
                     FNSQSTAAPGQKLAENKSQGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREK
                     KSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILE
                     YAPRGELYKELQKSRTFDEQRTATIMEELSDALTYCHKKKVIHRDIKPENLLLGLQGE
                     LKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNP
                     PFESPSHSETYRRIVKVDLKFPSSVPSGAQDLISKLLKHNPWQRLPLAEVAAHPWVRA
                     NSRRVLPPSAL"
     exon            373..475
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /inference="alignment:Splign:2.1.0"
     exon            476..545
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /inference="alignment:Splign:2.1.0"
     exon            546..737
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /inference="alignment:Splign:2.1.0"
     exon            738..876
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1025
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1200
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1965
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1935..1940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
     polyA_site      1965
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
ORIGIN      
        1 agagcgggag attcgaaagc gtccgggtcg cggggtaaac cggttctccg tgtgcgagcg
       61 cctagtggcg taggctgcgg ctttgcgggg aactgcgggg gctgcagtgg tccacggggc
      121 tgatcgggtt ccgttgggcg gatccacgtg cccgctatcc gcctggaagg agaggtgcag
      181 gagtaccccc gaccttggct gcgtgctgac tcgcttcctt ctgcccgccc aggcttgcac
      241 tccccgggga tctgcctctg catctcttgc cttcgctgtt gtttccctct ctgtccagct
      301 cccctcccgc tctcgccctg gagaatggct cagaaggaga acgcctaccc gtggccctac
      361 ggctcaaaga cgtctcagtc tggcctgaac acgttgtccc agagagtcct acggaaggag
      421 cccgccacga catctgcgct tgctctcgtg aaccggttca acagccagtc cacagctgcc
      481 cctggccaga agttggctga gaacaagagt cagggctcca ctgcctcgca aggatcccag
      541 aacaagcagc ctttcactat tgacaacttt gagattgggc gtcctttggg caaaggcaaa
      601 tttggaaacg tgtacttggc tcgggagaag aagagccgtt tcatcgtggc actcaagatc
      661 ctcttcaagt ctcagattga gaaggagggg gtagagcacc agcttcgccg agagatcgaa
      721 atccaggcgc acctgaaaca tcccaacatc cttcaactct acaactactt ctacgaccag
      781 cagaggatct acttaatcct ggaatacgcc cctcgcgggg aactctacaa ggaactgcag
      841 aagagtcgga ccttcgatga gcagcggact gccacgatca tggaggaact gtcagatgcc
      901 ctgacctact gccacaagaa gaaggtaatt cacagagaca taaagccgga gaacctgctg
      961 ttaggtctgc agggagaact gaagattgca gactttggct ggtcggtgca tgccccatcc
     1021 ctgaggagga agaccatgtg cggcacgctg gactatctgc ccccagagat gattgagggg
     1081 cgcatgcata atgaaatggt agatctatgg tgcatcgggg tgctctgcta tgaactgatg
     1141 gtggggaacc cacccttcga gagccctagc cacagtgaga cgtatcgtcg gattgtcaag
     1201 gtggacctga agttcccctc ttctgtgcct tcgggcgccc aggacctcat ctccaagctg
     1261 ctcaaacata acccctggca acggctgccc ctggcggagg ttgcagctca cccttgggtc
     1321 cgggccaact caaggagggt tctgcctccc tctgcccttt agcctgctcc ttggtttttt
     1381 gtccctgtca tttttcagtg ttctttgtat gtctgtgtat gtgttctgag aaggggtggg
     1441 aactggaaac tattcctagc tccagttcta ggggatctga tctctcttct gacctctaca
     1501 ggcaaaatta ggcacccctg tggtgcacat atatgcacac caaacacatg aagttacaaa
     1561 caaacaacaa acacacagat agtgctggag agatggctcg gtagttaaaa gcactggctg
     1621 ctcttcccag gaacctagaa ctcaattcta gcactacatg gtgctcacga ccactgtctg
     1681 taacacccag tcctggggaa tctggggcct tcgagcctct gcagacacta ggcatggatg
     1741 tggtatacat gtatgcaggc aaaacaccca tgcactgact tttaagaaac cctctagtct
     1801 gattcctttc aatttgtcaa atgttgaatg ttatttttaa aatattataa gccatttaat
     1861 acaatttttc tttgaaacat ggtatagcct agtctgtctt aaattcagaa aaattatgaa
     1921 gaacaacatt ttataataaa gtcttaaatg tttcatgttt ttgaaaaaaa aaaaaaaaaa
     1981 a
//
