LOCUS       NP_035626                345 aa            linear   ROD 12-JUN-2025
DEFINITION  aurora kinase B isoform 1 [Mus musculus].
ACCESSION   NP_035626 XP_181344
VERSION     NP_035626.1
DBSOURCE    REFSEQ: accession NM_011496.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 345)
  AUTHORS   Blengini,C.S., Vaskovicova,M., Schier,J., Drutovic,D. and
            Schindler,K.
  TITLE     Spatio-temporal requirements of Aurora kinase A in mouse oocyte
            meiotic spindle building
  JOURNAL   iScience 27 (8), 110451 (2024)
   PUBMED   39081293
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 345)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 345)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   4  (residues 1 to 345)
  AUTHORS   Vial,Y., Nardelli,J., Bonnard,A.A., Rousselot,J., Souyri,M.,
            Gressens,P., Cave,H. and Drunat,S.
  TITLE     Mcph1, mutated in primary microcephaly, is also crucial for
            erythropoiesis
  JOURNAL   EMBO Rep 25 (5), 2418-2440 (2024)
   PUBMED   38605277
REFERENCE   5  (residues 1 to 345)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 345)
  AUTHORS   Giet,R. and Prigent,C.
  TITLE     Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic
            serine-threonine kinases
  JOURNAL   J Cell Sci 112 (Pt 21), 3591-3601 (1999)
   PUBMED   10523496
  REMARK    Review article
REFERENCE   7  (residues 1 to 345)
  AUTHORS   Shindo,M., Nakano,H., Kuroyanagi,H., Shirasawa,T., Mihara,M.,
            Gilbert,D.J., Jenkins,N.A., Copeland,N.G., Yagita,H. and Okumura,K.
  TITLE     cDNA cloning, expression, subcellular localization, and chromosomal
            assignment of mammalian aurora homologues, aurora-related kinase
            (ARK) 1 and 2
  JOURNAL   Biochem Biophys Res Commun 244 (1), 285-292 (1998)
   PUBMED   9514916
REFERENCE   8  (residues 1 to 345)
  AUTHORS   Gopalan,G., Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and
            Donovan,P.J.
  TITLE     Chromosome localization of two new mammalian kinases related to
            yeast and fly chromosome segregation-regulators
  JOURNAL   Mamm Genome 9 (1), 86-87 (1998)
   PUBMED   9434955
REFERENCE   9  (residues 1 to 345)
  AUTHORS   Kimura,M., Matsuda,Y., Yoshioka,T., Sumi,N. and Okano,Y.
  TITLE     Identification and characterization of STK12/Aik2: a human gene
            related to aurora of Drosophila and yeast IPL1
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 147-152 (1998)
   PUBMED   9858806
REFERENCE   10 (residues 1 to 345)
  AUTHORS   Niwa,H., Abe,K., Kunisada,T. and Yamamura,K.
  TITLE     Cell-cycle-dependent expression of the STK-1 gene encoding a novel
            murine putative protein kinase
  JOURNAL   Gene 169 (2), 197-201 (1996)
   PUBMED   8647446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645902.6.
            
            On Sep 3, 2004 this sequence version replaced XP_181344.1.
            
            Summary: This gene encodes a member of the aurora kinase subfamily
            of serine/threonine kinases. The genes encoding the other two
            members of this subfamily are located on chromosomes 2 and 7. These
            kinases participate in the regulation of alignment and segregation
            of chromosomes during mitosis and meiosis through association with
            microtubules. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003261.1, AK075951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.32 cM"
     Protein         1..345
                     /product="aurora kinase B isoform 1"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 12; aurora-related kinase
                     2; serine/threonine-protein kinase 12; ARK-2; aurora 1;
                     aurora/IPL1-related kinase 2; serine/threonine-protein
                     kinase 5; serine/threonine-protein kinase aurora-B; aurora
                     B; serine/threonine kinase 5; aurora- and IPL1-like
                     midbody-associated protein 1"
                     /calculated_mol_wt=39253
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70126.2)"
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96GD4; propagated from
                     UniProtKB/Swiss-Prot (O70126.2)"
     Region          50..77
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70126.2)"
     Site            62
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96GD4; propagated from
                     UniProtKB/Swiss-Prot (O70126.2)"
     Region          77..344
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(88..91,94,96,109,111,143,159..162,205,209..210,212,
                     222..223)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Site            220
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96GD4; propagated from
                     UniProtKB/Swiss-Prot (O70126.2)"
     Site            232
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96GD4; propagated from
                     UniProtKB/Swiss-Prot (O70126.2)"
     Site            237
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q96GD4; propagated from
                     UniProtKB/Swiss-Prot (O70126.2)"
     CDS             1..345
                     /gene="Aurkb"
                     /gene_synonym="Aik2; AIM-1; Aim1; AIRK2; Ark2; AurB; IPL1;
                     STK-1; Stk12; Stk5"
                     /coded_by="NM_011496.3:311..1348"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24877.1"
                     /db_xref="GeneID:20877"
                     /db_xref="MGI:MGI:107168"
ORIGIN      
        1 maqkenaypw pygsktsqsg lntlsqrvlr kepattsala lvnrfnsqst aapgqklaen
       61 ksqgstasqg sqnkqpftid nfeigrplgk gkfgnvylar ekksrfival kilfksqiek
      121 egvehqlrre ieiqahlkhp nilqlynyfy dqqriylile yaprgelyke lqksrtfdeq
      181 rtatimeels daltychkkk vihrdikpen lllglqgelk iadfgwsvha pslrrktmcg
      241 tldylppemi egrmhnemvd lwcigvlcye lmvgnppfes pshsetyrri vkvdlkfpss
      301 vpsgaqdlis kllkhnpwqr lplaevaahp wvransrrvl ppsal
//
