LOCUS       NM_025338               1209 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus aurora kinase A interacting protein 1 (Aurkaip1),
            mRNA.
ACCESSION   NM_025338
VERSION     NM_025338.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1209)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1209)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 1209)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   4  (bases 1 to 1209)
  AUTHORS   Lim,S.K. and Gopalan,G.
  TITLE     Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A
            degradation through an alternative ubiquitin-independent pathway
  JOURNAL   Biochem J 403 (1), 119-127 (2007)
   PUBMED   17125467
  REMARK    GeneRIF: There exists an Ub-independent alternative pathway that
            promotesAurora-A degradation and AURKAIP1 promotes Aurora-A
            degradation through this Ub-independent yet proteasome-dependent
            pathway.
REFERENCE   5  (bases 1 to 1209)
  AUTHORS   Kiat,L.S., Hui,K.M. and Gopalan,G.
  TITLE     Aurora-A kinase interacting protein (AIP), a novel negative
            regulator of human Aurora-A kinase
  JOURNAL   J Biol Chem 277 (47), 45558-45565 (2002)
   PUBMED   12244051
REFERENCE   6  (bases 1 to 1209)
  AUTHORS   Bachmanov,A.A., Li,X., Reed,D.R., Ohmen,J.D., Li,S., Chen,Z.,
            Tordoff,M.G., de Jong,P.J., Wu,C., West,D.B., Chatterjee,A.,
            Ross,D.A. and Beauchamp,G.K.
  TITLE     Positional cloning of the mouse saccharin preference (Sac) locus
  JOURNAL   Chem Senses 26 (7), 925-933 (2001)
   PUBMED   11555487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX233396.1, AL670236.9 and AK003442.1.
            
            On Dec 16, 2011 this sequence version replaced NM_025338.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166049.1, AK002737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               CX233396.1         1-312
            313-425             AL670236.9         138171-138283
            426-1168            AK003442.1         50-792
            1169-1209           AL670236.9         139648-139688
FEATURES             Location/Qualifiers
     source          1..1209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.55 cM"
     gene            1..1209
                     /gene="Aurkaip1"
                     /gene_synonym="0610033H09Rik; Aip; Akip; MRP-S38"
                     /note="aurora kinase A interacting protein 1"
                     /db_xref="GeneID:66077"
                     /db_xref="MGI:MGI:1913327"
     exon            1..467
                     /gene="Aurkaip1"
                     /gene_synonym="0610033H09Rik; Aip; Akip; MRP-S38"
                     /inference="alignment:Splign:2.1.0"
     exon            468..555
                     /gene="Aurkaip1"
                     /gene_synonym="0610033H09Rik; Aip; Akip; MRP-S38"
                     /inference="alignment:Splign:2.1.0"
     CDS             501..1103
                     /gene="Aurkaip1"
                     /gene_synonym="0610033H09Rik; Aip; Akip; MRP-S38"
                     /note="aurora kinase A-interacting protein;
                     AURKA-interacting protein; Aurora-A kinase interacting
                     protein; 28S ribosomal protein S38, mitochondrial"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS38"
                     /protein_id="NP_079614.1"
                     /db_xref="CCDS:CCDS19043.1"
                     /db_xref="GeneID:66077"
                     /db_xref="MGI:MGI:1913327"
                     /translation="MFLARLTSRLARTVVPWAGFSRSCPGSGVIGSYAFRPLYSLQPA
                     SPSRAASLPGKRTQSELEEFLVPRKMAISPLESWLTAQYLLPRRNVEVPVTLAPSQFY
                     ECPPRQGEEEAQQGVREAWDATPVQCKNVLKIRRRKMNHHKYRKLVKRTRFLRRKVRE
                     GRLKKKQIKFEKDLKRIWLKAGLKEAPENWQTPKIYLKNK"
     exon            556..1001
                     /gene="Aurkaip1"
                     /gene_synonym="0610033H09Rik; Aip; Akip; MRP-S38"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1209
                     /gene="Aurkaip1"
                     /gene_synonym="0610033H09Rik; Aip; Akip; MRP-S38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1151..1156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aurkaip1"
                     /gene_synonym="0610033H09Rik; Aip; Akip; MRP-S38"
                     /note="hexamer: AATAAA"
     polyA_site      1180
                     /gene="Aurkaip1"
                     /gene_synonym="0610033H09Rik; Aip; Akip; MRP-S38"
                     /note="major polyA site"
ORIGIN      
        1 gcctatccca caggactatt aaacgacctg ccgccctaac aggaggagcg ccacttgtca
       61 cttccgcagt cctacggtcc atggcggtac ccggaggcta accggcttgg gagagacgaa
      121 aggaaaaaaa tatatatata tatactgtaa agtccgcgtg cacgcagaga gcactctccg
      181 ggattgtggt gggtgtcggg tgtgggcact ttttacccgg aacgttgttg ctgctggaca
      241 acagcggcag gggaagcgtc ccctccaacc ggaagcgatc gccttcgggc acgcaaggat
      301 cgagttagcg cagagccggg caccagaggg cgctgcgtag gaccagggac cggaagtggt
      361 cgaggtcaga ggcgacctga tcggtcctaa cttccgggat tcggtgggcc tgttgcgggg
      421 ctcagatgat gagcggcggc ggagctcgct tggcctgcgt ctgtttgctt tgagcgctgc
      481 cgccggacca actgctcacc atgttcctgg cgcgcctgac ttcacggctg gccaggactg
      541 ttgttccctg ggcaggtttc agtcgttcct gccctggctc cggggtgatt ggcagctatg
      601 cttttcgacc cctttacagt ttgcagcctg caagcccaag tcgggctgcc tccctccctg
      661 gtaagaggac ccagtcagag cttgaggagt tcctggtccc caggaagatg gccatcagtc
      721 ctctagagag ctggctgact gctcaatact tattgcccag acggaatgtc gaggtcccag
      781 tgactctggc tccctcccag ttctacgaat gtccacctag gcagggggag gaggaagccc
      841 agcagggagt cagggaagcc tgggatgcca ctccagtgca gtgcaaaaac gtgctgaaga
      901 tccgaaggcg aaagatgaac caccacaagt accgtaaact ggtcaaaagg acccggtttc
      961 tacgtcgcaa ggtccgggaa ggacgtttga agaagaagca gatcaaattt gagaaagact
     1021 tgaagcgcat ctggcttaag gcaggcctga aggaagcccc tgagaactgg cagaccccga
     1081 agatctacct gaagaacaaa taatctgggt tcctgtccct ctggctctct tgctgcttct
     1141 gacccactat aataaatatt ggaaggactc aattattcta ggccgaccta gagtttcttt
     1201 ggcttggtg
//
